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    Chemistry

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    Also known as: Calcium folinate, Calcium citrovorum factor, Folinic acid calcium salt, Folinic acid-sf, calcium salt, (+)-l-folinic acid, calcium salt, 1492-18-8
    Molecular Formula
    C20H23CaN7O7+2
    Molecular Weight
    513.5  g/mol
    InChI Key
    KVUAALJSMIVURS-ZEDZUCNESA-N
    Calcium Folinate
    The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
    1 2D Structure

    Calcium Folinate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
    2.1.2 InChI
    InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/t12?,13-;/m0./s1
    2.1.3 InChI Key
    KVUAALJSMIVURS-ZEDZUCNESA-N
    2.1.4 Canonical SMILES
    C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.[Ca+2]
    2.1.5 Isomeric SMILES
    C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.[Ca+2]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. 5 Formyltetrahydrofolate

    2. 5 Formyltetrahydropteroylglutamate

    3. 5-formyltetrahydrofolate

    4. 5-formyltetrahydropteroylglutamate

    5. Acid, Folinic

    6. Calcium Folinate

    7. Citrovorum Factor

    8. Factor, Citrovorum

    9. Folinate, Calcium

    10. Folinic Acid

    11. Folinic Acid Sf

    12. Folinic Acid-sf

    13. Leucovorin

    14. Leucovorin, (d)-isomer

    15. Leucovorin, (dl)-isomer

    16. Leucovorin, (r)-isomer

    17. Leucovorin, Calcium

    18. Leucovorin, Calcium (1:1) Salt

    19. Leucovorin, Calcium (1:1) Salt, (dl)-isomer

    20. Leucovorin, Calcium (1:1) Salt, Pentahydrate

    21. Leucovorin, Monosodium Salt

    22. Leukovorin

    23. Leukovorum

    24. Monosodium Salt Leucovorin

    25. N(5)-formyltetrahydrofolate

    26. Wellcovorin

    2.2.2 Depositor-Supplied Synonyms

    1. Calcium Folinate

    2. Calcium Citrovorum Factor

    3. Folinic Acid Calcium Salt

    4. Folinic Acid-sf, Calcium Salt

    5. (+)-l-folinic Acid, Calcium Salt

    6. 1492-18-8

    7. Nsc3590

    8. Sr-05000001662

    9. Pharmakon1600-01500364

    10. Nsc757083

    11. Nsc-757083

    12. Sr-05000001662-1

    13. Sr-05000001662-2

    14. Glutamic Acid,6,7,8-tetrahydro-4-hydroxy-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), L-

    15. L-glutamic Acid,4,5,6,7,8-hexahydro-4-oxo-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), (s)-

    2.3 Create Date
    2019-01-15
    3 Chemical and Physical Properties
    Molecular Weight 513.5 g/mol
    Molecular Formula C20H23CaN7O7+2
    Hydrogen Bond Donor Count7
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count9
    Exact Mass513.1284869 g/mol
    Monoisotopic Mass513.1284869 g/mol
    Topological Polar Surface Area216 Ų
    Heavy Atom Count35
    Formal Charge2
    Complexity911
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antidotes

    Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)

    Vitamin B Complex

    A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

    4.2 ATC Code

    V - Various

    V03 - All other therapeutic products

    V03A - All other therapeutic products

    V03AF - Detoxifying agents for antineoplastic treatment

    V03AF03 - Calcium folinate

    API Reference Price

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    22-Sep-2021
    31-Dec-2024
    KGS
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    ABOUT THIS PAGE

    Looking for 1492-18-8 / Calcium Folinate API manufacturers, exporters & distributors?

    Calcium Folinate manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Calcium Folinate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Calcium Folinate manufacturer or Calcium Folinate supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Calcium Folinate manufacturer or Calcium Folinate supplier.

    PharmaCompass also assists you with knowing the Calcium Folinate API Price utilized in the formulation of products. Calcium Folinate API Price is not always fixed or binding as the Calcium Folinate Price is obtained through a variety of data sources. The Calcium Folinate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Calcium Folinate

    Synonyms

    Calcium citrovorum factor, Folinic acid calcium salt, Folinic acid-sf, calcium salt, (+)-l-folinic acid, calcium salt, 1492-18-8, Nsc3590

    Cas Number

    1492-18-8

    About Calcium Folinate

    The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

    Leucovorin Calcium Manufacturers

    A Leucovorin Calcium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Leucovorin Calcium, including repackagers and relabelers. The FDA regulates Leucovorin Calcium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Leucovorin Calcium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Leucovorin Calcium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Leucovorin Calcium Suppliers

    A Leucovorin Calcium supplier is an individual or a company that provides Leucovorin Calcium active pharmaceutical ingredient (API) or Leucovorin Calcium finished formulations upon request. The Leucovorin Calcium suppliers may include Leucovorin Calcium API manufacturers, exporters, distributors and traders.

    click here to find a list of Leucovorin Calcium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Leucovorin Calcium USDMF

    A Leucovorin Calcium DMF (Drug Master File) is a document detailing the whole manufacturing process of Leucovorin Calcium active pharmaceutical ingredient (API) in detail. Different forms of Leucovorin Calcium DMFs exist exist since differing nations have different regulations, such as Leucovorin Calcium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Leucovorin Calcium DMF submitted to regulatory agencies in the US is known as a USDMF. Leucovorin Calcium USDMF includes data on Leucovorin Calcium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Leucovorin Calcium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Leucovorin Calcium suppliers with USDMF on PharmaCompass.

    Leucovorin Calcium JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Leucovorin Calcium Drug Master File in Japan (Leucovorin Calcium JDMF) empowers Leucovorin Calcium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Leucovorin Calcium JDMF during the approval evaluation for pharmaceutical products. At the time of Leucovorin Calcium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Leucovorin Calcium suppliers with JDMF on PharmaCompass.

    Leucovorin Calcium KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Leucovorin Calcium Drug Master File in Korea (Leucovorin Calcium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Leucovorin Calcium. The MFDS reviews the Leucovorin Calcium KDMF as part of the drug registration process and uses the information provided in the Leucovorin Calcium KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Leucovorin Calcium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Leucovorin Calcium API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Leucovorin Calcium suppliers with KDMF on PharmaCompass.

    Leucovorin Calcium CEP

    A Leucovorin Calcium CEP of the European Pharmacopoeia monograph is often referred to as a Leucovorin Calcium Certificate of Suitability (COS). The purpose of a Leucovorin Calcium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Leucovorin Calcium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Leucovorin Calcium to their clients by showing that a Leucovorin Calcium CEP has been issued for it. The manufacturer submits a Leucovorin Calcium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Leucovorin Calcium CEP holder for the record. Additionally, the data presented in the Leucovorin Calcium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Leucovorin Calcium DMF.

    A Leucovorin Calcium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Leucovorin Calcium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Leucovorin Calcium suppliers with CEP (COS) on PharmaCompass.

    Leucovorin Calcium WC

    A Leucovorin Calcium written confirmation (Leucovorin Calcium WC) is an official document issued by a regulatory agency to a Leucovorin Calcium manufacturer, verifying that the manufacturing facility of a Leucovorin Calcium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Leucovorin Calcium APIs or Leucovorin Calcium finished pharmaceutical products to another nation, regulatory agencies frequently require a Leucovorin Calcium WC (written confirmation) as part of the regulatory process.

    click here to find a list of Leucovorin Calcium suppliers with Written Confirmation (WC) on PharmaCompass.

    Leucovorin Calcium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Leucovorin Calcium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Leucovorin Calcium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Leucovorin Calcium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Leucovorin Calcium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Leucovorin Calcium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Leucovorin Calcium suppliers with NDC on PharmaCompass.

    Leucovorin Calcium GMP

    Leucovorin Calcium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Leucovorin Calcium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Leucovorin Calcium GMP manufacturer or Leucovorin Calcium GMP API supplier for your needs.

    Leucovorin Calcium CoA

    A Leucovorin Calcium CoA (Certificate of Analysis) is a formal document that attests to Leucovorin Calcium's compliance with Leucovorin Calcium specifications and serves as a tool for batch-level quality control.

    Leucovorin Calcium CoA mostly includes findings from lab analyses of a specific batch. For each Leucovorin Calcium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Leucovorin Calcium may be tested according to a variety of international standards, such as European Pharmacopoeia (Leucovorin Calcium EP), Leucovorin Calcium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Leucovorin Calcium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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