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Lobeline Sulfate

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ACTIVE PHARMA INGREDIENTS

1 API Suppliers, 1 USDMF

1 API Suppliers
1 USDMF

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

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PATENTS & EXCLUSIVITIES

US Patents

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Health Canada Patents

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GLOBAL SALES INFORMATION

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Finished Drug Prices

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0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 134-64-5, Lobeline sulphate, Lobelin sulphate, 4cj480v2hp, Bantron, Lobeline (sulfate)

Molecular Formula

C₄₄H₅₆N₂O₈S

Molecular Weight

773.0 g/mol

InChI Key

GRZMOSSVIPFGFF-GNJLJDPWSA-N

FDA UNII

4CJ480V2HP

An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation.

1 2D Structure

Lobeline Sulfate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;sulfuric acid

2.1.2 InChI

InChI=1S/2C22H27NO2.H2O4S/c2*1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;1-5(2,3)4/h2*2-7,9-12,19-21,24H,8,13-16H2,1H3;(H2,1,2,3,4)/t2*19-,20+,21-;/m00./s1

2.1.3 InChI Key

GRZMOSSVIPFGFF-GNJLJDPWSA-N

2.1.4 Canonical SMILES

CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O.CN1C(CCCC1CC(=O)C2=CC=CC=C2)CC(C3=CC=CC=C3)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CN1[C@@H](CCC[C@@H]1CC(=O)C2=CC=CC=C2)C[C@@H](C3=CC=CC=C3)O.CN1[C@@H](CCC[C@@H]1CC(=O)C2=CC=CC=C2)C[C@@H](C3=CC=CC=C3)O.OS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

4CJ480V2HP

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Lobeline

2. Smokeless

3. Sulfate, Lobeline

2.3.2 Depositor-Supplied Synonyms

1. 134-64-5

2. Lobeline Sulphate

3. Lobelin Sulphate

4. 4cj480v2hp

5. Bantron

6. Lobeline (sulfate)

7. Lobelin Sulfate

8. 2-[(2r,6s)-6-[(2s)-2-hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone;sulfuric Acid

9. 2-(6-(2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone Sulfate

10. Einecs 205-151-8

11. Unii-4cj480v2hp

12. Smokeless (tn)

13. Lobeline, Sulfate (2:1) (salt)

14. Inflatine Sulfate

15. Inflatine Sulphate

16. Lobeline Sulfate, Aldrichcpr

17. Lobeline Sulfate [mi]

18. Schembl3686934

19. .alpha.-lobeline Sulfate

20. .alpha.-lobeline Sulphate

21. Dtxsid80158452

22. Lobeline Sulfate [mart.]

23. Lobeline Sulfate [who-dd]

24. Hms3886l05

25. Mfcd00135592

26. S5844

27. Akos032428277

28. Ethanone, 2-(6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenyl-, (2theta-(2alpha,6alpha(s)))-, Sulfate (2:1) (salt)

29. Hy-128420

30. Cs-0099255

31. D08138

32. J-006568

33. Q27259407

34. 2-(6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone Sulfate

35. 2-(6-(.beta.-hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone Sulphate

36. 2-((2r,6s)-6-((2s)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone Sulfate

37. 2-((2r,6s)-6-((2s)-2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone Sulphate

38. 2-((2r,6s)-6-((s)-2-hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone Hemisulfate

2.4 Create Date

2005-07-19

3 Chemical and Physical Properties

Molecular Formula	C₄₄H₅₆N₂O₈S
Molecular Weight	773.0 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	12
Exact Mass	772.37573792 g/mol
Monoisotopic Mass	772.37573792 g/mol
Topological Polar Surface Area	164 Å²
Heavy Atom Count	55
Formal Charge	0
Complexity	494
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Respiratory System Agents

Drugs used for their effects on the respiratory system. (See all compounds classified as Respiratory System Agents.)

Nicotinic Agonists

Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission. (See all compounds classified as Nicotinic Agonists.)

Ganglionic Stimulants

Agents that mimic neural transmission by stimulation of the nicotinic receptors on postganglionic autonomic neurons. Drugs that indirectly augment ganglionic transmission by increasing the release or slowing the breakdown of acetylcholine or by non-nicotinic effects on postganglionic neurons are not included here nor are the nonspecific cholinergic agonists. (See all compounds classified as Ganglionic Stimulants.)

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ABOUT THIS PAGE

Lobeline Sulfate Manufacturers

A Lobeline Sulfate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lobeline Sulfate, including repackagers and relabelers. The FDA regulates Lobeline Sulfate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lobeline Sulfate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lobeline Sulfate Suppliers

A Lobeline Sulfate supplier is an individual or a company that provides Lobeline Sulfate active pharmaceutical ingredient (API) or Lobeline Sulfate finished formulations upon request. The Lobeline Sulfate suppliers may include Lobeline Sulfate API manufacturers, exporters, distributors and traders.

click here to find a list of Lobeline Sulfate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lobeline Sulfate USDMF

A Lobeline Sulfate DMF (Drug Master File) is a document detailing the whole manufacturing process of Lobeline Sulfate active pharmaceutical ingredient (API) in detail. Different forms of Lobeline Sulfate DMFs exist exist since differing nations have different regulations, such as Lobeline Sulfate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Lobeline Sulfate DMF submitted to regulatory agencies in the US is known as a USDMF. Lobeline Sulfate USDMF includes data on Lobeline Sulfate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lobeline Sulfate USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Lobeline Sulfate suppliers with USDMF on PharmaCompass.

Lobeline Sulfate GMP

Lobeline Sulfate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lobeline Sulfate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lobeline Sulfate GMP manufacturer or Lobeline Sulfate GMP API supplier for your needs.

Lobeline Sulfate CoA

A Lobeline Sulfate CoA (Certificate of Analysis) is a formal document that attests to Lobeline Sulfate's compliance with Lobeline Sulfate specifications and serves as a tool for batch-level quality control.

Lobeline Sulfate CoA mostly includes findings from lab analyses of a specific batch. For each Lobeline Sulfate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lobeline Sulfate may be tested according to a variety of international standards, such as European Pharmacopoeia (Lobeline Sulfate EP), Lobeline Sulfate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lobeline Sulfate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.