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Chemistry

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Also known as: Loxapine hcl, Loxitane c, Loxitane im, 54810-23-0, Loxapine (hydrochloride), 376myl4mal
Molecular Formula
C18H19Cl2N3O
Molecular Weight
364.3  g/mol
InChI Key
JSXBVMKACNEMKY-UHFFFAOYSA-N
FDA UNII
376MYL4MAL

Loxapine Hydrochloride
An antipsychotic agent used in schizophrenia.
1 2D Structure

Loxapine Hydrochloride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine;hydrochloride
2.1.2 InChI
InChI=1S/C18H18ClN3O.ClH/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;/h2-7,12H,8-11H2,1H3;1H
2.1.3 InChI Key
JSXBVMKACNEMKY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
376MYL4MAL
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-chloro-11-(4-methyl-1-piperazinyl)-dibenz(b,f)(1,4)oxazepine

2. Cl 71,563

3. Cl-71,563

4. Cl71,563

5. Cloxazepine

6. Hydrochloride, Loxapine

7. Loxapine

8. Loxapine Monohydrochloride

9. Loxapine Succinate

10. Loxapinsuccinate

11. Loxipine Maleate

12. Loxipine Succinate

13. Loxitane

14. Maleate, Loxipine

15. Oxilapine

16. Succinate, Loxapine

2.3.2 Depositor-Supplied Synonyms

1. Loxapine Hcl

2. Loxitane C

3. Loxitane Im

4. 54810-23-0

5. Loxapine (hydrochloride)

6. 376myl4mal

7. Desconex (tn)

8. Loxapine Monohydrochloride

9. Unii-376myl4mal

10. 2-chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine Monohydrochloride

11. Schembl41625

12. Chembl1201060

13. Dtxsid70203304

14. Hy-17390b

15. Loxapine Hydrochloride [vandf]

16. Loxapine Hydrochloride [mart.]

17. Loxapine Hydrochloride [who-dd]

18. Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-, Monohydrochloride

19. Loxapine Hydrochloride [orange Book]

20. Cs-0031021

21. Ft-0670868

22. D08148

23. Q27256644

24. 8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine;hydrochloride

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 364.3 g/mol
Molecular Formula C18H19Cl2N3O
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass363.0905176 g/mol
Monoisotopic Mass363.0905176 g/mol
Topological Polar Surface Area28.1 Ų
Heavy Atom Count24
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antipsychotic Agents

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)


Dopamine Antagonists

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)


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ABOUT THIS PAGE

Loxapine Hydrochloride Manufacturers

A Loxapine Hydrochloride manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Loxapine Hydrochloride, including repackagers and relabelers. The FDA regulates Loxapine Hydrochloride manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Loxapine Hydrochloride API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Loxapine Hydrochloride manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Loxapine Hydrochloride Suppliers

A Loxapine Hydrochloride supplier is an individual or a company that provides Loxapine Hydrochloride active pharmaceutical ingredient (API) or Loxapine Hydrochloride finished formulations upon request. The Loxapine Hydrochloride suppliers may include Loxapine Hydrochloride API manufacturers, exporters, distributors and traders.

click here to find a list of Loxapine Hydrochloride suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Loxapine Hydrochloride GMP

Loxapine Hydrochloride Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Loxapine Hydrochloride GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Loxapine Hydrochloride GMP manufacturer or Loxapine Hydrochloride GMP API supplier for your needs.

Loxapine Hydrochloride CoA

A Loxapine Hydrochloride CoA (Certificate of Analysis) is a formal document that attests to Loxapine Hydrochloride's compliance with Loxapine Hydrochloride specifications and serves as a tool for batch-level quality control.

Loxapine Hydrochloride CoA mostly includes findings from lab analyses of a specific batch. For each Loxapine Hydrochloride CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Loxapine Hydrochloride may be tested according to a variety of international standards, such as European Pharmacopoeia (Loxapine Hydrochloride EP), Loxapine Hydrochloride JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Loxapine Hydrochloride USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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