Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

Contact Supplier

Jai Radhe Sales is your partner for all your sourcing needs.

ACCESS ALL DATA
Browse all information
CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 2 USDMF, 2 EU WC, 3 NDC API, 5 Listed Suppliers, $ API Reference Price

6 API Suppliers
2 USDMF
2 EU WC
3 NDC API
5 Listed Suppliers
$ API Reference Price

DEVELOPMENTS

3 Drugs in Development

3 Drugs in Development

INTERMEDIATES

2 Intermediates Suppliers

2 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

18 FDF Dossiers, 6 FDA Orange Book, 9 Europe, 3 Canada

18 FDF Dossiers
6 FDA Orange Book
9 Europe
3 Canada

DIGITAL CONTENT

14 NEWS #PharmaBuzz

media
14 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

1 US Medicaid Prescriptions, 6 Finished Drug Prices

globalSalesInformation
1 US Medicaid Prescriptions
6 Finished Drug Prices

MARKET PLACE

1 APIs

marketPlace
1 APIs

PATENTS & EXCLUSIVITIES

48 US Patents, 3 Health Canada Patents

patents
48 US Patents
3 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

8,527,542

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

Click the arrow to open the dropdown

Click the button for full data set

Also known as: 202914-84-9, Bms 201038-04, Lomitapide (mesylate), Aegr-733 mesylate, Bms-201038-04, Lomitapide mesilate

Molecular Formula

C₄₀H₄₁F₆N₃O₅S

Molecular Weight

789.8 g/mol

InChI Key

QKVKOFVWUHNEBX-UHFFFAOYSA-N

FDA UNII

X4S83CP54E

Lomitapide Mesylate is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.

1 2D Structure

Lomitapide

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methanesulfonic acid;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

2.1.2 InChI

InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45;1-5(2,3)4/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49);1H3,(H,2,3,4)

2.1.3 InChI Key

QKVKOFVWUHNEBX-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

2.2 Other Identifiers

2.2.1 UNII

X4S83CP54E

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 202914-84-9

2. Bms 201038-04

3. Lomitapide (mesylate)

4. Aegr-733 Mesylate

5. Bms-201038-04

6. Lomitapide Mesilate

7. Lomitapide Mesylate [usan]

8. Aegr-733 Mesilate

9. X4s83cp54e

10. Chebi:72299

11. 202914-84-9 (mesylate)

12. N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)biphenyl-2-ylcarboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

13. Lomitapide Mesilate (jan)

14. Lomitapide Mesylate (usan)

15. N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

16. Lomitapide Mesilate [jan]

17. 9h-fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-, Methanesulfonate

18. Methanesulfonic Acid;n-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide

19. Unii-x4s83cp54e

20. Juxtapid (tn)

21. N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulfonate

22. N-(2,2,2-trifluoroethyl)-9-{4-(4-({(4'-(trifluoromethyl)biphenyl-2-yl)carbonyl}amino)piperidin-1-yl)butyl}-9h-fluorene-9-carboxamide Methanesulfonate

23. N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9h-fluorene-9-carboxamide Methanesulfonate

24. Lojuxta (tn)

25. Lomitapide Monomesylate

26. Lomitapide Methanesulfonate

27. Bms-201038 Mesylate

28. Schembl2731380

29. Chembl2105662

30. Dtxsid60174170

31. Ex-a502

32. Bms-201038ma

33. Glxc-25701

34. Amy38734

35. Bcp10696

36. Cia91484

37. Lomitapide Mesilate [who-dd]

38. Mfcd19443682

39. S7633

40. Akos025149431

41. Ccg-270481

42. Cs-3424

43. Lomitapide Mesylate [orange Book]

44. Ac-33863

45. As-56518

46. Da-33433

47. Hy-14668

48. Ft-0700260

49. D09638

50. J-690260

51. Q27139887

52. 1-(4-{9-[(2,2,2-trifluoroethyl)carbamoyl]-9h-fluoren-9-yl}butyl)-4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidinium Methanesulfonate

53. 2059395-52-5

54. 9h-fluorene-9-carboxamide, N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-1-piperidinyl)butyl)-, Methanesulphonate

55. Aegr-733 Mesylate;bms-201038 Mesylate;aegr733 Mesylate;bms201038 Mesylate;aegr 733 Mesylate;bms 201038 Mesylate

56. N-(2,2,2-trifluoroethyl)-9-(4-(4-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)piperidin-1-yl)butyl)-9h-fluorene-9-carboxamide Methanesulphonate

57. N-(2,2,2-trifluoroethyl)-9-[4-(4-{2-[4-(trifluoromethyl)phenyl]benzamido}piperidin-1-yl)butyl]-9h-fluorene-9-carboxamide; Methanesulfonic Acid

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₄₀H₄₁F₆N₃O₅S
Molecular Weight	789.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	10
Exact Mass	789.26711156 g/mol
Monoisotopic Mass	789.26711156 g/mol
Topological Polar Surface Area	124 Å²
Heavy Atom Count	55
Formal Charge	0
Complexity	1200
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Juxtapid
PubMed Health	Lomitapide (By mouth)
Drug Classes	Antihyperlipidemic
Drug Label	JUXTAPID capsules contain lomitapide mesylate, a synthetic lipid-lowering agent for oral administration.The chemical name of lomitapide mesylate is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-pi
Active Ingredient	Lomitapide mesylate
Dosage Form	Capsule
Route	Oral
Strength	eq 5mg base; eq 20mg base; eq 10mg base
Market Status	Prescription
Company	Aegerion

2 of 2
Drug Name	Juxtapid
PubMed Health	Lomitapide (By mouth)
Drug Classes	Antihyperlipidemic
Drug Label	JUXTAPID capsules contain lomitapide mesylate, a synthetic lipid-lowering agent for oral administration.The chemical name of lomitapide mesylate is N-(2,2,2-trifluoroethyl)-9-[4-[4-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-1-pi
Active Ingredient	Lomitapide mesylate
Dosage Form	Capsule
Route	Oral
Strength	eq 5mg base; eq 20mg base; eq 10mg base
Market Status	Prescription
Company	Aegerion

5 Pharmacology and Biochemistry

5.1 FDA Pharmacological Classification

5.1.1 Pharmacological Classes

Microsomal Triglyceride Transfer Protein Inhibitor [EPC]; Microsomal Triglyceride Transfer Protein Inhibitors [MoA]; P-Glycoprotein Inhibitors [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]

API SUPPLIERS