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Chemistry

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Also known as: 105-67-9, 2,4-xylenol, M-xylenol, Phenol, 2,4-dimethyl-, 4,6-dimethylphenol, 1-hydroxy-2,4-dimethylbenzene
Molecular Formula
C8H10O
Molecular Weight
122.16  g/mol
InChI Key
KUFFULVDNCHOFZ-UHFFFAOYSA-N
FDA UNII
5OD803C081

Lysol Brand disinfectant
gallex is a natural product found in Apis cerana with data available.
1 2D Structure

Lysol Brand disinfectant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2,4-dimethylphenol
2.1.2 InChI
InChI=1S/C8H10O/c1-6-3-4-8(9)7(2)5-6/h3-5,9H,1-2H3
2.1.3 InChI Key
KUFFULVDNCHOFZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=CC(=C(C=C1)O)C
2.2 Other Identifiers
2.2.1 UNII
5OD803C081
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2,4-dimethylphenol Potassium

2. 2,4-dimethylphenol Sodium

3. 2,4-dimethylphenol Titanium (+4)

4. 2,4-dmp

5. 2,4-xylenol

2.3.2 Depositor-Supplied Synonyms

1. 105-67-9

2. 2,4-xylenol

3. M-xylenol

4. Phenol, 2,4-dimethyl-

5. 4,6-dimethylphenol

6. 1-hydroxy-2,4-dimethylbenzene

7. 4-hydroxy-1,3-dimethylbenzene

8. Rcra Waste Number U101

9. 2,4-dimethyl Phenol

10. Nsc 3829

11. 2,4-dimethyl-phenol

12. Chebi:34241

13. Nsc-3829

14. Mfcd00002233

15. 5od803c081

16. Dsstox_cid_1864

17. Dsstox_rid_76371

18. Dsstox_gsid_21864

19. Caswell No. 907a

20. Lysol Brand Disinfectant

21. Cas-105-67-9

22. Bulk Lysol Brand Disinfectant

23. Ccris 721

24. Hsdb 4253

25. 2,4-dmp

26. Gable-tite Dark Creosote (creola)

27. Benzene, 2,4-dimethyl-1-hydroxy-

28. Du Cor Concentrated Fly Insecticide

29. Gable-tite Light Creosote (creola)

30. Einecs 203-321-6

31. Rcra Waste No. U101

32. Epa Pesticide Chemical Code 086804

33. Brn 0636244

34. Ai3-17612

35. Unii-5od803c081

36. 2,4dimethylphenol

37. 2.4-dimethylphenol

38. 4-hydroxy-m-xylene

39. Ec 203-321-6

40. Schembl92167

41. 2,4-dimethylphenol, 98%

42. 4-06-00-03126 (beilstein Handbook Reference)

43. Mls002152861

44. Bidd:er0275

45. Chembl29878

46. Wln: Qr B1 D1

47. Dimethylphenol, 2,4-

48. 1,3-dimethyl-4-hydroxybenzene

49. 2,4-xylenol, >=98%

50. Dtxsid2021864

51. Nsc3829

52. 2,4-dimethylphenol 2,4-xylenol

53. Hms3039j10

54. Xylenol 2,4-dimethylphenol

55. 2,4-dimethylphenol [hsdb]

56. Act00460

57. Zinc1672873

58. Tox21_201787

59. Tox21_300051

60. Bbl011443

61. Stl146554

62. Akos000121556

63. Am62796

64. 2,4-dimethylphenol, Analytical Standard

65. Ncgc00091611-01

66. Ncgc00091611-02

67. Ncgc00091611-03

68. Ncgc00091611-04

69. Ncgc00091611-05

70. Ncgc00253938-01

71. Ncgc00259336-01

72. Xylenol 2,4-dimethylphenol [mi]

73. Ps-11923

74. Smr001224485

75. Db-010714

76. Metacresol Impurity F [ep Impurity]

77. D0774

78. Ft-0610239

79. 2,4-dimethylphenol 100 Microg/ml In Methanol

80. Q2437536

81. W-108780

82. 2,4-dimethylphenol, Pestanal(r), Analytical Standard

83. F0001-0111

84. N0d

2.4 Create Date
2005-03-26
3 Chemical and Physical Properties
Molecular Weight 122.16 g/mol
Molecular Formula C8H10O
XLogP32.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass122.073164938 g/mol
Monoisotopic Mass122.073164938 g/mol
Topological Polar Surface Area20.2 Ų
Heavy Atom Count9
Formal Charge0
Complexity90.6
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 Absorption, Distribution and Excretion

SUBJECTS WERE EXPOSED TO M-XYLENE AT CONCN OF ABOUT 3.9 MMOL/CU M FOR 5 DAYS, 6 HR/DAY. RATE OF 2,4-XYLENOL EXCRETION SHORTLY AFTER EXPOSURE WAS ABOUT 1-2% OF THAT FOR METHYLHIPPURIC ACID EXCRETION AND PULMONARY EXCRETION OF UNCHANGED XYLENE WAS ABOUT 4% OF UPTAKE.

RIIHIMAKI V ET AL; SCAND J WORK ENVIRON HEALTH 5 (3): 217-31 (1979)


The concn of 2,4-dimethylphenol was determined /in/ several tissues of the rat after 6 hr constant iv infusion and after iv bolus injection. 2,4-dimethylphenol was distributed rapidly in the brain and liver, /and had/ high tissue-plasma concn ratios for the brain, liver, and fat. Accumulation of 2,4-dimethylphenol in these tissues was negligible.

PMID:7067652 Kata JS et al; Ecotoxicol Environ Saf 6 (1): 35-40 (1982)


FOLLOWING IV ADMIN OF 17 MG/KG OF THE 2,4-ISOMER TO RATS, THE BRAIN ACCUMULATED THE HIGHEST AMT ON A PER G BASIS, FOLLOWED BY FAT AND LIVER. RATIOS OF BRAIN, LIVER AND FAT TO PLASMA /CONCN/ WERE APPROX 1, 1.5 AND 2, RESPECTIVELY.

SOMANI SM; FED PROC FED AM SOC EXP BIOL 40 (3PT1): 698 (1981)


2,4-DIMETHYLPHENOL DISTRIBUTED RAPIDLY THROUGH THE BODY AFTER IV BOLUS ADMIN OF 30 MG/KG. PLASMA, LIVER AND FAT CONCN DISAPPEARED PRIOR TO 60 MIN BUT PERSISTED IN THE BRAIN.

SOMANI SM; FED PROC FED AM SOC EXP BIOL 40 (3PT1): 698 (1981)


Associations between o-cresol, p-cresol, m-cresol, 2,4-xylenol, 2,5-xylenol, 3,4-xylenol, and 3,5-xylenol exposure levels and urinary phenol excretion were examined in the coke facility industry. The subjects consisted of 76 exposed workers employed in the tar distillation process and 34 controls. ... Urinary metabolite levels were corrected for specific gravity and creatinine. The time weighted average exposure concentrations in the breathing zones of the tar distillation workers were ... 0.02 to 0.04 mg/cu m for xylenols. ... The urinary xylenol levels of exposed workers ranged from 0.12 to 0.97 mg/l with specific gravity correction. In control urine samples, the specific gravity corrected xylenol concentrations ranged from 25 x 10(-3) to 43 x 10(-3) mg/l. Significant correlations were observed between the ambient levels and urinary concentrations of phenol, o-cresol, and the xylenols, with coefficients ranging from 0.45 to 0.82. The author concludes that the biological monitoring of urinary xylenols may be used as a means of measuring xylenol exposure in coke facility workers.

PMID:9352337 Bieniek G; International Archives of Occupational and Environmental Health 70 (5): 334-40 (1997)


4.2 Metabolism/Metabolites

METABOLISM OF 2,4-DIMETHYLPHENOL IN ANIMALS IS VERY SIMILAR TO THAT OF CRESOLS ... .

National Research Council. Drinking Water & Health Volume 1. Washington, DC: National Academy Press, 1977., p. 730


Rats were admin 2,4-dimethylphenol for 6 hr constantly by iv infusion or iv bolus injection. 2,4-Dimethylphenol was rapidly metabolized to its conjugates (94.3%) within 30 min; the glucuronide constituted 53% and other conjugates 41% /in plasma/.

PMID:7067652 Kata JS et al; Ecotoxicol Environ Saf 6 (1): 35-40 (1982)


IN WORKERS SIMULTANEOUSLY EXPOSED TO ETHYLBENZENES AND XYLENES, 2,4-DIMETHYLPHENOL, A METABOLITE OF M-XYLENE, COULD NOT BE DETECTED.

PMID:437902 ANGERER J, LEHNERT G; INT ARCH OCCUP ENVIRON HEALTH 43 (2): 145-50 (1979)


HYDROXYLATION OF AROMATIC HYDROCARBONS WAS STUDIED FOLLOWING THEIR ORAL ADMINISTRATION TO RATS THAT ALSO RECEIVED A PURIFIED DIET CONTAINING NEOMYCIN TO REDUCE THE LEVELS OF NORMALLY OCCURRING SIMPLE URINARY PHENOLS. PHENOLIC METABOLITES WERE QUANTITATIVELY ESTIMATED IN HYDROLYZED URINE SAMPLES BY GAS CHROMATOGRAPHY. M-XYLENE ADMINISTERED AT A DOSE OF 100 MG/KG WAS METABOLIZED TO 2,4-DIMETHYLPHENOL TO THE EXTENT OF 0.9% OF THE DOSE GIVEN.

PMID:5422210 BAKKE OM, SCHELINE RR; TOXICOL APPL PHARMACOL 16 (3): 691-700 (1970)


For more Metabolism/Metabolites (Complete) data for 2,4-DIMETHYLPHENOL (6 total), please visit the HSDB record page.


2,4-Dimethylphenol is a known human metabolite of m-xylene.

S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560


ABOUT THIS PAGE

Looking for 105-67-9 / Lysol Brand disinfectant API manufacturers, exporters & distributors?

Lysol Brand disinfectant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Lysol Brand disinfectant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Lysol Brand disinfectant manufacturer or Lysol Brand disinfectant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Lysol Brand disinfectant manufacturer or Lysol Brand disinfectant supplier.

PharmaCompass also assists you with knowing the Lysol Brand disinfectant API Price utilized in the formulation of products. Lysol Brand disinfectant API Price is not always fixed or binding as the Lysol Brand disinfectant Price is obtained through a variety of data sources. The Lysol Brand disinfectant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Lysol Brand disinfectant

Synonyms

105-67-9, 2,4-xylenol, M-xylenol, Phenol, 2,4-dimethyl-, 4,6-dimethylphenol, 1-hydroxy-2,4-dimethylbenzene

Cas Number

105-67-9

Unique Ingredient Identifier (UNII)

5OD803C081

About Lysol Brand disinfectant

gallex is a natural product found in Apis cerana with data available.

Lysol Brand disinfectant Manufacturers

A Lysol Brand disinfectant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Lysol Brand disinfectant, including repackagers and relabelers. The FDA regulates Lysol Brand disinfectant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Lysol Brand disinfectant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Lysol Brand disinfectant Suppliers

A Lysol Brand disinfectant supplier is an individual or a company that provides Lysol Brand disinfectant active pharmaceutical ingredient (API) or Lysol Brand disinfectant finished formulations upon request. The Lysol Brand disinfectant suppliers may include Lysol Brand disinfectant API manufacturers, exporters, distributors and traders.

Lysol Brand disinfectant GMP

Lysol Brand disinfectant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Lysol Brand disinfectant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Lysol Brand disinfectant GMP manufacturer or Lysol Brand disinfectant GMP API supplier for your needs.

Lysol Brand disinfectant CoA

A Lysol Brand disinfectant CoA (Certificate of Analysis) is a formal document that attests to Lysol Brand disinfectant's compliance with Lysol Brand disinfectant specifications and serves as a tool for batch-level quality control.

Lysol Brand disinfectant CoA mostly includes findings from lab analyses of a specific batch. For each Lysol Brand disinfectant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Lysol Brand disinfectant may be tested according to a variety of international standards, such as European Pharmacopoeia (Lysol Brand disinfectant EP), Lysol Brand disinfectant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Lysol Brand disinfectant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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