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ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 1 USDMF, 1 EU WC, 4 KDMF, 3 Listed Suppliers, $ API Reference Price

4 API Suppliers
1 USDMF
1 EU WC
4 KDMF
3 Listed Suppliers
$ API Reference Price

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1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers, 5 Listed Dossiers

5 FDF Dossiers
5 Listed Dossiers

MARKET PLACE

3 APIs, 2 FDF Dossiers

marketPlace
3 APIs
2 FDF Dossiers

Synopsis

ACTIVE PHARMA INGREDIENTS

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JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

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Chemistry

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Also known as: 150566-71-5, (s)-amlodipine besylate, Levamlodipine besilate, (-)-amlodipine besylate, Levamlodipine besilate [who-dd], S-amlodipine benzenesulfonate

Molecular Formula

C₂₆H₃₁ClN₂O₈S

Molecular Weight

567.1 g/mol

InChI Key

ZPBWCRDSRKPIDG-LMOVPXPDSA-N

FDA UNII

885H5YC40L

1 2D Structure

Levoamlodipine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

benzenesulfonic acid;3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

2.1.2 InChI

InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)/t17-;/m0./s1

2.1.3 InChI Key

ZPBWCRDSRKPIDG-LMOVPXPDSA-N

2.1.4 Canonical SMILES

CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

2.1.5 Isomeric SMILES

CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

885H5YC40L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

2. 3-ethyl 5-methyl (4s)-2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydro-3,5-pyridinedicarboxylate Benzenesulfonate (1:1)

2.3.2 Depositor-Supplied Synonyms

1. 150566-71-5

2. (s)-amlodipine Besylate

3. Levamlodipine Besilate

4. (-)-amlodipine Besylate

5. Levamlodipine Besilate [who-dd]

6. S-amlodipine Benzenesulfonate

7. Levoamlodipine Besylate

8. 885h5yc40l

9. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

10. 3,5-pyridinedicarboxylic Acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Monobenzenesulfonate

11. Benzenesulfonic Acid;3-o-ethyl 5-o-methyl (4s)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

12. 3,5-pyridinedicarboxylic Acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl Ester, (4s)-, Benzenesulfonate (1:1)

13. Unii-885h5yc40l

14. (s)-amlodipinebesylate

15. Hy-14744a

16. Cs-0090891

17. 129l824

18. Q27269892

19. (s)-amlodipine Besylate (103129-82-4(free Base))

20. 192583-58-7

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₂₆H₃₁ClN₂O₈S
Molecular Weight	567.1 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	11
Exact Mass	566.1489648 g/mol
Monoisotopic Mass	566.1489648 g/mol
Topological Polar Surface Area	163 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	830
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

API SUPPLIERS

01

Smruthi Organics

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich

Not Confirmed

02

Arene Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich

Not Confirmed

03

Nishchem International Pvt. Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich

Not Confirmed

04

Lunan Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

euroPLX 86 Munich

Not Confirmed

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USDMF

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EU WC

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KDMF

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Listed Suppliers

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1693765800,"product":"S(-) AMLODIPINE BESILATE (LEVAMLODIPINEBESILATE)","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"AVVA RUS JSC","customerCountry":"RUSSIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"378","totalValueFC":"2349.2","currency":"EUR","unitRateINR":32500,"date":"04-Sep-2023","totalValueINR":"195000","totalValueInUsd":"2349.2","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"3692509","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q3","strtotime":1695234600,"product":"PHARMA INGREDIENTS - S(-)AMLODIPINE BESYLATE (LEVAMLODIPINE BESYLATE) D90 LESS THAN 20MCM","address":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,","city":"AHMEDABAD","supplier":"GREENCROSS EXPORT PRIVATE ","supplierCountry":"INDIA","foreign_port":"SHEREMETYEVO","customer":"TO THE ORDER .....\/\/\/\/\/.....\/\/\/\/","customerCountry":"RUSSIA","quantity":"6.00","actualQuantity":"6","unit":"KGS","unitRateFc":"42500","totalValueFC":"2891.3","currency":"INR","unitRateINR":40000,"date":"21-Sep-2023","totalValueINR":"240000","totalValueInUsd":"2891.3","indian_port":"Ahmedabad Air","hs_no":"29242190","bill_no":"4090841","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Ahmedabad Air","supplierAddress":"30, AROHI VILLA, S.P. RING ROAD, BOPAL,, AHMEDABAD","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696357800,"product":"PHARMACEUTICAL RAW MATERIAL ITEM: S (-)AMLODIPINE MALEATE ( LEVAMLODIPINE MALEATE )BATCH NO. SAM-001\/23-MM MFG.DATE APR","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"JEDDAH","customer":"SAUDI ARABIAN JAPANESE ","customerCountry":"SAUDI ARABIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"1336","totalValueFC":"660.8","currency":"USD","unitRateINR":110000,"date":"04-Oct-2023","totalValueINR":"55000","totalValueInUsd":"660.8","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"4385529","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696357800,"product":"PHARMACEUTICAL RAW MATERIAL ITEM: S (-)AMLODIPINE MALEATE ( LEVAMLODIPINE MALEATE )BATCH NO. SAM-001\/23-P MFG.DATE APR-","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"JEDDAH","customer":"SAUDI ARABIAN JAPANESE ","customerCountry":"SAUDI ARABIA","quantity":"0.50","actualQuantity":"0.5","unit":"KGS","unitRateFc":"1336","totalValueFC":"660.8","currency":"USD","unitRateINR":110000,"date":"04-Oct-2023","totalValueINR":"55000","totalValueInUsd":"660.8","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"4385529","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1696962600,"product":"S(-) AMLODIPINE MALEATE ( LEVAMLODIPINEMALEATE )","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"COMMERCIAL BANK OF ","customerCountry":"BANGLADESH","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"375","totalValueFC":"5478.8","currency":"USD","unitRateINR":30400,"date":"11-Oct-2023","totalValueINR":"456000","totalValueInUsd":"5478.8","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"4561241","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1708021800,"product":"S(-)AMLODIPINE MALEATE (LEVAMLODIPINE MALEATE)","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"MOSCOW","customer":"?AVVA RUS? JSC","customerCountry":"RUSSIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"696","totalValueFC":"723.8","currency":"EUR","unitRateINR":60059.300000000003,"date":"16-Feb-2024","totalValueINR":"60059.3","totalValueInUsd":"723.8","indian_port":"Bombay Air","hs_no":"29333990","bill_no":"7576956","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"RUSSIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1711132200,"product":"S(-) AMLODIPINE MALEATE (LEVAMLODIPINE MALEATE)","address":"165 A, BALAJI BHAVAN, 1ST FLOOR,","city":"SOLAPUR\/MAH","supplier":"ORGANICS","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"COMMERCIAL BANK OF ","customerCountry":"BANGLADESH","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"375","totalValueFC":"5500.6","currency":"USD","unitRateINR":30450,"date":"23-Mar-2024","totalValueINR":"456750","totalValueInUsd":"5500.6","indian_port":"Hyderabad Air","hs_no":"29333990","bill_no":"8591348","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Hyderabad Air","supplierAddress":"165 A, BALAJI BHAVAN, 1ST FLOOR,, SOLAPUR\/MAH","customerAddress":""}]

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

4 API Suppliers

1 USDMF

1 EU WC

4 KDMF

3 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

5 FDF Dossiers

5 Listed Dossiers

MARKET PLACE

3 APIs

2 FDF Dossiers

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 441

MARKET PLACE

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FINISHED DOSAGE FORMULATIONS

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DIGITAL CONTENT

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