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Chemistry

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Also known as: 1632032-53-1, 0c1juu9s0l, Lb100, Lb 100, Empm, (1r,4s)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
Molecular Formula
C13H20N2O4
Molecular Weight
268.31  g/mol
InChI Key
JUQMLSGOTNKJKI-IZUQBHJASA-N
FDA UNII
0C1JUU9S0L

LB-100
Protein Phosphatase 2A Inhibitor LB-100 is a water soluble inhibitor of the protein phosphatase 2A (PP2A), with potential chemo- and radiotherapy enhancing activity. Upon injection, PP2A inhibitor LB-100 inhibits the removal of phosphate groups from proteins essential for cell cycle progression. When used with radio- or chemotherapy treatment, this agent prevents the activation of PP2A-mediated repair mechanisms and allows for malignant cells to progress through the cell cycle without having their damaged DNA repaired. This enhances the cytotoxic effect of the chemotherapeutic or radiotherapeutic agent and results in tumor cell apoptosis. PP2A, a serine/threonine phosphatase that plays a key role in the control of cell growth and DNA damage repair.
1 2D Structure

LB-100

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
2.1.2 InChI
InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H,2-7H2,1H3,(H,17,18)/t8-,9+,10?,11?/m0/s1
2.1.3 InChI Key
JUQMLSGOTNKJKI-IZUQBHJASA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C(=O)C2C3CCC(C2C(=O)O)O3
2.1.5 Isomeric SMILES
CN1CCN(CC1)C(=O)C2[C@@H]3CC[C@H](C2C(=O)O)O3
2.2 Other Identifiers
2.2.1 UNII
0C1JUU9S0L
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Lb100

2.3.2 Depositor-Supplied Synonyms

1. 1632032-53-1

2. 0c1juu9s0l

3. Lb100

4. Lb 100

5. Empm

6. (1r,4s)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic Acid

7. 3-((4-methylpiperazin-1-yl)carbonyl)-7-oxabicyclo(2.2.1)heptane-2-carboxylic Acid

8. 7-oxabicyclo(2.2.1)heptane-2-carboxylic Acid, 3-((4-methyl-1-piperazinyl)carbonyl)-, (1r,4s)-rel-

9. 7-oxabicyclo[2.2.1]heptane-2-carboxylic Acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1r,4s)-rel-

10. 3-[(4-methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic Acid

11. Unii-0c1juu9s0l

12. Schembl9880148

13. (1r,4s)-lb-100

14. Chembl4297300

15. Gtpl11105

16. Dtxsid201132163

17. Mfcd28167839

18. Db15412

19. Q27895894

20. (1r,4s)-3-[(4-methylpiperazin-1-yl)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic Acid

2.4 Create Date
2010-04-12
3 Chemical and Physical Properties
Molecular Weight 268.31 g/mol
Molecular Formula C13H20N2O4
XLogP3-3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass268.14230712 g/mol
Monoisotopic Mass268.14230712 g/mol
Topological Polar Surface Area70.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity392
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)


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ABOUT THIS PAGE

Looking for 1632032-53-1 / LB-100 API manufacturers, exporters & distributors?

LB-100 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of LB-100 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right LB-100 manufacturer or LB-100 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred LB-100 manufacturer or LB-100 supplier.

PharmaCompass also assists you with knowing the LB-100 API Price utilized in the formulation of products. LB-100 API Price is not always fixed or binding as the LB-100 Price is obtained through a variety of data sources. The LB-100 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

LB-100

Synonyms

1632032-53-1, 0c1juu9s0l, Lb100, Lb 100, Empm, (1r,4s)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Cas Number

1632032-53-1

Unique Ingredient Identifier (UNII)

0C1JUU9S0L

About LB-100

Protein Phosphatase 2A Inhibitor LB-100 is a water soluble inhibitor of the protein phosphatase 2A (PP2A), with potential chemo- and radiotherapy enhancing activity. Upon injection, PP2A inhibitor LB-100 inhibits the removal of phosphate groups from proteins essential for cell cycle progression. When used with radio- or chemotherapy treatment, this agent prevents the activation of PP2A-mediated repair mechanisms and allows for malignant cells to progress through the cell cycle without having their damaged DNA repaired. This enhances the cytotoxic effect of the chemotherapeutic or radiotherapeutic agent and results in tumor cell apoptosis. PP2A, a serine/threonine phosphatase that plays a key role in the control of cell growth and DNA damage repair.

LB 100 Manufacturers

A LB 100 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LB 100, including repackagers and relabelers. The FDA regulates LB 100 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LB 100 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

LB 100 Suppliers

A LB 100 supplier is an individual or a company that provides LB 100 active pharmaceutical ingredient (API) or LB 100 finished formulations upon request. The LB 100 suppliers may include LB 100 API manufacturers, exporters, distributors and traders.

LB 100 GMP

LB 100 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of LB 100 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right LB 100 GMP manufacturer or LB 100 GMP API supplier for your needs.

LB 100 CoA

A LB 100 CoA (Certificate of Analysis) is a formal document that attests to LB 100's compliance with LB 100 specifications and serves as a tool for batch-level quality control.

LB 100 CoA mostly includes findings from lab analyses of a specific batch. For each LB 100 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

LB 100 may be tested according to a variety of international standards, such as European Pharmacopoeia (LB 100 EP), LB 100 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LB 100 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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