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Chemistry

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Also known as: 1421-65-4, L-3,4-dihydroxyphenylalanine methyl ester hydrochloride, Melevodopa hydrochloride, Methyl l-dopa hydrochloride, L-dopa methyl ester hydrochloride, Levodopa methyl ester hydrochloride
Molecular Formula
C10H14ClNO4
Molecular Weight
247.67  g/mol
InChI Key
WFGNJLMSYIJWII-FJXQXJEOSA-N
FDA UNII
JFU1A8866V

Levodopa Methyl Ester
1 2D Structure

Levodopa Methyl Ester

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride
2.1.2 InChI
InChI=1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
2.1.3 InChI Key
WFGNJLMSYIJWII-FJXQXJEOSA-N
2.1.4 Canonical SMILES
COC(=O)C(CC1=CC(=C(C=C1)O)O)N.Cl
2.1.5 Isomeric SMILES
COC(=O)[C@H](CC1=CC(=C(C=C1)O)O)N.Cl
2.2 Other Identifiers
2.2.1 UNII
JFU1A8866V
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Dl-dopa Methyl Ester

2. Dopa Methyl Ester, (d)-isomer

3. L-dopa Methyl Ester

4. Levodopa Methyl Ester

5. Levodopa Methyl Ester Hydrochloride

6. Levodopa Methyl Ester Hydrochloride, (dl)-isomer

7. Melevodopa

8. Methyl L-dopa

2.3.2 Depositor-Supplied Synonyms

1. 1421-65-4

2. L-3,4-dihydroxyphenylalanine Methyl Ester Hydrochloride

3. Melevodopa Hydrochloride

4. Methyl L-dopa Hydrochloride

5. L-dopa Methyl Ester Hydrochloride

6. Levodopa Methyl Ester Hydrochloride

7. L-tyrosine, 3-hydroxy-, Methyl Ester, Hydrochloride

8. L-dopa Me Ester Hydrochloride

9. L-tyrosine, 3-hydroxy-, Methyl Ester, Hydrochloride (1:1)

10. Mfcd00038958

11. Alanine, 3-(3,4-dihydroxyphenyl)-, Methyl Ester, Hydrochloride, L-

12. St 41769

13. St-41769

14. Jfu1a8866v

15. 3,4-dihydroxyphenyl-l-alanine Methyl Ester Hydrochloride

16. Methyl L-3-(3,4-dihydroxyphenyl)alaninate Hydrochloride

17. Ncgc00093792-01

18. Alanine, 3-(3,4-dihydroxyphenyl)-, Methyl Ester, Hydrochloride

19. L-3,4-dihydroxyphenylalanine Methyl Ester Hcl

20. Dsstox_cid_25763

21. Dsstox_rid_81105

22. Dsstox_gsid_45763

23. 3,4-dihydroxy-l-phenylalanine Methyl Ester Hydrochloride

24. Methyl (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride

25. Cas-1421-65-4

26. Unii-jfu1a8866v

27. Nsc-295453

28. Mls002153271

29. Schembl453411

30. Chembl1255756

31. Dtxsid4045763

32. Act09358

33. Amy31294

34. Tox21_111221

35. Tox21_500356

36. H-phe{3,4-(oh)2}-ome.hcl

37. L-dopa Methyl Ester (hydrochloride)

38. Akos015912904

39. Tox21_111221_1

40. Ccg-221660

41. Cs-w012679

42. Lp00356

43. Nsc 295453

44. Ncgc00162132-03

45. Ncgc00261041-01

46. As-10467

47. Smr001230709

48. Eu-0100356

49. D 1507

50. I10411

51. L-3,4-dihydroxyphenylalanine Benzyl Ester

52. Sr-01000075804

53. J-007612

54. Sr-01000075804-1

55. Q27281493

56. 3-(3,4-dihydroxyphenyl)-l-alanine Methyl Ester Hydrochloride

57. L-3,4-dihydroxyphenylalanine Methyl Ester Hydrochloride, Solid

58. Methyl (s)-2-amino-3-(3,4-dihydroxyphenyl)propanoate Hydrochloride

2.4 Create Date
2006-10-25
3 Chemical and Physical Properties
Molecular Weight 247.67 g/mol
Molecular Formula C10H14ClNO4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass247.0611356 g/mol
Monoisotopic Mass247.0611356 g/mol
Topological Polar Surface Area92.8 Ų
Heavy Atom Count16
Formal Charge0
Complexity222
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


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Levodopa Methyl Ester Manufacturers

A Levodopa Methyl Ester manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Levodopa Methyl Ester, including repackagers and relabelers. The FDA regulates Levodopa Methyl Ester manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Levodopa Methyl Ester API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Levodopa Methyl Ester manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Levodopa Methyl Ester Suppliers

A Levodopa Methyl Ester supplier is an individual or a company that provides Levodopa Methyl Ester active pharmaceutical ingredient (API) or Levodopa Methyl Ester finished formulations upon request. The Levodopa Methyl Ester suppliers may include Levodopa Methyl Ester API manufacturers, exporters, distributors and traders.

click here to find a list of Levodopa Methyl Ester suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Levodopa Methyl Ester USDMF

A Levodopa Methyl Ester DMF (Drug Master File) is a document detailing the whole manufacturing process of Levodopa Methyl Ester active pharmaceutical ingredient (API) in detail. Different forms of Levodopa Methyl Ester DMFs exist exist since differing nations have different regulations, such as Levodopa Methyl Ester USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Levodopa Methyl Ester DMF submitted to regulatory agencies in the US is known as a USDMF. Levodopa Methyl Ester USDMF includes data on Levodopa Methyl Ester's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Levodopa Methyl Ester USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Levodopa Methyl Ester suppliers with USDMF on PharmaCompass.

Levodopa Methyl Ester GMP

Levodopa Methyl Ester Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Levodopa Methyl Ester GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Levodopa Methyl Ester GMP manufacturer or Levodopa Methyl Ester GMP API supplier for your needs.

Levodopa Methyl Ester CoA

A Levodopa Methyl Ester CoA (Certificate of Analysis) is a formal document that attests to Levodopa Methyl Ester's compliance with Levodopa Methyl Ester specifications and serves as a tool for batch-level quality control.

Levodopa Methyl Ester CoA mostly includes findings from lab analyses of a specific batch. For each Levodopa Methyl Ester CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Levodopa Methyl Ester may be tested according to a variety of international standards, such as European Pharmacopoeia (Levodopa Methyl Ester EP), Levodopa Methyl Ester JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Levodopa Methyl Ester USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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