Find Losmapimod manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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API Suppliers

API Suppliers

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USDMF

US DMFs Filed

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CEP/COS

CEP/COS Certifications

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JDMF

JDMFs Filed

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EU WC

EU WC

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KDMF

KDMF

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NDC API

NDC API

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VMF

NDC API

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Listed Suppliers

Other Suppliers

0INTERMEDIATES

REF. STANDARDS OR IMPURITIES

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EDQM

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USP

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JP

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Others

FINISHED DOSAGE FORMULATIONS

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FDA Orange Book

FDA (Orange Book)

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Europe

Europe

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Canada

Canada

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Australia

Australia

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South Africa

South Africa

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DRUG PRODUCT COMPOSITIONS

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

PATENTS & EXCLUSIVITIES

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US Patents

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US Exclusivities

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Health Canada Patents

API REF. PRICE (USD/KG)

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GLOBAL SALES INFORMATION

US Medicaid

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Chemistry

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Also known as: 585543-15-3, Gsk-ahab, Gw856553, Gw856553x, Gw-856553, Gskahab
Molecular Formula
C22H26FN3O2
Molecular Weight
383.5  g/mol
InChI Key
KKYABQBFGDZVNQ-UHFFFAOYSA-N
FDA UNII
F2DQF16BXE

Losmapimod
Losmapimod is an orally bioavailable inhibitor of the alpha and beta isoforms of p38 mitogen-activated protein kinase (MAPK), with potential immunomodulating and anti-inflammatory activities. Upon oral administration, losmapimod inhibits the activity of p38alpha/beta MAPK, thereby preventing p38alpha/beta MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines. p38 MAPK, a serine/threonine protein kinase, plays an important role in regulating the transcription and translation of cytokines involved in inflammation including tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1, IL-6 and IL-8.
1 2D Structure

Losmapimod

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-N-(2,2-dimethylpropyl)pyridine-3-carboxamide
2.1.2 InChI
InChI=1S/C22H26FN3O2/c1-13-17(9-15(10-18(13)23)21(28)26-16-6-7-16)19-8-5-14(11-24-19)20(27)25-12-22(2,3)4/h5,8-11,16H,6-7,12H2,1-4H3,(H,25,27)(H,26,28)
2.1.3 InChI Key
KKYABQBFGDZVNQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C
2.2 Other Identifiers
2.2.1 UNII
F2DQF16BXE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylprpyl)-3-pyridinecarboxamide

2. Gsk-ahab

3. Gw856553

2.3.2 Depositor-Supplied Synonyms

1. 585543-15-3

2. Gsk-ahab

3. Gw856553

4. Gw856553x

5. Gw-856553

6. Gskahab

7. 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-n-(2,2-dimethylpropyl)pyridine-3-carboxamide

8. F2dqf16bxe

9. Losmapimod (gw856553x)

10. Ftx1821

11. Ftx-1821

12. Gw-856553x

13. Gsk-ahab;gw856553x;sb856553

14. 6-(5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl)-n-neopentylnicotinamide

15. 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-n-(2,2-dimethylpropyl)pyridine-3-carboxamide.

16. Losmapimod [usan:inn]

17. Unii-f2dqf16bxe

18. 3-pyridinecarboxamide, 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylpropyl)-

19. 3-pyridinecarboxamide, 6-[5-[(cyclopropylamino)carbonyl]-3-fluoro-2-methylphenyl]-n-(2,2-dimethylpropyl)-

20. Gw 856553x

21. Sb 856553

22. Losmapimod [inn]

23. Losmapimod (usan/inn)

24. Losmapimod [usan]

25. Losmapimod,gw-856553

26. Losmapimod [who-dd]

27. Gtpl7835

28. Schembl1070401

29. Chembl1088752

30. Dtxsid30974109

31. Ex-a486

32. Chebi:131167

33. Hms3653g19

34. Hms3673k13

35. Losmapimod Pound>>gw-856553

36. Bcp09909

37. Bdbm50418610

38. Mfcd16619322

39. Nsc785336

40. Nsc800785

41. S7215

42. Zinc35793138

43. Akos015994587

44. Ccg-268442

45. Cs-3235

46. Db12270

47. Ge-0056

48. Nsc-785336

49. Nsc-800785

50. Sb16761

51. Ncgc00386332-03

52. Ncgc00481552-01

53. Ac-35781

54. Da-33431

55. Gs856553

56. Hy-10402

57. Sb856553

58. Gw 856553

59. B4620

60. Ft-0700337

61. Sw219307-1

62. D09639

63. 543c153

64. Q6683687

65. 6-(5-cyclopropylcarbamoyl-3-fluoro-2-methyl-phenyl)-n-(2,2-dimethylpropyl)-nicotinamide

66. 6-[5-(cyclopropylcarbamoyl)-3-fluoro-2-methylphenyl]-n-(2,2-dimethylpropyl)nicotinamide

67. 6-(5-((cyclopropylamino)carbonyl)-3-fluoro-2-methylphenyl)-n-(2,2-dimethylpropyl)-3-pyridinecarboxamide

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 383.5 g/mol
Molecular Formula C22H26FN3O2
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass383.20090524 g/mol
Monoisotopic Mass383.20090524 g/mol
Topological Polar Surface Area71.1 Ų
Heavy Atom Count28
Formal Charge0
Complexity573
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Looking for 585543-15-3 / Losmapimod API manufacturers, exporters & distributors?

Losmapimod manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Losmapimod API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Losmapimod manufacturer or Losmapimod supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Losmapimod manufacturer or Losmapimod supplier.

PharmaCompass also assists you with knowing the Losmapimod API Price utilized in the formulation of products. Losmapimod API Price is not always fixed or binding as the Losmapimod Price is obtained through a variety of data sources. The Losmapimod Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Losmapimod

Synonyms

585543-15-3, Gsk-ahab, Gw856553, Gw856553x, Gw-856553, Gskahab

Cas Number

585543-15-3

Unique Ingredient Identifier (UNII)

F2DQF16BXE

About Losmapimod

Losmapimod is an orally bioavailable inhibitor of the alpha and beta isoforms of p38 mitogen-activated protein kinase (MAPK), with potential immunomodulating and anti-inflammatory activities. Upon oral administration, losmapimod inhibits the activity of p38alpha/beta MAPK, thereby preventing p38alpha/beta MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines. p38 MAPK, a serine/threonine protein kinase, plays an important role in regulating the transcription and translation of cytokines involved in inflammation including tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1, IL-6 and IL-8.

Losmapimod Manufacturers

A Losmapimod manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Losmapimod, including repackagers and relabelers. The FDA regulates Losmapimod manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Losmapimod API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Losmapimod Suppliers

A Losmapimod supplier is an individual or a company that provides Losmapimod active pharmaceutical ingredient (API) or Losmapimod finished formulations upon request. The Losmapimod suppliers may include Losmapimod API manufacturers, exporters, distributors and traders.

Losmapimod GMP

Losmapimod Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Losmapimod GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Losmapimod GMP manufacturer or Losmapimod GMP API supplier for your needs.

Losmapimod CoA

A Losmapimod CoA (Certificate of Analysis) is a formal document that attests to Losmapimod's compliance with Losmapimod specifications and serves as a tool for batch-level quality control.

Losmapimod CoA mostly includes findings from lab analyses of a specific batch. For each Losmapimod CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Losmapimod may be tested according to a variety of international standards, such as European Pharmacopoeia (Losmapimod EP), Losmapimod JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Losmapimod USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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