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Chemistry

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Also known as: Lifirafenib, Bgb-283, 1446090-77-2, 1446090-79-4, Bgb283, Lifirafenib [usan]
Molecular Formula
C25H17F3N4O3
Molecular Weight
478.4  g/mol
InChI Key
NGFFVZQXSRKHBM-FKBYEOEOSA-N
FDA UNII
8762XZS5ZF

Lifirafenib
Lifirafenib is an inhibitor of the serine/threonine protein kinase B-raf (BRAF) and epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Lifirafenib selectively binds to and inhibits the activity of BRAF and certain BRAF mutant forms, and EGFR. This prevents BRAF- and EGFR-mediated signaling and inhibits the proliferation of tumor cells that either contain a mutated BRAF gene or express over-activated EGFR. In addition, BGB-283 inhibits mutant forms of the Ras proteins K-RAS and N-RAS. BRAF and EGFR are mutated or upregulated in many tumor cell types.
1 2D Structure

Lifirafenib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
5-[[(1R,1aS,6bR)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one
2.1.2 InChI
InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/m0/s1
2.1.3 InChI Key
NGFFVZQXSRKHBM-FKBYEOEOSA-N
2.1.4 Canonical SMILES
C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC5C4C5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
2.1.5 Isomeric SMILES
C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)O[C@H]5[C@@H]4[C@@H]5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
2.2 Other Identifiers
2.2.1 UNII
8762XZS5ZF
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 5-((1-(6-(trifluoromethyl)-1h-benzo(d)imidazol-2-yl)-1a,6b-dihydro-1h-cyclopropa(b)benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyrdin-2(1h)-one

2. Bgb-283

3. Lifrafenib

2.3.2 Depositor-Supplied Synonyms

1. Lifirafenib

2. Bgb-283

3. 1446090-77-2

4. 1446090-79-4

5. Bgb283

6. Lifirafenib [usan]

7. 5-(((1r,1as,6br)-1-(6-(trifluoromethyl)-1h-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1h-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one

8. Bgb 283

9. 8762xzs5zf

10. 5-(((1r,1as,6br)-1-(6-(trifluoromethyl)-1h-benzimidazol-2-yl)-1a,6b-dihydro-1h-cyclopropa(b)benzofuran-5-yl)oxy)-3,4-dihydro-1h-1,8-naphthyridin-2-one

11. 5-[[(1r,1as,6br)-1-[6-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1h-1,8-naphthyridin-2-one

12. 1,8-naphthyridin-2(1h)-one, 5-(((1r,1as,6br)-1a,6b-dihydro-1-(6-(trifluoromethyl)-1h-benzimidazol-2-yl)-1h-cyclopropa(b)benzofuran-5-yl)oxy)-3,4-dihydro-

13. 5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one

14. Compound 2.2b

15. 5-{{(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy}-3,4-dihydro-1,8-naphthyridin-2(1h)-one

16. Lifirafenib [inn]

17. Lifirafenib (usan/inn)

18. Unii-8762xzs5zf

19. Bgb-283;beigene-283

20. Lifirafenib [who-dd]

21. Gtpl8958

22. Chembl4209157

23. Schembl15085288

24. Bdbm372968

25. Ex-a1473

26. Us9895376, Compound 2.2b

27. Whc09077

28. Whc09079

29. Lifirafenib;bgb-283;beigene-283

30. Bdbm50453816

31. Who 10554

32. Zinc68764621

33. Cs-6308

34. Db14773

35. Ac-35880

36. Ac-36373

37. Hy-18957

38. D11410

39. A900647

40. Q27075193

41. 3k3

2.4 Create Date
2015-02-13
3 Chemical and Physical Properties
Molecular Weight 478.4 g/mol
Molecular Formula C25H17F3N4O3
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count3
Exact Mass478.12527490 g/mol
Monoisotopic Mass478.12527490 g/mol
Topological Polar Surface Area89.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity845
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Lifirafenib Manufacturers

A Lifirafenib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lifirafenib, including repackagers and relabelers. The FDA regulates Lifirafenib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lifirafenib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lifirafenib Suppliers

A Lifirafenib supplier is an individual or a company that provides Lifirafenib active pharmaceutical ingredient (API) or Lifirafenib finished formulations upon request. The Lifirafenib suppliers may include Lifirafenib API manufacturers, exporters, distributors and traders.

Lifirafenib GMP

Lifirafenib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lifirafenib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lifirafenib GMP manufacturer or Lifirafenib GMP API supplier for your needs.

Lifirafenib CoA

A Lifirafenib CoA (Certificate of Analysis) is a formal document that attests to Lifirafenib's compliance with Lifirafenib specifications and serves as a tool for batch-level quality control.

Lifirafenib CoA mostly includes findings from lab analyses of a specific batch. For each Lifirafenib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lifirafenib may be tested according to a variety of international standards, such as European Pharmacopoeia (Lifirafenib EP), Lifirafenib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lifirafenib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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