menu
    • menu

    Find Lithium Citrate manufacturers, exporters & distributors on PharmaCompass

    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    PATENTS & EXCLUSIVITIES

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    2

    API Suppliers

    API Suppliers

    2

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    0

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 117

    MARKET PLACE

    0

    API

    0

    FDF

    0INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    6

    FDF Dossiers

    FDF Dossiers

    5

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    1

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    0 DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    1

    US Exclusivities

    0

    Health Canada Patents

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    2

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Finished Drug Prices

    NA

    103 RELATED EXCIPIENT COMPANIES

    164EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: 919-16-4, Trilithium citrate, Litarex, Citric acid trilithium salt, Lithium citrate anhydrous, Lithium (citrate)
    Molecular Formula
    C6H5Li3O7
    Molecular Weight
    210.0  g/mol
    InChI Key
    WJSIUCDMWSDDCE-UHFFFAOYSA-K
    FDA UNII
    3655633623
    Lithium Citrate
    Lithium Citrate is the citrate salt of lithium, a monovalent cation with antimanic activity. Although the exact mechanism is unclear, lithium might exert its mood-stabilizing effect via reduction of catecholamine concentration mediated through transneuronal membrane transport of sodium ion by sodium-potassium-stimulated adenosine triphosphatase (Na-K-ATPase). Alternatively, lithium may decrease cyclic adenosine monophosphate (cAMP) concentrations, which would desensitize hormonal-sensitive adenylyl cyclase receptors. Furthermore, lithium, in recommended dosage, blocks the activity of inositol-1-phosphatase, thereby resulting in the subsequent decrease of postsynaptic second messengers, diacylglycerol and inositol triphosphate, that contribute to chronic cell stimulation by altering electrical activity in the neuron.
    1 2D Structure

    Lithium Citrate

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    trilithium;2-hydroxypropane-1,2,3-tricarboxylate
    2.1.2 InChI
    InChI=1S/C6H8O7.3Li/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
    2.1.3 InChI Key
    WJSIUCDMWSDDCE-UHFFFAOYSA-K
    2.1.4 Canonical SMILES
    [Li+].[Li+].[Li+].C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O
    2.2 Other Identifiers
    2.2.1 UNII
    3655633623
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Litarex

    2. Monolithium Citrate

    2.3.2 Depositor-Supplied Synonyms

    1. 919-16-4

    2. Trilithium Citrate

    3. Litarex

    4. Citric Acid Trilithium Salt

    5. Lithium Citrate Anhydrous

    6. Lithium (citrate)

    7. Citric Acid, Trilithium Salt

    8. Lithium Citrate (anhydrous)

    9. Lithium Citrate Tribasic Tetrahydrate

    10. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Trilithium Salt

    11. Anhydrous Lithium Citrate

    12. Demalit; Litarex; Lithonate S

    13. 6680-58-6

    14. Demalit

    15. Chebi:64735

    16. Lithium 2-hydroxypropane-1,2,3-tricarboxylate

    17. Trilithium;2-hydroxypropane-1,2,3-tricarboxylate

    18. 1,2,3-propanetricarboxylic Acid, 2-hydroxy-, Lithium Salt (1:3)

    19. Einecs 213-045-8

    20. Citric Acid, Lithium Salt

    21. Trilithium 2-hydroxypropane-1,2,3-tricarboxylate

    22. Einecs 233-819-9

    23. Anh. Lithium Citrate

    24. Unii-3655633623

    25. Lithium Citrate (anh.)

    26. Citric Acid,lithium Salt

    27. Lithium Citrate [mi]

    28. Spectrum1504269

    29. Chembl1201170

    30. Dtxsid70883185

    31. Hms1923k13

    32. Hms2093g04

    33. Lithium Citrate Tribasic 4-hydrate

    34. 2-hydroxy-1,2,3-propanetricarboxylic Acid Lithium Salt (1:3)

    35. Akos015839591

    36. Akos015902460

    37. Ccg-213298

    38. Db14507

    39. Ncgc00095267-01

    40. Ncgc00095267-02

    41. 1313437-84-1

    42. Db-054961

    43. Ft-0636234

    44. Lithium2-hydroxypropane-1,2,3-tricarboxylate

    45. Lithium 3-carboxy-3,5-dihydroxy-5-oxopentanoate

    46. Q2351742

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 210.0 g/mol
    Molecular Formula C6H5Li3O7
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass210.0515378 g/mol
    Monoisotopic Mass210.0515378 g/mol
    Topological Polar Surface Area141 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity211
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count4
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameLithium citrate
    Active IngredientLithium citrate
    Dosage FormSyrup
    RouteOral
    Strengtheq 300mg carbonate/5ml
    Market StatusPrescription
    CompanyWockhardt; Roxane

    2 of 2  
    Drug NameLithium citrate
    Active IngredientLithium citrate
    Dosage FormSyrup
    RouteOral
    Strengtheq 300mg carbonate/5ml
    Market StatusPrescription
    CompanyWockhardt; Roxane

    4.2 Drug Indication

    Lithium is used as a mood stabilizer, and is used for treatment of depression and mania. It is often used in bipolar disorder treatment.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Although lithium has been used for over 50 years in treatment of bipolar disorder, the mechanism of action is still unknown. Lithium's therapeutic action may be due to a number of effects, ranging from inhibition of enzymes such as glycogen synthase kinase 3, inositol phosphatases, or modulation of glutamate receptors.

    5.2 Mechanism of Action

    The precise mechanism of action of Li+ as a mood-stabilizing agent is currently unknown. It is possible that Li+ produces its effects by interacting with the transport of monovalent or divalent cations in neurons. An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the key factor in understanding how lithium works. Lithium has been shown to change the inward and outward currents of glutamate receptors (especially GluR3), without a shift in reversal potential. Lithium has been found to exert a dual effect on glutamate receptors, acting to keep the amount of glutamate active between cells at a stable, healthy level, neither too much nor too little. It is postulated that too much glutamate in the space between neurons causes mania, and too little, depression. Another mechanism by which lithium might help to regulate mood include the non-competitive inhibition of an enzyme called inositol monophosphatase. Alternately lithium's action may be enhanced through the deactivation of the GSK-3B enzyme. The regulation of GSK-3B by lithium may affect the circadian clock. GSK-3 is known for phosphorylating and thus inactivating glycogen synthase. GSK-3B has also been implicated in the control of cellular response to damaged DNA. GSK-3 normally phosphorylates beta catenin, which leads to beta catenin degratation. When GSK-3 is inhibited, beta catenin increases and transgenic mice with overexpression of beta catenin express similar behaviour to mice treated with lithium. These results suggest that increase of beta catenin may be a possible pathway for the therapeutic action of lithium.

    API Reference Price

    read-more
    read-more
    [{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1665426600,"product":"LITHIUM CITRATE TETRAHYDRATE","address":"818\/819, 8TH FLOOR CORPORATE AVENUE SONAWALA ROAD, GOREAGOAN,","city":"MUMBAI","supplier":"S K CHEMICAL ","supplierCountry":"INDIA","foreign_port":"BRUSSELS","customer":"ACROS OITOANLCS BVBA","customerCountry":"BELGIUM","quantity":"10.00","actualQuantity":"10","unit":"KGS","unitRateFc":"99","totalValueFC":"960.1","currency":"EUR","unitRateINR":7900,"date":"11-Oct-2022","totalValueINR":"79000","totalValueInUsd":"960.1","indian_port":"BOMBAY AIR","hs_no":"29181590","bill_no":"4730187","productDescription":"API","marketType":"REGULATED MARKET","country":"BELGIUM","selfForZScoreResived":"Pharma Grade","supplierPort":"BOMBAY AIR","supplierAddress":"818\/819, 8TH FLOOR CORPORATE AVENUE SONAWALA ROAD, GOREAGOAN,, MUMBAI","customerAddress":""},{"dataSource":"API Import","activeIngredients":"","year":"2023","qtr":"Q4","strtotime":1698345000,"product":"TRI-LITHIUM CITRATE TETRAHYDRATE EMPROVE ESSENTIAL PH EUR,BP 9PCS X 20KG (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"180.00","actualQuantity":"180","unit":"KGS","unitRateFc":"9441.3","totalValueFC":"20486","currency":"INR","unitRateINR":"9472.4","date":"27-Oct-2023","totalValueINR":"1705037.26","totalValueInUsd":"20486","indian_port":"Bombay Air","hs_no":"29181590","bill_no":"8497450","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720204200,"product":"TRI-LITHIUM CITRATE TETRAHYDRATE EMPROVE ESSENTIAL PH EUR,BP 2PCS X 20KG (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"9857.9","totalValueFC":"4729","currency":"INR","unitRateINR":"9882.5","date":"06-Jul-2024","totalValueINR":"395300.63","totalValueInUsd":"4729","indian_port":"Bombay Air","hs_no":"29181590","bill_no":"4362095","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1720549800,"product":"TRI-LITHIUM CITRATE TETRAHYDRATE EMPROVE ESSENTIAL PH EUR,BP 2PCS X 20KG (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"40.00","actualQuantity":"40","unit":"KGS","unitRateFc":"9857.9","totalValueFC":"4729","currency":"INR","unitRateINR":"9882.5","date":"10-Jul-2024","totalValueINR":"395300.63","totalValueInUsd":"4729","indian_port":"Bombay Air","hs_no":"29181590","bill_no":"4424609","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 250, 64293 Darmstadt,(BENEFICIARY MERCKFINANCIALSSERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1724610600,"product":"TRI-LITHIUM CITRATE TETRAHYDRATE EMPROVE ESSENTIAL PH EUR,BP 24PCS X 20KG (PHARMA GRADE)","address":"50A , RING ROAD,","city":"BANGALORE, KARNATAKA","supplier":"MERCK LIFE SCIENCE KGAA","supplierCountry":"GERMANY","foreign_port":"FRANKFURT\/MAIN INT\\'L","customer":"MERCK GROUP","customerCountry":"INDIA","quantity":"480.00","actualQuantity":"480","unit":"KGS","unitRateFc":"9857.9","totalValueFC":"56553.3","currency":"INR","unitRateINR":"9882.5","date":"26-Aug-2024","totalValueINR":"4743607.53","totalValueInUsd":"56553.3","indian_port":"Bombay Air","hs_no":"29181590","bill_no":"5251260","productDescription":"API","marketType":"REGULATED MARKET","country":"GERMANY","selfForZScoreResived":"Pharma Grade","supplierPort":"FRANKFURT\/MAIN INT\\'L","supplierAddress":"Frankfurter Strasse 25064293 Darmstadt Germany (BENEFICIARY MERCKFINANCIAL SERVICES GMBH) GERMANY","customerAddress":"50A , RING ROAD,"}]
    11-Oct-2022
    26-Aug-2024
    KGS
    overview
    Loading...

    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

    Upgrade, download data, analyse, strategize, subscribe with us contact

    Related Excipient Companies

    Upload your portfolio for free, ask us

    Excipients by Applications

    Click here to find the perfect excipient manufacturers by their capabilities

    Fillers, Diluents & Binders

    read-more
    read-more

    Direct Compression

    read-more
    read-more

    Thickeners and Stabilizers

    read-more
    read-more

    Disintegrants & Superdisintegrants

    read-more
    read-more

    Coating Systems & Additives

    read-more
    read-more

    Lubricants & Glidants

    read-more
    read-more

    Co-Processed Excipients

    read-more
    read-more

    Film Formers & Plasticizers

    read-more
    read-more

    Granulation

    read-more
    read-more

    Taste Masking

    read-more
    read-more

    Empty Capsules

    read-more
    read-more

    Controlled & Modified Release

    read-more
    read-more

    Chewable & Orodispersible Aids

    read-more
    read-more

    Coloring Agents

    read-more
    read-more

    Parenteral

    read-more
    read-more

    Solubilizers

    read-more
    read-more

    Surfactant & Foaming Agents

    read-more
    read-more

    Topical

    read-more
    read-more

    Rheology Modifiers

    read-more
    read-more

    Soft Gelatin

    read-more
    read-more

    API Stability Enhancers

    read-more
    read-more

    Digital Content read-more

    Create Content with PharmaCompass, ask us

    NEWS #PharmaBuzz

    read-more
    read-more

    Patents & EXCLUSIVITIES

    Check the patents & exclusivity for this product

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search