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Chemistry

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Also known as: Cg806, 1616428-23-9, Luxeptinib [usan], Cg026806, Cg'806, Tq6pbx1ju0
Molecular Formula
C25H17F4N5O2
Molecular Weight
495.4  g/mol
InChI Key
MWHHJYUHCZWSLS-UHFFFAOYSA-N
FDA UNII
TQ6PBX1JU0

Luxeptinib
Luxeptinib is an orally bioavailable reversible, pan-inhibitor of both FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2) and Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase), with potential antineoplastic activity. Upon oral administration, luxeptinib targets, non-covalently binds to and inhibits the activity of both FLT3, including both wild-type (WT) FLT3 and FLT3-ITD (internal tandem duplications), tyrosine kinase domain (FLT3-TKD), and gatekeeper (FLT3-F691L) mutant forms, and BTK, including both the WT and its C481S mutant (BTK-C481S) form. This inhibits both uncontrolled FLT3-mediated and B-cell antigen receptor (BCR)-mediated signaling, respectively. This results in the inhibition of proliferation in tumor cells overexpressing FLT3 and BTK. In addition, CG-806 also inhibits, to a lesser degree, other oncogenic kinases, such as MET, RET, discoidin domain-containing receptor 2 (DDR2), Aurora kinase A, and interleukin-2-inducible T-cell kinase (ITK). FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias (AMLs), and plays a key role in tumor cell proliferation. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases essential to BCR signaling, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes.
1 2D Structure

Luxeptinib

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-[3-fluoro-4-[7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydroisoindol-4-yl]phenyl]-3-(2,4,6-trifluorophenyl)urea
2.1.2 InChI
InChI=1S/C25H17F4N5O2/c1-11-9-30-23(32-11)16-5-4-14(17-10-31-24(35)21(16)17)15-3-2-13(8-18(15)27)33-25(36)34-22-19(28)6-12(26)7-20(22)29/h2-9H,10H2,1H3,(H,30,32)(H,31,35)(H2,33,34,36)
2.1.3 InChI Key
MWHHJYUHCZWSLS-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CN=C(N1)C2=C3C(=C(C=C2)C4=C(C=C(C=C4)NC(=O)NC5=C(C=C(C=C5F)F)F)F)CNC3=O
2.2 Other Identifiers
2.2.1 UNII
TQ6PBX1JU0
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Cg806

2. 1616428-23-9

3. Luxeptinib [usan]

4. Cg026806

5. Cg'806

6. Tq6pbx1ju0

7. Cg-026806

8. 1-[3-fluoro-4-[7-(5-methyl-1h-imidazol-2-yl)-1-oxo-2,3-dihydroisoindol-4-yl]phenyl]-3-(2,4,6-trifluorophenyl)urea

9. Urea, N-(4-(2,3-dihydro-7-(5-methyl-1h-imidazol-2-yl)-1-oxo-1h-isoindol-4-yl)-3-fluorophenyl)-n'-(2,4,6-trifluorophenyl)-

10. Urea, N-[4-[2,3-dihydro-7-(5-methyl-1h-imidazol-2-yl)-1-oxo-1h-isoindol-4-yl]-3-fluorophenyl]-n'-(2,4,6-trifluorophenyl)-

11. Luxeptinib [inn]

12. Unii-tq6pbx1ju0

13. Luxeptinib [who-dd]

14. Chembl4594420

15. Schembl17219212

16. Us9758508, Compound 7

17. Gtpl11671

18. Bdbm340031

19. Glxc-25679

20. Example 7 [us9758508b2]

21. Nsc791692

22. Nsc834160

23. Who 11799

24. Nsc-791692

25. Nsc-834160

26. Hy-139535

27. Cs-0204021

28. D96116

29. 1-{3-fluoro-4-[7-(5-methyl-1h-imidazol-2- Yl)-1-oxo-2,3-dihydro-1h-isoindol-4-yl]- Phenyl}-3-(2,4,6-trifluoro-phenyl)-urea

30. 3-{3-fluoro-4-[7-(4-methyl-1h-imidazol-2-yl)-1-oxo-2,3-dihydro-1h-isoindol-4-yl]phenyl-1-(2,4,6-trifluorophenyl)urea

31. 32,72,74,76-tetrafluoro-14-methyl-21,23-dihydro-11h-4,6-diaza-2(4,7)-isoindola- 1(2)-imidazola-3(1,4),7(1)-dibenzenaheptaphane-2,35-dione

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 495.4 g/mol
Molecular Formula C25H17F4N5O2
XLogP33.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass495.13183745 g/mol
Monoisotopic Mass495.13183745 g/mol
Topological Polar Surface Area98.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity811
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1

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ABOUT THIS PAGE

Luxeptinib Manufacturers

A Luxeptinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Luxeptinib, including repackagers and relabelers. The FDA regulates Luxeptinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Luxeptinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Luxeptinib Suppliers

A Luxeptinib supplier is an individual or a company that provides Luxeptinib active pharmaceutical ingredient (API) or Luxeptinib finished formulations upon request. The Luxeptinib suppliers may include Luxeptinib API manufacturers, exporters, distributors and traders.

Luxeptinib GMP

Luxeptinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Luxeptinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Luxeptinib GMP manufacturer or Luxeptinib GMP API supplier for your needs.

Luxeptinib CoA

A Luxeptinib CoA (Certificate of Analysis) is a formal document that attests to Luxeptinib's compliance with Luxeptinib specifications and serves as a tool for batch-level quality control.

Luxeptinib CoA mostly includes findings from lab analyses of a specific batch. For each Luxeptinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Luxeptinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Luxeptinib EP), Luxeptinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Luxeptinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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