menu
    • menu

    API Export of LUT-014 obtained from Indian Customs Trade Statistics

    Client Email Product
    EUROAPI, the leading small molecules API player, provides both API sales & CDMO services.

    Virtual Booth

    Contact Supplier

    Bora Pharmaceuticals- Making success more certain.

    Virtual Booth

    Contact Supplier

    Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

    Virtual Booth

    Contact Supplier

    Minakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.

    Virtual Booth

    Contact Supplier

    Axplora- The partner of choice for complex APIs.

    Virtual Booth

    Contact Supplier

    Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

    Virtual Booth

    Contact Supplier

    DEVELOPMENTS

    PharmaCompass

    Synopsis

    Product SearchProduct Search

    Synopsis

    ACTIVE PHARMA INGREDIENTS

    0

    API Suppliers

    API Suppliers

    0

    USDMF

    US DMFs Filed

    0

    CEP/COS

    CEP/COS Certifications

    0

    JDMF

    JDMFs Filed

    0

    EU WC

    EU WC

    0

    KDMF

    KDMF

    0

    NDC API

    NDC API

    0

    VMF

    NDC API

    0

    Listed Suppliers

    Other Suppliers

    API REF. PRICE (USD/KG)

    $
    $ 0

    MARKET PLACE

    0

    API

    0

    FDF

    0INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

    0

    FDF Dossiers

    FDF Dossiers

    0

    FDA Orange Book

    FDA (Orange Book)

    0

    Europe

    Europe

    0

    Canada

    Canada

    0

    Australia

    Australia

    0

    South Africa

    South Africa

    0

    Listed Dossiers

    Listed Dossiers

    4DRUGS IN DEVELOPMENT

    FDF Dossiers

    DRUG PRODUCT COMPOSITIONS

    REF. STANDARDS OR IMPURITIES

    0

    EDQM

    0

    USP

    0

    JP

    0

    Others

    PATENTS & EXCLUSIVITIES

    0

    US Patents

    0

    US Exclusivities

    0

    Health Canada Patents

    DIGITAL CONTENT

    0

    Data Compilation #PharmaFlow

    0

    Stock Recap #PipelineProspector

    0

    Weekly News Recap #Phispers

    0

    News #PharmaBuzz

    GLOBAL SALES INFORMATION

    US Medicaid

    NA

    Annual Reports

    NA

    Finished Drug Prices

    NA

    0RELATED EXCIPIENT COMPANIES

    0EXCIPIENTS BY APPLICATIONS

    Chemistry

    Click the arrow to open the dropdown
    read-moreClick the button for full data set
    read-moreClick the button for full data set
    Also known as: Lut014, 2274819-46-2, Lut-014, T4e4i523ry, Lut-014 [who-dd], 6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]-1-n-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine
    Molecular Formula
    C27H19F3N8O
    Molecular Weight
    528.5  g/mol
    InChI Key
    FZPYULHBUBXPIG-UHFFFAOYSA-N
    FDA UNII
    T4E4I523RY
    LUT-014
    BRAF Inhibitor LUT014 is a topically bioavailable small molecule inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential chemoprotective activity. Upon topical administration, BRAF inhibitor LUT014 targets and binds BRAF and, through the paradoxical effect of BRAF inhibition, induces mitogen-activated protein kinase (MAPK) signaling, which leads to the proliferation and migration of healthy human keratinocytes. This decreases dermal toxicities associated with epidermal growth factor (EGFR) inhibitor therapy. BRAF, a member of the raf family of serine/threonine protein kinases, plays a role in the regulation of MAPK/extracellular signal-regulated kinase (ERK) signaling pathways.
    1 2D Structure

    LUT-014

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]-1-N-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine
    2.1.2 InChI
    InChI=1S/C27H19F3N8O/c1-15-7-8-19-18(9-11-32-24(19)37-16-4-2-5-17(12-16)39-27(28,29)30)21(15)38-25-20(6-3-10-31-25)22-23-26(35-13-33-22)36-14-34-23/h2-14H,1H3,(H,31,38)(H,32,37)(H,33,34,35,36)
    2.1.3 InChI Key
    FZPYULHBUBXPIG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC(=CC=C3)OC(F)(F)F)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6
    2.2 Other Identifiers
    2.2.1 UNII
    T4E4I523RY
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 6-methyl-5-n-(3-(7h-purin-6-yl)pyridin-2-yl)-1-n-(3-(trifluoromethoxy)phenyl)isoquinoline-1,5-diamine

    2. Lut014

    2.3.2 Depositor-Supplied Synonyms

    1. Lut014

    2. 2274819-46-2

    3. Lut-014

    4. T4e4i523ry

    5. Lut-014 [who-dd]

    6. 6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]-1-n-[3-(trifluoromethoxy)phenyl]isoquinoline-1,5-diamine

    7. 1,5-isoquinolinediamine, 6-methyl-n5-(3-(9h-purin-6-yl)-2-pyridinyl)-n1-(3-(trifluoromethoxy)phenyl)-

    8. 1,5-isoquinolinediamine, 6-methyl-n5-[3-(9h-purin-6-yl)-2-pyridinyl]-n1-[3-(trifluoromethoxy)phenyl]-

    9. Unii-t4e4i523ry

    10. Schembl22356326

    11. Gtpl11568

    12. Ex-a2985

    13. Zqd81946

    14. Mfcd32062738

    15. Zb1544

    16. Ac-35618

    17. Hy-111940

    18. Cs-0094163

    19. D81245

    20. N5-(3-(9h-purin-6-yl)pyridin-2-yl)-6-methyl-n1-(3-(trifluoromethoxy)phenyl)isoquinoline-1,5-diamine

    2.4 Create Date
    2019-05-15
    3 Chemical and Physical Properties
    Molecular Weight 528.5 g/mol
    Molecular Formula C27H19F3N8O
    XLogP36.2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count6
    Exact Mass528.16339175 g/mol
    Monoisotopic Mass528.16339175 g/mol
    Topological Polar Surface Area114 Ų
    Heavy Atom Count39
    Formal Charge0
    Complexity808
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Protein Kinase Inhibitors

    Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)

    ABOUT THIS PAGE

    Ask Us for Pharmaceutical Supplier and Partner
    Ask Us, Find A Supplier / Partner
    No Commissions, No Strings Attached, Get Connected for FREE

    What are you looking for?

    How can we help you?

    The request can't be empty

    Please read our Privacy Policy carefully

    You must agree to the privacy policy

    The name can't be empty
    The company can't be empty.
    The email can't be empty Please enter a valid email.
    The mobile can't be empty

    Market Place

    Market Place

    PharmaCompass

    Home

    Market Place

    Menu

    Post Enquiry

    Post Enquiry

    Market Place

    Market Place

    Search