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Chemistry

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Also known as: Lysuride, 18016-80-3, Lisuride [inn], Lisurida, Lisuridum, Lisuride maleate
Molecular Formula
C20H26N4O
Molecular Weight
338.4  g/mol
InChI Key
BKRGVLQUQGGVSM-KBXCAEBGSA-N
FDA UNII
E0QN3D755O

Lisuride
An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).
1 2D Structure

Lisuride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
3-[(6aR,9S)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
2.1.2 InChI
InChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18+/m0/s1
2.1.3 InChI Key
BKRGVLQUQGGVSM-KBXCAEBGSA-N
2.1.4 Canonical SMILES
CCN(CC)C(=O)NC1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C
2.1.5 Isomeric SMILES
CCN(CC)C(=O)N[C@@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C
2.2 Other Identifiers
2.2.1 UNII
E0QN3D755O
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Arolac

2. Carbamide, Methylergol

3. Cuvalit

4. Dopergin

5. Dopergine

6. Hydrochloride, Lisuride

7. Hydrogen Maleate, Lysuride

8. Lisuride Hydrochloride

9. Lisuride Maleate

10. Lisuride Maleate (1:1)

11. Lisuride Maleate, (8beta)-isomer

12. Lisuride Mesylate

13. Lisuride Phosphate (1:1)

14. Lisuride, (8alpha)-(+-)-isomer

15. Lysenyl

16. Lysurid

17. Lysuride Hydrogen Maleate

18. Maleate, Lisuride

19. Mesylate, Lisuride

20. Methylergol Carbamide

21. Revanil

2.3.2 Depositor-Supplied Synonyms

1. Lysuride

2. 18016-80-3

3. Lisuride [inn]

4. Lisurida

5. Lisuridum

6. Lisuride Maleate

7. Lisuride (inn)

8. 140387-89-9

9. Lisuride (s)(-)

10. N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-n,n-diethylurea

11. S-(-)-lisuride

12. Chembl157138

13. E0qn3d755o

14. Chebi:51164

15. 1,1-diethyl-3-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea

16. 18016-80-3 (free Base)

17. Lisuridum [inn-latin]

18. Lysuride Maleate

19. Lisurida [inn-spanish]

20. N,n-diethyl-n'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea

21. Dopergin

22. Dl-lisuride

23. 1,1-diethyl-3-((6ar,9s)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinolin-9-yl)urea

24. 3-[(6ar,9s)-7-methyl-6,6a,8,9-tetrahydro-4h-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea

25. 3,3-diethyl-1-[(4s,7r)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaen-4-yl]urea

26. Lisuride [inn:ban]

27. Einecs 241-925-1

28. Unii-e0qn3d755o

29. (+)-lisuride

30. H8g

31. Lisuride, (s)

32. Prestwick_525

33. 3-(9,10-didehydro-6-methylergolin-8alpha-yl)-1,1-diethylurea

34. Lisuride [mi]

35. Prestwick0_000106

36. Prestwick1_000106

37. Prestwick2_000106

38. Prestwick3_000106

39. Urea, N'-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-n,n-diethyl-

40. Gtpl43

41. Lisuride [who-dd]

42. Lopac0_000751

43. Schembl43950

44. Bspbio_000092

45. Spbio_002031

46. Bpbio1_000102

47. Dtxsid3023217

48. Dtxsid30274075

49. Hms1568e14

50. Zinc3831001

51. Bdbm50056445

52. Ccg-204836

53. Db00589

54. Ncgc00179663-02

55. Hy-12713

56. Cs-0012290

57. D08132

58. Q424446

59. 1,1-diethyl-3-(9,10-didehydro-6-methyl-8alpha-ergolinyl)urea

60. 3-(9,10-didehydro-6-methyl-8alpha-ergolinyl)-1,1-diethylurea

61. 3-(9,10-didehydro-6-methylergolin-8.alpha.-yl)-1,1-diethylurea

62. N''-((8alpha)-9,10-didehydro-6-methylergolin-8-yl)-n,n-diethylurea

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 338.4 g/mol
Molecular Formula C20H26N4O
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count3
Exact Mass338.21066147 g/mol
Monoisotopic Mass338.21066147 g/mol
Topological Polar Surface Area51.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity544
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

For the management of Parkinson's Disease


5 Pharmacology and Biochemistry
5.1 Pharmacology

There is evidence that lisuride lowers prolactin levels and, in low doses, prevents migraine attacks.


5.2 MeSH Pharmacological Classification

Serotonin Receptor Agonists

Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)


Antiparkinson Agents

Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. (See all compounds classified as Antiparkinson Agents.)


Dopamine Agonists

Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)


5.3 ATC Code

G - Genito urinary system and sex hormones

G02 - Other gynecologicals

G02C - Other gynecologicals

G02CB - Prolactine inhibitors

G02CB02 - Lisuride


N - Nervous system

N02 - Analgesics

N02C - Antimigraine preparations

N02CA - Ergot alkaloids

N02CA07 - Lisuride


5.4 Mechanism of Action

Lisuride is an anti-Parkinson drug chemically related to the dopaminergic ergoline Parkinson's drugs. Lisuride binds to the 5-HT(1A) and 5-HT(2A/2C) receptors. It is also thought to bind to the dopamine receptor and to act as a dopamine agonist. Evidence has also emerged that Lisuride also binds to the Histamine H1 receptor.


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ABOUT THIS PAGE

Looking for 18016-80-3 / Lisuride API manufacturers, exporters & distributors?

Lisuride manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lisuride API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lisuride manufacturer or Lisuride supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lisuride manufacturer or Lisuride supplier.

PharmaCompass also assists you with knowing the Lisuride API Price utilized in the formulation of products. Lisuride API Price is not always fixed or binding as the Lisuride Price is obtained through a variety of data sources. The Lisuride Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lisuride

Synonyms

Lysuride, 18016-80-3, Lisuride [inn], Lisurida, Lisuridum, Lisuride maleate

Cas Number

18016-80-3

Unique Ingredient Identifier (UNII)

E0QN3D755O

About Lisuride

An ergot derivative that acts as an agonist at dopamine D2 receptors (DOPAMINE AGONISTS). It may also act as an antagonist at dopamine D1 receptors, and as an agonist at some serotonin receptors (SEROTONIN RECEPTOR AGONISTS).

Lisuride Manufacturers

A Lisuride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lisuride, including repackagers and relabelers. The FDA regulates Lisuride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lisuride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lisuride Suppliers

A Lisuride supplier is an individual or a company that provides Lisuride active pharmaceutical ingredient (API) or Lisuride finished formulations upon request. The Lisuride suppliers may include Lisuride API manufacturers, exporters, distributors and traders.

click here to find a list of Lisuride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lisuride USDMF

A Lisuride DMF (Drug Master File) is a document detailing the whole manufacturing process of Lisuride active pharmaceutical ingredient (API) in detail. Different forms of Lisuride DMFs exist exist since differing nations have different regulations, such as Lisuride USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Lisuride DMF submitted to regulatory agencies in the US is known as a USDMF. Lisuride USDMF includes data on Lisuride's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lisuride USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Lisuride suppliers with USDMF on PharmaCompass.

Lisuride GMP

Lisuride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lisuride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lisuride GMP manufacturer or Lisuride GMP API supplier for your needs.

Lisuride CoA

A Lisuride CoA (Certificate of Analysis) is a formal document that attests to Lisuride's compliance with Lisuride specifications and serves as a tool for batch-level quality control.

Lisuride CoA mostly includes findings from lab analyses of a specific batch. For each Lisuride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lisuride may be tested according to a variety of international standards, such as European Pharmacopoeia (Lisuride EP), Lisuride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lisuride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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