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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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FINISHED DOSAGE FORMULATIONS

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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FDF Dossiers

DRUG PRODUCT COMPOSITIONS

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0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

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Chemistry

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Also known as: Gpr30 agonist, g-1, G-1, 881639-98-1, Lns8801, Lns-8801, Tfs4qe36zg
Molecular Formula
C21H18BrNO3
Molecular Weight
412.3  g/mol
InChI Key
VHSVKVWHYFBIFJ-HKZYLEAXSA-N
FDA UNII
TFS4QE36ZG

LNS8801
G Protein-coupled Estrogen Receptor Agonist LNS8801 is an orally bioavailable selective agonist of the G protein-coupled estrogen receptor (G protein-coupled estrogen receptor 1; GPER; GPER1; GPR30), with potential immunomodulating and antineoplastic activities. Upon oral administration, LNS8801 targets, binds to and activates GPER. This activates GPER-mediated signaling and suppresses the expression of various tumor-associated genes, such as c-Myc and programmed cell death-ligand 1 (PD-L1). This leads to an inhibition of tumor cell proliferation. GPER activation may also induce immune memory. GPER is a membrane protein and a member of the G-protein coupled receptors (GPCRs) that are widely distributed in various tissues. GPER is a tumor suppressor in a wide range of cell cancer types.
1 2D Structure

LNS8801

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[(3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
2.1.2 InChI
InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1
2.1.3 InChI Key
VHSVKVWHYFBIFJ-HKZYLEAXSA-N
2.1.4 Canonical SMILES
CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5
2.1.5 Isomeric SMILES
CC(=O)C1=CC2=C(C=C1)N[C@H]([C@@H]3[C@H]2C=CC3)C4=CC5=C(C=C4Br)OCO5
2.2 Other Identifiers
2.2.1 UNII
TFS4QE36ZG
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone

2. G-1 Cpd

2.3.2 Depositor-Supplied Synonyms

1. Gpr30 Agonist, G-1

2. G-1

3. 881639-98-1

4. Lns8801

5. Lns-8801

6. Tfs4qe36zg

7. Y3v5bv7okm

8. G 1 (anti-tumor Agent)

9. Chembl569766

10. 1-[(3as,4r,9br)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta[c]quinolin-8-yl]ethanone

11. G1

12. 925419-53-0

13. Ethanone, 1-((3as,4r,9br)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)-

14. G-1 Cpd

15. Sr-01000506928

16. Gper Agonist

17. Unii-tfs4qe36zg

18. Unii-y3v5bv7okm

19. G 1 (gper Agonist)

20. Gtpl1014

21. Schembl12700948

22. Cid_3136849

23. Cid_5322399

24. Chebi:156296

25. Hms3414a07

26. Hms3650i22

27. Hms3678a07

28. Ml051

29. Ex-a3642

30. Zinc4172149

31. Bdbm50303803

32. Stk330808

33. Akos015969580

34. 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)ethanone

35. Hy-107216

36. Cs-0027669

37. Unm000000675701

38. Unm000011063001

39. Sr-01000506928-1

40. Sr-01000506928-3

41. Q27077759

42. G 1 (g Protein-coupled Estrogen Receptor Agonist)

43. (+/-)-1-[(3ar*,4s*,9bs*)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta[c]quinolin-8-yl]- Ethanone

44. 1-((3as,4r,9br)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta[c]quinolin-8-yl)ethanone

45. 1-[4-(6-bromo-benzo[1,3]dioxol-5-yl)-3-alpha-4,5,9-beta-tetrahydro-3h-cyclopenta[c]quinolin-8-yl]-ethanone

46. Ethanone, 1-((3ar,4s,9bs)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3h-cyclopenta(c)quinolin-8-yl)-, Rel-

2.4 Create Date
2006-01-19
3 Chemical and Physical Properties
Molecular Weight 412.3 g/mol
Molecular Formula C21H18BrNO3
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass411.04701 g/mol
Monoisotopic Mass411.04701 g/mol
Topological Polar Surface Area47.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 925419-53-0 / LNS8801 API manufacturers, exporters & distributors?

LNS8801 manufacturers, exporters & distributors 1

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PharmaCompass offers a list of LNS8801 API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right LNS8801 manufacturer or LNS8801 supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred LNS8801 manufacturer or LNS8801 supplier.

PharmaCompass also assists you with knowing the LNS8801 API Price utilized in the formulation of products. LNS8801 API Price is not always fixed or binding as the LNS8801 Price is obtained through a variety of data sources. The LNS8801 Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

LNS8801

Synonyms

Gpr30 agonist, g-1, G-1, 881639-98-1, Lns-8801, Tfs4qe36zg, Y3v5bv7okm

Cas Number

925419-53-0

Unique Ingredient Identifier (UNII)

TFS4QE36ZG

About LNS8801

G Protein-coupled Estrogen Receptor Agonist LNS8801 is an orally bioavailable selective agonist of the G protein-coupled estrogen receptor (G protein-coupled estrogen receptor 1; GPER; GPER1; GPR30), with potential immunomodulating and antineoplastic activities. Upon oral administration, LNS8801 targets, binds to and activates GPER. This activates GPER-mediated signaling and suppresses the expression of various tumor-associated genes, such as c-Myc and programmed cell death-ligand 1 (PD-L1). This leads to an inhibition of tumor cell proliferation. GPER activation may also induce immune memory. GPER is a membrane protein and a member of the G-protein coupled receptors (GPCRs) that are widely distributed in various tissues. GPER is a tumor suppressor in a wide range of cell cancer types.

LNS8801 Manufacturers

A LNS8801 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of LNS8801, including repackagers and relabelers. The FDA regulates LNS8801 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. LNS8801 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

LNS8801 Suppliers

A LNS8801 supplier is an individual or a company that provides LNS8801 active pharmaceutical ingredient (API) or LNS8801 finished formulations upon request. The LNS8801 suppliers may include LNS8801 API manufacturers, exporters, distributors and traders.

LNS8801 GMP

LNS8801 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of LNS8801 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right LNS8801 GMP manufacturer or LNS8801 GMP API supplier for your needs.

LNS8801 CoA

A LNS8801 CoA (Certificate of Analysis) is a formal document that attests to LNS8801's compliance with LNS8801 specifications and serves as a tool for batch-level quality control.

LNS8801 CoA mostly includes findings from lab analyses of a specific batch. For each LNS8801 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

LNS8801 may be tested according to a variety of international standards, such as European Pharmacopoeia (LNS8801 EP), LNS8801 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (LNS8801 USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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