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Synopsis

Chemistry

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Also known as: 148553-50-8, Lyrica, (s)-3-(aminomethyl)-5-methylhexanoic acid, 3-isobutyl gaba, (3s)-3-(aminomethyl)-5-methylhexanoic acid, Ci-1008
Molecular Formula
C8H17NO2
Molecular Weight
159.23  g/mol
InChI Key
AYXYPKUFHZROOJ-ZETCQYMHSA-N
FDA UNII
55JG375S6M

Pregabalin
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.
1 2D Structure

Pregabalin

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(3S)-3-(aminomethyl)-5-methylhexanoic acid
2.1.2 InChI
InChI=1S/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h6-7H,3-5,9H2,1-2H3,(H,10,11)/t7-/m0/s1
2.1.3 InChI Key
AYXYPKUFHZROOJ-ZETCQYMHSA-N
2.1.4 Canonical SMILES
CC(C)CC(CC(=O)O)CN
2.1.5 Isomeric SMILES
CC(C)C[C@@H](CC(=O)O)CN
2.2 Other Identifiers
2.2.1 UNII
55JG375S6M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (r-)-3-isobutyl Gaba

2. (s)-3-(aminomethyl)-5-methylhexanoic Acid

3. (s+)-3-isobutyl Gaba

4. 1008, Ci

5. 3 Isobutyl Gaba

6. 3-(aminomethyl)-5-methylhexanoic Acid

7. 3-isobutyl Gaba

8. Ci 1008

9. Ci-1008

10. Ci1008

11. Gaba, 3-isobutyl

12. Lyrica

2.3.2 Depositor-Supplied Synonyms

1. 148553-50-8

2. Lyrica

3. (s)-3-(aminomethyl)-5-methylhexanoic Acid

4. 3-isobutyl Gaba

5. (3s)-3-(aminomethyl)-5-methylhexanoic Acid

6. Ci-1008

7. (s)-pregabalin

8. Hexanoic Acid, 3-(aminomethyl)-5-methyl-, (3s)-

9. Vronogabic

10. Ci 1008

11. Pregabalin Mylan

12. Pregabalin Sandoz

13. Pd 144723

14. Pd-144723

15. Pregabalin Zentiva

16. Pregabalin Sandoz Gmbh

17. (s)-3-isobutyl Gaba

18. Chembl1059

19. Chebi:64356

20. (3s)-3-(aminomethyl)-5-methyl-hexanoic Acid

21. 55jg375s6m

22. Ynp-1807

23. Nsc-759256

24. Hexanoic Acid, 3-(aminomethyl)-5-ethyl-, (3s)-

25. (r-)-3-isobutyl Gaba

26. Pregabalin [usan]

27. Hexanoic Acid, 3-(aminomethyl)-5-methyl-, (s)-

28. Pregabalina

29. Pregabaline

30. Nervalin

31. Pregablin

32. Unii-55jg375s6m

33. Hsdb 7530

34. Pregabalin [usan:inn:ban:jan]

35. Ncgc00095186-01

36. Pregabalin- Bio-x

37. Lyrica (tn)

38. Mfcd00917044

39. Lyrica Cr

40. Pregabalin [mi]

41. (s)-3-(aminomethyl)-5-methylhexanoicacid

42. Pregabalin [inn]

43. Pregabalin [jan]

44. Pregabalin [hsdb]

45. Pregabalin [vandf]

46. Pregabalin [mart.]

47. Schembl8227

48. Dsstox_cid_25950

49. Dsstox_rid_81246

50. Pregabalin [usp-rs]

51. Pregabalin [who-dd]

52. Dsstox_gsid_45950

53. Pregabalin (jan/usan/inn)

54. Pregabalin [ema Epar]

55. Pregabalin Mylan Pharma

56. (s)-(+)-4-amino-3-(2-methylpropyl)butanoic Acid

57. Gtpl5484

58. Zinc5152

59. Dea No. 2782

60. Pregabalin, >=97% (nmr)

61. Dtxsid1045950

62. Pregabalin [orange Book]

63. Pregabalin [ep Monograph]

64. Hms3715j16

65. Pregabalin [usp Monograph]

66. Pregabalin 1.0 Mg/ml In Methanol

67. Tox21_111475

68. Bdbm50164279

69. Akos001476611

70. Akos005145504

71. Lyrica;ci-1008;pd-144723

72. Ac-1158

73. Ccg-221247

74. Cs-1247

75. Db00230

76. Ks-5378

77. Nsc 759256

78. (s)-3-aminomethyl-5-methylhexanoic Acid

79. Ncgc00346738-01

80. 121ge001

81. Bp163672

82. Hy-17414

83. (s)-3-aminomethyl-5-methyl-hexanoic Acid

84. Am20080369

85. Cas-148553-50-8

86. P2840

87. En300-92104

88. (3s)-3-(aminomethyl)-5-methyl Hexanoic Acid

89. (s)-(+)-3-aminomethyl-5-methylhexanoic Acid

90. D02716

91. Ab01563007_01

92. 553p508

93. A808784

94. Q412174

95. Sr-01000942257

96. Sr-01000942257-2

97. Pregabalin, Europepharmacopoeia (ep) Reference Standard

98. Z2757554242

99. 1414928-41-8

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 159.23 g/mol
Molecular Formula C8H17NO2
XLogP3-1.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass159.125928785 g/mol
Monoisotopic Mass159.125928785 g/mol
Topological Polar Surface Area63.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity123
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Information
1 of 4  
Drug NameLyrica
PubMed HealthPregabalin (By mouth)
Drug ClassesAnticonvulsant, Neuropathic Pain Agent
Drug LabelPregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:Pregabalin is a white to off-white, crystalline solid with...
Active IngredientPregabalin
Dosage FormCapsule; Solution
Routeoral; Oral
Strength20mg/ml; 200mg; 25mg; 150mg; 300mg; 75mg; 100mg; 50mg; 225mg
Market StatusPrescription
CompanyPf Prism; Cp Pharms

2 of 4  
Drug NamePregabalin
PubMed HealthPregabalin (By mouth)
Drug ClassesAnticonvulsant, Neuropathic Pain Agent
Drug LabelPregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:Pregabalin is a white to off-white, crystalline solid with...
Active IngredientPregabalin
Dosage FormCapsule; Solution
Routeoral; Oral
Strength20mg/ml; 200mg; 25mg; 150mg; 300mg; 75mg; 100mg; 50mg; 225mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Lupin; Sandoz; Watson Labs; Actavis Elizabeth; Teva Pharms; Wockhardt Usa

3 of 4  
Drug NameLyrica
PubMed HealthPregabalin (By mouth)
Drug ClassesAnticonvulsant, Neuropathic Pain Agent
Drug LabelPregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:Pregabalin is a white to off-white, crystalline solid with...
Active IngredientPregabalin
Dosage FormCapsule; Solution
Routeoral; Oral
Strength20mg/ml; 200mg; 25mg; 150mg; 300mg; 75mg; 100mg; 50mg; 225mg
Market StatusPrescription
CompanyPf Prism; Cp Pharms

4 of 4  
Drug NamePregabalin
PubMed HealthPregabalin (By mouth)
Drug ClassesAnticonvulsant, Neuropathic Pain Agent
Drug LabelPregabalin is described chemically as (S)-3-(aminomethyl)-5-methylhexanoic acid. The molecular formula is C8H17NO2 and the molecular weight is 159.23. The chemical structure of pregabalin is:Pregabalin is a white to off-white, crystalline solid with...
Active IngredientPregabalin
Dosage FormCapsule; Solution
Routeoral; Oral
Strength20mg/ml; 200mg; 25mg; 150mg; 300mg; 75mg; 100mg; 50mg; 225mg
Market StatusTentative Approval; Prescription
CompanyMylan Pharms; Apotex; Lupin; Sandoz; Watson Labs; Actavis Elizabeth; Teva Pharms; Wockhardt Usa

4.2 Therapeutic Uses

Pregabalin is indicated for management of post-herpetic neuralgia. /Included in US product label/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2412


Pregabalin is indicated for management of neuropathic pain associated with diabetic peripheral neuropathy. /Included in US product labe/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2412


Pregabalin is indicated as an adjunctive therapy for adult patients with partial onset seizures. /Included in US product label/

Thomson/Micromedex. Drug Information for the Health Care Professional. Volume 1, Greenwood Village, CO. 2007., p. 2412


The U.S. Food and Drug Administration ... has approved Lyrica (pregabalin), the first drug to treat fibromyalgia, a disorder characterized by pain, fatigue and sleep problems.

FDA; FDA News (P07-107). Available from, as of July 31, 2007: https://www.fda.gov/bbs/topics/NEWS/2007/NEW01656.html


4.3 Drug Warning

Known hypersensitivity to pregabalin or any ingredient in the formulation.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2247


Because of the possibility of increased seizure frequency, anticonvulsant drugs, including pregabalin, should be withdrawn gradually and dosage reduced slowly over at least 1 week. Abrupt discontinuance of pregabalin has been associated with insomnia, nausea, headache, and diarrhea.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2247


In controlled studies, blurred vision, which was reported in 6 or 2% of patients receiving pregabalin or placebo, respectively, resolved in the majority of cases with continued dosing; less than 1% of patients required discontinuance of the drug. In addition, decreased visual acuity was reported in 7 or 5% of patients receiving pregabalin or placebo, respectively, while visual field changes were detected in 13 or 12% of patients receiving the drug or placebo, respectively, and funduscopic changes were observed in 2% of patients receiving pregabalin or placebo. The clinical importance of these ophthalmologic findings has not been elucidated. If visual disturbance persists, further ocular assessment should be considered, while more frequent assessment is recommended in patients who already are monitored for ocular conditions.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2247


Weight gain, which was related to dosage and duration of exposure to pregabalin, has been reported in patients receiving pregabalin. Weight gain did not appear to be associated with baseline body mass index (BMI), gender, or age and was not limited to patients with edema.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2247


For more Drug Warnings (Complete) data for PREGABALIN (20 total), please visit the HSDB record page.


4.4 Drug Indication

Pregabalin is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, neuropathic pain associated with spinal cord injury, and as adjunctive therapy for the treatment of partial-onset seizures in patients 1 month of age and older.


FDA Label


* Neuropathic pain:

- Lyrica is indicated for the treatment of peripheral and central neuropathic pain in adults.

* Epilepsy :

- Lyrica is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised anxiety disorder:

- Lyrica is indicated for the treatment of generalised anxiety disorder (GAD) in adults.


* Epilepsy :

Pregabalin Mylan Pharma is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised Anxiety Disorder:

Pregabalin Mylan Pharma is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


* Neuropathic pain:

Pregabalin Mylan is indicated for the treatment of peripheral and central neuropathic pain in adults.

* Epilepsy :

Pregabalin Mylan is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised Anxiety Disorder:

Pregabalin Mylan is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


Neuropathic pain

- Pregabalin Pfizer is indicated for the treatment of peripheral and central neuropathic pain in adults.

Epilepsy

- Pregabalin Pfizer is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

Generalised Anxiety Disorder

- Pregabalin Pfizer is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


* Neuropathic pain:

- Pregabalin Zentiva k. s. is indicated for the treatment of peripheral and central neuropathic pain in adults.

* Epilepsy :

- Pregabalin Zentiva k. s. is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised anxiety disorder:

- Pregabalin Zentiva k. s. is indicated for the treatment of generalised anxiety disorder (GAD) in adults.


Epilepsy

- Pregabalin Accord is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

Generalised Anxiety Disorder

- Pregabalin Accord is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


* Neuropathic pain:

- Pregabalin Zentiva is indicated for the treatment of peripheral and central neuropathic pain in adults.

* Epilepsy :

- Pregabalin Zentiva is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised anxiety disorder:

- Pregabalin Zentiva is indicated for the treatment of generalised anxiety disorder (GAD) in adults.


* Epilepsy :

Pregabalin Sandoz GmbH is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised Anxiety Disorder:

Pregabalin Sandoz GmbH is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


* Neuropathic pain:

Pregabalin Sandoz is indicated for the treatment of peripheral and central neuropathic pain in adults.

* Epilepsy :

Pregabalin Sandoz is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

* Generalised Anxiety Disorder:

Pregabalin Sandoz is indicated for the treatment of Generalised Anxiety Disorder (GAD) in adults.


Alleviation of acute anxiety and fear associated with transportation and veterinary visits.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Although the structure of pregabalin is similar to gamma-aminobutyric acid (GABA), it does not bind to GABA receptors. Instead, it binds the alpha2-delta subunit of presynaptic voltage-gated calcium channels in the central nervous system. Pregabalin does not modulate dopamine receptors, serotonin receptors, opiate receptors, sodium channels or cyclooxygenase activity.


5.2 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


Analgesics

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)


Calcium Channel Blockers

A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)


Anticonvulsants

Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)


5.3 ATC Code

N03AX16


N03AX16


N03AX16


N03AX16


N03AX16


N03AX16


N03AX16


N03AX16


N03AX16


QN03AX16


N03AX16

S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355


N - Nervous system

N03 - Antiepileptics

N03A - Antiepileptics

N03AX - Other antiepileptics

N03AX16 - Pregabalin


5.4 Absorption, Distribution and Excretion

Absorption

After oral dosing administered in the fasted state, pregabalin absorption is rapid, and extensive. Pregabalin oral bioavailability is reported to be 90% regardless of the dose. Cmax is attained within 1.5 hours after single or multiple doses, and steady state is attained within 24-48 hours with repeated administration. Both Cmax and AUC appear to be dose proportional. Food decreases the rate of pregabalin absorption and as a result, lowers the Cmax by an estimated 25-30% and increases the Tmax to approximately 3 hours. However, the effect of food does not appear to impact the total absorption of pregabalin in a way that is clinically relevant. As a result, pregabalin can be administered with or without food.


Route of Elimination

Pregabalin is almost exclusively eliminated in the urine. Further, based on preclinical studies, pregabalin does not appear to undergo racemization to the R enantiomer in the body.


Volume of Distribution

After oral administration of pregabalin, the reported apparent volume of distribution is roughly 0.5 L/kg. Although pregabalin is not very lipophilic, it is able to cross the blood brain barrier(BBB). System L transporters facilitate the transport of large amino acids across the BBB and it has been confirmed that pregabalin is a substrate. This information suggests that system L transporters are responsible for pregabalin uptake into the BBB. In rat models, pregabalin has been shown to cross the placenta.


Clearance

In young healthy subjects the mean renal clearance is estimated to be 67.0 to 80.9 mL mL/min. Given pregabalin's lack of plasma protein binding, this clearance rate suggests that renal tubular reabsorption is involved.


Pregabalin is well absorbed after oral administration ...

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2539


Following oral administration of pregabalin capsules under fasting conditions, peak plasma concentrations occur within 1.5 hours. Pregabalin oral bioavailability is >/=90% and is independent of dose. Following single- (25 to 300 mg) and multiple-dose (75 to 900 mg/day) administration, maximum plasma concentrations (C max ) and area under the plasma concentration-time curve (AUC) values increase linearly. Following repeated administration, steady state is achieved within 24 to 48 hours. Multiple-dose pharmacokinetics can be predicted from single-dose data.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2539


The rate of pregabalin absorption is decreased when given with food, resulting in a decrease in Cmax of approximately 25% to 30% and an increase in Tmax to approximately 3 hours. However, administration of pregabalin with food has no clinically relevant effect on the total absorption of pregabalin. Therefore, pregabalin can be taken with or without food.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2539


Pregabalin does not bind to plasma proteins. The apparent volume of distribution of pregabalin following oral administration is approximately 0.5 L/kg. Pregabalin is a substrate for system L transporter which is responsible for the transport of large amino acids across the blood brain barrier. Although there are no data in humans, pregabalin has been shown to cross the blood brain barrier in mice, rats, and monkeys. In addition, pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2539


For more Absorption, Distribution and Excretion (Complete) data for PREGABALIN (8 total), please visit the HSDB record page.


5.5 Metabolism/Metabolites

Less than 2% of pregabalin is metabolized and it is excreted virtually unchanged in the urine.


Pregabalin undergoes negligible metabolism in humans. Following a dose of radiolabeled pregabalin, approximately 90% of the administered dose was recovered in the urine as unchanged pregabalin. The N-methylated derivative of pregabalin, the major metabolite of pregabalin found in urine, accounted for 0.9% of the dose. In preclinical studies, pregabalin (S-enantiomer) did not undergo racemization to the R-enantiomer in mice, rats, rabbits, or monkeys.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2540


5.6 Biological Half-Life

The elimination half life of pregabalin is 6.3 hours.


Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug with a mean elimination half-life of 6.3 hours in subjects with normal renal function.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2540


5.7 Mechanism of Action

Although the mechanism of action has not been fully elucidated, studies involving structurally related drugs suggest that presynaptic binding of pregabalin to voltage-gated calcium channels is key to the antiseizure and antinociceptive effects observed in animal models. By binding presynaptically to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system, pregabalin modulates the release of several excitatory neurotransmitters including glutamate, substance-P, norepinephrine, and calcitonin gene related peptide. In addition, pregabalin prevents the alpha2-delta subunit from being trafficked from the dorsal root ganglia to the spinal dorsal horn, which may also contribute to the mechanism of action. Although pregabalin is a structural derivative of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), it does not bind directly to GABA or benzodiazepine receptors.


Pregabalin is an anticonvulsant that is structurally related to the inhibitory CNS neurotransmitter gamma-aminobutyric acid (GABA). Pregabalin also has demonstrated analgesic activity. Although pregabalin was developed as a structural analog of GABA, the drug does not bind directly to GABA-A, GABA-B, or benzodiazepine receptors; does not augment GABA-A responses in cultured neurons; and does not alter brain concentrations of GABA in rats or affect GABA uptake or degradation. However, in cultured neurons, prolonged application of pregabalin increases the density of GABA transporter protein and increases the rate of functional GABA transport.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2248


Pregabalin binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in CNS tissues. ... In vitro, pregabalin reduces the calcium-dependent release of several neurotransmitters, including glutamate, norepinephrine, and substance P, possibly by modulation of calcium channel function.

McEvoy, G.K. (ed.). American Hospital Formulary Service. AHFS Drug Information. American Society of Health-System Pharmacists, Bethesda, MD. 2007., p. 2248


Pregabalin does not block sodium channels, is not active at opiate receptors, and does not alter cyclooxygenase enzyme activity. It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.

Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2539


Pregabalin is a potent ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system that exhibits potent anticonvulsant, analgesic, and anxiolytic activity in a range of animal models. ... Potent binding to the alpha-2-delta site reduces depolarization-induced calcium influx with a consequential modulation in excitatory neurotransmitter release. Pregabalin has no demonstrated effects on GABAergic mechanisms. ...

PMID:15315511 Ben-Menachem E; Epilepsia 45 Suppl 6: 13-8 (2004)


For more Mechanism of Action (Complete) data for PREGABALIN (6 total), please visit the HSDB record page.


API Reference Price

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02-Jan-2021
30-Nov-2024
KGS
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Drugs in Development

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Details:

USFDA approved generic version of Pregabalin treatment of fibromyalgia. It binds to the alpha2-delta subunit which is involved in anti-nociceptive and antiseizure effects.


Lead Product(s): Pregabalin

Therapeutic Area: Musculoskeletal Brand Name: Lyrica-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable January 25, 2024

Strides Pharma Science

01

Pharma, Lab & Chemical Expo
Not Confirmed

Lead Product(s) : Pregabalin

Therapeutic Area : Musculoskeletal

Highest Development Status : Approved

Partner/Sponsor/Collaborator : Not Applicable

Deal Size : Not Applicable

Deal Type : Not Applicable

Details : USFDA approved generic version of Pregabalin treatment of fibromyalgia. It binds to the alpha2-delta subunit which is involved in anti-nociceptive and antiseizure effects.

Brand Name : Lyrica-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

January 25, 2024

Strides Pharma Science

Details:

Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Lyrica-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 21, 2024

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02

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.

Brand Name : Lyrica-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

May 21, 2024

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Details:

Pregabalin Prolonged Release Tablets is a unique formulation helps in increasing patient's adherence, it is the backbone medication indicated in the treatment of Neuropathic pain.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Lyrica CR-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 22, 2023

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03

Adalvo

U.S.A
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Adalvo

U.S.A
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Pregabalin Prolonged Release Tablets is a unique formulation helps in increasing patient's adherence, it is the backbone medication indicated in the treatment of Neuropathic pain.

Brand Name : Lyrica CR-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 22, 2023

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Details:

Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Lyrica-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable March 30, 2023

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04

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.

Brand Name : Lyrica-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

March 30, 2023

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Details:

AFD-NP is a combination of Nortriptyline and Pregabalin which has approved for the treatment of moderate to severe neuropathic pain.


Lead Product(s): Pregabalin,Nortriptyline

Therapeutic Area: Neurology Brand Name: AFD-NP

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable February 27, 2023

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05

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : AFD-NP is a combination of Nortriptyline and Pregabalin which has approved for the treatment of moderate to severe neuropathic pain.

Brand Name : AFD-NP

Molecule Type : Small molecule

Upfront Cash : Not Applicable

February 27, 2023

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Details:

Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Lyrica-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 22, 2022

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06

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.

Brand Name : Lyrica-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 22, 2022

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Details:

Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Lyrica-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable December 10, 2022

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07

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Lyrica-Generic (pregabalin) is a calcium channel alpha-2/delta-1 subunit binder, indicated for Neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia & fibromyalgia.

Brand Name : Lyrica-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

December 10, 2022

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Details:

Pregabalin, to market a generic equivalent of Lyrica® Capsules, is used to treat pain caused by nerve damage due to diabetes or to shingles (herpes zoster) infection.


Lead Product(s): Pregabalin

Therapeutic Area: Neurology Brand Name: Pregabalin-Generic

Study Phase: ApprovedProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable May 06, 2022

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08

Lupin Ltd

India
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Lupin Ltd

India
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Details : Pregabalin, to market a generic equivalent of Lyrica® Capsules, is used to treat pain caused by nerve damage due to diabetes or to shingles (herpes zoster) infection.

Brand Name : Pregabalin-Generic

Molecule Type : Small molecule

Upfront Cash : Not Applicable

May 06, 2022

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Details:

With the acquisition, Endo controls all remaining development, approval, launch and commercialization activities for the product candidates, NVK009 (Gabapentin). Endo's Par Sterile Products business will commercialize the products in the United States.


Lead Product(s): Gabapentin,Pregabalin,Paracetamol

Therapeutic Area: Neurology Brand Name: NVK009

Study Phase: Phase IIProduct Type: Small molecule

Sponsor: Endo International

Deal Size: $35.0 million Upfront Cash: Undisclosed

Deal Type: Acquisition May 02, 2022

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09

Nevakar

U.S.A
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Nevakar

U.S.A
arrow
Pharma, Lab & Chemical Expo
Not Confirmed

Details : With the acquisition, Endo controls all remaining development, approval, launch and commercialization activities for the product candidates, NVK009 (Gabapentin). Endo's Par Sterile Products business will commercialize the products in the United States.

Brand Name : NVK009

Molecule Type : Small molecule

Upfront Cash : Undisclosed

May 02, 2022

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Details:

XG005 is a drug conjugate of naproxen and pregabalin which is being investigated for the management of acute pain.


Lead Product(s): Pregabalin,Naproxen

Therapeutic Area: Neurology Brand Name: XG005

Study Phase: Phase IProduct Type: Small molecule

Sponsor: Not Applicable

Deal Size: Not Applicable Upfront Cash: Not Applicable

Deal Type: Not Applicable April 22, 2020

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10

Pharma, Lab & Chemical Expo
Not Confirmed
Pharma, Lab & Chemical Expo
Not Confirmed

Details : XG005 is a drug conjugate of naproxen and pregabalin which is being investigated for the management of acute pain.

Brand Name : XG005

Molecule Type : Small molecule

Upfront Cash : Not Applicable

April 22, 2020

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 165M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 165MG

USFDA APPLICATION NUMBER - 209501

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 330M...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 330MG

USFDA APPLICATION NUMBER - 209501

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DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 82.5...DOSAGE - TABLET, EXTENDED RELEASE;ORAL - 82.5MG

USFDA APPLICATION NUMBER - 209501

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DOSAGE - CAPSULE;ORAL - 100MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 150MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 200MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 225MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 25MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 300MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 50MG

USFDA APPLICATION NUMBER - 21446

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DOSAGE - CAPSULE;ORAL - 75MG

USFDA APPLICATION NUMBER - 21446

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