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Chemistry

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Also known as: Ativan, 846-49-1, O-chloroxazepam, O-chlorooxazepam, Temesta, Loraz

Molecular Formula

C₁₅H₁₀Cl₂N₂O₂

Molecular Weight

321.2 g/mol

InChI Key

DIWRORZWFLOCLC-UHFFFAOYSA-N

FDA UNII

O26FZP769L

A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Lorazepam is a Benzodiazepine.

1 2D Structure

Lorazepam

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

2.1.2 InChI

InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

2.1.3 InChI Key

DIWRORZWFLOCLC-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl

2.2 Other Identifiers

2.2.1 UNII

O26FZP769L

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Apo Lorazepam

2. Apo-lorazepam

3. Ativan

4. Donix

5. Duralozam

6. Durazolam

7. Idalprem

8. Laubeel

9. Lorazep Von Ct

10. Lorazepam Medical

11. Lorazepam Neuraxpharm

12. Lorazepam Ratiopharm

13. Lorazepam-neuraxpharm

14. Lorazepam-ratiopharm

15. Medical, Lorazepam

16. Novo Lorazem

17. Novo-lorazem

18. Nu Loraz

19. Nu-loraz

20. Orfidal Wyeth

21. Sedicepan

22. Sinestron

23. Somagerol

24. Tmesta

25. Temesta

26. Tolid

27. Von Ct, Lorazep

28. Wy 4036

29. Wy-4036

30. Wy4036

31. Wyeth, Orfidal

2.3.2 Depositor-Supplied Synonyms

1. Ativan

2. 846-49-1

3. O-chloroxazepam

4. O-chlorooxazepam

5. Temesta

6. Loraz

7. Tavor

8. Delormetazepam

9. Almazine

10. Anxiedin

11. Bonatranquan

12. Duralozam

13. Emotival

14. Lorabenz

15. Sedatival

16. Laubeel

17. Orfidal

18. Punktyl

19. Lorax

20. Quait

21. Wypax

22. Apo-lorazepam

23. Lorazepam Intensol

24. Norlormetazepam

25. Anzepam

26. Aplacasse

27. Azurogen

28. Efasedan

29. Equitam

30. Kalmalin

31. Larpose

32. Lorapam

33. Lorazene

34. Lorazep

35. Lorazin

36. Lorenin

37. Loridem

38. Lorsedal

39. Lozepam

40. Novhepar

41. Renaquil

42. Rocosgen

43. Sedizepan

44. Sidenar

45. Silence

46. Tranqipam

47. Anxira

48. Aripax

49. Bonton

50. Loram

51. Lorat

52. Merlit

53. Stapam

54. Trapax

55. Upan

56. Nervistop L

57. Wy-4036

58. Demethyllormetazepam

59. Lorazepamum

60. Wy 4036

61. (+/-)-lorazepam

62. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

63. Lorazepam Preservative Free

64. Lorazepam Civ

65. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-

66. Nsc 289758

67. Idalprem

68. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepin-2-one

69. Aplacassee

70. Sinestron

71. Donix

72. Tolid

73. Chembl580

74. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1h-1,4-benzodiazepin-2(3h)-one

75. Lorazepam Medical

76. Nu Loraz

77. 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepin-2-one

78. O26fzp769l

79. Nervistopl

80. Novolorazem

81. Emotion

82. Lomesta

83. Lorafen

84. Lorazon

85. Lorivan

86. Somagerol

87. Vigiten

88. Lorans

89. Lorzem

90. Lopam

91. Lorazepam Fabra

92. Lorazepam-efeka

93. Lorazepan Chobet

94. Lorazepan Richet

95. Max Pax

96. Nsc289758

97. Lorazepam Genericon

98. Lorazepam Lannacher

99. Nsc-289758

100. Ncgc00159439-02

101. Lorsilan

102. Securit

103. Sedazin

104. Pro Dorm

105. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2h-1,4-benzodiazepin-2-one

106. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-

107. Lorazepamum [inn-latin]

108. Ativan (tn)

109. Einecs 212-687-6

110. Brn 0759084

111. Unii-o26fzp769l

112. Dea No. 2885

113. Lorazepam [usan:usp:inn:ban:jan]

114. Loreev Xr

115. Lorazepam [inn]

116. Lorazepam [jan]

117. Lorazepam [mi]

118. Lorazepam [usan]

119. (.+/-.)-lorazepam

120. Lorazepam [vandf]

121. Dsstox_cid_3225

122. Lorazepam [mart.]

123. Lorazepam [who-dd]

124. (+-)-7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepin-2-one

125. Dsstox_rid_76932

126. Dsstox_gsid_23225

127. Schembl26961

128. 5-25-02-00248 (beilstein Handbook Reference)

129. Mls001424236

130. Divk1c_000965

131. Lorazepam (jp17/usp/inn)

132. Chebi:6539

133. Gtpl5884

134. Lorazepam [ep Impurity]

135. Lorazepam [orange Book]

136. Lorazepam Civ [usp-rs]

137. Dtxsid7023225

138. Lorazepam [ep Monograph]

139. Hms503a11

140. Kbio1_000965

141. Lorazepam [usp Monograph]

142. Ninds_000965

143. Hms2052h07

144. Hms3394h07

145. Bcp13713

146. Tox21_111669

147. Bdbm50292627

148. Lorazepam 0.1 Mg/ml In Acetonitrile

149. Lorazepam 1.0 Mg/ml In Acetonitrile

150. Akos015904303

151. Ccg-101170

152. Db00186

153. Nc00420

154. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)-

155. Idi1_000965

156. Cas-846-49-1

157. Smr000058410

158. Wln: T67 Gmv Jn Ihj Cg Iq Kr Bg

159. L-230

160. D00365

161. 846l491

162. A840886

163. Q408265

164. 7-chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one

165. Brd-a11990600-001-01-8

166. Lorazepam, British Pharmacopoeia (bp) Reference Standard

167. Lorazepam, European Pharmacopoeia (ep) Reference Standard

168. 2h-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-

169. 2h-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-

170. Lorazepam, United States Pharmacopeia (usp) Reference Standard

171. O-chloroxazepam; O-chlorooxazepam; Almazine; Wy 4036; Wy-4036; Wy4036

172. 7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one

173. 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2h-1,4-benzodiazepine-2-one

174. 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2h-1,4-benzodiazepine-2-one

175. 7-chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one

176. 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepine-2-one

177. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one.

178. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2h-1,4-benzodiazepin-2-one #

179. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1h-benzo[e][1,4]diazepin-2(3h)-one

180. 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1h-1,4-benzodiazepin-2-one

181. Lorazepam For System Suitability, European Pharmacopoeia (ep) Reference Standard

182. Lorazepam Solution, 1.0 Mg/ml In Acetonitrile, Ampule Of 1 Ml, Certified Reference Material

183. Lorazepam7-chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one

184. (+/-)-7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2h-1,4-benzodiazepin-2-one

185. (rs)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one

186. 2h-1,4-benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+/-)-

187. 7-chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam)

2.4 Create Date

2005-03-25

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₁₀Cl₂N₂O₂
Molecular Weight	321.2 g/mol
XLogP3	2.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	320.0119330 g/mol
Monoisotopic Mass	320.0119330 g/mol
Topological Polar Surface Area	61.7 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	443
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Drug Information

1 of 8
Drug Name	Ativan
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Drug Label	Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1, 4-benzo...
Active Ingredient	Lorazepam
Dosage Form	Injectable; Tablet
Route	Injection; Oral
Strength	2mg/ml; 4mg/ml; 0.5mg; 2mg; 1mg
Market Status	Prescription
Company	Valeant Intl; Hikma Maple

2 of 8
Drug Name	Lorazepam
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Drug Label	Lorazepam, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one:It is a nearly white powder almost insoluble in water. Each lorazepam tablet, to be taken orally, contains 0.5 mg,...
Active Ingredient	Lorazepam
Dosage Form	Tablet; Concentrate; Injectable
Route	Injection; Oral
Strength	2mg/ml; 0.5mg; 1mg; 4mg/ml; 2mg
Market Status	Prescription
Company	Vintage Pharms; Amneal Pharms; Ranbaxy; Excellium; Hi-tech Pharma; Hospira; Pharm Assoc; Lupin; Sandoz; Watson Labs; Ivax Sub Teva Pharms; Intl Medication Sys; Paddock; Mylan; Akorn

3 of 8
Drug Name	Lorazepam intensol
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Active Ingredient	Lorazepam
Dosage Form	Concentrate
Route	Oral
Strength	2mg/ml
Market Status	Prescription
Company	Roxane

4 of 8
Drug Name	Lorazepam preservative free
Active Ingredient	Lorazepam
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml; 4mg/ml
Market Status	Prescription
Company	Bedford Labs

5 of 8
Drug Name	Ativan
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Drug Label	Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1, 4-benzo...
Active Ingredient	Lorazepam
Dosage Form	Injectable; Tablet
Route	Injection; Oral
Strength	2mg/ml; 4mg/ml; 0.5mg; 2mg; 1mg
Market Status	Prescription
Company	Valeant Intl; Hikma Maple

6 of 8
Drug Name	Lorazepam
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Drug Label	Lorazepam, an antianxiety agent, has the chemical formula, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one:It is a nearly white powder almost insoluble in water. Each lorazepam tablet, to be taken orally, contains 0.5 mg,...
Active Ingredient	Lorazepam
Dosage Form	Tablet; Concentrate; Injectable
Route	Injection; Oral
Strength	2mg/ml; 0.5mg; 1mg; 4mg/ml; 2mg
Market Status	Prescription
Company	Vintage Pharms; Amneal Pharms; Ranbaxy; Excellium; Hi-tech Pharma; Hospira; Pharm Assoc; Lupin; Sandoz; Watson Labs; Ivax Sub Teva Pharms; Intl Medication Sys; Paddock; Mylan; Akorn

7 of 8
Drug Name	Lorazepam intensol
PubMed Health	Lorazepam
Drug Classes	Antianxiety, Anticonvulsant, Skeletal Muscle Relaxant
Active Ingredient	Lorazepam
Dosage Form	Concentrate
Route	Oral
Strength	2mg/ml
Market Status	Prescription
Company	Roxane

8 of 8
Drug Name	Lorazepam preservative free
Active Ingredient	Lorazepam
Dosage Form	Injectable
Route	Injection
Strength	2mg/ml; 4mg/ml
Market Status	Prescription
Company	Bedford Labs

4.2 Drug Indication

Lorazepam is FDA-approved for the short-term relief of anxiety symptoms related to anxiety disorders and anxiety associated with depressive symptoms such as anxiety-associated insomnia. It is as well used as an anesthesia premedication in adults to relieve anxiety or to produce sedation/amnesia and for the treatment of status epilepticus. Some off-label indications of lorazepam include rapid tranquilization of an agitated patient, alcohol withdrawal delirium, alcohol withdrawal syndrome, muscle spasms, insomnia, panic disorder, delirium, chemotherapy-associated anticipatory nausea and vomiting, and psychogenic catatonia.

FDA Label

5 Pharmacology and Biochemistry

5.1 Pharmacology

The effect of lorazepam in GABA-A receptors produces an increase in the frequency of opening of the chloride ion channel. However, for its effect to generate, the neurotransmitter is required. The anticonvulsant properties of lorazepam are thought to be related to the binding to voltage-dependent sodium channels in which the sustained repetitive firing gets limited by the slow recovery of sodium channels due to the benzodiazepine effect. The effect of lorazepam seems to be very compartmental which was observed with a different generation of sleepiness and a dizziness effect.

5.2 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

5.3 FDA Pharmacological Classification

5.3.1 Active Moiety

LORAZEPAM

5.3.2 FDA UNII

O26FZP769L

5.3.3 Pharmacological Classes

Benzodiazepines [CS]; Benzodiazepine [EPC]

5.4 ATC Code

N05BA06

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

N - Nervous system

N05 - Psycholeptics

N05B - Anxiolytics

N05BA - Benzodiazepine derivatives

N05BA06 - Lorazepam

5.5 Absorption, Distribution and Excretion

Absorption

Readily absorbed with an absolute bioavailability of 90% when given orally. When intramuscularly administered a dose of 4 mg, lorazepam is completely and rapidly absorbed and achieves a maximal serum concentration of 48 ng/ml in 15-30 minutes. When administered orally, the time to attained maximum concentration is observed to be of 2 hours.

Route of Elimination

When a single 2 mg oral dose is given to healthy subjects, 88% of the administered dose is recovered in urine and 7% was recovered in feces. From the excreted dose in urine, the major form is the glucuronide version that represents 74% while only 0.3% of the dose is recovered as unchanged lorazepam.

Volume of Distribution

The reported volume of distribution of lorazepam is 1.3 L/kg. It is important to mention that due to the lipophilicity of lorazepam, it does not redistribute as fast in the brain.

Clearance

_In vivo_ studies with lorazepam have shown a clearance rate of 5.8 ml.min/kg.

5.6 Metabolism/Metabolites

Lorazepam is hepatically metabolized by CYP450 isoenzymes and extensively conjugated to the 3-0-phenolic glucuronide. This is an inactive metabolite and is eliminated mainly by the kidneys.

Lorazepam has known human metabolites that include Lorazepam glucuronide.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560

5.7 Biological Half-Life

When administered parentally, the registered half-life of lorazepam is of 14 hours.

5.8 Mechanism of Action

Lorazepam allosterically binds on the benzodiazepine receptors in the post-synaptic GABA-A ligand-gated chloride channel in different sites of the central nervous system (CNS). This binding will result in an increase on the GABA inhibitory effects which is translated as an increase in the flow of chloride ions into the cell causing hyperpolarization and stabilization of the cellular plasma membrane. According to the binding site of lorazepam, we can observe different activities as the binding in the amygdala is known to help mainly in anxiety disorders while the binding in the cerebral cortex helps in seizure disorders.

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Malladi Drugs & Pharmaceuticals Lim...

India

CPHI Middle east

Not Confirmed

Malladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.

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India

Virtual Booth

Digital Content

Lorazepam

About the Company : Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few years, Malladi established itself as a leader in manufacturing ephedrine an...

Malladi Drugs & Pharmaceuticals Ltd was founded in 1980 by microbiologist Mr. M L N Sastry. Within a few years, Malladi established itself as a leader in manufacturing ephedrine and pseudoephedrine salts. Today, it is the leading manufacturer of APIs in the cough and cold segment. It also has a dominant presence in several therapeutic segments like antihistamines, anti-convulsants, anti-depressants and anxiolytics (CNS). Malladi exports its products to around 60 countries and over 85% of its revenue is generated from exports. Its manufacturing facilities have been approved by the FDA, EDQM, KFDA, TGA and various other regulatory agencies.

02

LGM Pharma

U.S.A

CPHI Middle east

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

Virtual Booth

Digital Content

Lorazepam

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

03

Evonik

Germany

IPPE

Attending

Evonik's CDMO solutions for APIs and HPAPIs: It specializes where the client needs it most!

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Germany

Virtual Booth

Digital Content

Lorazepam

About the Company : Evonik is one of the world leaders in specialty chemicals.
The company is active in >100 countries around the world & generated sales of €15.3 billion & an operating profit ...

Evonik is one of the world leaders in specialty chemicals. The company is active in >100 countries around the world & generated sales of €15.3 billion & an operating profit (adjusted EBITDA) of €1.66 billion in 2023. Evonik is one of the world’s largest CDMOs with capabilities to manufacture customized APIs & HPAPIs. To address the specific needs of large or complex projects, they have established a broad portfolio of differentiating technologies. These technologies include catalytic & biocatalytic reactions, large-scale cryogenic chemistry, continuous processing, fermentation, PEGs & mPEGs, catalysts, & polymer APIs.

04

Nuray Chemicals Private Limited

India

CPHI Middle east

Not Confirmed

Nuray is an expert in the synthesis of Niche novel APIs, the first to launch Generics, NCEs, Advanced Intermediates // USFDA certified.

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India

Virtual Booth

Digital Content

Lorazepam

About the Company : Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in th...

Established in 2012, Nuray Chemicals Pvt Ltd is an API manufacturer for highly regulated markets. Its manufacturing facility with state-of-the-art R&D is located near Chennai in the Indian state of Tamil Nadu. Nuray’s expertise and experience lie in developing the chemistry requirements of the pharmaceutical industry, including the synthesis of NCEs, impurities, metabolites, method development, advanced intermediates and APIs for commercial launch. With its focus on maintaining the highest levels of quality, reliability and transparency, Nuray has emerged as a trusted partner in the global generic market.

05

HRV Global Life Sciences

India

CPHI Middle east

Attending

HRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

Contact Supplier

India

Virtual Booth

Digital Content

Lorazepam

About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.

06

Cambrex Corporation

U.S.A

India

CPHI Middle east

Not Confirmed

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API Reference Price

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OF","customerCountry":"PAKISTAN","quantity":"2.10","actualQuantity":"2.1","unit":"KGS","unitRateFc":"1300","totalValueFC":"2697.1","currency":"USD","unitRateINR":107916.83809523808,"date":"18-Oct-2024","totalValueINR":"226625.36","totalValueInUsd":"2697.1","indian_port":"Bombay Air","hs_no":"29339100","bill_no":"4917149","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"CENTAUR HOUSE, SHANTI NAGAR,, MUMBAI ,MAHARASHTRA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"PHARMACEUTICAL RAW MATERIAL LORAZEPAM BPBATCH NO.814024002A MFG DATE.APRIL-2024EXP DATE.MARCH-2029","address":"5TH FLOOR,LAXMINARAYAN COMPLEX","city":"BANGALORE, KARNATAKA","supplier":"LAKE CHEMICALS PRIVATE ","supplierCountry":"INDIA","foreign_port":"COLOMBO","customer":"TO THE ORDER OF,,","customerCountry":"SRI LANKA","quantity":"0.15","actualQuantity":"0.15","unit":"KGS","unitRateFc":"3270","totalValueFC":"418.7","currency":"USD","unitRateINR":234546.06666666671,"date":"25-Oct-2024","totalValueINR":"35181.91","totalValueInUsd":"418.7","indian_port":"Bangalore Air","hs_no":"29339100","bill_no":"5128236","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SRI LANKA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"5TH FLOOR,LAXMINARAYAN COMPLEX, BANGALORE, KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1729794600,"product":"PHARMACEUTICAL RAW MATERIAL LORAZEPAM PHEUR BATCH NO.814024008A MFG DATE. SEPTEMBER-2024 EXP DATE.AUGUST-2029","address":"5TH FLOOR,LAXMINARAYAN COMPLEX","city":"BANGALORE, KARNATAKA","supplier":"LAKE CHEMICALS PRIVATE ","supplierCountry":"INDIA","foreign_port":"MADRID","customer":"TO THE ORDER OF,,,","customerCountry":"SPAIN","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"785","totalValueFC":"20604.2","currency":"EUR","unitRateINR":69251.993199999997,"date":"25-Oct-2024","totalValueINR":"1731299.83","totalValueInUsd":"20604.2","indian_port":"Bangalore Air","hs_no":"29339100","bill_no":"5128230","productDescription":"API","marketType":"REGULATED MARKET","country":"SPAIN","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"5TH FLOOR,LAXMINARAYAN COMPLEX, BANGALORE, KARNATAKA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q4","strtotime":1730226600,"product":"PHARMACEUTICAL BULK DRUG - LORAZEPAM\/USP- BATCH NUMBER: LPZ\/224017, MFG. DATE:OCTOBER 2024, RETEST DATE: SEPTEMBER 2029","address":"RAY HOUSE, HIG 2000,,MOTHER DIARY","city":"BANGALORE,KARNATAKA","supplier":"R L FINE CHEM","supplierCountry":"INDIA","foreign_port":"JAKARTA","customer":"TO THE ORDER OF","customerCountry":"INDONESIA","quantity":"42.00","actualQuantity":"42","unit":"KGS","unitRateFc":"3400","totalValueFC":"141253.8","currency":"USD","unitRateINR":282596.89333333331,"date":"30-Oct-2024","totalValueINR":"11869069.52","totalValueInUsd":"141253.8","indian_port":"Bangalore Air","hs_no":"29339100","bill_no":"5273191","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"INDONESIA","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"RAY HOUSE, HIG 2000,,MOTHER DIARY, BANGALORE,KARNATAKA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"LORAZEPAM","year":"2021","qtr":"Q2","strtotime":1620844200,"product":"LORAZEPAM USP\/EP [440 GMS]","address":"T-184, MIDC, BHOSARI,PUNE","city":"PUNE-MAHARASHTRA","supplier":"F.I.S. FABBRICA ITALIANA SINTETICI","supplierCountry":"ITALY","foreign_port":"MILAN - MALPENSA","customer":"EMCURE PHARMACEUTICALS","customerCountry":"INDIA","quantity":"0.44","actualQuantity":"0.44","unit":"KGS","unitRateFc":"2727.3","totalValueFC":"1478.5","currency":"EUR","unitRateINR":"246136.4","date":"13-May-2021","totalValueINR":"108300","totalValueInUsd":"1478.5","indian_port":"BOMBAY AIR","hs_no":"29339990","bill_no":"3940303","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"MILAN - MALPENSA","supplierAddress":"","customerAddress":"T-184, MIDC, BHOSARI,PUNE"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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Drugs in Development

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Europe

01

WINTHROP PHARM.ITALIA Srl

U.S.A

Medlab Asia & Asia Health

Not Confirmed

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Registration Country : Italy

Lorazepam

Brand Name : Lorazepam

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Dosage Strength : 20 Cpr 1 Mg

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Registration Country : Italy

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02

WINTHROP PHARM.ITALIA Srl

U.S.A

Medlab Asia & Asia Health

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Registration Country : Italy

Lorazepam

Brand Name : Lorazepam

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Dosage Strength : 20 Cpr Riv 2.5 Mg

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Registration Country : Italy

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03

WINTHROP PHARM.ITALIA Srl

U.S.A

Medlab Asia & Asia Health

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Lorazepam

Brand Name : Lorazepam

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Dosage Strength : Gtt Os 10 Ml 2 Mg/Ml

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04

Orion Corporation

Finland

Medlab Asia & Asia Health

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Registration Country : Sweden

lorazepam

Brand Name : Lorazepam Orion

Dosage Form : TABLET

Dosage Strength : 1 MG

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Medlab Asia & Asia Health

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 0.5MG

USFDA APPLICATION NUMBER - 17794

DOSAGE - TABLET;ORAL - 1MG

USFDA APPLICATION NUMBER - 17794

DOSAGE - TABLET;ORAL - 2MG

USFDA APPLICATION NUMBER - 17794

DOSAGE - INJECTABLE;INJECTION - 2MG/ML

USFDA APPLICATION NUMBER - 18140

DOSAGE - INJECTABLE;INJECTION - 4MG/ML

USFDA APPLICATION NUMBER - 18140

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FDF DOSSIERS

Tender// Various Finished Dosage Formulations needed in Slovenia [ENA17226]

Psihiatricna Bolnisnica Vojnik is looking for supplies of Various Finished Dosage Formulations for commercial purposes. The deadline is 26-June-2023. 1. Lorazepam (1 mg) Tablets. The required quantity is 24,600 units. 2. Biperiden (2 mg) Tablets. The required quantity is 14,000 units.

03 Jun 2023

Lorazepam Tablets & Injections needed in Albania [ENA11592]

A company that deals in the import & distribution of pharmaceutical products and medical equipments is looking for suppliers of Lorazepam Tablets & Injections for commercial purpose. The suppliers must support this enquiry with EMA or FDA. 1. Lorazepam (0.5 mg, 1 mg & 2 mg) Tablets. The required quantity is 100,000 units. 2. Lorazepam (2 mg/ ml & 4 mg/ ml) Injections. The required quantity is 60,000 units.

07 Oct 2021

Tender// Various Finished Dosage Formulations needed in Poland [ENA11506]

27 Sep 2021

Tender// Various Finished Dosage Formulations needed in Poland [ENA10961]

27 Jul 2021

Tender// Various Finished Dosage Formulations needed in Poland [ENA10945]

24 Jul 2021

Lorazepam Ampoules needed in the Czech Republic [ENA10341]

Bakter Medical, a company that deals in pharmaceutical products is looking for suppliers of Lorazepam Ampoules. Interested suppliers can contact them via their email: kalina@baktermedical.cz.

05 May 2021

Tender// Marijampole Hospital is looking for Various Finished Dosage Formulations [ENA09216]

Marijampole Hospital is looking for supplies of Various Finished Dosage Formulations. The deadline is 21-Dec-2020. 1. Atropine Sulfate (1 mg/ ml) Solution for Injection. The required quantity is 1,200 units. 2. Ethamsylate (250 mg/ 2 ml). Solution for Injection. The required quantity is 1,900 units. 3. Heparin Sodium (1000 TV / g) Gel. The required quantity is 8,000 units. 4. Clonazepam (2 mg) Tablets. The required quantity is 1,800 units. 5. Lorazepam (2.5 mg) Film-coated Tablets. The required quantity is 2,100. 6. Paracetamol (500 mg) Tablets. The required quantity is 5,000 units.

05 Dec 2020

Tender// Various Finished Formulations needed in Poland [ENA09054]

Institute of Tuberculosis and Lung Diseases is looking for supply of medicinal products. The deadline is 23-Nov-2020. 1. Morphine Sulfate (10 mg / 1 ml) Solution for IV, SC and IM Injections 2. Fentanyl (2.75 mg, release rate 25 µg / h) Transdermal Patch 3. Oxycodone Hydrochloride (5 mg) Tablets 4. Alprazolam (0.25 mg) Tablets 5. Buprenorphine (20 mg patch, release rate 35 µg / h) Transdermal Patch 6. Clonazepam (0.5 mg) Tablets 7. Clozapine (100 mg) Tablets 8. Diazepam (10 mg / 2 ml) Ampoules 9. Phenobarbital (100 mg) Tablets 10. Lorazepam (1 mg) Tablets 11. Midazolam (7.5 mg) Tablets 12. Zolpidem (10 mg) Tablets 13. Haloperidol (5 mg) Injections 14. Allopurinol (100 mg) Tablets 15. Ambroxol (30 mg) Tablets 16. Atorvastatin (20 mg) Tablets 17. Cholecalciferol (1000 IU) Tablets 18. Dexamethasone (1 mg) Tablets 19. Digoxin (100 µg) Tablets 20. Paracetamol (500 mg) Tablets

14 Nov 2020

Lorazepam tablets (2.5 mg) needed in Hungary [ENA04725]

A very successful pharmaceutical wholesale company with a strong reputation for providing top quality products is looking for the suppliers of Lorazepam tablets (2.5 mg). The required volume forecast is about 10,000 units and the preferred pack size is 30.

26 Jul 2019

Ketamine (100mg/2ml) vial and other finished formulations needed in India [ENA01964]

Lorx pharmaceuticals a growing and developing pharmaceutical company based in India is looking for suppliers of the following finished formulations: 1) Ketamine (100mg/2ml) vial 2) Pentazocin Injection 3) Tramadol Injection 4) Lorazepam Injection Interested suppliers must contact Virender Pachreecha via E-mail: virinder_pasrija@yahoo.com or Tel: 9813179812.

18 Sep 2018

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REF. STANDARDS & IMPURITIES

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

24 API Suppliers

12 USDMF

6 CEP/COS

2 JDMF

6 EU WC

14 NDC API

16 Listed Suppliers

$ API Reference Price

DEVELOPMENTS

1 Drugs in Development

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

259 FDF Dossiers

113 FDA Orange Book

81 Europe

26 Canada

8 South Africa

31 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 0.5MG

TABLET;ORAL - 1MG

TABLET;ORAL - 2MG

INJECTABLE;INJECTION - 2MG/ML

INJECTABLE;INJECTION - 4MG/ML

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25 Disintegrants & Superdisintegrants

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17 Granulation

17 Lubricants & Glidants