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1 Rochem International Inc, 13 SPI Pharma, 2 Seqens, 3 DKSH, 1 Jai Radhe Sales, 3 Faran Shimi Pharmaceutical, 7 Gangwal Healthcare, 1 Pfanstiehl, 3 Actylis, 1 Aeon Procare, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 10 BASF, 9 Corel Pharma Chem, 3 DFE Pharma, 1 Finar, 7 Gangwal Chemicals, 3 Ideal Cures Pvt Ltd, 2 Ingredion Pharma Solutions, 9 Kerry, 1 Kima Chemical, 9 Microlex e.U, 2 Nomisma Healthcare, 1 Novo Excipients, 1 Pharmatrans-Sanaq, 3 Pluviaendo, 3 Prachin Chemical, 13 Roquette, 4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 1 Shijiazhuang Huaxu Pharmaceutical, 10 Sigachi Industries, 1 The Dow Chemical Company, 3 Vasa Pharmachem

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Chemistry

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Also known as: Lorcaserin hcl, 846589-98-8, Lorqess, Lorcaserin (hydrochloride), Apd-356, Belviq

Molecular Formula

C₁₁H₁₅Cl₂N

Molecular Weight

232.15 g/mol

InChI Key

ITIHHRMYZPNGRC-QRPNPIFTSA-N

FDA UNII

0QJF08GDPE

1 2D Structure

Lorcaserin HCl

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine;hydrochloride

2.1.2 InChI

InChI=1S/C11H14ClN.ClH/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9;/h2-3,6,8,13H,4-5,7H2,1H3;1H/t8-;/m0./s1

2.1.3 InChI Key

ITIHHRMYZPNGRC-QRPNPIFTSA-N

2.1.4 Canonical SMILES

CC1CNCCC2=C1C=C(C=C2)Cl.Cl

2.1.5 Isomeric SMILES

C[C@H]1CNCCC2=C1C=C(C=C2)Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

0QJF08GDPE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (1r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine

2. 8-chloro-2,3,4,5-tetrahydro-1-methyl-1h-3-benzazepine

3. Apd 356

4. Apd-356

5. Apd356

6. Ar-10a

7. Belviq

8. Lorcaserin

2.3.2 Depositor-Supplied Synonyms

1. Lorcaserin Hcl

2. 846589-98-8

3. Lorqess

4. Lorcaserin (hydrochloride)

5. Apd-356

6. Belviq

7. (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine Hydrochloride

8. Apd356

9. Lorcaserin Hydrochloride [usan]

10. Belviq Xr

11. 0qjf08gdpe

12. Chebi:65350

13. (1r)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1h-3-benzazepine Hydrochloride

14. 846589-98-8 (hcl)

15. Belviq (tn)

16. (r)-1h-3-benzazepine,8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride

17. Lorcaserin Hydrochloride (usan)

18. (1r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Hydrochloride

19. Unii-0qjf08gdpe

20. Apd 356

21. Schembl173899

22. Chembl2095211

23. Dtxsid60233650

24. Act10402

25. Bcp22731

26. Ex-a1697

27. Lorcaserin Hydrochloride (>50% Ee)

28. Lorcaserin Hydrochloride [mi]

29. Mfcd09833667

30. (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Hydrochloride

31. Akos005145786

32. Ac-8945

33. Bcp9000859

34. Cs-0752

35. Ks-1439

36. 1h-3-benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, Hydrochloride (1:1), (1r)-

37. Lorcaserin Hydrochloride [vandf]

38. Lorcaserin Hydrochloride [who-dd]

39. Lorcaserin Hydrochloride Anhydrous

40. Hy-15368

41. Sw219573-1

42. Lorcaserin Hydrochloride [orange Book]

43. D06613

44. Lorcaserin Hcl; Apd 356; Apd-356; Apd356;

45. Q27888442

46. (1r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepinium Chloride

47. (5r)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine;hydrochloride

48. (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine Hydrochloride Salt

49. (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-benzo[d]azepine Hydrochloride Hemihydrate

50. 1h-3-benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-, Hydrochloride, (1r)-

51. 1h-3-benzazepine, 8-chloro-2,3,4,5-tetrahydro-1-methyl-,hydrochloride, (1r)-

2.4 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₁₁H₁₅Cl₂N
Molecular Weight	232.15 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	0
Exact Mass	231.0581549 g/mol
Monoisotopic Mass	231.0581549 g/mol
Topological Polar Surface Area	12 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	172
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 2
Drug Name	Belviq
PubMed Health	Lorcaserin (By mouth)
Drug Classes	Antiobesity Agent
Drug Label	BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor agonist for oral administration used for chronic weight management. Its chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate. The empirical f...
Active Ingredient	Lorcaserin hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	10mg
Market Status	Prescription
Company	Eisai

2 of 2
Drug Name	Belviq
PubMed Health	Lorcaserin (By mouth)
Drug Classes	Antiobesity Agent
Drug Label	BELVIQ (lorcaserin hydrochloride) is a serotonin 2C receptor agonist for oral administration used for chronic weight management. Its chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate. The empirical f...
Active Ingredient	Lorcaserin hydrochloride
Dosage Form	Tablet
Route	Oral
Strength	10mg
Market Status	Prescription
Company	Eisai

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Fillers, Diluents & Binders

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Direct Compression

Controlled & Modified Release

Thickeners and Stabilizers

Disintegrants & Superdisintegrants

Granulation

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Lubricants & Glidants

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Chewable & Orodispersible Aids

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ABOUT THIS PAGE

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Lorcaserin HCl

ACCESS ALL DATA

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CHEMISTRY

Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

13 API Suppliers

4 USDMF

2 EU WC

1 KDMF

3 NDC API

10 Listed Suppliers

DEVELOPMENTS

2 Drugs in Development

INTERMEDIATES

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

2 FDF Dossiers

1 FDA Orange Book

1 Listed Dossiers

RELATED EXCIPIENT COMPANIES

1 Rochem International Inc

13 SPI Pharma

2 Seqens

3 DKSH

1 Jai Radhe Sales

3 Faran Shimi Pharmaceutical

7 Gangwal Healthcare

1 Pfanstiehl

3 Actylis

1 Aeon Procare

5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd

10 BASF

9 Corel Pharma Chem

3 DFE Pharma

1 Finar

7 Gangwal Chemicals

3 Ideal Cures Pvt Ltd

2 Ingredion Pharma Solutions

9 Kerry

1 Kima Chemical

9 Microlex e.U

2 Nomisma Healthcare

1 Novo Excipients

1 Pharmatrans-Sanaq

3 Pluviaendo

3 Prachin Chemical

13 Roquette

4 Shanghai Shenmei Pharmaceutical Technology Co., Ltd

1 Shijiazhuang Huaxu Pharmaceutical

10 Sigachi Industries

1 The Dow Chemical Company

3 Vasa Pharmachem

EXCIPIENTS BY APPLICATIONS

41 Fillers, Diluents & Binders

25 Coating Systems & Additives

22 Direct Compression

16 Controlled & Modified Release

16 Thickeners and Stabilizers

15 Disintegrants & Superdisintegrants

13 Granulation

13 Taste Masking

13 Lubricants & Glidants

12 Co-Processed Excipients

11 Chewable & Orodispersible Aids

8 Topical

7 Parenteral

6 Film Formers & Plasticizers

4 Solubilizers

3 API Stability Enhancers

3 Emulsifying Agents

2 Coloring Agents

2 Rheology Modifiers

DIGITAL CONTENT

3 DATA COMPILATION #PharmaFlow

41 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

3 Annual Reports

MARKET PLACE