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Chemistry

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Also known as: 546-93-0, Magnesite, Carbonic acid, magnesium salt, 13717-00-5, Carbonic acid, magnesium salt (1:1), Magnesium carbonate anhydrous
Molecular Formula
CMgO3
Molecular Weight
84.31  g/mol
InChI Key
ZLNQQNXFFQJAID-UHFFFAOYSA-L

Magnesium Carbonate
Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach.
1 2D Structure

Magnesium Carbonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
magnesium;carbonate
2.1.2 InChI
InChI=1S/CH2O3.Mg/c2-1(3)4;/h(H2,2,3,4);/q;+2/p-2
2.1.3 InChI Key
ZLNQQNXFFQJAID-UHFFFAOYSA-L
2.1.4 Canonical SMILES
C(=O)([O-])[O-].[Mg+2]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Anhydrous Magnesium Carbonate

2. C.i. 77713

3. Carbonic Acid, Magnesium Salt (1:1), Hydrate

4. Ci 77713

5. E-504

6. Magnesite

7. Magnesite (mg(co3))

8. Magnesium Carbonate (1:1) Hydrate

9. Magnesium Carbonate Anhydrous

10. Mgco3.3h2o

11. Nesquehonite

2.2.2 Depositor-Supplied Synonyms

1. 546-93-0

2. Magnesite

3. Carbonic Acid, Magnesium Salt

4. 13717-00-5

5. Carbonic Acid, Magnesium Salt (1:1)

6. Magnesium Carbonate Anhydrous

7. Magnesite Dust

8. Magnesite (mg(co3))

9. Magnesium;carbonate

10. Hydromagnesite

11. Magmaster

12. Magnesium Carbonate (1:1)

13. 7757-69-9

14. Carbonate Magnesium

15. C.i. 77713

16. Stan-mag Magnesium Carbonate

17. Magnesium Carbonate,light

18. Magnesium Carbonate (mgco3)

19. Dci Light Magnesium Carbonate

20. Ins No.504(i)

21. Anhydrous Magnesium Carbonate

22. Ins-504(i)

23. Magnesium Carbonate Gold Star

24. Magnesium(ii) Carbonate (1:1)

25. Chebi:31793

26. E-504(i)

27. Mfcd00064632

28. Nsc-83511

29. 0ihc698356

30. Giobertite

31. Kimboshi

32. Apolda

33. Destab

34. Magfy

35. Magnesium Carbonate, Hydrated

36. Caswell No. 530

37. Gp 20 (carbonate)

38. Ma 70 (carbonate)

39. Gold Star (carbonate)

40. Magnesium Carbonate [usan]

41. Australian Magnesite

42. Hsdb 211

43. Einecs 208-915-9

44. Nsc 83511

45. Epa Pesticide Chemical Code 073503

46. Ci 77713

47. Ai3-00768

48. Magnesiumkarbonat

49. Unii-0ihc698356

50. Einecs 231-817-2

51. Carbonic Acid, Magnesium Salt (1:?)

52. Mgco3

53. Magnesium Carbonate Usp

54. Ec 208-915-9

55. Magnesium Carbonate, Usp Grade

56. Chembl1200736

57. Dtxsid4049660

58. Magnesium Carbonate Microparticles

59. Cs-b1764

60. Magnesium Carbonate [who-dd]

61. Akos015903527

62. Db09481

63. E504

64. Anhydrous Magnesium Carbonate [mart.]

65. Ft-0774766

66. Q407931

67. Cyclopentanecarboxylic Acid, 3-methyl-2-oxo-, Methyl Ester

68. 53678-75-4

2.3 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 84.31 g/mol
Molecular Formula CMgO3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass83.9697855 g/mol
Monoisotopic Mass83.9697855 g/mol
Topological Polar Surface Area63.2 Ų
Heavy Atom Count5
Formal Charge0
Complexity18.8
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Therapeutic Uses

THE CARBONATE ... /SALT/ OF MAGNESIUM /IS/ USED AS /ANTACID/, USUALLY IN COMBINATION WITH ALUMINUM HYDROXIDE.

American Medical Association, Council on Drugs. AMA Drug Evaluations Annual 1994. Chicago, IL: American Medical Association, 1994., p. 909


ALTHOUGH 1 G CONTAINS APPROX 20 MEQ ONLY FRACTION MAY BE AVAILABLE FOR NEUTRALIZATION IN VIVO. USUAL ANTACID DOSE OF 500 MG TO 2 G MAY BE INADEQUATE

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 993


MEDICATION (VET): WHEN INSOL IN DIGESTIVE TRACT IT IS ANTIDIARRHEAL & COATS MUCOSAE; WHEN SLIGHTLY SOL FORM IS USED IT CAN BE AS LAXATIVE AS MAGNESIUM OXIDE. ... COMMERCIALLY AVAILABLE COSMETIC GRADES EXIST FOR RARE USE AS TOPICAL PROTECTANT, MOISTURE & FAT ABSORBENT.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 319


AS AN ANTACID, IT IS RELATIVELY WEAK (1 G NEUTRALIZES APPROX 7 ML OF 0.1 N HCL IN 10 MIN & 17 ML IN 2 HR).

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 735


For more Therapeutic Uses (Complete) data for MAGNESIUM CARBONATE (8 total), please visit the HSDB record page.


4.2 Minimum/Potential Fatal Human Dose

3= MODERATELY TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) 0.5-5 G/KG; BETWEEN 1 OZ & 1 PINT (OR 1 LB) FOR 70 KG PERSON (150 LB).

Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-127


4.3 Drug Indication

Used as an over the counter antacid.


FDA Label


5 Pharmacology and Biochemistry
5.1 Pharmacology

Neutralizes acid in the stomach.


5.2 MeSH Pharmacological Classification

Bleaching Agents

Chemicals that are used to oxidize pigments and thus effect whitening. (See all compounds classified as Bleaching Agents.)


Hygroscopic Agents

Materials that readily absorb moisture from their surroundings. (See all compounds classified as Hygroscopic Agents.)


5.3 ATC Code

A - Alimentary tract and metabolism

A02 - Drugs for acid related disorders

A02A - Antacids

A02AA - Magnesium compounds

A02AA01 - Magnesium carbonate


A - Alimentary tract and metabolism

A06 - Drugs for constipation

A06A - Drugs for constipation

A06AD - Osmotically acting laxatives

A06AD01 - Magnesium carbonate


5.4 Absorption, Distribution and Excretion

Absorption

About 40-60% of magnesium is absorbed following oral administration. Percent absorption decreases as dose increases.


Route of Elimination

Primarily eliminated in urine.


Volume of Distribution

Vd for magnesium is 0.2-0.4L/kg. About 50% distributes to bone.


Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance.


IN SHEEP TRIAL REAGENT GRADE MATERIAL DEMONSTRATED 72% TRUE ABSORPTION VALUES, WHILE COMMERCIAL MAGNESITE HAD ONLY 14% VALUE DRAMATIZING NEED FOR MORE BIOLOGIC AVAILABILITY STUDIES ON MANY FEED INGREDIENTS.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 319


5.5 Metabolism/Metabolites

Magnesium does not appear to be metabolized in any way.


5.6 Biological Half-Life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult.


5.7 Mechanism of Action

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach.


... Rapidly reacts with hydrochloric acid to form ... carbon dioxide /and magnesium chloride/.

McEvoy, G.K. (ed.). American Hospital Formulary Service- Drug Information 2002. Bethesda, MD: American Society of Health-System Pharmacists, Inc. 2002 (Plus Supplements)., p. 2774


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DMF Review : N/A

Rev. Date :

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DMF Number : 11047

Submission : 1994-08-23

Status : Active

Type : II

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API Reference Price

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[{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1650997800,"product":"MAGNESIUM CARBONATE LIGHT BP","address":"129\/1\/A GIDC ESTATE","city":"NANDESARI","supplier":"SUDEEP PHARMA","supplierCountry":"INDIA","foreign_port":"DURBAN","customer":"TO THE ORDER","customerCountry":"SOUTH AFRICA","quantity":"320.00","actualQuantity":"0.32","unit":"MTS","unitRateFc":"4150","totalValueFC":"1166.4","currency":"USD","unitRateINR":275000,"date":"27-Apr-2022","totalValueINR":"88000","totalValueInUsd":"1166.4","indian_port":"HAZIRA","hs_no":"29157090","bill_no":"9991519","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"SOUTH AFRICA","selfForZScoreResived":"Pharma Grade","supplierPort":"HAZIRA","supplierAddress":"129\/1\/A GIDC ESTATE, NANDESARI","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2022","qtr":"Q4","strtotime":1668796200,"product":"MAGNESIUM CARBONATE HEAVY [USP]","address":"129\/1\/A GIDC ESTATE","city":"NANDESARI","supplier":"SUDEEP PHARMA","supplierCountry":"INDIA","foreign_port":"TORONTO","customer":"TO THE ORDER","customerCountry":"CANADA","quantity":"6500.00","actualQuantity":"6.5","unit":"MTS","unitRateFc":"3990","totalValueFC":"23427.7","currency":"USD","unitRateINR":294153.84615384613,"date":"19-Nov-2022","totalValueINR":"1912000","totalValueInUsd":"23427.7","indian_port":"BARODA","hs_no":"29157090","bill_no":"5574699","productDescription":"API","marketType":"REGULATED MARKET","country":"CANADA","selfForZScoreResived":"Pharma Grade","supplierPort":"BARODA","supplierAddress":"129\/1\/A GIDC ESTATE, NANDESARI","customerAddress":""}]
27-Apr-2022
19-Nov-2022
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