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Lipoprotein Lipase Activator

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ACTIVE PHARMA INGREDIENTS

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Synopsis

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Also known as: 133208-93-2, No-1886, Lipoprotein lipase activator, Opf 009, Opf-009, Diethyl (4-((4-bromo-2-cyanophenyl)carbamoyl)benzyl)phosphonate

Molecular Formula

C₁₉H₂₀BrN₂O₄P

Molecular Weight

451.2 g/mol

InChI Key

KPRTURMJVWXURQ-UHFFFAOYSA-N

FDA UNII

07H1561618

Ibrolipim is a lipoprotein lipase (LPL) activator with antihyperlipidemic activity. Activation of LDL by ibrolipim lowers plasma triglycerides, with a concomitant elevation of high-density lipoprotein cholesterol.

1 2D Structure

Lipoprotein Lipase Activator

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide

2.1.2 InChI

InChI=1S/C19H20BrN2O4P/c1-3-25-27(24,26-4-2)13-14-5-7-15(8-6-14)19(23)22-18-10-9-17(20)11-16(18)12-21/h5-11H,3-4,13H2,1-2H3,(H,22,23)

2.1.3 InChI Key

KPRTURMJVWXURQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CCOP(=O)(CC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)Br)C#N)OCC

2.2 Other Identifiers

2.2.1 UNII

07H1561618

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-diethoxyphosphorylmethyl-n-(4-bromo-2-cyanophenyl)benzamide

2. No 1886

3. No-1886

2.3.2 Depositor-Supplied Synonyms

1. 133208-93-2

2. No-1886

3. Lipoprotein Lipase Activator

4. Opf 009

5. Opf-009

6. Diethyl (4-((4-bromo-2-cyanophenyl)carbamoyl)benzyl)phosphonate

7. Phosphonic Acid, ((4-(((4-bromo-2-cyanophenyl)amino)carbonyl)phenyl)methyl)-, Diethyl Ester

8. Phosphonic Acid, [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-, Diethyl Ester

9. Diethyl 4-((4-bromo-2-cyanophenyl)carbamoyl)benzylphosphonate

10. 07h1561618

11. Diethyl 4-[(4-bromo-2-cyanoanilino)carbonyl]benzylphosphonate

12. Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate

13. Ibrolipim [usan:inn]

14. 4-diethoxyphosphorylmethyl-n-(4-bromo-2-cyanophenyl)benzamide

15. No 1886

16. Ibrolipim [usan]

17. Unii-07h1561618

18. Ibrolipim [inn]

19. N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide

20. Ibrolipim (usan/inn)

21. Mls006011667

22. Chembl34234

23. Schembl493918

24. Dtxsid20157989

25. Zinc1552570

26. Akos005067076

27. Ss-3273

28. Ncgc00481428-01

29. Smr002529695

30. Hy-117549

31. Cs-0066427

32. D03747

33. D83803

34. J-006332

35. Q5984863

36. 4-diethoxyphosphinoylmethyl-n-(4-bromo-2-cyanophenyl)benzamide

37. Diethyl4-((4-bromo-2-cyanophenyl)carbamoyl)benzylphosphonate

38. Diethyl (4-((4-bromo-2-cyanophenyl)carbamoyl)benzyl)phosphonate

39. Diethyl 4-[n-(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₉H₂₀BrN₂O₄P
Molecular Weight	451.2 g/mol
XLogP3	3.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	8
Exact Mass	450.03441 g/mol
Monoisotopic Mass	450.03441 g/mol
Topological Polar Surface Area	88.4 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	576
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Hypolipidemic Agents

Substances that lower the levels of certain LIPIDS in the BLOOD. They are used to treat HYPERLIPIDEMIAS. (See all compounds classified as Hypolipidemic Agents.)

Lipoprotein Lipase Activators

Compounds that increase the enzymatic activity of LIPOPROTEIN LIPASE. Lipoprotein lipase activators have a potential role in the treatment of OBESITY by increasing LIPID METABOLISM. Note that substances that increase the synthesis of lipoprotein lipase are not included here. (See all compounds classified as Lipoprotein Lipase Activators.)

4.2 Metabolism/Metabolites

Ibrolipim has known human metabolites that include [4-[(4-Bromo-2-cyanophenyl)carbamoyl]phenyl]methyl-ethoxyphosphinic acid.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

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ABOUT THIS PAGE

Lipoprotein Lipase Activator Manufacturers

A Lipoprotein Lipase Activator manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lipoprotein Lipase Activator, including repackagers and relabelers. The FDA regulates Lipoprotein Lipase Activator manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lipoprotein Lipase Activator API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lipoprotein Lipase Activator Suppliers

A Lipoprotein Lipase Activator supplier is an individual or a company that provides Lipoprotein Lipase Activator active pharmaceutical ingredient (API) or Lipoprotein Lipase Activator finished formulations upon request. The Lipoprotein Lipase Activator suppliers may include Lipoprotein Lipase Activator API manufacturers, exporters, distributors and traders.

click here to find a list of Lipoprotein Lipase Activator suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lipoprotein Lipase Activator USDMF

A Lipoprotein Lipase Activator DMF (Drug Master File) is a document detailing the whole manufacturing process of Lipoprotein Lipase Activator active pharmaceutical ingredient (API) in detail. Different forms of Lipoprotein Lipase Activator DMFs exist exist since differing nations have different regulations, such as Lipoprotein Lipase Activator USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Lipoprotein Lipase Activator DMF submitted to regulatory agencies in the US is known as a USDMF. Lipoprotein Lipase Activator USDMF includes data on Lipoprotein Lipase Activator's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lipoprotein Lipase Activator USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Lipoprotein Lipase Activator suppliers with USDMF on PharmaCompass.

Lipoprotein Lipase Activator GMP

Lipoprotein Lipase Activator Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lipoprotein Lipase Activator GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lipoprotein Lipase Activator GMP manufacturer or Lipoprotein Lipase Activator GMP API supplier for your needs.

Lipoprotein Lipase Activator CoA

A Lipoprotein Lipase Activator CoA (Certificate of Analysis) is a formal document that attests to Lipoprotein Lipase Activator's compliance with Lipoprotein Lipase Activator specifications and serves as a tool for batch-level quality control.

Lipoprotein Lipase Activator CoA mostly includes findings from lab analyses of a specific batch. For each Lipoprotein Lipase Activator CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lipoprotein Lipase Activator may be tested according to a variety of international standards, such as European Pharmacopoeia (Lipoprotein Lipase Activator EP), Lipoprotein Lipase Activator JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lipoprotein Lipase Activator USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.