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ACTIVE PHARMA INGREDIENTS

11 API Suppliers, 6 CEP/COS, 22 KDMF, 8 Listed Suppliers, $ API Reference Price

11 API Suppliers
6 CEP/COS
22 KDMF
8 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

11 FDF Dossiers, 7 Europe, 4 Listed Dossiers

11 FDF Dossiers
7 Europe
4 Listed Dossiers

DIGITAL CONTENT

1 NEWS #PharmaBuzz

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1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

6 Finished Drug Prices

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6 Finished Drug Prices

MARKET PLACE

6 APIs

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6 APIs

REF. STANDARDS & IMPURITIES

4 EDQM

otherSolutions
4 EDQM

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 99291-25-5, (s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol, Levotuss, Danka, (-)-dropropizine, Levdropropizine

Molecular Formula

C₁₃H₂₀N₂O₂

Molecular Weight

236.31 g/mol

InChI Key

PTVWPYVOOKLBCG-ZDUSSCGKSA-N

FDA UNII

3O31P6T4G3

Levodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).

1 2D Structure

Levodropropizine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

2.1.2 InChI

InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1

2.1.3 InChI Key

PTVWPYVOOKLBCG-ZDUSSCGKSA-N

2.1.4 Canonical SMILES

C1CN(CCN1CC(CO)O)C2=CC=CC=C2

2.1.5 Isomeric SMILES

C1CN(CCN1C[C@@H](CO)O)C2=CC=CC=C2

2.2 Other Identifiers

2.2.1 UNII

3O31P6T4G3

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Df 526

2. Df-526

3. Dipropizine

4. Dipropizine, (s)-isomer

5. Ditustat

6. Dropropizine

7. Levotuss

8. Tautoss

9. Zyplo

2.3.2 Depositor-Supplied Synonyms

1. 99291-25-5

2. (s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

3. Levotuss

4. Danka

5. (-)-dropropizine

6. Levdropropizine

7. (s)-(-)-dropropizine

8. Rapitux

9. Levodropropizina

10. (2s)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

11. Levodropropizinum

12. Levopront

13. Levodropropizine [inn]

14. L-dropropizine

15. Dipropizine, (s)-isomer

16. 99291-24-4

17. Dropropizine, (s)-

18. (-)-(s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

19. 1,2-propanediol, 3-(4-phenyl-1-piperazinyl)-, (2s)-

20. Chebi:82722

21. 3o31p6t4g3

22. Df-526

23. Levodropropizine (inn)

24. Dropropizine S-form

25. Levodropropizinum [inn-latin]

26. Levodropropizina [inn-spanish]

27. Df 526

28. Levodropropizine [inn:ban]

29. Salvituss

30. Unii-3o31p6t4g3

31. Levopront (tn)

32. (s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

33. Cas-17692-31-8

34. S(-)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

35. Lvdp

36. Levodropropizine Impurity A

37. Schembl29043

38. Chembl1288810

39. Dtxsid8023210

40. Levodropropizine [mart.]

41. 1,2-propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-

42. Dropropizine S-form [mi]

43. Levodropropizine [who-dd]

44. Levodropropizine (s-dropropizine)

45. Hms3885b07

46. Hy-b1895

47. Bbl036696

48. Mfcd00866852

49. S4131

50. Stl559075

51. Zinc19594545

52. Akos015889397

53. Ac-2084

54. Ac-8088

55. Bcp9000850

56. Ccg-266840

57. Cs-5212

58. Db12472

59. Levodropropizine [ep Monograph]

60. Ncgc00016730-01

61. Ncgc00018230-01

62. Ncgc00018230-06

63. As-12822

64. Bcp0726000048

65. L0339

66. D08119

67. F15098

68. 291l244

69. A845991

70. Ao-022/43512153

71. Q408131

72. Q-100916

73. Brd-k83551379-001-02-6

74. S-(-)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

75. (2s)-3-(4-phenyl-1-piperazinyl)-1,2-propanediol

76. 1,2-propanediol, 3-(4-phenyl-1-piperazinyl)-, (s)-

2.4 Create Date

2005-07-07

3 Chemical and Physical Properties

Molecular Formula	C₁₃H₂₀N₂O₂
Molecular Weight	236.31 g/mol
XLogP3	0.6
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	236.152477885 g/mol
Monoisotopic Mass	236.152477885 g/mol
Topological Polar Surface Area	46.9 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	212
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antitussive Agents

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)

4.2 ATC Code

R - Respiratory system

R05 - Cough and cold preparations

R05D - Cough suppressants, excl. combinations with expectorants

R05DB - Other cough suppressants

R05DB27 - Levodropropizine

API SUPPLIERS

01

Cohance Lifesciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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USDMF CEP/COS

JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Amsa Spa

Italy

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

03

Precise Group

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

04

Tecoland Corporation

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

05

DAEHE Biopharma

South Korea

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

AES 2024

Not Confirmed

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CEP/COS

01

COHANCE LIFESCIENCES LIMITED Hydera...

India

AES 2024

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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Levodropropizine

Certificate Number : CEP 2023-110 - Rev 00

Status : Valid

Issue Date : 2024-05-24

Type : Chemical

Substance Number : 1535

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MACLEODS PHARMACEUTICALS LIMITED Mu...

India

AES 2024

Not Confirmed

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KDMF

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Listed Suppliers

01

Cohance Lifesciences

India

AES 2024

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

Contact Supplier

India

Virtual Booth

Digital Content

Levodropropizine

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.

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About the Company : Indian Pharmaceutical Company, Precise Group is emerging as a global player in several verticals in healthcare. The Mumbai based drug manufacturing company’s strength lies in a s...

Indian Pharmaceutical Company, Precise Group is emerging as a global player in several verticals in healthcare. The Mumbai based drug manufacturing company’s strength lies in a strong network of industry professionals who care capable of handling the development of APIs, several Ready-to-fill Pellets and other intermediates, and chemicals. The company’s influence has a universal reach coordinating with multi-levels of global healthcare service providers for generic drugs. It holds a valued equity in niche pharma sectors in USA, Europe and Africa. Precise Group’s business encompasses the protection of the interest of their shareholders, is complaint with international regulatory bodies and meets the protocol favored in any region as a pharma suppler spanning developed and new markets. The technologically advanced manufacturing hub near Mumbai conducts manufacturing programs to sustain quality drugs at cost effect prices.

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08

Tecoland Corporation

U.S.A

AES 2024

Not Confirmed

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API Reference Price

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