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Also known as: 16674-78-5, Magnesium;diacetate;tetrahydrate, Magnesiumacetatetetrahydrate, Mfcd00149214, Magnesium diacetate tetrahydrate, Acetic acid, magnesium salt, tetrahydrate
Molecular Formula
C4H14MgO8
Molecular Weight
214.45  g/mol
InChI Key
XKPKPGCRSHFTKM-UHFFFAOYSA-L
FDA UNII
I01G0EJC3B

Magnesium Acetate Tetrahydrate
Magnesium Acetate Tetrahydrate is the hydrated acetate salt form of magnesium. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium.
1 2D Structure

Magnesium Acetate Tetrahydrate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
magnesium;diacetate;tetrahydrate
2.1.2 InChI
InChI=1S/2C2H4O2.Mg.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2
2.1.3 InChI Key
XKPKPGCRSHFTKM-UHFFFAOYSA-L
2.1.4 Canonical SMILES
CC(=O)[O-].CC(=O)[O-].O.O.O.O.[Mg+2]
2.2 Other Identifiers
2.2.1 UNII
I01G0EJC3B
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. 16674-78-5

2. Magnesium;diacetate;tetrahydrate

3. Magnesiumacetatetetrahydrate

4. Mfcd00149214

5. Magnesium Diacetate Tetrahydrate

6. Acetic Acid, Magnesium Salt, Tetrahydrate

7. I01g0ejc3b

8. Magnesium Diacetate Tetrahydrate; Magnesium(2+) Acetate Tetrahydrate

9. Magnesium Diethanoate Tetrahydrate

10. Unii-i01g0ejc3b

11. Magnesium Acetate Tetra Hydrate

12. Chembl3989858

13. Dtxsid60168170

14. Akos022185858

15. Db09409

16. Magnesium Acetate Tetrahydrate Acs Grade

17. Magnesium Acetate Tetrahydrate [mi]

18. Ft-0628071

19. Magnesium Acetate Tetrahydrate [vandf]

20. Magnesium Acetate Tetrahydrate, Puratronic(r)

21. Magnesium Acetate Tetrahydrate [who-dd]

22. Magnesium Acetate (mg(oac)2) Tetrahydrate

23. J-010308

24. Magnesium Acetate Tetrahydrate [ep Monograph]

25. Magnesium Acetate Tetrahydrate [orange Book]

26. Q27280179

27. Acetic Acid, Magnesium Salt, Hydrate (2:1:4)

28. Magnesium Acetate Tetrahydrate, Molecular Biology Grade

29. Magnesium Acetate Tetrahydrate, Trace Metals Grade 99.95%

2.4 Create Date
2005-07-19
3 Chemical and Physical Properties
Molecular Weight 214.45 g/mol
Molecular Formula C4H14MgO8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count8
Rotatable Bond Count0
Exact Mass214.0539091 g/mol
Monoisotopic Mass214.0539091 g/mol
Topological Polar Surface Area84.3 Ų
Heavy Atom Count13
Formal Charge0
Complexity25.5
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count7
4 Drug and Medication Information
4.1 Drug Indication

Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention. Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.


5 Pharmacology and Biochemistry
5.1 Pharmacology

Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.


5.2 Absorption, Distribution and Excretion

Absorption

Intestinal absorption is achieved mainly through passive diffusion.


Route of Elimination

Mainly renal exctretion, where up to 97% of magnesium may be excreted renally during hypermagnesemia.


Volume of Distribution

Magnesium ions display approximate volume of distribution of 0.2 to 0.4 L/kg


5.3 Biological Half-Life

Elimination half-life has been reported to be 27.7 hours following an overdose of 400mEq magnesium in an adult.


5.4 Mechanism of Action

Magnesium ions electrostatically stabilize the adenylyl cyclase complex and enhance its catalytic actions and production of cAMP. They also regulate the level of phosphorylation in various pathways by formation of transition state of phosphoryl transfer reaction by protein kinases and stabilize ATP binding to protein kinases via electrostatic interactions. Many metabolic enzymes involved in glycolysis and Krebs cycle are magnesium-dependent. Magnesium-containing laxatives cause diarrhea through water retention and increased fecal mass that stimulates peristalsis. When used as an electrolyte supplementation, magnesium acetate tetrahydrate induces diuresis and metabolic alkalinizing effect. Magnesium ions enhance reactivity of arteries to vasoconstrictors, promotes vasoconstriction, and increases peripheral resistance, leading to increased blood pressure through potential competition with calcium ions in the vascular system. Magnesium ions also regulate other ions entering and exiting the cell membrane by acting as a ligand in N-methyl-D-aspartate receptor.


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GROUP","supplierCountry":"INDIA","foreign_port":"CHICAGO, IL","customer":"SIGMA ALDRICH CHEMICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"15.00","actualQuantity":"15","unit":"KGS","unitRateFc":"28.2","totalValueFC":"426.6","currency":"USD","unitRateINR":"2416.5","date":"13-Dec-2024","totalValueINR":"36247.48","totalValueInUsd":"426.6","indian_port":"Bangalore Air","hs_no":"29152990","bill_no":"7207579","productDescription":"Re-Import","marketType":"LESS REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"CHICAGO, IL","supplierAddress":"6000 N TEUTONIA AVE MILWAUKEE WI MI LWAUKEE - 53209-3645, , United Sta tes United States","customerAddress":"PLOT.NO.12,BOMMASANDRA-JIGANI LINK"}]
02-Feb-2021
19-Feb-2025
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Looking for 16674-78-5 / Magnesium Acetate Tetrahydrate API manufacturers, exporters & distributors?

Magnesium Acetate Tetrahydrate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Magnesium Acetate Tetrahydrate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Magnesium Acetate Tetrahydrate manufacturer or Magnesium Acetate Tetrahydrate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Magnesium Acetate Tetrahydrate manufacturer or Magnesium Acetate Tetrahydrate supplier.

PharmaCompass also assists you with knowing the Magnesium Acetate Tetrahydrate API Price utilized in the formulation of products. Magnesium Acetate Tetrahydrate API Price is not always fixed or binding as the Magnesium Acetate Tetrahydrate Price is obtained through a variety of data sources. The Magnesium Acetate Tetrahydrate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Magnesium Acetate Tetrahydrate

Synonyms

16674-78-5, Magnesium;diacetate;tetrahydrate, Magnesiumacetatetetrahydrate, Mfcd00149214, Magnesium diacetate tetrahydrate, Acetic acid, magnesium salt, tetrahydrate

Cas Number

16674-78-5

Unique Ingredient Identifier (UNII)

I01G0EJC3B

About Magnesium Acetate Tetrahydrate

Magnesium Acetate Tetrahydrate is the hydrated acetate salt form of magnesium. Magnesium is a divalent cation essential for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions. About 350 enzymes involved in glycolysis and the Krebs cycle, formation of cyclic-AMP and ATP, cellular signal transduction and protein and nucleic acid synthesis are dependent on magnesium.

Magnesium Acetate Tetrahydrate Manufacturers

A Magnesium Acetate Tetrahydrate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Magnesium Acetate Tetrahydrate, including repackagers and relabelers. The FDA regulates Magnesium Acetate Tetrahydrate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Magnesium Acetate Tetrahydrate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Magnesium Acetate Tetrahydrate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Magnesium Acetate Tetrahydrate Suppliers

A Magnesium Acetate Tetrahydrate supplier is an individual or a company that provides Magnesium Acetate Tetrahydrate active pharmaceutical ingredient (API) or Magnesium Acetate Tetrahydrate finished formulations upon request. The Magnesium Acetate Tetrahydrate suppliers may include Magnesium Acetate Tetrahydrate API manufacturers, exporters, distributors and traders.

click here to find a list of Magnesium Acetate Tetrahydrate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Magnesium Acetate Tetrahydrate CEP

A Magnesium Acetate Tetrahydrate CEP of the European Pharmacopoeia monograph is often referred to as a Magnesium Acetate Tetrahydrate Certificate of Suitability (COS). The purpose of a Magnesium Acetate Tetrahydrate CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Magnesium Acetate Tetrahydrate EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Magnesium Acetate Tetrahydrate to their clients by showing that a Magnesium Acetate Tetrahydrate CEP has been issued for it. The manufacturer submits a Magnesium Acetate Tetrahydrate CEP (COS) as part of the market authorization procedure, and it takes on the role of a Magnesium Acetate Tetrahydrate CEP holder for the record. Additionally, the data presented in the Magnesium Acetate Tetrahydrate CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Magnesium Acetate Tetrahydrate DMF.

A Magnesium Acetate Tetrahydrate CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Magnesium Acetate Tetrahydrate CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Magnesium Acetate Tetrahydrate suppliers with CEP (COS) on PharmaCompass.

Magnesium Acetate Tetrahydrate GMP

Magnesium Acetate Tetrahydrate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Magnesium Acetate Tetrahydrate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Magnesium Acetate Tetrahydrate GMP manufacturer or Magnesium Acetate Tetrahydrate GMP API supplier for your needs.

Magnesium Acetate Tetrahydrate CoA

A Magnesium Acetate Tetrahydrate CoA (Certificate of Analysis) is a formal document that attests to Magnesium Acetate Tetrahydrate's compliance with Magnesium Acetate Tetrahydrate specifications and serves as a tool for batch-level quality control.

Magnesium Acetate Tetrahydrate CoA mostly includes findings from lab analyses of a specific batch. For each Magnesium Acetate Tetrahydrate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Magnesium Acetate Tetrahydrate may be tested according to a variety of international standards, such as European Pharmacopoeia (Magnesium Acetate Tetrahydrate EP), Magnesium Acetate Tetrahydrate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Magnesium Acetate Tetrahydrate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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