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Chemistry

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Also known as: (-)-menthol, 2216-51-5, Levomenthol, L-(-)-menthol, Menthomenthol, Menthacamphor

Molecular Formula

C₁₀H₂₀O

Molecular Weight

156.26 g/mol

InChI Key

NOOLISFMXDJSKH-KXUCPTDWSA-N

FDA UNII

BZ1R15MTK7

Levomenthol is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.

1 2D Structure

Levomenthol

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol

2.1.2 InChI

InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1

2.1.3 InChI Key

NOOLISFMXDJSKH-KXUCPTDWSA-N

2.1.4 Canonical SMILES

CC1CCC(C(C1)O)C(C)C

2.1.5 Isomeric SMILES

C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C

2.2 Other Identifiers

2.2.1 UNII

BZ1R15MTK7

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. (-)-menthol

2. 2216-51-5

3. Levomenthol

4. L-(-)-menthol

5. Menthomenthol

6. Menthacamphor

7. Peppermint Camphor

8. (1r,2s,5r)-2-isopropyl-5-methylcyclohexanol

9. U.s.p. Menthol

10. Levomentholum

11. Racementhol

12. (1r,2s,5r)-(-)-menthol

13. (-)-menthyl Alcohol

14. (-)-(1r,3r,4s)-menthol

15. Menthol Racemic

16. Hexahydrothymol

17. (1r)-(-)-menthol

18. D,l-menthol

19. (r)-(-)-menthol

20. 89-78-1

21. D-(-)-menthol

22. Menthol, Dl-

23. I-menthol

24. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-

25. P-menthan-3-ol

26. (-)-trans-p-menthan-cis-ol

27. Rac-menthol

28. 1-menthol

29. (l)-menthol

30. Menthol(-)

31. (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol

32. Menthol, (1r,3r,4s)-(-)-

33. (1r,3r,4s)-(-)-menthol

34. Nci-c50000

35. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1r,2s,5r)-rel-

36. 1r-menthol

37. Nsc 62788

38. Racemic Menthol

39. Water-soluble Menthol

40. (1r,2s,5r)-menthol

41. 5-methyl-2-(1-methylethyl)cyclohexanol

42. (1r,2s,5r)-2-isopropyl-5-methylcyclohexan-1-ol

43. (1r,2s,5r)-rel-2-isopropyl-5-methylcyclohexanol

44. Bz1r15mtk7

45. (1r,2s,5r)-5-methyl-2-(1-methylethyl)cyclohexanol

46. (1r-(1-alpha,2-beta,5-alpha))-5-methyl-2-(1-methylethyl)cyclohexanol

47. (1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexan-1-ol

48. Menthol Crystals

49. Chembl470670

50. Ys08xha860

51. Chebi:15409

52. Menthol Natural

53. Nsc2603

54. (1r,2s,5r)-2-isopropyl-5-methyl-cyclohexanol

55. (1r,2s,5s)-2-isopropyl-5-methyl-cyclohexanol

56. Headache Crystals

57. Nsc-2603

58. Fema No. 2665

59. Nsc-62788

60. Menthol (van)

61. Racementholum

62. Thymomenthol

63. Menthol, Cis-1,3,trans-1,4-

64. Racementol

65. L-menthol (natural)

66. Nsc 2603

67. (+-)-menthol

68. Dsstox_cid_2180

69. Menthol Racemique

70. Levomenthol [inn:ban]

71. Racementhol [inn:ban]

72. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1r-(1.alpha.,2.beta.,5.alpha.)]-

73. Dsstox_rid_75798

74. Dsstox_rid_76516

75. Dsstox_gsid_20805

76. Dsstox_gsid_22180

77. Menthol Natural, Brazilian

78. Menthol, L-

79. Racementol [inn-spanish]

80. Rel-(1r,2s,5r)-2-isopropyl-5-methylcyclohexanol

81. Levomentholum [inn-latin]

82. Menthol Racemique [french]

83. Racementholum [inn-latin]

84. Tra-kill Tracheal Mite Killer

85. (1alpha,2beta,5alpha)-5-methyl-2(1-methylethyl)cyclohexanol

86. Mfcd00062979

87. Cas-89-78-1

88. Ccris 375

89. Cas-2216-51-5

90. L-menthol (tn)

91. Ccris 3728

92. Ccris 4666

93. Hsdb 5662

94. Sr-05000001936

95. (-)-p-menthan-3-ol

96. Einecs 201-939-0

97. Einecs 218-690-9

98. Einecs 239-388-3

99. Unii-bz1r15mtk7

100. Brn 1902288

101. Brn 3194263

102. Levomentol

103. Unii-ys08xha860

104. (+-)-(1r*,3r*,4s*)-menthol

105. Ss-bisabolol

106. Ai3-52408

107. Laevo-menthol

108. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1.alpha.,2.beta.,5.alpha.)-

109. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1r-(1alpha,2beta,5alpha))-

110. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1r-(1.alpha.,2.beta.,5.alpha.))-

111. L-menthol Natural

112. 1 -menthol

113. Ncgc00159382-02

114. Dextro,laevo-menthol

115. Meggezone

116. Menthol Crystals Usp

117. L-mentholum

118. L-menthol (jp17)

119. Spectrum_000305

120. Levomenthol [ii]

121. Menthol [mi]

122. 5-methyl-2-(1-methylethyl)cyclohexanol, (1alpha,2beta,5alpha)-

123. L-menthol [jan]

124. Menthol, (+/-)-

125. Spectrum2_000855

126. Spectrum3_001561

127. Spectrum5_001060

128. Levomenthol [inn]

129. Racementhol [inn]

130. M0545

131. Dl-menthol [jan]

132. Menthol [who-dd]

133. Menthol,3,trans-1,4-

134. Levomenthol [hsdb]

135. Racementhol [hsdb]

136. Ec 201-939-0

137. Ec 218-690-9

138. Schembl4613

139. Bspbio_003062

140. Kbioss_000785

141. Levomenthol [who-dd]

142. 2-06-00-00052 (beilstein Handbook Reference)

143. 4-06-00-00151 (beilstein Handbook Reference)

144. Mls002207256

145. Divk1c_000820

146. Menthol Racemate [mi]

147. Spectrum1503134

148. Menthol,3r,4s)-(-)-

149. Spbio_000869

150. Gtpl2430

151. Npo-11

152. Dtxsid1020805

153. Dtxsid1022180

154. (-)-menthol, Usp, 97%

155. Hms502i22

156. Kbio1_000820

157. Kbio2_000785

158. Kbio2_003353

159. Kbio2_005921

160. Kbio3_002562

161. Noolisfmxdjskh-kxucptdwsa-

162. (-)-menthol, Analytical Standard

163. Ninds_000820

164. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1r,3r,4s)-

165. Hms1922g13

166. Hms2092l14

167. Hms3885j18

168. Levomenthol [ep Monograph]

169. Pharmakon1600-01503134

170. Cyclohexanol, 2-isopropyl-5-methyl

171. Nsc62788

172. Zinc1482164

173. L-menthol, >=99%, Fcc, Fg

174. Tox21_111620

175. Tox21_201823

176. Tox21_201919

177. Tox21_202608

178. Tox21_302999

179. Tox21_303028

180. Wln: L6tj Ay1&1 Bq D1

181. Bdbm50318482

182. Ccg-40300

183. Cyclohexanol, 2-isopropyl-5-methyl-

184. Cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1alpha,2beta,5alpha)-

185. Nsc758395

186. S4714

187. Akos016842647

188. (1r, 2s, 5r-)-(-)-menthol

189. Bs-3863

190. Db00825

191. Lmpr0102090001

192. Nsc-758395

193. Sdccgmls-0066659.p001

194. (-)-trans-p-methan-cis-3-ol

195. 1-iso Propyl-4-methyl Cyclohexan-2-ol

196. Idi1_000820

197. Wln: L6tj Ay1&1 Dq D1 -l

198. Ncgc00164247-01

199. Ncgc00164247-02

200. Ncgc00164247-03

201. Ncgc00256525-01

202. Ncgc00256561-01

203. Ncgc00259372-01

204. Ncgc00259468-01

205. Ncgc00260156-01

206. D-(-)-phenylglycine Dane Potassium Salt

207. Fema No. 2665, (-)-

208. Smr001306785

209. L-menthol, Natural, >=99%, Fcc, Fg

210. Sbi-0051777.p002

211. N1950

212. S5868

213. Fema No. 2665, (+/-)-

214. Menthol (racemic) 100 Microg/ml In Methanol

215. (+/-)-(1r*,3r*,4s*)-menthol

216. (1r,2s,5r)-(-)-menthol, Synthetic Pellets

217. C00400

218. Cyclohexanol, (1.alpha.,2.beta.,5.alpha.)-

219. D00064

220. D70313

221. (1r,2r,5s)-2-isopropyl-5-methyl-cyclohexanol

222. Ab00052320_02

223. L-menthol

224. Levomenthol

225. Menthomenthol

226. Menthacamphor

227. (1r,2s,5r)-(-)-menthol, >=99%, Sublimed

228. A843308

229. Q407418

230. Q-201316

231. Sr-05000001936-1

232. Sr-05000001936-2

233. (-)-menthol, Primary Pharmaceutical Reference Standard

234. (1r,2s,5r)-(-)-menthol, Reagentplus(r), 99%

235. 2-isopropyl-5-methylcyclohexanol-, (1r,2s,5r)- #

236. Cyclohexanol, [1r-(1.alpha.,2.beta.,5.alpha.)]-

237. (1r,2s,5r)-5-methyl-2-propan-2-yl-cyclohexan-1-ol

238. Z1698549655

239. (1r,2s,5r)-(-)-menthol, Vetec(tm) Reagent Grade, 98%

240. 6c6a4a8c-a054-468c-a1f0-f29e39838cf2

241. (1r, 2s, 5r)-5-methyl-2-(1-methylethyl)cyclohexyl Alcohol

242. Menthol, United States Pharmacopeia (usp) Reference Standard

243. (1r,2s,5r)-rel-5-methyl-2-(1-methylethyl)cyclohexanol

244. L-menthol, Pharmaceutical Secondary Standard; Certified Reference Material

245. (-)-menthol, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, 98.0-102.0%

246. (1r-(1-.alpha.,2-.beta.,5-.alpha.))-5-methyl-2-(1-methylethyl)cyclohexanol

247. 114376-98-6

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	C₁₀H₂₀O
Molecular Weight	156.26 g/mol
XLogP3	3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	156.151415257 g/mol
Monoisotopic Mass	156.151415257 g/mol
Topological Polar Surface Area	20.2 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	120
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

INHALERS CONTAINING MENTHOL COMPRESSED INTO BLOCKS OR CONES ARE COMMONLY USED FOR THE RELIEF OF NASAL CONGESTION, HEADACHE, AND NEURALGIA. IT IS NOW RARELY ADMINISTERED INTERNALLY. /MENTHOL/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 722

TOPICAL ANTIPRURITIC; MEDICATION (VET): HAS BEEN USED AS A MILD LOCAL ANESTHETIC, ANTISEPTIC & INTERNALLY AS A CARMINATIVE & GASTRIC SEDATIVE /MENTHOL/

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 757

IN LIQUEURS, CONFECTIONERY, PERFUMERY, CIGARETTES, COUGH DROPS, AND NASAL INHALERS /MENTHOL/

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 757

4.2 Drug Warning

"COOLING" EFFECT OF L-MENTHOL WAS FOUND...TO BE SUPERIOR TO THAT PRODUCED BY OTHER ISOMERS; ODOR AND TASTE, TOO OF L-MENTHOL WERE SUPERIOR, WITH SOME OF THE ISOMERS PRODUCING SHARP, IRRITATING AND DISAGREEABLE PERCEPTIONS.

Osol, A., and R. Pratt. (eds.). The United States Dispensatory. 27th ed. Philadelphia: J.B. Lippincott, 1973., p. 697

4.3 Drug Indication

Used to treat occasional minor irritation, pain, sore mouth, and sore throat as well as cough associated with a cold or inhaled irritants.

5 Pharmacology and Biochemistry

5.1 Pharmacology

Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Menthol induces a cooling sensation on the skin upon inhalation, oral ingestion, or topical application by stimulating the cold-sensitive receptors expressed on the skin, without actually causing a drop in the skin temperature.

5.2 Absorption, Distribution and Excretion

...THE PERCENTAGE OF A DOSE OF L-MENTHOL THAT IS EXCRETED COMBINED WITH GLUCURONIC ACID IN THE RABBIT DEPENDS ON THE MAGNITUDE OF THE DOSE; THE LARGER THE DOSE, THE LESS IS THE CONJUGATION.

Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 519

5.3 Metabolism/Metabolites

L-MENTHOL CONJUGATES READILY IN RABBIT FORMING L-MENTHYL-BETA-D-GLUCURONIDE. ABOUT HALF OF THE L-MENTHOL FED TO RABBITS IS EXCRETED COMBINED WITH GLUCURONIC ACID; THE FATE OF OTHER HALF IS NOT KNOWN, BUT IT IS POSSIBLE THAT RING FISSION OCCURS WITH CONSIDERABLE DEGRADATION OF THE MENTHOL MOLECULE.

Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 519

IN DOGS, MUCH OXIDATION OF MENTHOL TAKES PLACE AND ONLY ABOUT 5% OF THE DOSE CAN BE RECOVERED IN URINE AS THE GLUCURONIDE. /MENTHOL/

Opdyke, D.L.J. (ed.). Monographs on Fragrance Raw Materials. New York: Pergamon Press, 1979., p. 519

L-MENTHOL WAS RAPIDLY BUT INCOMPLETELY GLUCURONIDATED. THE OUTPUT OF L-MENTHOL GLUCURONIDE WAS INCR IN ALL BUT 1 SUBJECT PRETREATED WITH CIMETIDINE (1 G/DAY FOR 1 WK), AN INHIBITOR OF OXIDATIVE DRUG METABOLISM, & IN ALL SUBJECTS PRETREATED WITH A DRUG-METABOLIZING ENZYME INDUCER, PHENOBARBITONE (60 MG NIGHTLY FOR 10 DAYS).

BELL GD ET AL; BR J CLIN PHARMACOL 12 (2): 274 (1981)

Corynebacterium sp. strain RWM1 grew with (-)-menthol, (-)-menthone and other acyclic monoterpenes as sole carbon sources. Growth on menthol was very slow, with a doubling time of more than 24 h, and was not rapid with (-)-menthone (doubling time 12 h). Concentrations of either carbon source greater than 0.025% inhibited growth. (-)-Menthone-grown cultures transiently accumulated 3,7-dimethyl-6-hydroxyoctanoate during growth, and (-)-menthol-grown cells oxidized (-)-menthol, (-)-menthone, 3,7-dimethyl-6-octanolide and 3,7-dimethyl-6-hydroxyoctanoate. Although neither a menthol oxidase nor a menthol dehydrogenase could be detected in extracts of (-)-menthol- or (-)-menthone-grown cells, an induced NADPH-linked monooxygenase with activity towards (-)-menthone was readily detected. With crude cell extracts, only 3,7-dimethyl-6-hydroxyoctanoate was detected as the reaction product. When the (-)-menthone monooxygenase was separated from an induced 3,7-dimethyl-6-octanolide hydrolase by chromatography on hydroxyapatite, the lactone 3,7-dimethyl-6-octanolide was shown to be the product of oxygenation.

Williams DR, PW Trudgill; Microbiology (Reading) 140 (3): 611-6 (1994)

(-)-Menthol has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxyoxane-2-carboxylic acid and p-Menthane-3,-8-diol.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.4 Mechanism of Action

Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.

API SUPPLIERS

01

S D Fine Chem Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

02

Mentha & Allied Products

India

Japan

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

08

Swati Menthol

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

09

Symrise

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

10

BASF

Germany

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

BIO Partnering at JPM

Not Confirmed

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JDMF

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EU WC

01

Bhagat Aromatics

India

PharmaVenue

Not Confirmed

02

Mentha & Allied Products

India

PharmaVenue

Not Confirmed

03

Nectar Lifesciences

India

PharmaVenue

Not Confirmed

04

Nectar Lifesciences

India

PharmaVenue

Not Confirmed

05

Norex Flavours

India

PharmaVenue

Not Confirmed

06

Sharp Mint Limited

India

PharmaVenue

Not Confirmed

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NDC API

01

Anhui Yinfeng Pharmaceutical Co., L...

China

China

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05

Spectrum Laboratory Products, Inc.

U.S.A

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API Reference Price

[{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1659378600,"product":"LEVOMENTHOL CRYSTALS BP","address":"12A, BAKHTAWAR, 12th FLOOR, 229, NARIMAN POINT,","city":"MUMBAI","supplier":"JINDAL DRUGS","supplierCountry":"INDIA","foreign_port":"FELIXSTOWE","customer":"BELL, SONS & CO. (DRUGGISTS) LTD.","customerCountry":"UNITED KINGDOM","quantity":"2700.00","actualQuantity":"2700","unit":"KGS","unitRateFc":"25","totalValueFC":"62689.2","currency":"USD","unitRateINR":1847.4074074074074,"date":"02-Aug-2022","totalValueINR":"4988000","totalValueInUsd":"62689.2","indian_port":"JNPT","hs_no":"29061100","bill_no":"3237990","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED KINGDOM","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"12A, BAKHTAWAR, 12th FLOOR, 229, NARIMAN POINT,, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q3","strtotime":1662661800,"product":"LEVOMENTHOL BP\/EP","address":"2 K.M. STONE, MORADABAD ROAD,,","city":"SAMBAHAL,UTTAR PRADESH","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"TEL AVIV YAFO","customer":"REKAH PHARMACEUTICAL INDUSTRY","customerCountry":"ISRAEL","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"70","totalValueFC":"686.3","currency":"USD","unitRateINR":5500,"date":"09-Sep-2022","totalValueINR":"55000","totalValueInUsd":"686.3","indian_port":"DELHI AIR","hs_no":"29061100","bill_no":"4063381","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ISRAEL","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,,, SAMBAHAL,UTTAR PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668105000,"product":"LEVOMENTHOL BP\/PERPPERMINT SAT.BOLD CRYS","address":"NEELAM CENTRE, B WING 4TH FLOOR HIND CYCLE ROAD, WORLI","city":"MUMBAI","supplier":"J.B.CHEMICALS & PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"ALGIERS","customer":"BNP PARIBAS ELDJAZAIR","customerCountry":"ALGERIA","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"28","totalValueFC":"1409.1","currency":"USD","unitRateINR":2300,"date":"11-Nov-2022","totalValueINR":"115000","totalValueInUsd":"1409.1","indian_port":"BOMBAY AIR","hs_no":"29061100","bill_no":"5389248","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ALGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"NEELAM CENTRE, B WING 4TH FLOOR HIND CYCLE ROAD, WORLI, MUMBAI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q1","strtotime":1676658600,"product":"MENTHOL (LEVOMENTHOL) BATCH NO.GR-02-100","address":"101 CIVIL LINES,NEAR BUDAUN CLUB","city":"BUDAUN,UTTAR PRADESH","supplier":"GRAMME PRODUCTS","supplierCountry":"INDIA","foreign_port":"TASHKENT","customer":"NIKA PHARM","customerCountry":"UZBEKISTAN","quantity":"5.00","actualQuantity":"5","unit":"KGS","unitRateFc":"105","totalValueFC":"339","currency":"USD","unitRateINR":5600,"date":"18-Feb-2023","totalValueINR":"28000","totalValueInUsd":"339","indian_port":"DELHI AIR","hs_no":"29061100","bill_no":"7877991","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"UZBEKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"101 CIVIL LINES,NEAR BUDAUN CLUB, BUDAUN,UTTAR PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1682706600,"product":"MENTHOL(LEVOMENTHOL BP) BATCH NO H2-090\/","address":"PLOT NO-9, LSC,,GUJRANWALA TOWN-I","city":"DELHI,DELHI","supplier":"SHARP MINT LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO","customerCountry":"BANGLADESH","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"35","totalValueFC":"1720.5","currency":"USD","unitRateINR":2820,"date":"29-Apr-2023","totalValueINR":"141000","totalValueInUsd":"1720.5","indian_port":"DELHI AIR","hs_no":"29061100","bill_no":"9648479","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"DELHI AIR","supplierAddress":"PLOT NO-9, LSC,,GUJRANWALA TOWN-I, DELHI,DELHI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1685989800,"product":"LEVOMENTHOL BP\/EP (BATCH NO.MLC-2305039","address":"2 K.M. STONE, MORADABAD ROAD,,","city":"SAMBAHAL,UTTAR PRADESH","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"VITEBSK","customer":"TO ORDER","customerCountry":"BELARUS","quantity":"500.00","actualQuantity":"500","unit":"KGS","unitRateFc":"14.8","totalValueFC":"7810.6","currency":"EUR","unitRateINR":1284.000354,"date":"06-Jun-2023","totalValueINR":"642000.177","totalValueInUsd":"7810.6","indian_port":"JNPT","hs_no":"29061100","bill_no":"0","productDescription":"API","marketType":"REGULATED MARKET","country":"BELARUS","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,,, SAMBAHAL,UTTAR PRADESH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703874600,"product":"LEVOMENTHOL BP\/PERPPERMINT SAT.BOLD CRYSTALS","address":"NEELAM CENTRE, B WING, 4TH FLOOR,","city":"MUMBAI, MAHARASHTRA.","supplier":"J.B.CHEMICALS & PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"ALGIERS","customer":"BIOPHARM SPA","customerCountry":"ALGERIA","quantity":"199.87","actualQuantity":"199.865","unit":"KGS","unitRateFc":"33.5","totalValueFC":"5550","currency":"USD","unitRateINR":2311.5603032046629,"date":"30-Dec-2023","totalValueINR":"462000","totalValueInUsd":"5550","indian_port":"Bombay Air","hs_no":"29061100","bill_no":"6436610","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ALGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"NEELAM CENTRE, B WING, 4TH FLOOR,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1703874600,"product":"LEVOMENTHOL BP\/PERPPERMINT SAT.BOLD CRYSTALS","address":"NEELAM CENTRE, B WING, 4TH FLOOR,","city":"MUMBAI, MAHARASHTRA.","supplier":"J.B.CHEMICALS & PHARMACEUTICALS","supplierCountry":"INDIA","foreign_port":"ALGIERS","customer":"BIOPHARM SPA","customerCountry":"ALGERIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"33.5","totalValueFC":"5550","currency":"USD","unitRateINR":2310,"date":"30-Dec-2023","totalValueINR":"462000","totalValueInUsd":"5550","indian_port":"Bombay Air","hs_no":"29061100","bill_no":"6436610","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"ALGERIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"NEELAM CENTRE, B WING, 4TH FLOOR,, MUMBAI, MAHARASHTRA.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q1","strtotime":1709058600,"product":"MENTHOL CRYSTALS (LEVOMENTHOL) BP. BATCHNO. MLC-2402017 MFG DATE:- 13\/02\/2024 EXPIRY DATE:- 12\/02\/2029","address":"2 K.M. STONE, MORADABAD ROAD,","city":"DISTT. MORADABAD.","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"JEDDAH","customer":"TO","customerCountry":"SAUDI ARABIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"17.8","totalValueFC":"3244.5","currency":"USD","unitRateINR":1346.05,"date":"28-Feb-2024","totalValueINR":"269210","totalValueInUsd":"3244.5","indian_port":"Delhi Air","hs_no":"29061100","bill_no":"7917932","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SAUDI ARABIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,, DISTT. MORADABAD.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q2","strtotime":1716921000,"product":"MENTHOL (LEVOMENTHOL) B.NO. MLC-2405051","address":"2 K.M. STONE, MORADABAD ROAD,","city":"DISTT. MORADABAD.","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"GDYNIA","customer":"TO ORDER","customerCountry":"POLAND","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"14.7","totalValueFC":"72879.1","currency":"USD","unitRateINR":1214.9549999999999,"date":"29-May-2024","totalValueINR":"6074775","totalValueInUsd":"72879.1","indian_port":"JNPT","hs_no":"29061100","bill_no":"1267234","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,, DISTT. MORADABAD.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721586600,"product":"MENTHOL (LEVOMENTHOL BP) (BATCH NO.H2-017\/L\/24-25 M.11-05-2024 E.10-05-2029)","address":"PLOT NO-9, LSC,","city":"DELHI.","supplier":"SHARP MINT LIMITED","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO ORDER","customerCountry":"BANGLADESH","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"35","totalValueFC":"1721.6","currency":"USD","unitRateINR":2878.2399999999998,"date":"22-Jul-2024","totalValueINR":"143912","totalValueInUsd":"1721.6","indian_port":"Delhi Air","hs_no":"29061100","bill_no":"2605304","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"PLOT NO-9, LSC,, DELHI.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"LEVOMENTHOL BP. B.NO. MLC-2405051 BATCHNO. MLC-2405051 MFG DATE. 21\/05\/2024 EXPIRY DATE. 20\/05\/2029","address":"2 K.M. STONE, MORADABAD ROAD,","city":"DISTT. MORADABAD.","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"25","totalValueFC":"1698.1","currency":"USD","unitRateINR":1892.6666666666667,"date":"31-Jul-2024","totalValueINR":"141950","totalValueInUsd":"1698.1","indian_port":"Delhi Air","hs_no":"29061100","bill_no":"2845431","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,, DISTT. MORADABAD.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1722364200,"product":"LEVOMENTHOL BP. B.NO. MLC-2405051 BATCHNO. MLC-2405051 MFG DATE. 21\/05\/2024 EXPIRY DATE. 20\/05\/2029","address":"2 K.M. STONE, MORADABAD ROAD,","city":"DISTT. MORADABAD.","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"DHAKA","customer":"TO THE ORDER OF","customerCountry":"BANGLADESH","quantity":"75.00","actualQuantity":"75","unit":"KGS","unitRateFc":"25","totalValueFC":"1845.3","currency":"USD","unitRateINR":2056.6666666666665,"date":"31-Jul-2024","totalValueINR":"154250","totalValueInUsd":"1845.3","indian_port":"Delhi Air","hs_no":"29061100","bill_no":"2844045","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"BANGLADESH","selfForZScoreResived":"Pharma Grade","supplierPort":"Delhi Air","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,, DISTT. MORADABAD.","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729449000,"product":"MENTHOL (LEVOMENTHOL BP LARGE CRYSTAL) (120 X 25 KG. NETT) AE-6227 PRODUCT CODE:1MOL9200SA BATCH NO.: AE\/MC\/030\/23-24","address":"B6-9 ROSHAN BAGH INDUSTRIAL ESTATE","city":"N\/A","supplier":"AGGARWWAL EXPORTS","supplierCountry":"INDIA","foreign_port":"MARSEILLE","customer":"TO ORDER","customerCountry":"FRANCE","quantity":"3000.00","actualQuantity":"3000","unit":"KGS","unitRateFc":"14.8","totalValueFC":"42281","currency":"USD","unitRateINR":1184.2410666666667,"date":"21-Oct-2024","totalValueINR":"3552723.2","totalValueInUsd":"42281","indian_port":"JNPT","hs_no":"29061110","bill_no":"4991137","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"B6-9 ROSHAN BAGH INDUSTRIAL ESTATE, N\/A","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730917800,"product":"LEVOMENTHOL B.NO. MLC-2410103 MFG DT. 11\/10\/2024 EXPIRY DT.10\/10\/2029","address":"2 K.M. STONE, MORADABAD ROAD,","city":"DISTT. MORADABAD.","supplier":"ARORA AROMATICS PVT LTD","supplierCountry":"INDIA","foreign_port":"GDYNIA","customer":"TO ORDER","customerCountry":"POLAND","quantity":"5000.00","actualQuantity":"5000","unit":"KGS","unitRateFc":"14.7","totalValueFC":"72465.1","currency":"USD","unitRateINR":1223.04,"date":"07-Nov-2024","totalValueINR":"6115200","totalValueInUsd":"72465.1","indian_port":"JNPT","hs_no":"29061110","bill_no":"5428462","productDescription":"API","marketType":"REGULATED MARKET","country":"POLAND","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"2 K.M. STONE, MORADABAD ROAD,, DISTT. MORADABAD.","customerAddress":""}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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FDF Dossiers

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Europe

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Canada

01

DOMINION VETERINARY LABORATORIES LTD.

Canada

PharmaVenue

Not Confirmed

02

DOMINION VETERINARY LABORATORIES LTD.

Canada

PharmaVenue

Not Confirmed

03

RB HEALTH (CANADA) INC.

United Kingdom

PharmaVenue

Not Confirmed

04

RB HEALTH (CANADA) INC.

United Kingdom

PharmaVenue

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USP

ABOUT THIS PAGE

Levomenthol Manufacturers

A Levomenthol manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Levomenthol, including repackagers and relabelers. The FDA regulates Levomenthol manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Levomenthol API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Levomenthol manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Levomenthol Suppliers

A Levomenthol supplier is an individual or a company that provides Levomenthol active pharmaceutical ingredient (API) or Levomenthol finished formulations upon request. The Levomenthol suppliers may include Levomenthol API manufacturers, exporters, distributors and traders.

click here to find a list of Levomenthol suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Levomenthol USDMF

A Levomenthol DMF (Drug Master File) is a document detailing the whole manufacturing process of Levomenthol active pharmaceutical ingredient (API) in detail. Different forms of Levomenthol DMFs exist exist since differing nations have different regulations, such as Levomenthol USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Levomenthol DMF submitted to regulatory agencies in the US is known as a USDMF. Levomenthol USDMF includes data on Levomenthol's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Levomenthol USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Levomenthol suppliers with USDMF on PharmaCompass.

Levomenthol JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Levomenthol Drug Master File in Japan (Levomenthol JDMF) empowers Levomenthol API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Levomenthol JDMF during the approval evaluation for pharmaceutical products. At the time of Levomenthol JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Levomenthol suppliers with JDMF on PharmaCompass.

Levomenthol CEP

A Levomenthol CEP of the European Pharmacopoeia monograph is often referred to as a Levomenthol Certificate of Suitability (COS). The purpose of a Levomenthol CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Levomenthol EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Levomenthol to their clients by showing that a Levomenthol CEP has been issued for it. The manufacturer submits a Levomenthol CEP (COS) as part of the market authorization procedure, and it takes on the role of a Levomenthol CEP holder for the record. Additionally, the data presented in the Levomenthol CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Levomenthol DMF.

A Levomenthol CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Levomenthol CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Levomenthol suppliers with CEP (COS) on PharmaCompass.

Levomenthol WC

A Levomenthol written confirmation (Levomenthol WC) is an official document issued by a regulatory agency to a Levomenthol manufacturer, verifying that the manufacturing facility of a Levomenthol active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Levomenthol APIs or Levomenthol finished pharmaceutical products to another nation, regulatory agencies frequently require a Levomenthol WC (written confirmation) as part of the regulatory process.

click here to find a list of Levomenthol suppliers with Written Confirmation (WC) on PharmaCompass.

Levomenthol NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Levomenthol as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Levomenthol API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Levomenthol as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Levomenthol and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Levomenthol NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Levomenthol suppliers with NDC on PharmaCompass.

Levomenthol GMP

Levomenthol Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Levomenthol GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Levomenthol GMP manufacturer or Levomenthol GMP API supplier for your needs.

Levomenthol CoA

A Levomenthol CoA (Certificate of Analysis) is a formal document that attests to Levomenthol's compliance with Levomenthol specifications and serves as a tool for batch-level quality control.

Levomenthol CoA mostly includes findings from lab analyses of a specific batch. For each Levomenthol CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Levomenthol may be tested according to a variety of international standards, such as European Pharmacopoeia (Levomenthol EP), Levomenthol JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Levomenthol USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.

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ACTIVE PHARMA INGREDIENTS

24 API Suppliers

13 USDMF

4 CEP/COS

6 JDMF

6 EU WC

5 NDC API

3 Listed Suppliers

$ API Reference Price

FINISHED DOSAGE FORMULATIONS

14 FDF Dossiers

6 Europe

4 Canada

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2 Shijiazhuang Huaxu Pharmaceutical

4 Sigachi Industries

4 The Dow Chemical Company

1 TopChem Pharmaceuticals

2 Ulanqab Kema New Material

2 Valens Pharmachem

2 Vasa Pharmachem

4 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

123 Topical

94 Fillers, Diluents & Binders