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10 Drugs in Development

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Also known as: Lp-184, L683vc69k8, (r)-1-hydroxy-1-((6'-hydroxy-2',4',6'-trimethyl-7'-oxo-6',7'-dihydrospiro(cyclopropane-1,5'-inden)-3'-yl)methyl)urea, 924835-67-6, N-(((6'r)-6',7'-dihydro-6'-hydroxy-2',4',6'-trimethyl-7'-oxospiro(cyclopropane-1,5'-(5h)inden)-3'-yl)methyl)-n-hydroxyurea, Urea, n-(((6'r)-6',7'-dihydro-6'-hydroxy-2',4',6'-trimethyl-7'-oxospiro(cyclopropane-1,5'-(5h)inden)-3'-yl)methyl)-n-hydroxy-

Molecular Formula

C₁₆H₂₀N₂O₄

Molecular Weight

304.34 g/mol

InChI Key

VWMPVAZEBAKLFR-HNNXBMFYSA-N

FDA UNII

L683VC69K8

1 2D Structure

LP-184

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-hydroxy-1-[[(5'R)-5'-hydroxy-2',5',7'-trimethyl-4'-oxospiro[cyclopropane-1,6'-indene]-1'-yl]methyl]urea

2.1.2 InChI

InChI=1S/C16H20N2O4/c1-8-6-10-12(11(8)7-18(22)14(17)20)9(2)16(4-5-16)15(3,21)13(10)19/h6,21-22H,4-5,7H2,1-3H3,(H2,17,20)/t15-/m0/s1

2.1.3 InChI Key

VWMPVAZEBAKLFR-HNNXBMFYSA-N

2.1.4 Canonical SMILES

CC1=C(C2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C)CN(C(=O)N)O

2.1.5 Isomeric SMILES

CC1=C(C2=C(C3(CC3)[C@@](C(=O)C2=C1)(C)O)C)CN(C(=O)N)O

2.2 Other Identifiers

2.2.1 UNII

L683VC69K8

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. Lp-184

2. L683vc69k8

3. (r)-1-hydroxy-1-((6'-hydroxy-2',4',6'-trimethyl-7'-oxo-6',7'-dihydrospiro(cyclopropane-1,5'-inden)-3'-yl)methyl)urea

4. 924835-67-6

5. N-(((6'r)-6',7'-dihydro-6'-hydroxy-2',4',6'-trimethyl-7'-oxospiro(cyclopropane-1,5'-(5h)inden)-3'-yl)methyl)-n-hydroxyurea

6. Urea, N-(((6'r)-6',7'-dihydro-6'-hydroxy-2',4',6'-trimethyl-7'-oxospiro(cyclopropane-1,5'-(5h)inden)-3'-yl)methyl)-n-hydroxy-

7. Unii-l683vc69k8

8. Chembl3781819

9. Schembl12200171

10. Hy-139453

11. Cs-0201987

2.4 Create Date

2007-03-07

3 Chemical and Physical Properties

Molecular Formula	C₁₆H₂₀N₂O₄
Molecular Weight	304.34 g/mol
XLogP3	-1.1
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	304.14230712 g/mol
Monoisotopic Mass	304.14230712 g/mol
Topological Polar Surface Area	104 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	697
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1