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Lobenzarit

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ACTIVE PHARMA INGREDIENTS

2 API Suppliers, 2 USDMF

2 API Suppliers
2 USDMF

Synopsis

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Chemistry

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Also known as: Lobenzarit disodium, 64808-48-6, Lobenzarit disodium salt, Carfenil, Lobenzarit sodium [usan], Disodium 4-chloro-2,2'-iminodibenzoate

Molecular Formula

C₁₄H₈ClNNa₂O₄

Molecular Weight

335.65 g/mol

InChI Key

QPJBONAWFAURGB-UHFFFAOYSA-L

FDA UNII

7Z9SP74BXF

1 2D Structure

Lobenzarit

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;2-(2-carboxylatoanilino)-4-chlorobenzoate

2.1.2 InChI

InChI=1S/C14H10ClNO4.2Na/c15-8-5-6-10(14(19)20)12(7-8)16-11-4-2-1-3-9(11)13(17)18;;/h1-7,16H,(H,17,18)(H,19,20);;/q;2*+1/p-2

2.1.3 InChI Key

QPJBONAWFAURGB-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1=CC=C(C(=C1)C(=O)[O-])NC2=C(C=CC(=C2)Cl)C(=O)[O-].[Na+].[Na+]

2.2 Other Identifiers

2.2.1 UNII

7Z9SP74BXF

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-((2-carboxyphenyl)amino)-4-chlorobenzoic Acid

2. 4-chloro-2,2'-iminodibenzoic Acid

3. Cca Lobenzarit

4. Disodium 4-chloro-2,2'-iminodibenzoate

5. Lobenzarit

6. Lobenzarit Disodium

7. Lobenzarit, Disodium Salt

8. Lobenzart

9. N-(2-carboxyphenyl)-4-chloroanthranilic Acid

2.3.2 Depositor-Supplied Synonyms

1. Lobenzarit Disodium

2. 64808-48-6

3. Lobenzarit Disodium Salt

4. Carfenil

5. Lobenzarit Sodium [usan]

6. Disodium 4-chloro-2,2'-iminodibenzoate

7. Sodium 2-((2-carboxylatophenyl)amino)-4-chlorobenzoate

8. 7z9sp74bxf

9. 2-((2-carboxyphenyl)amino)-4-chlorobenzoic Acid Disodium Salt

10. Benzoic Acid, 2-((2-carboxyphenyl)amino)-4-chloro-, Disodium Salt

11. Cca

12. Disodium;2-(2-carboxylatoanilino)-4-chlorobenzoate

13. Benzoic Acid, 2-[(2-carboxyphenyl)amino]-4-chloro, Disodium Salt

14. Ncgc00181760-01

15. Unii-7z9sp74bxf

16. Disodium 4-chloro-2,2'-iminobenzoate

17. Ccris 8090

18. Carfenil (tn)

19. N-(2-carboxyphenyl)-4-chloroanthranilic Acid Disodium Salt

20. Disodium Lobenzarit

21. Dsstox_cid_28532

22. Dsstox_rid_82804

23. Dsstox_gsid_48606

24. Schembl635305

25. Lobenzarit Sodium [jan]

26. Chembl2107179

27. Dtxsid8048606

28. Chebi:31778

29. Lobenzarit Sodium (jp17/usan)

30. Lobenzarit Sodium [mart.]

31. Lobenzarit Sodium [who-dd]

32. Tox21_112941

33. Mfcd00941422

34. Lobenzarit Disodium Salt [mi]

35. Akos025311428

36. Ac-26450

37. Cas-64808-48-6

38. L0278

39. D01808

40. H11986

41. A834889

42. Disodium N-(2-carboxyphenyl)-4-chloroanthranilate

43. Q27269066

44. Sodium 2-(2-carboxylatophenylamino)-4-chlorobenzoate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₈ClNNa₂O₄
Molecular Weight	335.65 g/mol
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	334.9937240 g/mol
Monoisotopic Mass	334.9937240 g/mol
Topological Polar Surface Area	92.3 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	365
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Adjuvants, Immunologic

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Immunosuppressive Agents

Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. (See all compounds classified as Immunosuppressive Agents.)

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