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    Also known as: Magnesiumhydroxide, Magnesium (as hydroxide), Chebi:6637, Ins no.528, 1909-42-8, Oxaine m
    Molecular Formula
    H2MgO2
    Molecular Weight
    58.320  g/mol
    InChI Key
    VTHJTEIRLNZDEV-UHFFFAOYSA-L
    FDA UNII
    NBZ3QY004S
    Magnesium Hydroxide
    An inorganic compound that occurs in nature as the mineral brucite. It acts as an antacid with cathartic effects.
    1 2D Structure

    Magnesium Hydroxide

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    magnesium;dihydroxide
    2.1.2 InChI
    InChI=1S/Mg.2H2O/h;2*1H2/q+2;;/p-2
    2.1.3 InChI Key
    VTHJTEIRLNZDEV-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    [OH-].[OH-].[Mg+2]
    2.2 Other Identifiers
    2.2.1 UNII
    NBZ3QY004S
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Acetamide, 2,2'-((2-hydroxyethyl)imino)bis-(n-(1,1-dimethyl-2-phenylethyl))-n-methyl-, Mixture With Aluminum Hydroxide (al(oh)3) And Magnesium Hydroxide (mg(oh)2)

    2. Acetamide, 2,2'-((2-hydroxyethyl)imino)bis-(n-(1,1-dimethyl-2-phenylethyl))-n-methyl-, Mixture With Aluminum Hydroxide And Magnesium Hydroxide

    3. Oxaine M

    4. Brucite

    5. Hydrate, Magnesium

    6. Hydroxide, Magnesium

    7. Magnesium Hydrate

    8. Magnesium Hydroxide

    9. Magnesium Hydroxide (mg(oh)4)

    2.3.2 Depositor-Supplied Synonyms

    1. Magnesiumhydroxide

    2. Magnesium (as Hydroxide)

    3. Chebi:6637

    4. Ins No.528

    5. 1909-42-8

    6. Oxaine M

    7. Ins-528

    8. E-528

    9. Magnesium Hydrate

    10. Magnesium Hydroxide Suspension

    11. 1317-43-7

    12. Magnesium Hydroxide (gilumag)

    13. Phenol,2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-(2-buten-1-yloxy)-

    14. Magnesium Hydroxide [jan]

    15. Magnesiumhydroxid

    16. Magnesii Hydroxidum

    17. Magnesium-hydroxide

    18. Magnesium(2+) Hydroxide

    19. Magnesium Hydroxide Powder

    20. Mg(oh)2

    21. Chembl1200718

    22. Dtxsid4049662

    23. Magnesium Hydroxide [ii]

    24. Magnesium Hydroxide [mi]

    25. Magnesium Hydroxide [fcc]

    26. Magnesium Hydroxide 100g

    27. Magnesium Hydroxide [hsdb]

    28. Magnesium Hydroxide [inci]

    29. Magnesium Hydroxide [vandf]

    30. Magnesium Hydroxide [mart.]

    31. Magnesium Hydroxide Gilumag D211

    32. Magnesium Hydroxide Gilumag D212

    33. Magnesium Hydroxide Gilumag D213

    34. Magnesium Hydroxide Gilumag D214

    35. Magnesium Hydroxide Gilumag D611

    36. Magnesium Hydroxide Gilumag D661

    37. Magnesium Hydroxide Gilumag D671

    38. Magnesium Hydroxide [usp-rs]

    39. Magnesium Hydroxide [who-dd]

    40. Akos015904092

    41. Db09104

    42. Magnesium Hydroxide [ep Impurity]

    43. Magnesium Hydroxide [orange Book]

    44. E528

    45. Magnesium Hydroxide [ep Monograph]

    46. Magnesii Hydroxidum [who-ip Latin]

    47. Magnesium Hydroxide [usp Monograph]

    48. Ft-0628085

    49. Ft-0693469

    50. C07876

    51. Pharmaceutical Grade Magnesium Hydroxide Hd ~ Usp

    52. Q407548

    53. J-005906

    54. Pepcid Complete Component Magnesium Hydroxide

    55. Magnesium Hydroxide Component Of Pepcid Complete

    2.4 Create Date
    2004-09-16
    3 Chemical and Physical Properties
    Molecular Weight 58.320 g/mol
    Molecular Formula H2MgO2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count0
    Exact Mass57.9905210 g/mol
    Monoisotopic Mass57.9905210 g/mol
    Topological Polar Surface Area2 Ų
    Heavy Atom Count3
    Formal Charge0
    Complexity0
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Indication

    Magnesium hydroxide can be used as an antacid or a laxative depending on the administered dose. As an antacid, it is used for the temporary relief of heartburn, upset stomach, sour stomach or acid indigestion. As a laxative, it is used for the relief of occasional constipation by promoting bowel movements for 30 minutes and up to 6 hours.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    As an antacid, magnesium hydroxide suspension neutralizes gastric acid by reacting with hydrochloric acid in the stomach to form magnesium chloride and water. It is practically insoluble in water and does not have any effect until it reacts with the hydrochloric acid in the stomach. There, it decreases the direct acid irritant effect and increases the pH in the stomach leading to inactivation of pepsin. Magnesium hydroxide enhances the integrity of the mucosal barrier of the stomach as well as improving the tone of both the gastric and esophageal sphincters. As a laxative, the magnesium hydroxide works by increasing the osmotic effect in the intestinal tract and drawing water in. This creates distension of the colon which results in an increase in peristaltic movement and bowel evacuation.

    5.2 MeSH Pharmacological Classification

    Antacids

    Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT. (See all compounds classified as Antacids.)

    5.3 FDA Pharmacological Classification
    5.3.1 Pharmacological Classes
    Increased Large Intestinal Motility [PE]; Inhibition Large Intestine Fluid/Electrolyte Absorption [PE]; Inhibition Small Intestine Fluid/Electrolyte Absorption [PE]; Magnesium Ion Exchange Activity [MoA]; Osmotic Activity [MoA]; Osmotic Laxative [EPC]; Stimulation Large Intestine Fluid/Electrolyte Secretion [PE]; Calculi Dissolution Agent [EPC]
    5.4 Absorption, Distribution and Excretion

    Absorption

    About 15%-50% of magnesium hydroxide is absorbed very slowly through the small intestine.

    Route of Elimination

    After oral administration, up to 50% of the magnesium hydroxide suspension may be absorbed as magnesium ions through the small intestines and then rapidly excreted in the urine through the kidneys. The unabsorbed drug is mainly excreted in the feces and saliva.

    Volume of Distribution

    The peak action and distribution of magnesium hydroxide are variable.

    Clearance

    Magnesium hydroxide is mainly excreted in the urine by the kidneys. Since the kidneys play a major role in its clearance, individuals with renal failure are at risk of hypermagnesemia with long term consumption as the appropriate amounts of magnesium may not be excreted.

    5.5 Metabolism/Metabolites

    Unless a patient is deficient in magnesium, very little is absorbed by the intestine. Overall, about 15%-50% of the magnesium hydroxide suspension is absorbed systemically. However, it does not undergo any metabolism as it is rapidly excreted in the urine.

    5.6 Biological Half-Life

    N/A

    5.7 Mechanism of Action

    The suspension of magnesium hydroxide is ingested and enters the stomach. According to the amount ingested, the magnesium hydroxide will either act as an antacid or a laxative. Through the ingestion of 0.5-1.5 grams (in adults) the magnesium hydroxide will act by simple acid neutralization in the stomach. The hydroxide ions from the magnesium hydroxide suspension will combine with the acidic H+ ions of the hydrochloric acid made by the stomachs parietal cells. This neutralization reaction will result in the formation of magnesium chloride and water. Through the ingestion of 2-5 grams (in adults) the magnesium hydroxide acts as a laxative in the colon. The majority of the suspension is not absorbed in the intestinal tract and will create an osmotic effect to draw water into the gut from surrounding tissues. With this increase of water in the intestines, the feces will soften and the intraluminal volume of the feces will increase. These effects still stimulate intestinal motility and induce the urge to defecate. Magnesium hydroxide will also release cholecystokinin (CKK) in the intestines which will accumulate water and electrolytes in the lumen and furthermore increase intestinal motility.

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LIMITED","supplierCountry":"INDIA","foreign_port":"APAPA","customer":"SUN PHARMACEUTICAL INDUSTRIES LIMITED","customerCountry":"NIGERIA","quantity":"200.00","actualQuantity":"200","unit":"KGS","unitRateFc":"5.1","totalValueFC":"946.5","currency":"USD","unitRateINR":390,"date":"03-Dec-2022","totalValueINR":"78000","totalValueInUsd":"946.5","indian_port":"INDORE-DHANNAD","hs_no":"29159099","bill_no":"5910766","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"NIGERIA","selfForZScoreResived":"Micronized","supplierPort":"INDORE-DHANNAD","supplierAddress":"SPARC TANDALJA, VADODARA","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2023","qtr":"Q2","strtotime":1684175400,"product":"PHARMACEUTICAL RAW MATERIAL FOR PHARMACEUTICAL GRADE FAMOTINE CALCIUM CARBONATEMAGNESIUM HYDROXIDE DIRECTLY COMPRESSIBL","address":"FLAT NO.8, KSHITIJ CO-OP.HSG.SOCIET BEHIND MAHARSHINAGAR POLICE CHOWKY,","city":"SALISBURY PARK,PUNE\/MAH","supplier":"MAXIM PHARMACEUTICALS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"KARACHI","customer":"THE SCHAZOO PHARMACEUTICALS ","customerCountry":"PAKISTAN","quantity":"1800.00","actualQuantity":"1800","unit":"KGS","unitRateFc":"9.6","totalValueFC":"16977.7","currency":"USD","unitRateINR":776.11111111111109,"date":"16-May-2023","totalValueINR":"1397000","totalValueInUsd":"16977.7","indian_port":"JNPT","hs_no":"29420034","bill_no":"0","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"PAKISTAN","selfForZScoreResived":"Pharma Grade","supplierPort":"JNPT","supplierAddress":"FLAT NO.8, KSHITIJ CO-OP.HSG.SOCIET BEHIND MAHARSHINAGAR POLICE CHOWKY,, SALISBURY PARK,PUNE\/MAH","customerAddress":""},{"dataSource":"API Export","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1726079400,"product":"GRANULATED LIPOSOMAL MAGNESIUM HYDROXIDE(BATCH NO:240810136","address":"Koyikkalethu Veeyapuram","city":"Alappuzha","supplier":"MOLECULES BIO LABS PRIVATE LIMITED","supplierCountry":"INDIA","foreign_port":"MARSEILLE","customer":"SAS PHARMA NATURE","customerCountry":"FRANCE","quantity":"50.00","actualQuantity":"50","unit":"KGS","unitRateFc":"49","totalValueFC":"2356.8","currency":"USD","unitRateINR":3950.0584000000003,"date":"12-Sep-2024","totalValueINR":"197502.92","totalValueInUsd":"2356.8","indian_port":"Bangalore Air","hs_no":"29369000","bill_no":"3952849","productDescription":"API","marketType":"REGULATED MARKET","country":"FRANCE","selfForZScoreResived":"Pharma Grade","supplierPort":"Bangalore Air","supplierAddress":"Koyikkalethu Veeyapuram, Alappuzha","customerAddress":""}]
    08-Apr-2021
    12-Sep-2024
    KGS
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Europe

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    01

    SANOFI SpA

    France
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    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
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    Virtual BoothSanofi is a pioneer in Diabetes Solutions, Human Vaccines, Innovative Drugs, Consumer Healthcare, and the new Genzyme.

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    Flag France
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    Regulatory Info :

    Registration Country : Italy

    Aspirin; Magnesium Hydroxide

    Brand Name : Ariptin

    Dosage Form : Acetylsalicylic Acid+Magnesium Hydroxide+Algeldrato 300Mg 20 Joined' Oral Use

    Dosage Strength : 20 cpr div 300 mg

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Italy

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    02

    Melisana AG

    Switzerland
    Antibody Engineering
    Not Confirmed
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    Melisana AG

    Switzerland
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    Antibody Engineering
    Not Confirmed
    • fda
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    Flag Switzerland
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    Regulatory Info :

    Registration Country : Switzerland

    Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

    Brand Name : Alucol Gel

    Dosage Form : Susp Fruit

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    03

    Melisana AG

    Switzerland
    Antibody Engineering
    Not Confirmed
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    Melisana AG

    Switzerland
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    Antibody Engineering
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    Regulatory Info :

    Registration Country : Switzerland

    Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

    Brand Name : Alucol Gel

    Dosage Form : Susp Fruit

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    04

    Melisana AG

    Switzerland
    Antibody Engineering
    Not Confirmed
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    Melisana AG

    Switzerland
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    Antibody Engineering
    Not Confirmed
    • fda
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    Flag Switzerland
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    Regulatory Info :

    Registration Country : Switzerland

    Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

    Brand Name : Alucol Gel

    Dosage Form : Susp Peppermint

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

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    05

    Melisana AG

    Switzerland
    Antibody Engineering
    Not Confirmed
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    Melisana AG

    Switzerland
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    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
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    Flag Switzerland
    Virtual Booth Virtual Booth
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    Regulatory Info :

    Registration Country : Switzerland

    Aluminium oxide hydrochloride (Algeldratum); Magnesium hydroxide

    Brand Name : Alucol Gel

    Dosage Form : Susp Peppermint

    Dosage Strength :

    Packaging :

    Approval Date :

    Application Number :

    Regulatory Info :

    Registration Country : Switzerland

    blank

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    06

    Seid S.A.

    Spain
    Antibody Engineering
    Not Confirmed
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    Seid S.A.

    Spain
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    Antibody Engineering
    Not Confirmed
    • fda
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    Flag Spain
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    Regulatory Info : Generic Dossier- Nees/eCTD

    Registration Country : Spain

    Magnesium Hydroxide

    Brand Name : Magnesia Seid

    Dosage Form : POWDER FOR ORAL SUSPENSION IN SINGLE-DOSE SACHETS

    Dosage Strength : 2.4MG/G

    Packaging : 14 Individual Sachets

    Approval Date :

    Application Number :

    Regulatory Info : Generic Dossier- Nees/eCTD

    Registration Country : Spain

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    07

    World Medicine Ilac San ve tic LTD STl

    Turkey
    Antibody Engineering
    Not Confirmed
    arrow

    World Medicine Ilac San ve tic LTD STl

    Turkey
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    Antibody Engineering
    Not Confirmed
    • fda
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    Flag Turkey
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Generic

    Registration Country : Turkey

    Acetylsalicylic Acid; Magnesium Hydroxide

    Brand Name :

    Dosage Form : FILM COATED TABLET

    Dosage Strength : 75MG; 15.2MG

    Packaging : 30, 100 Tablets

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : Turkey

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    08

    World Medicine Ilac San ve tic LTD STl

    Turkey
    Antibody Engineering
    Not Confirmed
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    World Medicine Ilac San ve tic LTD STl

    Turkey
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    Antibody Engineering
    Not Confirmed
    • fda
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    Flag Turkey
    Virtual Booth Virtual Booth
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    Regulatory Info : Generic

    Registration Country : Turkey

    Acetylsalicylic Acid; Magnesium Hydroxide

    Brand Name :

    Dosage Form : FILM COATED TABLET

    Dosage Strength : 150MG; 30.4MG

    Packaging : 30, 100 Tablets

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : Turkey

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    09

    World Medicine Ilac San ve tic LTD STl

    Turkey
    Antibody Engineering
    Not Confirmed
    arrow

    World Medicine Ilac San ve tic LTD STl

    Turkey
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
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    Flag Turkey
    Virtual Booth Virtual Booth
    Digital Content Digital Content

    Regulatory Info : Generic

    Registration Country : Turkey

    Aluminum; Magnesium Hydroxide; Simethicone

    Brand Name :

    Dosage Form : SUSPENSION

    Dosage Strength : 405MG; 100MG; 125MG

    Packaging : 250 Ml/Bottle

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : Turkey

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    10

    World Medicine Ilac San ve tic LTD STl

    Turkey
    Antibody Engineering
    Not Confirmed
    arrow

    World Medicine Ilac San ve tic LTD STl

    Turkey
    arrow
    Antibody Engineering
    Not Confirmed
    • fda
    • EDQM
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    Flag Turkey
    Virtual Booth Virtual Booth
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    Regulatory Info : Generic

    Registration Country : Turkey

    Famotidine; Calcium Carbonate; Magnesium Hydroxide

    Brand Name :

    Dosage Form : CHEWABLE TABLET

    Dosage Strength : 10MG; 800MG; 165MG

    Packaging : 24 Chewable Tablets

    Approval Date :

    Application Number :

    Regulatory Info : Generic

    Registration Country : Turkey

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    turkeypng-1602828403png-1622460951png-1622462103.png
    EP Grade Magnesium Hydroxide API needed in Turkey [ENA20284]
    A group of companies that focuses on manufacturing, development & distribution of various finished formulations is looking for suppliers of EP Grade Magnesium Hydroxide API for development purposes. The suppliers must support this enquiry with CEP, DMF and CoA.
    16 Aug 2024

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    16 Aug 2024

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    Reply Comment (4)

    16 Aug 2024

    india-flag.png
    Ph. Eur. & USP Grade Magnesium Hydroxide (2 kg) API needed in India [ENA19873]
    A CDO that focuses on development of various pharmaceutical dosage forms which includes parentals, tablets, capsules, powder, semi-solids and liquids is looking for suppliers of Ph. Eur. & USP Grade Magnesium Hydroxide (2 kg) API for development purposes. The suppliers must support this enquiry with USDMF & CoA.
    04 Jul 2024

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    04 Jul 2024

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    Reply Comment (3)

    04 Jul 2024

    Denmark.png
    EP Grade Magnesium Hydroxide (48 MT/ annum) API needed in Denmark [ENA18975]
    A company that focuses on the marketing and distribution of various pharmaceutical products is looking for suppliers of EP Grade Magnesium Hydroxide (48 MT/ annum) API for commercial purposes. The suppliers must support this enquiry with CoA.
    31 Jan 2024

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    31 Jan 2024

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    Reply Comment (10)

    31 Jan 2024

    Denmark.png
    EP Grade Magnesium Hydroxide (48 MT/ annum) API needed in Denmark [ENA18767]
    A company that focuses on the marketing and distribution of various pharmaceutical products is looking for suppliers of EP Grade Magnesium Hydroxide (48 MT/ annum) API for commercial purposes. The suppliers must support this enquiry with CoA.
    14 Dec 2023

    Reply

    14 Dec 2023

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    Reply Comment (9)

    14 Dec 2023

    Zimbabwe.png
    Magnesium Hydroxide (MOQ) API needed in Zimbabwe [ENA18121]
    A generic pharmaceutical company that focuses on the development, manufacturing, sale, marketing and distribution of oral solids, liquids, creams & ointments is looking for suppliers of Magnesium Hydroxide (MOQ) API for development purposes. The suppliers must support this enquiry with open part DMF & CoA.
    22 Sep 2023

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    22 Sep 2023

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    Reply Comment (5)

    22 Sep 2023

    india-flag.png
    Ph. Eur & USP Grade Magnesium Hydroxide (25 kg) API needed in India [ENA16863]
    A company that has a facility for contract research which is into developing novel formulation and process technologies giving continuous manufacturing capabilities for all dosage forms is looking for suppliers of Ph. Eur & USP Grade Magnesium Hydroxide (25 kg) API for both development and commercial purposes. The suppliers must support this enquiry with CoA.
    11 Apr 2023

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    11 Apr 2023

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    Reply Comment (5)

    11 Apr 2023

    Bangladesh.png
    Magnesium Hydroxide (10 kg) API needed in Bangladesh [ENA16163]
    A company that deals in the distribution of various pharmaceutical products is looking for suppliers of Magnesium Hydroxide (10 kg) API for commercial purposes. The suppliers must support this enquiry with CoA.
    20 Jan 2023

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    20 Jan 2023

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    Reply Comment (4)

    20 Jan 2023

    Argentina.png
    Various APIs needed in Argentina [ENA15474]
    A group of companies that deals in the development of pharmaceutical products for veterinary use is looking for suppliers of Various APIs. The suppliers must support this enquiry with CoA. 1. Magnesium Hydroxide API. The required quantity is 2.5 kg for R&D and later 475 kg for commercial purposes. 2. Calcium Carbonate API. The required quantity is 12 kg for R&D and later 2.5 MT for commercial purposes. 3. Levocetirizine Dihydrochloride API. The required quantity is 1 kg for R&D and later 3 kg for commercial purposes. 4. Pitofenone HCl API. The required quantity is 100 g for R&D and later 48 kg for commercial purposes. 5. Fenpiverinium Bromide API. The required quantity is 2 g for R&D and later 960 g for commercial purposes.
    05 Nov 2022

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    05 Nov 2022

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    05 Nov 2022

    india-flag.png
    Various APIs needed in India [ENA14204]
    A company that deals in various pharmaceutical products like injections, syrups & hygiene products is looking for suppliers of Various APIs for commercial purpose. The suppliers must support this enquiry with CoA. 1. Ornidazole (50 kg) API 2. Magnesium Hydroxide (100 kg) API 3. Dicalcium Phosphate (500 kg) API 4. Doxylamine Succinate (25 kg) API
    04 Jul 2022

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    04 Jul 2022

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    04 Jul 2022

    Russia-big.png
    Various APIs needed in Russia [ENA13327]
    A pharmaceutical company that deals in the manufacturing of tablets, capsules, suspensions, solutions, ointments, pastes, tinctures & extracts is looking for suppliers of Various APIs for commercial purpose. The required quantity is 1 kg for each. The suppliers must support this enquiry with CoA. 1. Algeldrate API 2. Magnesium Dihydroxide API 3. Tetrafluoroethane API 4. Chlorobutanol API
    15 Apr 2022

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    15 Apr 2022

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    Reply Comment (7)

    15 Apr 2022

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