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Chemistry

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Also known as: Lorecivivint, 1467093-03-3, Sm04690, Lorecivivint [usan], N-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide, Adavivint (sm04690)
Molecular Formula
C29H24FN7O
Molecular Weight
505.5  g/mol
InChI Key
AQDWDWAYVBQMAM-UHFFFAOYSA-N
FDA UNII
42EK42WHI5

Lorecivivint
Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).
1 2D Structure

Lorecivivint

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]pyridin-3-yl]-3-methylbutanamide
2.1.2 InChI
InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28(37-36-24)29-34-25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,(H,33,38)(H,34,35)(H,36,37)
2.1.3 InChI Key
AQDWDWAYVBQMAM-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C(C=C2)NN=C3C4=NC5=C(N4)C=NC=C5C6=CC(=CC=C6)F
2.2 Other Identifiers
2.2.1 UNII
42EK42WHI5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Lorecivivint

2. N-(5-((3z)-3-(7-(3-fluorophenyl)imidazo(4,5-c)pyridin-2-ylidene)-1,2-dihydroindazol-5-yl)pyridin-3-yl)-3-methylbutanamide

3. Sm-04690

4. Sm04690

2.3.2 Depositor-Supplied Synonyms

1. Lorecivivint

2. 1467093-03-3

3. Sm04690

4. Lorecivivint [usan]

5. N-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide

6. Adavivint (sm04690)

7. Sm-04690

8. 42ek42whi5

9. 1467093-03-3 (free Base)

10. N-(5-(3-(7-(3-fluorophenyl)-3h-imidazo(4,5-c)pyridin-2-yl)-1h-indazol-5- Yl)-pyridin-3-yl)-3-methylbutanamide

11. Adavivint [inn]

12. N-[5-[3-[7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl]-1h-indazol-5-yl]pyridin-3-yl]-3-methylbutanamide

13. Adavivint; Sm04690

14. Lorecivivint (usan/inn)

15. Lorecivivint [inn]

16. Adavivint (deprecated Inn)

17. Unii-42ek42whi5

18. Gtpl9620

19. Chembl4297639

20. Schembl15302155

21. Bcp30409

22. Ex-a2711

23. Mfcd30489411

24. S8761

25. Who 10389

26. Db14883

27. Ac-31570

28. As-84223

29. Sm0-4690

30. Hy-109049

31. Cs-0031495

32. D11588

33. D83694

34. A934079

35. Sm04690; Sm-04690; Sm 04690 Pound>>cas:1467013-03-3

36. Butanamide, N-(5-(3-(7-(3-fluorophenyl)-3h-imidazo(4,5-c)pyridin-2-yl)-1h- Indazol-5-yl)-3-pyridinyl)-3-methyl-

37. N-(5-((3z)-3-(7-(3-fluorophenyl)imidazo(4,5-c)pyridin-2-ylidene)-1,2-dihydroindazol-5-yl)pyridin-3-yl)-3-methylbutanamide

38. N-(5-{3-[7-(3-fluorophenyl)-1h-imidazo[4,5-c]pyridin-2-yl]-1h-indazol-5-yl}pyridin-3-yl)-3-methylbutanamide

2.4 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 505.5 g/mol
Molecular Formula C29H24FN7O
XLogP34.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass505.20263658 g/mol
Monoisotopic Mass505.20263658 g/mol
Topological Polar Surface Area112 Ų
Heavy Atom Count38
Formal Charge0
Complexity816
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents

Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)


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ABOUT THIS PAGE

Looking for 1467093-03-3 / Lorecivivint API manufacturers, exporters & distributors?

Lorecivivint manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lorecivivint API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lorecivivint manufacturer or Lorecivivint supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lorecivivint manufacturer or Lorecivivint supplier.

PharmaCompass also assists you with knowing the Lorecivivint API Price utilized in the formulation of products. Lorecivivint API Price is not always fixed or binding as the Lorecivivint Price is obtained through a variety of data sources. The Lorecivivint Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lorecivivint

Synonyms

1467093-03-3, Sm04690, Lorecivivint [usan], N-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide, Adavivint (sm04690), Sm-04690

Cas Number

1467093-03-3

Unique Ingredient Identifier (UNII)

42EK42WHI5

About Lorecivivint

Lorecivivint is under investigation in clinical trial NCT03246399 (A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease).

Lorecivivint Manufacturers

A Lorecivivint manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lorecivivint, including repackagers and relabelers. The FDA regulates Lorecivivint manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lorecivivint API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lorecivivint Suppliers

A Lorecivivint supplier is an individual or a company that provides Lorecivivint active pharmaceutical ingredient (API) or Lorecivivint finished formulations upon request. The Lorecivivint suppliers may include Lorecivivint API manufacturers, exporters, distributors and traders.

Lorecivivint GMP

Lorecivivint Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lorecivivint GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lorecivivint GMP manufacturer or Lorecivivint GMP API supplier for your needs.

Lorecivivint CoA

A Lorecivivint CoA (Certificate of Analysis) is a formal document that attests to Lorecivivint's compliance with Lorecivivint specifications and serves as a tool for batch-level quality control.

Lorecivivint CoA mostly includes findings from lab analyses of a specific batch. For each Lorecivivint CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lorecivivint may be tested according to a variety of international standards, such as European Pharmacopoeia (Lorecivivint EP), Lorecivivint JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lorecivivint USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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