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Levobupivacaine Hydrochloride

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers, 2 USDMF, 2 JDMF, 3 EU WC, 3 NDC API, 9 Listed Suppliers, $ API Reference Price

15 API Suppliers
2 USDMF
2 JDMF
3 EU WC
3 NDC API
9 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

17 FDF Dossiers, 3 FDA Orange Book, 5 Europe, 2 South Africa, 7 Listed Dossiers

17 FDF Dossiers
3 FDA Orange Book
5 Europe
2 South Africa
7 Listed Dossiers

MARKET PLACE

7 APIs

marketPlace
7 APIs

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 1,701

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

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GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Levobupivacaine hcl, 27262-48-2, Chirocaine, Levobupivacaine hydrochloride [usan], Levobupivacaine (hydrochloride), (s)-1-butyl-2',6'-pipecoloxylidide monohydrochloride

Molecular Formula

C₁₈H₂₉ClN₂O

Molecular Weight

324.9 g/mol

InChI Key

SIEYLFHKZGLBNX-NTISSMGPSA-N

FDA UNII

J998RDZ51I

S-enantiomer of bupivacaine that is used as a local anesthetic and for regional nerve blocks, including EPIDURAL ANESTHESIA.

1 2D Structure

Levobupivacaine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride

2.1.2 InChI

InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H/t16-;/m0./s1

2.1.3 InChI Key

SIEYLFHKZGLBNX-NTISSMGPSA-N

2.1.4 Canonical SMILES

CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl

2.1.5 Isomeric SMILES

CCCCN1CCCC[C@H]1C(=O)NC2=C(C=CC=C2C)C.Cl

2.2 Other Identifiers

2.2.1 UNII

J998RDZ51I

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Chirocaine

2. Levobupivacaine

2.3.2 Depositor-Supplied Synonyms

1. Levobupivacaine Hcl

2. 27262-48-2

3. Chirocaine

4. Levobupivacaine Hydrochloride [usan]

5. Levobupivacaine (hydrochloride)

6. (s)-1-butyl-2',6'-pipecoloxylidide Monohydrochloride

7. (s)-1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

8. (s)-(-)-bupivacaine Hydrochloride

9. J998rdz51i

10. Chebi:31772

11. Bupivacaine (-)-form Hydrochloride

12. (2s)-1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide Hydrochloride

13. (s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamide Monohydrochloride

14. (s)-(-)-bupivacaine Monohydrochloride

15. 27262-48-2 (hcl)

16. Dsstox_cid_26071

17. Dsstox_rid_81319

18. Dsstox_gsid_46071

19. (s)-bupivacaine Hydrochloride

20. Levobupivacaine Free Base

21. Bupicaine Hydrochloride (-)

22. Cas-27262-48-2

23. Ncgc00159482-02

24. Unii-j998rdz51i

25. Popscaine

26. Chirocaine (tn)

27. Levobupivacaine Hydrochloride (anhydrous)

28. Schembl34174

29. (s)-(-)-bupivacaine Hcl

30. (-)-bupivacaine Hydrochloride

31. Levobupivacaine Monohydrochloride

32. Chembl1200749

33. Dtxsid9046071

34. Hy-b0653a

35. 2',6'-pipecoloxylidide, 1-butyl-, Hydrochloride, (-)-

36. Mr-8-a2

37. (s)-(-)-bupivacainehydrochloride

38. Levobupivacaine Hcl [vandf]

39. (-)-(s)-bupivacaine Hydrochloride

40. Act04726

41. Tox21_111706

42. Mfcd01704265

43. S4061

44. Akos016001444

45. Tox21_111706_1

46. Ac-2097

47. Ccg-267755

48. Cs-4301

49. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-, Monohydrochloride, (2s)-

50. Ncgc00178579-04

51. As-15053

52. Levobupivacaine Hydrochloride (jan/usan)

53. Levobupivacaine Hydrochloride [jan]

54. Levobupivacaine Hydrochloride [mart.]

55. Levobupivacaine Hydrochloride [who-dd]

56. Levobupivacaine Hydrochloride, >=98% (hplc)

57. D01287

58. Bupivacaine (-)-form Hydrochloride [mi]

59. (s)-1-butyl-2',6'-pipecoloxylidide Hydrochloride

60. 262b482

61. Levobupivacaine Hydrochloride [orange Book]

62. Q27114682

63. (2s)-1-butyl-2-[(2,6-dimethylphenyl)carbamoyl]piperidinium Chloride

64. (2s)-1-butyl-n-(2,6-dimethylphenyl)piperidine-2-carboxamide;hydrochloride

65. 2-piperidinecarboxamide, 1-butyl-n-(2,6-dimethylphenyl)-,monohydrochloride, (2s)-

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₈H₂₉ClN₂O
Molecular Weight	324.9 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	5
Exact Mass	324.1968412 g/mol
Monoisotopic Mass	324.1968412 g/mol
Topological Polar Surface Area	32.3 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	321
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anesthetics, Local

Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate. (See all compounds classified as Anesthetics, Local.)

API SUPPLIERS

01

Moehs Iberica

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI WW Frankfurt

Booth #11.0C6

Moehs Group, a reference company in the production of pharmaceutical active ingredients.

Contact Supplier

Spain

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Shandong Chenghui Shuangda Pharmac...

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI China

Attending

China's leading API and intermediate manufacturer, offering CMO/CDMO services and exports to 70+ countries, enhancing global health.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Shandong Chenghui Shuangda Pharmaceutical

Product Web Link

03

Shandong Loncom Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

Shandong Loncom is an R&D-focused manufacturer of Anti-cancer APIs.

Contact Supplier

China

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

Shandong Loncom Pharmaceutical company banner

04

Edmond Pharma

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

05

Dishman Carbogen Amcis

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

06

Cristalia Produtos Quimicos Farma....

Brazil

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

07

Green Stone Swiss Co ., Ltd

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

08

Pioneer Agro Extracts

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

09

Pioneer Agro Extracts

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

10

Fresenius Kabi Oncology Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Pharma, Lab & Chemical Expo

Not Confirmed

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USDMF

01

Dishman Carbogen Amcis Ltd

India

Pharma, Lab & Chemical Expo

Not Confirmed

02

Edmond Pharma Srl

India

Pharma, Lab & Chemical Expo

Not Confirmed

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JDMF

01

Aesica Queenborough Ltd.

United Kingdom

Pharma, Lab & Chemical Expo

Not Confirmed

02

Shiono Finesse Co., Ltd.

Japan

Pharma, Lab & Chemical Expo

Not Confirmed

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EU WC

01

Fresenius Kabi Oncology Limited

India

Pharma, Lab & Chemical Expo

Not Confirmed

02

Pioneer Agro Extracts

India

Pharma, Lab & Chemical Expo

Not Confirmed

03

Pioneer Agro Extracts

India

Pharma, Lab & Chemical Expo

Not Confirmed

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NDC API

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Listed Suppliers

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API Reference Price

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KGAA","supplierCountry":"INDIA","foreign_port":"OSLO","customer":"HP HALDEN PHARMA AS","customerCountry":"NORWAY","quantity":"62.43","actualQuantity":"62.426","unit":"KGS","unitRateFc":"1250","totalValueFC":"82376.3","currency":"EUR","unitRateINR":111357.23000032039,"date":"04-Nov-2024","totalValueINR":"6951586.44","totalValueInUsd":"82376.3","indian_port":"Delhi Air","hs_no":"29242990","bill_no":"5341935","productDescription":"API","marketType":"REGULATED MARKET","country":"NORWAY","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"B-310, SOM DATT CHAMBERS, 1,, NEW DELHI","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

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FDA Orange Book

01

PURDUE PHARMA LP

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

02

PURDUE PHARMA LP

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

03

PURDUE PHARMA LP

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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Europe

01

AbbVie Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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U.S.A

Virtual Booth

Digital Content

Regulatory Info :

Registration Country : Sweden

levobupivakainhydroklorid

Brand Name : Chirocaine

Dosage Form : SOLUTION FOR INFUSION

Dosage Strength : 0.625 MG / ML

Packaging :

Approval Date :

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Registration Country : Sweden

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Corporate PDF

02

AbbVie Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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U.S.A

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Digital Content

Regulatory Info :

Registration Country : Sweden

levobupivakainhydroklorid

Brand Name : Chirocaine

Dosage Form : SOLUTION FOR INFUSION

Dosage Strength : 1.25 MG / ML

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Regulatory Info :

Registration Country : Sweden

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03

AbbVie Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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U.S.A

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Digital Content

Regulatory Info :

Registration Country : Sweden

levobupivakainhydroklorid

Brand Name : Chirocaine

Dosage Form : INJECTION / CONCENTRATE FOR

Dosage Strength : 5 MG / ML

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Registration Country : Sweden

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04

AbbVie Inc

U.S.A

Pharma, Lab & Chemical Expo

Not Confirmed

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U.S.A

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Regulatory Info :

Registration Country : Sweden

levobupivakainhydroklorid

Brand Name : Chirocaine

Dosage Form : INJECTION / CONCENTRATE FOR

Dosage Strength : 2.5 MG / ML

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Registration Country : Sweden

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05

AbbVie Inc

U.S.A

Pharma, Lab & Chemical Expo

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U.S.A

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Regulatory Info :

Registration Country : Sweden

levobupivakainhydroklorid

Brand Name : Chirocaine

Dosage Form : INJECTION / CONCENTRATE FOR

Dosage Strength : 7.5 MG / ML

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South Africa

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ACTIVE PHARMA INGREDIENTS

15 API Suppliers

2 USDMF

2 JDMF

3 EU WC

3 NDC API

9 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

17 FDF Dossiers

3 FDA Orange Book

5 Europe

2 South Africa

7 Listed Dossiers

MARKET PLACE

7 APIs

ACTIVE PHARMA INGREDIENTS

API REF. PRICE (USD/KG)

$ 1,701

MARKET PLACE

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FINISHED DOSAGE FORMULATIONS

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REF. STANDARDS OR IMPURITIES

PATENTS & EXCLUSIVITIES

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Average Price (USD/KGS)

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

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