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    Also known as: 55-06-1, Cytomel, Triostat, 3,3',5-triiodo-l-thyronine sodium salt, Tertroxin, T3 sodium salt
    Molecular Formula
    C15H11I3NNaO4
    Molecular Weight
    672.95  g/mol
    InChI Key
    SBXXSUDPJJJJLC-YDALLXLXSA-M
    FDA UNII
    GCA9VV7D2N
    Liothyronine Sodium
    A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.
    1 2D Structure

    Liothyronine Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
    2.1.2 InChI
    InChI=1S/C15H12I3NO4.Na/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;/h1-4,6,12,20H,5,19H2,(H,21,22);/q;+1/p-1/t12-;/m0./s1
    2.1.3 InChI Key
    SBXXSUDPJJJJLC-YDALLXLXSA-M
    2.1.4 Canonical SMILES
    C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)[O-])N)I)I)O.[Na+]
    2.1.5 Isomeric SMILES
    C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])N)I)I)O.[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    GCA9VV7D2N
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3,3',5-triiodothyronine

    2. Cytomel

    3. Liothyronine

    4. T3 Thyroid Hormone

    5. Thyroid Hormone, T3

    6. Triiodothyronine

    2.3.2 Depositor-Supplied Synonyms

    1. 55-06-1

    2. Cytomel

    3. Triostat

    4. 3,3',5-triiodo-l-thyronine Sodium Salt

    5. Tertroxin

    6. T3 Sodium Salt

    7. Basoprocin

    8. Ibiothyron

    9. Cynomel

    10. Triiodothyronine Sodium

    11. L-triiodothyronine Sodium Salt

    12. Cytobin

    13. 3,3',5-triiodo-l-thyronine Sodium

    14. 3,3',5-triiodothyronine Sodium Salt

    15. Triiodothyronine Sodium Salt

    16. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Monosodium Salt

    17. Liotrix (t3)

    18. Chebi:6484

    19. Liothyronine (sodium)

    20. Monosodium L-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)alanine

    21. Gca9vv7d2n

    22. Liothyronine (l- Isomer) Sodium

    23. Rathyronine Sodium, (s)-

    24. Cytomel Sodium

    25. Lyothyronin

    26. Nsc-80774

    27. Nsc-758175

    28. 3,3'',5-triiodo-l-thyronine Sodium Salt

    29. Ro Thyronine

    30. Sodium Triiodothyronine

    31. Liothyronine Sodium Salt

    32. Alanine, 3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)-, Monosodium Salt, L-

    33. Sodium Liothyronine

    34. Sodium T3

    35. Sodium Triiodotironine

    36. Sodium-l-triiodothyronine

    37. Mls000028648

    38. L-triiodothyronine Hydrochloride

    39. Sodium (s)-2-amino-3-(4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl)propanoate

    40. Rathyronine Hydrochloride, (s)-

    41. Sodium Triiodothyronine, L-

    42. Sodium 3,5,3'-triiodothyronine

    43. Sodium L-3,5,3'-triiodothyronine

    44. Smr000059206

    45. Einecs 200-223-5

    46. Unii-gca9vv7d2n

    47. Mfcd00002594

    48. Nsc 80774

    49. Sodium 3,3',5-triiodo-l-thyronine

    50. Sodium 3,5,3'-triiodo-l-thyronine

    51. L-3,3',5-triiodothyronine Sodium Salt

    52. Triostat (tn)

    53. Cytomel (tn)

    54. Liothyronine Sodium [usp:ban:jan]

    55. Ibiot

    56. L-tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, Sodium Salt (1:1)

    57. Sodium;(2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

    58. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine Sodium Salt

    59. T-3

    60. Epitope Id:136777

    61. T3 (liotrix)

    62. T3, Na

    63. Dsstox_cid_27505

    64. Dsstox_rid_82385

    65. Dsstox_gsid_47505

    66. Schembl41654

    67. 3,3',5-l-triiodothyronine

    68. Spectrum1502047

    69. Chembl1201119

    70. Dtxsid8047505

    71. Liothyronine Sodium [jan]

    72. Nrp-409

    73. Liothyronine Sodium (jp17/usp)

    74. Hms1921h18

    75. Hms2092b14

    76. Liothyronine Sodium [vandf]

    77. Act03263

    78. Amy38143

    79. Hy-a0070

    80. Liothyronine Sodium [mart.]

    81. Sodium L-3,3',5-triiodothyronine

    82. Tox21_302514

    83. Triiodothyronine Sodium, Levo

    84. Ccg-39522

    85. Liothyronine Sodium [usp-rs]

    86. Liothyronine Sodium [who-dd]

    87. Liotrix (t3) [orange Book]

    88. S4217

    89. Liothyronine Sodium Salt [mi]

    90. Akos015918421

    91. Akos032949712

    92. Cs-3241

    93. 3,3',5-triiodo-l-thyronine (sodium)

    94. Cas-55-06-1

    95. Liothyronine Sodium [green Book]

    96. Liothyronine Sodium [orange Book]

    97. Ncgc00256816-01

    98. Ac-31934

    99. As-13674

    100. L-3,3',5-triiodothyronine, Sodium Salt

    101. Liothyronine Sodium [ep Monograph]

    102. Liothyronine Sodium [usp Monograph]

    103. 3,5,3'-triiodo-l-thyronine Monosodium Salt

    104. Sw219577-1

    105. D01011

    106. F20556

    107. A830467

    108. Q930170

    109. Q-201881

    110. 3,3',5-triiodo-l-thyronine Sodium Salt, >=95% (hplc)

    111. Liothyronine Sodium, European Pharmacopoeia (ep) Reference Standard

    112. O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-l-tyrosine, Monosodium Salt

    113. 3,3',5-triiodo-l-thyronine Sodium Salt, Powder, Bioreagent, Suitable For Cell Culture

    114. Liothyronine For Peak Identification, European Pharmacopoeia (ep) Reference Standard

    115. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate

    116. Sodium (2s)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate

    117. 3,3',5-triiodo-l-thyronine Sodium Salt, Gamma-irradiated, Powder, Bioxtra, Suitable For Cell Culture

    2.4 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 672.95 g/mol
    Molecular Formula C15H11I3NNaO4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass672.7720 g/mol
    Monoisotopic Mass672.7720 g/mol
    Topological Polar Surface Area95.6 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity408
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameCytomel
    PubMed HealthLiothyronine
    Drug ClassesDiagnostic Agent, Thyroid Function, Thyroid Supplement
    Drug LabelThyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
    Active IngredientLiothyronine sodium
    Dosage FormTablet
    RouteOral
    Strengtheq 0.05mg base; eq 0.025mg base; eq 0.005mg base
    Market StatusPrescription
    CompanyKing Pharms R And D

    2 of 6  
    Drug NameLiothyronine sodium
    Drug LabelThyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
    Active IngredientLiothyronine sodium
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strengtheq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
    Market StatusPrescription
    CompanyX Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

    3 of 6  
    Drug NameTriostat
    PubMed HealthLiothyronine
    Drug ClassesDiagnostic Agent, Thyroid Function, Thyroid Supplement
    Active IngredientLiothyronine sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.01mg base/ml
    Market StatusPrescription
    CompanyPar Sterile Products

    4 of 6  
    Drug NameCytomel
    PubMed HealthLiothyronine
    Drug ClassesDiagnostic Agent, Thyroid Function, Thyroid Supplement
    Drug LabelThyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
    Active IngredientLiothyronine sodium
    Dosage FormTablet
    RouteOral
    Strengtheq 0.05mg base; eq 0.025mg base; eq 0.005mg base
    Market StatusPrescription
    CompanyKing Pharms R And D

    5 of 6  
    Drug NameLiothyronine sodium
    Drug LabelThyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupli...
    Active IngredientLiothyronine sodium
    Dosage FormTablet; Injectable
    RouteInjection; Oral
    Strengtheq 0.05mg base; eq 0.025mg base; eq 0.005mg base; eq 0.01mg base/ml
    Market StatusPrescription
    CompanyX Gen Pharms; Coastal Pharms; Sigmapharm Labs; Mylan

    6 of 6  
    Drug NameTriostat
    PubMed HealthLiothyronine
    Drug ClassesDiagnostic Agent, Thyroid Function, Thyroid Supplement
    Active IngredientLiothyronine sodium
    Dosage FormInjectable
    RouteInjection
    Strengtheq 0.01mg base/ml
    Market StatusPrescription
    CompanyPar Sterile Products

    5 Pharmacology and Biochemistry
    5.1 FDA Pharmacological Classification
    5.1.1 Pharmacological Classes
    l-Triiodothyronine [EPC]; Triiodothyronine [CS]
    5.2 ATC Code

    H - Systemic hormonal preparations, excl. sex hormones and insulins

    H03 - Thyroid therapy

    H03A - Thyroid preparations

    H03AA - Thyroid hormones

    H03AA02 - Liothyronine sodium

    API Reference Price

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    19-Jan-2021
    04-Jul-2024
    KGS
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    Average Price (USD/KGS)

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    DOSAGE - TABLET;ORAL - EQ 0.005MG BASE

    USFDA APPLICATION NUMBER - 10379

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    DOSAGE - TABLET;ORAL - EQ 0.025MG BASE

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    DOSAGE - TABLET;ORAL - EQ 0.05MG BASE

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    DOSAGE - INJECTABLE;INJECTION - EQ 0.01MG BAS...DOSAGE - INJECTABLE;INJECTION - EQ 0.01MG BASE/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

    USFDA APPLICATION NUMBER - 20105

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    ABOUT THIS PAGE

    Liothyronine Sodium Manufacturers

    A Liothyronine Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Liothyronine Sodium, including repackagers and relabelers. The FDA regulates Liothyronine Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Liothyronine Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Liothyronine Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Liothyronine Sodium Suppliers

    A Liothyronine Sodium supplier is an individual or a company that provides Liothyronine Sodium active pharmaceutical ingredient (API) or Liothyronine Sodium finished formulations upon request. The Liothyronine Sodium suppliers may include Liothyronine Sodium API manufacturers, exporters, distributors and traders.

    click here to find a list of Liothyronine Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Liothyronine Sodium USDMF

    A Liothyronine Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Liothyronine Sodium active pharmaceutical ingredient (API) in detail. Different forms of Liothyronine Sodium DMFs exist exist since differing nations have different regulations, such as Liothyronine Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Liothyronine Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Liothyronine Sodium USDMF includes data on Liothyronine Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Liothyronine Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Liothyronine Sodium suppliers with USDMF on PharmaCompass.

    Liothyronine Sodium JDMF

    The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

    The Liothyronine Sodium Drug Master File in Japan (Liothyronine Sodium JDMF) empowers Liothyronine Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

    PMDA reviews the Liothyronine Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Liothyronine Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

    click here to find a list of Liothyronine Sodium suppliers with JDMF on PharmaCompass.

    Liothyronine Sodium KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Liothyronine Sodium Drug Master File in Korea (Liothyronine Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Liothyronine Sodium. The MFDS reviews the Liothyronine Sodium KDMF as part of the drug registration process and uses the information provided in the Liothyronine Sodium KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Liothyronine Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Liothyronine Sodium API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Liothyronine Sodium suppliers with KDMF on PharmaCompass.

    Liothyronine Sodium CEP

    A Liothyronine Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Liothyronine Sodium Certificate of Suitability (COS). The purpose of a Liothyronine Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Liothyronine Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Liothyronine Sodium to their clients by showing that a Liothyronine Sodium CEP has been issued for it. The manufacturer submits a Liothyronine Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Liothyronine Sodium CEP holder for the record. Additionally, the data presented in the Liothyronine Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Liothyronine Sodium DMF.

    A Liothyronine Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Liothyronine Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Liothyronine Sodium suppliers with CEP (COS) on PharmaCompass.

    Liothyronine Sodium WC

    A Liothyronine Sodium written confirmation (Liothyronine Sodium WC) is an official document issued by a regulatory agency to a Liothyronine Sodium manufacturer, verifying that the manufacturing facility of a Liothyronine Sodium active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Liothyronine Sodium APIs or Liothyronine Sodium finished pharmaceutical products to another nation, regulatory agencies frequently require a Liothyronine Sodium WC (written confirmation) as part of the regulatory process.

    click here to find a list of Liothyronine Sodium suppliers with Written Confirmation (WC) on PharmaCompass.

    Liothyronine Sodium NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Liothyronine Sodium as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Liothyronine Sodium API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Liothyronine Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Liothyronine Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Liothyronine Sodium NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Liothyronine Sodium suppliers with NDC on PharmaCompass.

    Liothyronine Sodium GMP

    Liothyronine Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Liothyronine Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Liothyronine Sodium GMP manufacturer or Liothyronine Sodium GMP API supplier for your needs.

    Liothyronine Sodium CoA

    A Liothyronine Sodium CoA (Certificate of Analysis) is a formal document that attests to Liothyronine Sodium's compliance with Liothyronine Sodium specifications and serves as a tool for batch-level quality control.

    Liothyronine Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Liothyronine Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Liothyronine Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Liothyronine Sodium EP), Liothyronine Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Liothyronine Sodium USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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