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Laureth 4

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ACTIVE PHARMA INGREDIENTS

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FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 3 Europe

3 FDF Dossiers
3 Europe

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Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

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Chemistry

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Also known as: 4536-30-5, Ethylene glycol monododecyl ether, 2-dodecoxyethanol, Ethanol, 2-(dodecyloxy)-, Lauryl ethoxylate, Laureth-1

Molecular Formula

C₁₄H₃₀O₂

Molecular Weight

230.39 g/mol

InChI Key

SFNALCNOMXIBKG-UHFFFAOYSA-N

FDA UNII

J89TKQ5R54

An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12??14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.

1 2D Structure

2-Dodecoxyethanol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-dodecoxyethanol

2.1.2 InChI

InChI=1S/C14H30O2/c1-2-3-4-5-6-7-8-9-10-11-13-16-14-12-15/h15H,2-14H2,1H3

2.1.3 InChI Key

SFNALCNOMXIBKG-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCCCCCCCCCCCOCCO

2.2 Other Identifiers

2.2.1 UNII

J89TKQ5R54

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aethoxysclerol

2. Aethoxysklerol

3. Aetoxisclerol

4. Alpha-dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl)

5. Atossisclerol

6. Atoxysclerol

7. Brij 30

8. Brij-30

9. Brij30

10. Dodecyl Ethyleneglycol Monoether

11. Dodecyl Ethyleneglycol Monoethers

12. Ether, Nonaethyleneglycol Monododecyl

13. Ether, Polyethylene Glycol-7-lauryl

14. Ether, Polyoxyethylene 9-lauryl

15. Ether, Polyoxyethylene Lauryl

16. Ether, Polyoxyethylene-4-dodecyl

17. Ether, Tetraethyleneglycol Lauryl

18. Ethoxysclerol

19. Ethyleneglycol Monoether, Dodecyl

20. Hydroxypolyethoxydodecane

21. Laureth

22. Laureth 1

23. Laureth 4

24. Laureth 7

25. Laureth 9

26. Laureth-1

27. Laureth-4

28. Laureth-7

29. Laureth-9

30. Laureths

31. Lauromacrogol

32. Lauromacrogol 400

33. Lauromacrogols

34. Lauryl Ether, Tetraethyleneglycol

35. Lubrol 12a9

36. Lubrol Px

37. Lubrol-px

38. Monododecyl Ether, Nonaethyleneglycol

39. Monoether, Dodecyl Ethyleneglycol

40. Nonaethylene Glycol Monododecyl Ether

41. Nonaethyleneglycol Monododecyl Ether

42. Nonaethyleneglycol Monododecyl Ethers

43. Polidocanol

44. Polidocanols

45. Polyethylene Glycol 7 Lauryl Ether

46. Polyethylene Glycol Monododecyl Ether

47. Polyethylene Glycol-7-lauryl Ether

48. Polyethylene Glycol-7-lauryl Ethers

49. Polyoxyethylene 4 Dodecyl Ether

50. Polyoxyethylene 9 Lauryl Ether

51. Polyoxyethylene 9-lauryl Ether

52. Polyoxyethylene 9-lauryl Ethers

53. Polyoxyethylene Lauryl Ether

54. Polyoxyethylene Lauryl Ethers

55. Polyoxyethylene(4) Lauryl Ether

56. Polyoxyethylene-4-dodecyl Ether

57. Polyoxyethylenedodecyl Ether

58. Polyoxyethylenedodecyl Ethers

59. Tetraethylene Glycol Dodecyl Ether

60. Tetraethyleneglycol Lauryl Ether

61. Tetraethyleneglycol Lauryl Ethers

62. Thesit

2.3.2 Depositor-Supplied Synonyms

1. 4536-30-5

2. Ethylene Glycol Monododecyl Ether

3. 2-dodecoxyethanol

4. Ethanol, 2-(dodecyloxy)-

5. Lauryl Ethoxylate

6. Laureth-1

7. Lauryl Monoethoxylate

8. Laureth 4

9. Aetoxisclerol

10. Atossisclerol

11. Ethoxysclerol

12. Lipocol L-1

13. Ethylene Glycol Monolauryl Ether

14. Lauryl Alcohol Oxy Ethanol

15. Ethoxylated Dodecyl Alcohol

16. 2-(dodecyloxy)ethan-1-ol

17. Dodecyl Ethyleneglycol Monoether

18. Ethylene Glycol Mono-n-dodecyl Ether

19. 2-hydroxyethyl Lauryl Ether

20. Ethylene Glycol Dodecyl Ether

21. J89tkq5r54

22. Chebi:78770

23. Aethoxysklerol

24. Laureth

25. Dsstox_cid_5218

26. Dsstox_rid_80389

27. Dsstox_gsid_44676

28. Lubrol 12a9

29. Cimagel

30. Hydroxypolyethoxydodecane

31. Ethanol,2-(dodecyloxy)-

32. Slovasol S

33. Rokanol L

34. Romopal Ln

35. Polyoxyethylenedodecyl Ether

36. Lubrol Px

37. Nikkol Bl

38. Aldosperse L 9

39. Actinol L3

40. Alkasurf Lan 1

41. Alkasurf Lan 3

42. Carsonol L 2

43. Carsonol L 3

44. Chimipal Ae 3

45. Actinol L 7

46. Laureth-11

47. Lauromacrogol 400

48. Noniolite Al 20

49. Texofor B 9

50. 40l (polyether)

51. Cas-4536-30-5

52. Adeka Carpol M 2

53. Akyporox Rlm 40

54. Ethosperse La 12

55. Ethosperse La 23

56. Mergital Lm 11

57. Polyoxyethylene 9-lauryl Ether

58. Simulsol P 23

59. Dodecanol, Ethoxylate

60. Bl 9 (polyglycol)

61. Peg-1 Lauryl Ether

62. Pegnol L 12

63. Akyporox Rlm 160

64. Akyporox Rlm 230

65. Noigen Et 160

66. Adekatol La 1275

67. Arapol 0712

68. Newcol 1203

69. Peg-11 Lauryl Ether

70. Nonaethyleneglycol Monododecyl Ether

71. Einecs 224-886-5

72. Ethoxylated Lauryl Alcohol

73. Adeka Carpol Mbf 100

74. Brn 1748129

75. Unii-j89tkq5r54

76. Ai3-09524

77. Polyoxyethylene Dodecyl Mono Ether

78. Varithena (tn)

79. Alpha-dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl)

80. Asclera (tn)

81. Polidocanol (jan)

82. Dodecyl Alcohol Polyoxyethylene Ether

83. Mfcd00042657

84. Brij35

85. Laureth- 23

86. 2-dodecyloxy-ethanol

87. Aethoxysklerol (tn)

88. Glycols, Polyethylene, Monododecyl Ether

89. Laureth 4 (usan)

90. Laureth 9 (usan)

91. Lipocol L1

92. Nikkol Bl 1sy

93. Alpha-dodecyl-omega-hydroxypoly(oxyethylene)

94. Bmse000753

95. Brij 30 (tn)

96. Ethoxylated Lauryl Alcohols

97. Laureth-1 [inci]

98. Schembl77030

99. 4-01-00-02386 (beilstein Handbook Reference)

100. Alpha-dodecyl-omega-hydroxypoly(oxy-1,2-ethanediyl)

101. Polyoxyethylene 23 Lauryl Ether

102. Chembl1201751

103. Dtxsid8044676

104. Poly(oxy-1,2-ethanediyl), Alpha-dodecyl-omega-hydroxy-

105. Chebi:31765

106. Zinc8437287

107. Tox21_113966

108. Tox21_301593

109. Stl452914

110. Akos024390811

111. Fp-0044

112. Ncgc00256261-01

113. Ncgc00274074-01

114. Monoethylene Glycol Monododecyl Ether

115. Cs-0310513

116. E0264

117. Ft-0722559

118. D01539

119. D01993

120. N-

121. A-z-n-

122. A-fmoc-l-2,4-diaminobutyric Acid

123. T72486

124. A902917

125. Q377036

126. Sr-01000944887

127. Sr-01000944887-1

128. Ethylene Glycol Monododecyl Ether, Bioxtra, >=99.0% (gc)

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₃₀O₂
Molecular Weight	230.39 g/mol
XLogP3	5.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	13
Exact Mass	230.224580195 g/mol
Monoisotopic Mass	230.224580195 g/mol
Topological Polar Surface Area	29.5 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	115
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	Varithena
PubMed Health	Polidocanol (Injection)
Drug Classes	Sclerosing Agent
Active Ingredient	Polidocanol
Dosage Form	Solution
Route	Intravenous
Strength	180mg/18ml (10mg/ml)
Market Status	Prescription
Company	Provensis

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Detergents

Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties. (See all compounds classified as Detergents.)

Sclerosing Solutions

Chemical agents injected into blood vessels and lymphatic sinuses to shrink or cause localized THROMBOSIS; FIBROSIS, and obliteration of the vessels. This treatment is applied in a number of conditions such as VARICOSE VEINS; HEMORRHOIDS; GASTRIC VARICES; ESOPHAGEAL VARICES; PEPTIC ULCER HEMORRHAGE. (See all compounds classified as Sclerosing Solutions.)

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