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Chemistry

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Also known as: Bms-820836, Liafensine [usan], 1198790-53-2, R34id086z6, Liafensine (usan), Liafensine [usan:inn]
Molecular Formula
C24H22N4
Molecular Weight
366.5  g/mol
InChI Key
VCIBGDSRPUOBOG-QFIPXVFZSA-N
FDA UNII
R34ID086Z6

Liafensine
Liafensine is under investigation in clinical trial NCT00892840 (Multiple-Ascending Dose Study).
1 2D Structure

Liafensine

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[(4S)-2-methyl-4-naphthalen-2-yl-3,4-dihydro-1H-isoquinolin-7-yl]pyridazin-3-amine
2.1.2 InChI
InChI=1S/C24H22N4/c1-28-14-20-13-19(23-10-11-24(25)27-26-23)8-9-21(20)22(15-28)18-7-6-16-4-2-3-5-17(16)12-18/h2-13,22H,14-15H2,1H3,(H2,25,27)/t22-/m0/s1
2.1.3 InChI Key
VCIBGDSRPUOBOG-QFIPXVFZSA-N
2.1.4 Canonical SMILES
CN1CC(C2=C(C1)C=C(C=C2)C3=NN=C(C=C3)N)C4=CC5=CC=CC=C5C=C4
2.1.5 Isomeric SMILES
CN1C[C@H](C2=C(C1)C=C(C=C2)C3=NN=C(C=C3)N)C4=CC5=CC=CC=C5C=C4
2.2 Other Identifiers
2.2.1 UNII
R34ID086Z6
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-(2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyridazin-3-amine

2. Bms-820836

2.3.2 Depositor-Supplied Synonyms

1. Bms-820836

2. Liafensine [usan]

3. 1198790-53-2

4. R34id086z6

5. Liafensine (usan)

6. Liafensine [usan:inn]

7. Unii-r34id086z6

8. Bms 820836

9. Liafensine [inn]

10. Liafensine [who-dd]

11. Schembl1120067

12. Chembl2364614

13. Dtxsid60152610

14. Chebi:177531

15. Bdbm50459930

16. Db14878

17. D10443

18. Q18353685

19. (5)-6-(2-methyl-4-(naphthalen-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyridazin-3-amine

20. (s)-6-(2-methyl-4-(naphthalen-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyridazin-3-amine

21. 6-[(4s)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine

22. 6-[(4s)-2-methyl-4-naphthalen-2-yl-3,4-dihydro-1h-isoquinolin-7-yl]pyridazin-3-amine

23. 3-pyridazinamine, 6-((4s)-1,2,3,4-tetrahydro-2-methyl-4-(2-naphthalenyl)-7-isoquinolinyl)-

24. 6-((4s)-2-methyl-4-(naphthalen-2-yl)-1,2,3,4-tetrahydroisoquinolin-7-yl)pyridazin-3-amine

2.4 Create Date
2012-08-19
3 Chemical and Physical Properties
Molecular Weight 366.5 g/mol
Molecular Formula C24H22N4
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass366.18444672 g/mol
Monoisotopic Mass366.18444672 g/mol
Topological Polar Surface Area55 Ų
Heavy Atom Count28
Formal Charge0
Complexity525
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Liafensine Manufacturers

A Liafensine manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Liafensine, including repackagers and relabelers. The FDA regulates Liafensine manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Liafensine API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Liafensine Suppliers

A Liafensine supplier is an individual or a company that provides Liafensine active pharmaceutical ingredient (API) or Liafensine finished formulations upon request. The Liafensine suppliers may include Liafensine API manufacturers, exporters, distributors and traders.

Liafensine GMP

Liafensine Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Liafensine GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Liafensine GMP manufacturer or Liafensine GMP API supplier for your needs.

Liafensine CoA

A Liafensine CoA (Certificate of Analysis) is a formal document that attests to Liafensine's compliance with Liafensine specifications and serves as a tool for batch-level quality control.

Liafensine CoA mostly includes findings from lab analyses of a specific batch. For each Liafensine CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Liafensine may be tested according to a variety of international standards, such as European Pharmacopoeia (Liafensine EP), Liafensine JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Liafensine USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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