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Synopsis

ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: Loprazolam mesilate, Dormonoct, Loprazolam methanesulfonate, Somnovit, Sonin, Havlane
Molecular Formula
C24H25ClN6O6S
Molecular Weight
561.0  g/mol
InChI Key
DDSDPQHQLNAGLJ-YEBWQKSTSA-N
FDA UNII
VKF8383J65

Loprazolam Mesilate
1 2D Structure

Loprazolam Mesilate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2Z)-6-(2-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4H-imidazo[1,2-a][1,4]benzodiazepin-1-one;methanesulfonic acid
2.1.2 InChI
InChI=1S/C23H21ClN6O3.CH4O3S/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24;1-5(2,3)4/h2-7,12,14H,8-11,13H2,1H3;1H3,(H,2,3,4)/b19-14-;
2.1.3 InChI Key
DDSDPQHQLNAGLJ-YEBWQKSTSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C=C2C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl.CS(=O)(=O)O
2.1.5 Isomeric SMILES
CN1CCN(CC1)/C=C\2/C(=O)N3C(=N2)CN=C(C4=C3C=CC(=C4)[N+](=O)[O-])C5=CC=CC=C5Cl.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
VKF8383J65
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 8-nitro-6-(o-chlorophenyl)-1,2-dihydro-2-(n-methylpiperazin-1-yl)methylene-1h,4h-imidazo (1,2-a)(1,4)benzodiazepin-1-one Methanesulfonate

2. Hr 158

3. Hr 458

4. Loprazolam

5. Ru 31158

6. Triazulenone

7. Triazulenone Mesylate

8. Triazulenone, (z)-isomer

2.3.2 Depositor-Supplied Synonyms

1. Loprazolam Mesilate

2. Dormonoct

3. Loprazolam Methanesulfonate

4. Somnovit

5. Sonin

6. Havlane

7. 70111-54-5

8. Ru-31158

9. Vkf8383j65

10. Hr-158

11. Triazulenone Mesylate

12. Unii-vkf8383j65

13. Havlane (tn)

14. Hr 158

15. Schembl352745

16. 61197-93-1

17. Loprazolam Mesilate [mart.]

18. Loprazolam Mesilate [who-dd]

19. Loprazolam Methanesulfonate [mi]

20. D08145

21. Q27291872

22. (2z)-6-(2-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methylidene]-8-nitro-4h-imidazo[1,2-a][1,4]benzodiazepin-1-one;methanesulfonic Acid

23. (z)-6-(2-chlorophenyl)-2-((4-methylpiperazin-1-yl)methylene)-8-nitro-2,4-dihydro-1h-benzo[f]imidazo[1,2-a][1,4]diazepin-1-one Methanesulfonate

24. 1h-imidazo(1,2-a)(1,4)benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-, (2z)-, Methanesulfonate (1:1)

25. 1h-imidazo(1,2-a)(1,4)benzodiazepin-1-one, 6-(2-chlorophenyl)-2,4-dihydro-2-((4-methyl-1-piperazinyl)methylene)-8-nitro-, Monomethanesulfonate

2.4 Create Date
2006-07-28
3 Chemical and Physical Properties
Molecular Weight 561.0 g/mol
Molecular Formula C24H25ClN6O6S
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Exact Mass560.1244814 g/mol
Monoisotopic Mass560.1244814 g/mol
Topological Polar Surface Area160 Ų
Heavy Atom Count38
Formal Charge0
Complexity984
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


ABOUT THIS PAGE

Loprazolam Mesilate Manufacturers

A Loprazolam Mesilate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Loprazolam Mesilate, including repackagers and relabelers. The FDA regulates Loprazolam Mesilate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Loprazolam Mesilate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Loprazolam Mesilate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Loprazolam Mesilate Suppliers

A Loprazolam Mesilate supplier is an individual or a company that provides Loprazolam Mesilate active pharmaceutical ingredient (API) or Loprazolam Mesilate finished formulations upon request. The Loprazolam Mesilate suppliers may include Loprazolam Mesilate API manufacturers, exporters, distributors and traders.

click here to find a list of Loprazolam Mesilate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Loprazolam Mesilate GMP

Loprazolam Mesilate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Loprazolam Mesilate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Loprazolam Mesilate GMP manufacturer or Loprazolam Mesilate GMP API supplier for your needs.

Loprazolam Mesilate CoA

A Loprazolam Mesilate CoA (Certificate of Analysis) is a formal document that attests to Loprazolam Mesilate's compliance with Loprazolam Mesilate specifications and serves as a tool for batch-level quality control.

Loprazolam Mesilate CoA mostly includes findings from lab analyses of a specific batch. For each Loprazolam Mesilate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Loprazolam Mesilate may be tested according to a variety of international standards, such as European Pharmacopoeia (Loprazolam Mesilate EP), Loprazolam Mesilate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Loprazolam Mesilate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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