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Chemistry

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Also known as: 146062-44-4, Leriglitazone, Hydroxy pioglitazone (m-iv), Min-102, Chebi:82937, Leriglitazone [usan]
Molecular Formula
C19H20N2O4S
Molecular Weight
372.4  g/mol
InChI Key
OXVFDZYQLGRLCD-UHFFFAOYSA-N
FDA UNII
K824X25AYA

Leriglitazone
Leriglitazone is under investigation in clinical trial NCT03917225 (A Clinical Study to Evaluate the Effect of MIN-102 on the Progression of Friedreich's Ataxia in Male and Female Patients).
1 2D Structure

Leriglitazone

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
2.1.2 InChI
InChI=1S/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)
2.1.3 InChI Key
OXVFDZYQLGRLCD-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3)O
2.2 Other Identifiers
2.2.1 UNII
K824X25AYA
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Leriglitazone

2.3.2 Depositor-Supplied Synonyms

1. 146062-44-4

2. Leriglitazone

3. Hydroxy Pioglitazone (m-iv)

4. Min-102

5. Chebi:82937

6. Leriglitazone [usan]

7. 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

8. K824x25aya

9. 2,4-thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-

10. 2,4-thiazolidinedione, 5-((4-(2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy)phenyl)methyl)-

11. Hydroxy Pioglitazone-d4 (m-iv) (deuterated)

12. Hydroxy Pioglitazone

13. 1-hydroxypioglitazone

14. Pioglitazone, Hydroxy

15. Leriglitazone [inn]

16. Leriglitazone (usan/inn)

17. Chembl1267

18. Unii-k824x25aya

19. Schembl4098326

20. Dtxsid30399914

21. Bdbm50530214

22. Who 10868

23. Zinc01482947

24. Akos015856344

25. Db15021

26. 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione

27. Hydroxy Pioglitazone (m-iv Metabolite)

28. Db-042820

29. Hy-117727

30. Cs-0067030

31. Ft-0643388

32. D11603

33. 062h444

34. U-91322

35. A1-01710

36. J-008187

37. Q27156475

38. 5-(4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione

39. 5-(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione

40. 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione

41. All-ambo-5-((4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)phenyl)methyl)-1,3-thiazole-2,4(3h,5h)-dione

2.4 Create Date
2005-09-13
3 Chemical and Physical Properties
Molecular Weight 372.4 g/mol
Molecular Formula C19H20N2O4S
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass372.11437830 g/mol
Monoisotopic Mass372.11437830 g/mol
Topological Polar Surface Area114 Ų
Heavy Atom Count26
Formal Charge0
Complexity496
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of adrenoleukodystrophy


5 Pharmacology and Biochemistry
5.1 Metabolism/Metabolites

5-[(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione is a known human metabolite of Pioglitazone.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


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ABOUT THIS PAGE

Leriglitazone Manufacturers

A Leriglitazone manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Leriglitazone, including repackagers and relabelers. The FDA regulates Leriglitazone manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Leriglitazone API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Leriglitazone Suppliers

A Leriglitazone supplier is an individual or a company that provides Leriglitazone active pharmaceutical ingredient (API) or Leriglitazone finished formulations upon request. The Leriglitazone suppliers may include Leriglitazone API manufacturers, exporters, distributors and traders.

Leriglitazone GMP

Leriglitazone Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Leriglitazone GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Leriglitazone GMP manufacturer or Leriglitazone GMP API supplier for your needs.

Leriglitazone CoA

A Leriglitazone CoA (Certificate of Analysis) is a formal document that attests to Leriglitazone's compliance with Leriglitazone specifications and serves as a tool for batch-level quality control.

Leriglitazone CoA mostly includes findings from lab analyses of a specific batch. For each Leriglitazone CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Leriglitazone may be tested according to a variety of international standards, such as European Pharmacopoeia (Leriglitazone EP), Leriglitazone JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Leriglitazone USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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