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Chemistry

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Also known as: 1800046-95-0, Gs-syk, Lanraplenib [inn], Lanraplenib [usan], Lanraplenib (gs-9876), A6u64ou57e
Molecular Formula
C23H25N9O
Molecular Weight
443.5  g/mol
InChI Key
XCIGZBVOUQVIPI-UHFFFAOYSA-N
FDA UNII
A6U64OU57E

Lanraplenib
Lanraplenib is an orally available inhibitor of spleen tyrosine kinase (Syk), with potential immunomodulating and antineoplastic activities. Upon oral administration, lanraplenib binds to and inhibits the activity of Syk. This inhibits B-cell receptor (BCR) signaling, which leads to the inhibition of B-cell activation, and prevents tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies; it plays a key role in B-cell receptor signaling.
1 2D Structure

Lanraplenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-(6-aminopyrazin-2-yl)-N-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine
2.1.2 InChI
InChI=1S/C23H25N9O/c24-21-12-25-11-19(28-21)20-13-32-6-5-26-23(32)22(29-20)27-16-1-3-17(4-2-16)30-7-9-31(10-8-30)18-14-33-15-18/h1-6,11-13,18H,7-10,14-15H2,(H2,24,28)(H,27,29)
2.1.3 InChI Key
XCIGZBVOUQVIPI-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCN1C2COC2)C3=CC=C(C=C3)NC4=NC(=CN5C4=NC=C5)C6=CN=CC(=N6)N
2.2 Other Identifiers
2.2.1 UNII
A6U64OU57E
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 1800046-95-0

2. Gs-syk

3. Lanraplenib [inn]

4. Lanraplenib [usan]

5. Lanraplenib (gs-9876)

6. A6u64ou57e

7. 6-(6-aminopyrazin-2-yl)-n-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]imidazo[1,2-a]pyrazin-8-amine

8. Gs-9876

9. 6-(6-amino-2-pyrazinyl)-n-[4-[4-(3-oxetanyl)-1-piperazinyl]phenyl]-imidazo[1,2-a]

10. 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine

11. 6-(6-amino-2-pyrazinyl)-n-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)imidazo(1,2-a)pyrazin-8-amine

12. Imidazo(1,2-a)pyrazin-8-amine, 6-(6-amino-2-pyrazinyl)-n-(4-(4-(3-oxetanyl)-1-piperazinyl)phenyl)-

13. 6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine

14. Gs-syk?

15. Lanraplenib (usan/inn)

16. Lanraplenib [usan:inn]

17. Unii-a6u64ou57e

18. Lanraplenib [who-dd]

19. Gtpl9764

20. Chembl3986824

21. Schembl16820581

22. Example 2 [us9290505]

23. Bdbm212271

24. Bcp30292

25. Ex-a3747

26. Gs9876

27. S9715

28. Who 10601

29. Db14770

30. Gs-9876gs-9876

31. Ex.-2, Us9290505

32. Us9290505, Ex.-2

33. Compound 39 [pmid: 32292557]

34. Ac-36571

35. Hy-109091

36. Cs-0039383

37. C92666

38. D11596

39. Gs-9876; Gs9876; Gs 9876

40. 6-(6-aminopyrazin-2-yl)-n-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazol[1,2-a]pyrazin-8-amine

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 443.5 g/mol
Molecular Formula C23H25N9O
XLogP31.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass443.21820645 g/mol
Monoisotopic Mass443.21820645 g/mol
Topological Polar Surface Area110 Ų
Heavy Atom Count33
Formal Charge0
Complexity635
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Lanraplenib Manufacturers

A Lanraplenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lanraplenib, including repackagers and relabelers. The FDA regulates Lanraplenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lanraplenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lanraplenib Suppliers

A Lanraplenib supplier is an individual or a company that provides Lanraplenib active pharmaceutical ingredient (API) or Lanraplenib finished formulations upon request. The Lanraplenib suppliers may include Lanraplenib API manufacturers, exporters, distributors and traders.

Lanraplenib GMP

Lanraplenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lanraplenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lanraplenib GMP manufacturer or Lanraplenib GMP API supplier for your needs.

Lanraplenib CoA

A Lanraplenib CoA (Certificate of Analysis) is a formal document that attests to Lanraplenib's compliance with Lanraplenib specifications and serves as a tool for batch-level quality control.

Lanraplenib CoA mostly includes findings from lab analyses of a specific batch. For each Lanraplenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lanraplenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Lanraplenib EP), Lanraplenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lanraplenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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