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Magnesium Salicylate

Synopsis, Chemistry

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Also known as: 18917-89-0, Magnesium disalicylate, Magnesiumsalicylate, Magan, Magnesium salicylate anhydrous, Jq69d454n1

Molecular Formula

C₁₄H₁₀MgO₆

Molecular Weight

298.53 g/mol

InChI Key

MQHWFIOJQSCFNM-UHFFFAOYSA-L

FDA UNII

JQ69D454N1

Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.

1 2D Structure

Magnesium Salicylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

magnesium;2-carboxyphenolate

2.1.2 InChI

InChI=1S/2C7H6O3.Mg/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2

2.1.3 InChI Key

MQHWFIOJQSCFNM-UHFFFAOYSA-L

2.1.4 Canonical SMILES

C1=CC=C(C(=C1)C(=O)O)[O-].C1=CC=C(C(=C1)C(=O)O)[O-].[Mg+2]

2.2 Other Identifiers

2.2.1 UNII

JQ69D454N1

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Keygesic-10

2. Magan

3. Mobidin

4. Momentum (magnesium Salicylate)

2.3.2 Depositor-Supplied Synonyms

1. 18917-89-0

2. Magnesium Disalicylate

3. Magnesiumsalicylate

4. Magan

5. Magnesium Salicylate Anhydrous

6. Jq69d454n1

7. Mobidin

8. Magnesium, Bis[2-(hydroxy-.kappa.o)benzoato-.kappa.o]-, (t-4)-

9. Backache Relief

10. Chebi:6640

11. Bis(salicylato)magnesium; Magan; Magnesium Bis(salicylate); Salicylic Acid, Magnesium Salt

12. Bis(salicylato)magnesium

13. Magnesium Bis(salicylate)

14. Unii-jq69d454n1

15. Magnesium, Bis(2-(hydroxy-.kappa.o)benzoato-.kappa.o)-, (t-4)-

16. Einecs 242-669-3

17. Analate

18. Lorisal

19. Triact

20. Salicylic Acid, Magnesium Salt (2:1)

21. Magnesium;2-carboxyphenolate

22. Schembl9981

23. Chembl2106755

24. Dtxsid00889392

25. Magnesium Salicylate [mi]

26. Magnesium Salicylate (1:2)

27. Akos015901813

28. Db01397

29. Magnesium, Bis(2-hydroxybenzoato-o1,o2)-

30. Q6731407

2.4 Create Date

2011-12-26

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₀MgO₆
Molecular Weight	298.53 g/mol
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	298.0327797 g/mol
Monoisotopic Mass	298.0327797 g/mol
Topological Polar Surface Area	121 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	133
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Indication

Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)

Cyclooxygenase Inhibitors

Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes. (See all compounds classified as Cyclooxygenase Inhibitors.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Central Nervous System Stimulation [PE]; Methylxanthine [EPC]; Xanthines [CS]; Central Nervous System Stimulant [EPC]

5.3 Mechanism of Action

Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.

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