Find Lofexidine manufacturers, exporters & distributors on PharmaCompass

Lofexidine Hydrochloride

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

4 API Suppliers, 3 USDMF, 2 EU WC, 5 NDC API, 1 Listed Suppliers, $ API Reference Price

4 API Suppliers
3 USDMF
2 EU WC
5 NDC API
1 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

2 Drugs in Development

2 Drugs in Development

FINISHED DOSAGE FORMULATIONS

3 FDF Dossiers, 2 FDA Orange Book, 1 Listed Dossiers

3 FDF Dossiers
2 FDA Orange Book
1 Listed Dossiers

DIGITAL CONTENT

2 DATA COMPILATION #PharmaFlow, 13 NEWS #PharmaBuzz

media
2 DATA COMPILATION #PharmaFlow
13 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions

globalSalesInformation
1 US Medicaid Prescriptions

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

1 US Exclusivities

patents
1 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

2,503,309

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 21498-08-8, Lofexidine hcl, Lofexidine.hcl, Lofexidine (hydrochloride), Britlofex, Mdl 14,042

Molecular Formula

C₁₁H₁₃Cl₃N₂O

Molecular Weight

295.6 g/mol

InChI Key

DWWHMKBNNNZGHF-UHFFFAOYSA-N

FDA UNII

V47G1SDI1B

1 2D Structure

Lofexidine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride

2.1.2 InChI

InChI=1S/C11H12Cl2N2O.ClH/c1-7(11-14-5-6-15-11)16-10-8(12)3-2-4-9(10)13;/h2-4,7H,5-6H2,1H3,(H,14,15);1H

2.1.3 InChI Key

DWWHMKBNNNZGHF-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

V47G1SDI1B

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-(alpha-(2,6-dichlorophenoxy)ethyl) Delta-2-imidazoline

2. Britlofex

3. Lofexidine

4. Lofexidine Mono-hydrochloride

5. Lofexidine Monohydrochloride

6. Lofexidine, (+-)-isomer

7. Lucemyra

2.3.2 Depositor-Supplied Synonyms

1. 21498-08-8

2. Lofexidine Hcl

3. Lofexidine.hcl

4. Lofexidine (hydrochloride)

5. Britlofex

6. Mdl 14,042

7. Lofexidine Hydrochloride [usan]

8. Mdl-14042

9. Nsc-759654

10. V47g1sdi1b

11. 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazole Hydrochloride

12. 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1h-imidazole;hydrochloride

13. Lucemyra

14. Lofetensin

15. Loxacor

16. Baq-168;mdl-14042

17. 2-(1-(2,6-dichlorophenoxy)ethyl)-2-imidazoline Monohydrochloride

18. 1h-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, Monohydrochloride

19. Lofexidine Hydrochloride (usan)

20. 2-(1-(2,6-dichlorophenoxy)ethyl)-2-imidazoline Hydrochloride

21. 2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline Hydrochloride

22. Loxacor Hydrochloride

23. Lofetensin Hydrochloride

24. Lofexidine Hcl

25. Lofexidine (tn)

26. Rmi-14042a

27. Lucemyra (tn)

28. Ba 168

29. Mfcd00917022

30. Unii-v47g1sdi1b

31. Mls001424245

32. Schembl124601

33. Chembl1788132

34. Dtxsid0020781

35. Pharmakon1600-01502357

36. Bcp30600

37. Hy-b1052

38. 2-(1-(2,6-dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid [german]

39. Lofexidine Hydrochloride [mi]

40. Nsc759654

41. Zb0287

42. 2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1h-imidazole Hydrochloride

43. 2-imidazoline, 2-(1-(2,6-dichlorophenoxy)ethyl)-, Monohydrochloride

44. Akos015902903

45. Ccg-101139

46. Ccg-213049

47. Cs-4574

48. Nc00389

49. Nsc 759654

50. (-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene Hydrochloride

51. Lofexidine Hydrochloride [mart.]

52. Lofexidine Hydrochloride [vandf]

53. Lofexidine Hydrochloride [who-dd]

54. As-31095

55. Smr000469232

56. Ft-0651655

57. Ft-0670833

58. Sw197769-3

59. Lofexidine Hydrochloride [orange Book]

60. D04765

61. 498l088

62. A815419

63. J-014106

64. Q27291521

65. 2-(1-(2,6-dichlorphenoxy)aethyl)-2-imidazolin-hydrochlorid

66. 2-[1-(2,6-dichlorophenoxy) -ethyl]2-imidazoline Hydrochloride

67. 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-1h-imidazolehydrochloride

68. Lofexidine Hcl;lofexidine Monohydrochloride;baq-168; Mdl-14042;ba 168;mdl 14,042

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₃Cl₃N₂O
Molecular Weight	295.6 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Exact Mass	294.009346 g/mol
Monoisotopic Mass	294.009346 g/mol
Topological Polar Surface Area	33.6 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	263
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Narcotic Antagonists

Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)

Adrenergic alpha-2 Receptor Agonists

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

Antihypertensive Agents

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

API SUPPLIERS