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ACTIVE PHARMA INGREDIENTS

53 API Suppliers, 4 USDMF, 43 JDMF, 1 EU WC, 53 KDMF, 2 NDC API, 10 Listed Suppliers, $ API Reference Price

53 API Suppliers
4 USDMF
43 JDMF
1 EU WC
53 KDMF
2 NDC API
10 Listed Suppliers
$ API Reference Price

INTERMEDIATES

3 Intermediates Suppliers

3 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 4 Listed Dossiers

4 FDF Dossiers
4 Listed Dossiers

DIGITAL CONTENT

1 DATA COMPILATION #PharmaFlow, 1 NEWS #PharmaBuzz

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1 DATA COMPILATION #PharmaFlow
1 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

7 Annual Reports

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7 Annual Reports

MARKET PLACE

11 APIs

marketPlace
11 APIs

REF. STANDARDS & IMPURITIES

4 JP , 6 Others

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4 JP
6 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

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DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

1,607

Finished Drug Prices

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Chemistry

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Also known as: 226721-96-6, Loxonin, Oxeno, Lobu, Loxoprofen sodium, Loxoprofen sodium hydrate

Molecular Formula

C₁₅H₂₁NaO₅

Molecular Weight

304.31 g/mol

InChI Key

BAZQYVYVKYOAGO-UHFFFAOYSA-M

FDA UNII

Z2DR42L11Y

1 2D Structure

Loxoprofen Sodium

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

sodium;2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate;dihydrate

2.1.2 InChI

InChI=1S/C15H18O3.Na.2H2O/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;2*1H2/q;+1;;/p-1

2.1.3 InChI Key

BAZQYVYVKYOAGO-UHFFFAOYSA-M

2.1.4 Canonical SMILES

CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)[O-].O.O.[Na+]

2.2 Other Identifiers

2.2.1 UNII

Z2DR42L11Y

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 156-s

2. 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic Acid

3. 2-ocppp

4. Cs 600

5. Cs-600

6. Loxoprofen

7. Loxoprofen Alcohol

8. Loxoprofen Sodium, (r*,s*)-isomer

9. Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate Dihydrate

10. Sodium Loxoprofen

2.3.2 Depositor-Supplied Synonyms

1. 226721-96-6

2. Loxonin

3. Oxeno

4. Lobu

5. Loxoprofen Sodium

6. Loxoprofen Sodium Hydrate

7. Loxoprofen Sodium Salt Dihydrate

8. 80382-23-6

9. Loxoprofen Sodium [mart.]

10. Loxoprofen Sodium Hydrate [jp]

11. Loxoprofen (monosodium)

12. Lobu; Loxonin;cs 600

13. Sodium;2-[4-[(2-oxocyclopentyl)methyl]phenyl]propanoate;dihydrate

14. Z2dr42l11y

15. Monosodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate Dihydrate

16. Sodium 2-(4-(2-oxocyclopentylmethyl)phenyl)propionate Dihydrate

17. Alpha-methyl-4-((2-oxocyclopentyl)methyl)benzeneacetate Sodium Salt Dihydrate

18. Unii-z2dr42l11y

19. Lorfenamin (tn)

20. Loxonin (tn)

21. Loxoprofensodiumdihydrate

22. Chebi:31786

23. Dtxsid601001203

24. Loxoprofen Sodium Hydrate (jp17)

25. Bja72196

26. Ac-555

27. Mfcd01745788

28. Akos015894920

29. Akos015963323

30. Benzeneacetic Acid, Alpha-methyl-4-((2-oxocyclopentyl)methyl)-, Sodium Salt, Hydrate (1:1:2)

31. (r)-2-chloro-3-methylbutyricacid

32. As-82727

33. Loxoprofen Sodium Dihydrate [who-dd]

34. D01709

35. Q27114685

36. Sodium 2-[4-(2-oxocyclopentylmethyl) Phenyl]-propionate Dihydrate

37. Sodium 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoate--water (1/1/2)

38. Sodium 2-{4-[(2-oxocyclopentyl)methyl]phenyl}propanoate--water (1/2)

39. Benzeneacetic Acid, .alpha.-methyl-4-((2-oxocyclopentyl)methyl)-, Sodium Salt, Hydrate (1:1:2)

2.4 Create Date

2008-02-05

3 Chemical and Physical Properties

Molecular Formula	C₁₅H₂₁NaO₅
Molecular Weight	304.31 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	304.12866805 g/mol
Monoisotopic Mass	304.12866805 g/mol
Topological Polar Surface Area	59.2 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	321
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	2
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

API SUPPLIERS

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USDMF

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JDMF

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EU WC

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KDMF

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NDC API

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Listed Suppliers

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API Reference Price

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