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Chemistry

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Also known as: Sodium folinate, Oncofolic, Folinic acid disodium, Disodium folinate, 4mxu9ljs4q, 163254-40-8
Molecular Formula
C20H21N7Na2O7
Molecular Weight
517.4  g/mol
InChI Key
FSDMNNPYPVJNAT-RIWFDJIXSA-L
FDA UNII
4MXU9LJS4Q

Leucovorin Sodium
Leucovorin Sodium is the sodium salt of leucovorin, an active metabolite of folic acid, used as an antidote to folic acid antagonists. Leucovorin does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonists and counteracts the toxic effects of these drugs. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. In comparison with the calcium salt, sodium salt does not form precipitate when mixed other folate antagonists.
1 2D Structure

Leucovorin Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate
2.1.2 InChI
InChI=1S/C20H23N7O7.2Na/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;/q;2*+1/p-2/t12?,13-;;/m0../s1
2.1.3 InChI Key
FSDMNNPYPVJNAT-RIWFDJIXSA-L
2.1.4 Canonical SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
2.1.5 Isomeric SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
2.2 Other Identifiers
2.2.1 UNII
4MXU9LJS4Q
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Sodium Folinate

2. Oncofolic

3. Folinic Acid Disodium

4. Disodium Folinate

5. 4mxu9ljs4q

6. 163254-40-8

7. Unii-4mxu9ljs4q

8. Chembl3707260

9. Sodium Folinate [mart.]

10. Sodium Folinate [who-dd]

11. Q27260173

12. L-glutamic Acid, N-(4-(((2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-, Disodium Salt

2.4 Create Date
2019-01-21
3 Chemical and Physical Properties
Molecular Weight 517.4 g/mol
Molecular Formula C20H21N7Na2O7
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass517.12978460 g/mol
Monoisotopic Mass517.12978460 g/mol
Topological Polar Surface Area221 Ų
Heavy Atom Count36
Formal Charge0
Complexity900
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Pharmacology and Biochemistry
4.1 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AF - Detoxifying agents for antineoplastic treatment

V03AF06 - Sodium folinate


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ABOUT THIS PAGE

Leucovorin Sodium Manufacturers

A Leucovorin Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Leucovorin Sodium, including repackagers and relabelers. The FDA regulates Leucovorin Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Leucovorin Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Leucovorin Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Leucovorin Sodium Suppliers

A Leucovorin Sodium supplier is an individual or a company that provides Leucovorin Sodium active pharmaceutical ingredient (API) or Leucovorin Sodium finished formulations upon request. The Leucovorin Sodium suppliers may include Leucovorin Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Leucovorin Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Leucovorin Sodium GMP

Leucovorin Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Leucovorin Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Leucovorin Sodium GMP manufacturer or Leucovorin Sodium GMP API supplier for your needs.

Leucovorin Sodium CoA

A Leucovorin Sodium CoA (Certificate of Analysis) is a formal document that attests to Leucovorin Sodium's compliance with Leucovorin Sodium specifications and serves as a tool for batch-level quality control.

Leucovorin Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Leucovorin Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Leucovorin Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Leucovorin Sodium EP), Leucovorin Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Leucovorin Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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