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Chemistry

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Also known as: Xanthophyll, 127-40-2, Bo-xan, Vegetable lutein, Vegetable luteol, All-trans-lutein
Molecular Formula
C40H56O2
Molecular Weight
568.9  g/mol
InChI Key
KBPHJBAIARWVSC-RGZFRNHPSA-N
FDA UNII
X72A60C9MT

Lutein
A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.
1 2D Structure

Lutein

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(1R)-4-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1R,4R)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol
2.1.2 InChI
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-25,35-37,41-42H,26-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36+,37-/m0/s1
2.1.3 InChI Key
KBPHJBAIARWVSC-RGZFRNHPSA-N
2.1.4 Canonical SMILES
CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)O)C)C)C
2.1.5 Isomeric SMILES
CC1=C(C(C[C@@H](C1)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/[C@H]2C(=C[C@@H](CC2(C)C)O)C)/C)/C
2.2 Other Identifiers
2.2.1 UNII
X72A60C9MT
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Beta,epsilon-carotene-3, 3'-diol, (3r,3'r,6's)-

2. Beta,epsilon-carotene-3,3'-diol, (3s,3'r,6's)-

3. Gamma Lutein

4. Lutein F

5. Lutein G

6. Lutein, Gamma

2.3.2 Depositor-Supplied Synonyms

1. Xanthophyll

2. 127-40-2

3. Bo-xan

4. Vegetable Lutein

5. Vegetable Luteol

6. All-trans-lutein

7. Xantofyl

8. Lutein Ester

9. Lutein A

10. All-trans-(+)-xanthophyll

11. Floraglo

12. Floraglo Lutein

13. Trans-lutein

14. Lutein, All-trans-

15. All-trans-xanthophyll

16. Oro Glo 7

17. E 161b

18. Beta,epsilon-carotene-3,3'-diol, (3r,3'r,6'r)-

19. Xanthophyll, All-trans-(+)-

20. (3r,3'r,6'r)-lutein

21. Beta,epsilon-carotene-3,3'-diol

22. Os 24

23. Lutein From Tagetes Erecta

24. Ins No.161b(i)

25. X72a60c9mt

26. E 161

27. Chebi:28838

28. Ins-161b(i)

29. E-161b

30. E-161b(i)

31. Nsc-59193

32. .beta.,.epsilon.-carotene-3,3'-diol

33. .beta.,.epsilon.-carotene-3,3'-diol, (3r,3'r,6'r)-

34. (1r)-4-[(1e,3e,5e,7e,9e,11e,13e,15e,17e)-18-[(1r,4r)-4-hydroxy-2,6,6-trimethylcyclohex-2-en-1-yl]-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethylcyclohex-3-en-1-ol

35. (1r,4r)-4-((1e,3e,5e,7e,9e,11e,13e,15e,17e)-18-((r)-4-hydroxy-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl)-3,5,5-trimethylcyclohex-2-enol

36. (3r,3'r,6'r)-beta,epsilon-carotene-3,3'-diol

37. 180580-60-3

38. 9-cis-lutein

39. Lutamax

40. 13-cis-lutein

41. Unii-x72a60c9mt

42. Leutein

43. Ncgc00167965-01

44. 15-cis-lutein

45. Einecs 204-840-0

46. 13'-cis-lutein

47. Nsc 59193

48. Lutein (xanthophyll)

49. (9'z)-lutein

50. Lutein - 5%

51. Leutein [vandf]

52. Xanthophyll (~80%)

53. Lutein [vandf]

54. E-carotene-3,3'-diol

55. Lutein - 10%

56. Lutein - 20%

57. Lutein [dsc]

58. Lutein [fcc]

59. Xanthophyll [mi]

60. Lutein [usp-rs]

61. Lutein [mart.]

62. Xanthophyll, From Marigold

63. Xantofyl [who-dd]

64. Lutein, Analytical Standard

65. Dsstox_cid_26749

66. Dsstox_rid_81874

67. Dsstox_gsid_46749

68. Schembl19342

69. 3,3'-dihydroxy-alpha-carotene

70. Chembl173929

71. Dtxsid8046749

72. (invertedexclamationmarka)-lutein

73. Bcbcmap01_000190

74. Hms3886i13

75. 29414-89-9

76. Hy-n6947

77. Zinc8221225

78. (3r,3'r)-dihydroxy-alpha-carotene

79. Tox21_112594

80. ( Inverted Exclamation Marka)-lutein

81. Bbl101804

82. Lmpr01070274

83. Mfcd00017353

84. S5103

85. Stl555601

86. Akos008901394

87. Ccg-270087

88. Db00137

89. Smp1_000317

90. As-63011

91. Cas-127-40-2

92. Xl176941

93. Xl176947

94. Xl176948

95. Cs-0015250

96. C08601

97. Q63409232

98. Lutein Solution, 1 Mg/l In Ethanol, Analytical Standard

99. 4',5'-didehydro-6'-hydro-.beta.-carotene-3,3'-diol #

100. Ab972dac-e626-49f1-898d-598af7729fd0

101. (3r,3'r,6r)-4,5-didehydro-5,6-dihydro-beta,beta-carotene-3,3'-diol

102. Lutein, Pharmaceutical Secondary Standard; Certified Reference Material

103. (3r,3'r,6r)-4,5-didehydro-5,6-dihydro-.beta.,.beta.-carotene-3,3'-diol

104. (3r,3'r,6r)-4,5-didehydro-5,6-dihydro-.beta.,.beta.-carotin-3,3'-diol

105. .beta.,.beta.-carotene-3,3'-diol, 4,5-didehydro-5,6-dihydro-, (3r,3'r,6r)-

106. (1r)-4-[(1e,3e,5e,7e,9e,11e,13e,15e,17e)-18-[(1r,4r)-4-hydroxy-2,6,6-trimethyl-cyclohex-2-en-1-yl]-3,7,12,16-tetramethyl-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-3,5,5-trimethyl-cyclohex-3-en-1-ol

107. (1r,4r)-4-((1e,3e,5e,7e,9e,11e,13e,15e,17e)-18-((4r)-4-hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaen-1-yl)-3,5,5-trimethyl-2-cyclohexen-1-ol

2.4 Create Date
2004-09-16
3 Chemical and Physical Properties
Molecular Weight 568.9 g/mol
Molecular Formula C40H56O2
XLogP311
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count10
Exact Mass568.42803102 g/mol
Monoisotopic Mass568.42803102 g/mol
Topological Polar Surface Area40.5 Ų
Heavy Atom Count42
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count9
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Xanthophylls are taken for nutritional supplementation, and also for treating dietary shortage or imbalance.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Lutein was found to be present in a concentrated area of the macula, a small area of the retina responsible for central vision. The hypothesis for the natural concentration is that lutein helps protect from oxidative stress and high-energy light. Several studies show that an increase in macula pigmentation decreases the risk for eye diseases such as Age-related Macular Degeneration (AMD).


5.2 Mechanism of Action

Xanthophylls have antioxidant activity and react with active oxygen species, producing biologically active degradation products. They also can inhibit peroxidation of membrane phospholipids and reduce lipofuscin formation, both of which contribute to their antioxidant properties. Lutein is naturally present in the macula of the human retina. It filters out potentially phototoxic blue light and near-ultraviolet radiation from the macula. The protective effect is due in part, to the reactive oxygen species quenching ability of these carotenoids. Lutein is more stable to decomposition by pro-oxidants than are other carotenoids such as beta-carotene and lycopene. Lutein is abundant in the region surrounding the fovea, and lutein is the predominant pigment at the outermost periphery of the macula. Zeaxanthin, which is fully conjugated (lutein is not), may offer somewhat better protection than lutein against phototoxic damage caused by blue and near-ultraviolet light radiation. Lutein is one of only two carotenoids that have been identified in the human lens, may be protective against age-related increases in lens density and cataract formation. Again, the possible protection afforded by lutein may be accounted for, in part, by its reactive oxygen species scavenging abilities. Carotenoids also provide protection from cancer. One of the mechanisms of this is by increasing the expression of the protein connexin-43, thereby stimulating gap junctional communication and preventing unrestrained cell proliferation.


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24-Dec-2024
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ABOUT THIS PAGE

Looking for 127-40-2 / Lutein API manufacturers, exporters & distributors?

Lutein manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lutein API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lutein manufacturer or Lutein supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lutein manufacturer or Lutein supplier.

PharmaCompass also assists you with knowing the Lutein API Price utilized in the formulation of products. Lutein API Price is not always fixed or binding as the Lutein Price is obtained through a variety of data sources. The Lutein Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lutein

Synonyms

Xanthophyll, 127-40-2, Bo-xan, Vegetable lutein, Vegetable luteol, All-trans-lutein

Cas Number

127-40-2

Unique Ingredient Identifier (UNII)

X72A60C9MT

About Lutein

A xanthophyll found in the major LIGHT-HARVESTING PROTEIN COMPLEXES of plants. Dietary lutein accumulates in the MACULA LUTEA.

Lutein Manufacturers

A Lutein manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lutein, including repackagers and relabelers. The FDA regulates Lutein manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lutein API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Lutein manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Lutein Suppliers

A Lutein supplier is an individual or a company that provides Lutein active pharmaceutical ingredient (API) or Lutein finished formulations upon request. The Lutein suppliers may include Lutein API manufacturers, exporters, distributors and traders.

click here to find a list of Lutein suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Lutein USDMF

A Lutein DMF (Drug Master File) is a document detailing the whole manufacturing process of Lutein active pharmaceutical ingredient (API) in detail. Different forms of Lutein DMFs exist exist since differing nations have different regulations, such as Lutein USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Lutein DMF submitted to regulatory agencies in the US is known as a USDMF. Lutein USDMF includes data on Lutein's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Lutein USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Lutein suppliers with USDMF on PharmaCompass.

Lutein GMP

Lutein Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lutein GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lutein GMP manufacturer or Lutein GMP API supplier for your needs.

Lutein CoA

A Lutein CoA (Certificate of Analysis) is a formal document that attests to Lutein's compliance with Lutein specifications and serves as a tool for batch-level quality control.

Lutein CoA mostly includes findings from lab analyses of a specific batch. For each Lutein CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lutein may be tested according to a variety of international standards, such as European Pharmacopoeia (Lutein EP), Lutein JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lutein USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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