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ACTIVE PHARMA INGREDIENTS

1 NDC API

1 NDC API

DEVELOPMENTS

1 Drugs in Development

1 Drugs in Development

FINISHED DOSAGE FORMULATIONS

1 FDF Dossiers, 1 FDA Orange Book

1 FDF Dossiers
1 FDA Orange Book

PATENTS & EXCLUSIVITIES

1 US Patents, 1 US Exclusivities

patents
1 US Patents
1 US Exclusivities

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 0

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

1DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Macrilen, D-87575 acetate, Macimorelin acetate [usan], 945212-59-9, Aqz1003rmg, Macimorelin acetate (usan)

Molecular Formula

C₂₈H₃₄N₆O₅

Molecular Weight

534.6 g/mol

InChI Key

WVDSKQXKCDZXLH-OHIDFYLOSA-N

FDA UNII

AQZ1003RMG

1 2D Structure

Macimorelin Acetate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

acetic acid;2-amino-N-[(2R)-1-[[(1R)-1-formamido-2-(1H-indol-3-yl)ethyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-methylpropanamide

2.1.2 InChI

InChI=1S/C26H30N6O3.C2H4O2/c1-26(2,27)25(35)31-22(11-16-13-28-20-9-5-3-7-18(16)20)24(34)32-23(30-15-33)12-17-14-29-21-10-6-4-8-19(17)21;1-2(3)4/h3-10,13-15,22-23,28-29H,11-12,27H2,1-2H3,(H,30,33)(H,31,35)(H,32,34);1H3,(H,3,4)/t22-,23-;/m1./s1

2.1.3 InChI Key

WVDSKQXKCDZXLH-OHIDFYLOSA-N

2.1.4 Canonical SMILES

CC(=O)O.CC(C)(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC3=CNC4=CC=CC=C43)NC=O)N

2.1.5 Isomeric SMILES

CC(=O)O.CC(C)(C(=O)N[C@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CNC4=CC=CC=C43)NC=O)N

2.2 Other Identifiers

2.2.1 UNII

AQZ1003RMG

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Aezs-130

2. Aib-dtrp-dgtrp-cho

3. Aib-trp-gtrp-cho

4. Aminoisobutyryl-tryptophyl-tryptophanamine-formyl

5. Ard-07

6. Ep 1572

7. Ep-1572

8. Ep1572

9. Jmv 1843

10. Jmv-1843

11. Jmv1843

12. Macimorelin

13. Macrilen

2.3.2 Depositor-Supplied Synonyms

1. Macrilen

2. D-87575 Acetate

3. Macimorelin Acetate [usan]

4. 945212-59-9

5. Aqz1003rmg

6. Macimorelin Acetate (usan)

7. D-tryptophanamide, 2-methylalanyl-n-((1r)-1-(formylamino)-2-(1h-indol-3-yl)ethyl)-, Acetate (1:1)

8. N2-(2-amino-2-methylpropanoyl-n1-((1r)-1-formamido-2-(1h-indol-3-yl)ethyl)- D-tryptophanamide Acetate

9. Ard 07 Acetate

10. Ep 1572 Acetate

11. Unii-aqz1003rmg

12. Aezs 130

13. Macrilen (tn)

14. Ard-07 Acetate

15. Aib-trp-gtrp-cho Acetate

16. Ep-1572 Acetate

17. Chembl2364617

18. Macimorelin Acetate [mi]

19. Dtxsid40241516

20. Macimorelin Acetate [who-dd]

21. Macimorelin Acetate [orange Book]

22. D10562

23. Q27274071

2.4 Create Date

2013-06-11

3 Chemical and Physical Properties

Molecular Formula	C₂₈H₃₄N₆O₅
Molecular Weight	534.6 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	9
Exact Mass	534.25906821 g/mol
Monoisotopic Mass	534.25906821 g/mol
Topological Polar Surface Area	182 Å²
Heavy Atom Count	39
Formal Charge	0
Complexity	792
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2