Find Lobeline Hydrochloride manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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CEP/COS

CEP/COS Certifications

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NDC API

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API

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FDF

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Chemistry

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Also known as: Lobeline hcl, 134-63-4, Alpha-lobeline hydrochloride, (-)-lobeline hydrochloride, L-lobeline hydrochloride, Lobeline (hydrochloride)
Molecular Formula
C22H28ClNO2
Molecular Weight
373.9  g/mol
InChI Key
MKMYPTLXLWOUSO-NFQNBQCWSA-N
FDA UNII
96J834CB88

Lobeline Hydrochloride
1 2D Structure

Lobeline Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;hydrochloride
2.1.2 InChI
InChI=1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H/t19-,20+,21-;/m0./s1
2.1.3 InChI Key
MKMYPTLXLWOUSO-NFQNBQCWSA-N
2.1.4 Canonical SMILES
CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O.Cl
2.1.5 Isomeric SMILES
CN1[C@@H](CCC[C@@H]1CC(=O)C2=CC=CC=C2)C[C@@H](C3=CC=CC=C3)O.Cl
2.2 Other Identifiers
2.2.1 UNII
96J834CB88
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Lobeline Hcl

2. 134-63-4

3. Alpha-lobeline Hydrochloride

4. (-)-lobeline Hydrochloride

5. L-lobeline Hydrochloride

6. Lobeline (hydrochloride)

7. Lobeline Hydrochloride [jan]

8. Zoolobelin

9. Mls000069392

10. Lobron

11. 96j834cb88

12. Smr000058465

13. Alpha-lobeline Hcl

14. 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone Hydrochloride

15. Lobeline Hydrochloride (jan)

16. Lobelin Hydrochlorde

17. Lobelin Hydrochloride

18. Lobelini Hydrochloridum

19. Lobelinum Hydrochloricum

20. Sr-01000000002

21. Lobeline Alpha (-) Hydrochoride

22. Sr-01000075960

23. Unii-96j834cb88

24. (-)-alpha-lobeline Hydrochloride

25. Einecs 205-150-2

26. A-lobeline Hydrochloride

27. Opera_id_410

28. Nsc-757421 Hydrochloride

29. Inflatine Hydrochloride

30. Mls000758290

31. Mls001148112

32. Mls001424136

33. Schembl467021

34. Chembl1257005

35. Dtxsid10928382

36. Hms1569f12

37. (-)-lobeline Hydrochloride, 98%

38. Lobeline Hydrochloride [mi]

39. 2-((2r,6s)-6-((s)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-one Hydrochloride

40. Act06730

41. Ex-a1345

42. Hy-b0979

43. Tox21_500698

44. S3972

45. .alpha.-lobeline Hydrochloride

46. Akos024282588

47. Lobeline Hydrochloride [mart.]

48. Am62794

49. Ccg-101032

50. Cs-4469

51. Lobeline Hydrochloride [who-dd]

52. Lp00698

53. Nc00282

54. Acetophenone, 2-(6-(beta-hydroxyphenethyl)-1-methyl-2-piperidyl)-, Hydrochloride, (-)-

55. Ncgc00094052-01

56. Ncgc00261383-01

57. As-48029

58. Eu-0100698

59. Lobeline Hydrochloride [ep Monograph]

60. D02202

61. F17567

62. L 4376

63. Sr-01000000002-2

64. Sr-01000000002-5

65. Sr-01000075960-1

66. Q27271904

67. Lobeline Hydrochloride, European Pharmacopoeia (ep) Reference Standard

68. 2-(6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone Hydrochloride

69. 2-[(2r,6s)-6-[(2s)-2-hydroxyphenethyl)]-1-methyl-2-piperidinyl]acetophenone Hydrochloride

70. 2-[6-(2-hydroxy-2-phenethyl)-1-methyl-2-piperidyl]acetophenone Hydrochloride

71. 2-((2r,6s)-6-((2s)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone Hydrochloride

72. 2-((2r,6s)-6-((s)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethan-1-onehydrochloride

73. 2-((2r,6s)-6-((s)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone Hydrochloride

74. 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;hydrochloride

75. Ethanone, 2-((2r,6s)-6-((2s)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, Hydrochloride

76. Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, Hydrochloride, (2r-(2alpha,6alpha(s*))-

77. Ethanone, 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-, Hydrochloride (1:1)

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 373.9 g/mol
Molecular Formula C22H28ClNO2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass373.1808568 g/mol
Monoisotopic Mass373.1808568 g/mol
Topological Polar Surface Area40.5 Ų
Heavy Atom Count26
Formal Charge0
Complexity412
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

HAS BEEN USED AS A RESPIRATORY STIMULANT; ALSO FOR TREATING TOBACCO ADDICTION. THE WATER-SOL HYDROCHLORIDE & SULFATE HAVE BEEN ADMIN BY PARENTERAL ROUTES.

Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 808


(VET) HAS BEEN USED AS A RESPIRATORY STIMULANT, RUMINATORIC /LOBELINE/

Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 873


5 Pharmacology and Biochemistry
5.1 Mechanism of Action

TWO NATURAL ALKALOIDS, NICOTINE & LOBELINE, OWE MUCH OF THEIR PHARMACOLOGICAL ACTIVITY TO THEIR ACTIONS AT AUTONOMIC GANGLIA. ... LOBELINE HAS MANY OF THE SAME ACTIONS IN THE BODY AS NICOTINE BUT IS LESS POTENT. /LOBELINE/

Gilman, A.G., T.W. Rall, A.S. Nies and P. Taylor (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 8th ed. New York, NY. Pergamon Press, 1990., p. 180


... Lobeline ... resembles nicotine and coniine in its action, causing first stimulation then paralysis of autonomic ganglia. /Lobeline/

Humphreys, D.J. Veterinary Toxicology. 3rd ed. London, England: Bailliere Tindell, 1988., p. 245


ABOUT THIS PAGE

Lobeline Hydrochloride Manufacturers

A Lobeline Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lobeline Hydrochloride, including repackagers and relabelers. The FDA regulates Lobeline Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lobeline Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Lobeline Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Lobeline Hydrochloride Suppliers

A Lobeline Hydrochloride supplier is an individual or a company that provides Lobeline Hydrochloride active pharmaceutical ingredient (API) or Lobeline Hydrochloride finished formulations upon request. The Lobeline Hydrochloride suppliers may include Lobeline Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Lobeline Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lobeline Hydrochloride GMP

Lobeline Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lobeline Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lobeline Hydrochloride GMP manufacturer or Lobeline Hydrochloride GMP API supplier for your needs.

Lobeline Hydrochloride CoA

A Lobeline Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Lobeline Hydrochloride's compliance with Lobeline Hydrochloride specifications and serves as a tool for batch-level quality control.

Lobeline Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Lobeline Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lobeline Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Lobeline Hydrochloride EP), Lobeline Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lobeline Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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