All Manufacturers, Suppliers, Distributors and Exporters of Manganese with approved Medicines Control Council in South Africa of Finished Dosage Form listed on PharmaCompass.com

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ACTIVE PHARMA INGREDIENTS

1 NDC API, $ API Reference Price

1 NDC API
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

105 FDF Dossiers, 100 South Africa, 5 Listed Dossiers

105 FDF Dossiers
100 South Africa
5 Listed Dossiers

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Chemistry

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Also known as: 7439-96-5, Manganese, Mn, Mangan, Colloidal manganese, Manganide

Molecular Formula

Molecular Weight

54.93804 g/mol

InChI Key

PWHULOQIROXLJO-UHFFFAOYSA-N

FDA UNII

42Z2K6ZL8P

A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)

1 2D Structure

Manganese

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

manganese

2.1.2 InChI

InChI=1S/Mn

2.1.3 InChI Key

PWHULOQIROXLJO-UHFFFAOYSA-N

2.1.4 Canonical SMILES

[Mn]

2.2 Other Identifiers

2.2.1 UNII

42Z2K6ZL8P

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Manganese

2.3.2 Depositor-Supplied Synonyms

1. 7439-96-5

2. Manganese

3. Mn

4. Mangan

5. Colloidal Manganese

6. Manganide

7. Manganese Metal

8. Manganese, Ion (mn1-)

9. Manganese(4+)

10. Manganese(1-)

11. 42z2k6zl8p

12. Manganese Powder

13. Mfcd00011111

14. Cutaval

15. Magnacat

16. Tronamang

17. Mangan [polish]

18. Manganese, Elemental

19. Manganese Powder, -325 Mesh

20. Manganese Metal Alloy

21. Manganeso

22. Manganese Fume

23. Manganese Compounds

24. Teprosyn M

25. Manganese Element

26. Mangan Nitridovany

27. Mangan Nitridovany [czech]

28. Manganese-55

29. Manganese(4 )

30. Manganese(7+)

31. Ccris 1579

32. Hsdb 550

33. Manganese Ion(4 )

34. Einecs 231-105-1

35. Manganese, Ion (mn4 )

36. Mne 06pb

37. Manganum

38. Unii-42z2k6zl8p

39. Manganese Atom

40. Manganese, Ion (mn(7+))

41. Manganese Chips

42. Manganese(0)

43. Manganese (iv)

44. Manganide(-i)

45. Manganese (0)

46. Manganide(1-)

47. Mn3

48. Manganese(4+) Ion

49. Manganese, 99%

50. Manganese(iv) Cation

51. Manganese [mi]

52. Mn(iv)

53. Manganese [hsdb]

54. Manganese [vandf]

55. Manganum Metallicum

56. 25mn

57. Manganese [mart.]

58. Ec 231-105-1

59. Manganese Pieces, Irregular

60. Manganese [who-dd]

61. Manganese Compounds, N.o.s.

62. Mn(-)

63. Mn(0)

64. Dtxsid2024169

65. Chebi:18291

66. Chebi:25158

67. Chebi:33011

68. Chebi:35154

69. Hsdb 6945

70. Mn(4+)

71. Dtxsid801314870

72. Manganum Metallicum [hpus]

73. Manganese Powder, Aps <10 Micron

74. Manganese Nanopowder, Aps 30-50nm

75. Manganese Powder, -140+325 Mesh

76. Akos015833390

77. Manganese Powder, 99.9% (metal Basis)

78. Mn4

79. N450

80. Q731

81. Manganese Pieces, 10mm & Down, Ultrapure

82. Ft-0689227

83. Manganese, Chips, Thickness <2.0 Mm, 99%

84. C00034

85. Manganese Granules, 0.8-3mm (0.03-0.12in)

86. Manganese, Powder, >=99.9% Trace Metals Basis

87. Q27109868

88. Q27115185

89. M008000000

90. Manganese Powder , -325 Mesh, =99% Trace Metals Basis

91. Manganese, Rod, 10mm, Diameter 4.0mm, Cast, 99.5%

92. Manganese, Rod, 35mm, Diameter 2.0mm, Cast, 99.5%

93. Manganese, Rod, 47mm, Diameter 2.0mm, Cast, 99.5%

94. Manganese, Rod, 50mm, Diameter 4.0mm, Cast, 99.5%

95. Manganese, Rod, 50mm, Diameter 6.35mm, Cast, 99.5%

96. Manganese, Flake, 25 Mm, Weight 100 G, Purity 99.95%

97. Manganese, Flake, 25 Mm, Weight 50 G, Purity 99.95%

98. Manganese, Flake, Weight 200 G, 25 Mm, Purity 99.95%

99. Manganese, Plasma Standard Solution, Specpure, Mn 10g/ml

100. Manganese, Powder, -325 Mesh, >=99% Trace Metals Basis

101. Manganese, Aas Standard Solution, Specpure?, Mn 1000?g/ml

102. Manganese, Oil Based Standard Solution, Specpure, Mn 5000g/g

103. Manganese, Plasma Standard Solution, Specpure?, Mn 1000?g/ml

104. Manganese, Foil, 25x25mm, Thickness 2mm, Hot-pressed, 99.95%

105. Manganese, Foil, 50x50mm, Thickness 2mm, Hot-pressed, 99.95%

106. Manganese, Oil Based Standard Solution, Specpure?, Mn 1000?g/g

107. Manganese, Plasma Standard Solution, Specpure?, Mn 10,000?g/ml

108. Manganese, Rod, 2.0 Mm Diameter, Length 52 Mm, Purity 99.5%

109. Manganese, Rod, Length 25 Mm, 2.0 Mm Diameter, Purity 99.5%

110. Manganese Standard For Aas, Ready-to-use, Traceable To Bam, In Nitric Acid

111. Manganese, Foil, Thickness 0.016 Mm, Size 25 X 25 Mm, Purity 98.7%

112. Manganese, Foil, Thickness 0.016 Mm, Size 50 X 50 Mm, Purity 98.7%

113. Manganese Sputtering Target, 50.8mm (2.0in) Dia X 3.18mm (0.125in) Thick

114. Manganese Sputtering Target, 50.8mm (2.0in) Dia X 6.35mm (0.250in) Thick

115. Manganese Sputtering Target, 76.2mm (3.0in) Dia X 3.18mm (0.125in) Thick

116. Manganese Sputtering Target, 76.2mm (3.0in) Dia X 6.35mm (0.250in) Thick

117. Manganese Standard For Ic, Certified Reference Material, Ready-to-use, Traceable To Bam

118. Manganese Standard For Icp, For Icp, Ready-to-use, Traceable To Bam, In Nitric Acid

119. Manganese, Powder, 300 Max. Part. Size (micron), Weight 1000 G, Purity 99.5%

120. Manganese, Powder, 300 Max. Part. Size (micron), Weight 2000 G, Purity 99.5%

121. Manganese, Powder, 45 Max. Part. Size (micron), Weight 2000 G, Purity 99.5%

122. Manganese, Powder, Max. Particle Size 300 Micron, Weight 100 G, Purity 99.5%

123. Manganese, Powder, Max. Particle Size 300 Micron, Weight 200 G, Purity 99.5%

124. Manganese, Powder, Max. Particle Size 300 Micron, Weight 500 G, Purity 99.5%

125. Manganese, Powder, Max. Particle Size 45 Micron, Weight 100 G, Purity 99.5%

126. Manganese, Powder, Max. Particle Size 45 Micron, Weight 1000 G, Purity 99.5%

127. Manganese, Powder, Max. Particle Size 45 Micron, Weight 200 G, Purity 99.5%

128. Manganese, Powder, Max. Particle Size 45 Micron, Weight 500 G, Purity 99.5%

129. Manganese, Foil, Not Light Tested, 100x100mm, Thickness 0.0125mm, Permanent Polyester Support, 98.7%

130. Manganese, Foil, Not Light Tested, 100x100mm, Thickness 0.015mm, Permanent Polyester Support, 98.7%

131. Manganese, Foil, Not Light Tested, 100x100mm, Thickness 0.01mm, Permanent Polyester Support, 98.7%

132. Manganese, Foil, Not Light Tested, 100x100mm, Thickness 0.025mm, Permanent Polyester Support, 98.7%

133. Manganese, Foil, Not Light Tested, 100x100mm, Thickness 0.02mm, Permanent Polyester Support, 98.7%

134. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.001mm, Permanent Polyester Support, 98.7%

135. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.0025mm, Permanent Polyester Support, 98.7%

136. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.002mm, Permanent Polyester Support, 98.7%

137. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.003mm, Permanent Polyester Support, 98.7%

138. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.004mm, Permanent Polyester Support, 98.7%

139. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.005mm, Permanent Polyester Support, 98.7%

140. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.006mm, Permanent Polyester Support, 98.7%

141. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.007mm, Permanent Polyester Support, 98.7%

142. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.008mm, Permanent Polyester Support, 98.7%

143. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.009mm, Permanent Polyester Support, 98.7%

144. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.0125mm, Permanent Polyester Support, 98.7%

145. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.015mm, Permanent Polyester Support, 98.7%

146. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.01mm, Permanent Polyester Support, 98.7%

147. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.025mm, Permanent Polyester Support, 98.7%

148. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.02mm, Permanent Polyester Support, 98.7%

149. Manganese, Foil, Not Light Tested, 25x25mm, Thickness 0.05mm, Permanent Polyester Support, 98.7%

150. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.001mm, Permanent Polyester Support, 98.7%

151. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.0025mm, Permanent Polyester Support, 98.7%

152. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.002mm, Permanent Polyester Support, 98.7%

153. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.003mm, Permanent Polyester Support, 98.7%

154. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.004mm, Permanent Polyester Support, 98.7%

155. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.005mm, Permanent Polyester Support, 98.7%

156. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.006mm, Permanent Polyester Support, 98.7%

157. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.007mm, Permanent Polyester Support, 98.7%

158. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.008mm, Permanent Polyester Support, 98.7%

159. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.009mm, Permanent Polyester Support, 98.7%

160. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.0125mm, Permanent Polyester Support, 98.7%

161. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.015mm, Permanent Polyester Support, 98.7%

162. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.01mm, Permanent Polyester Support, 98.7%

163. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.025mm, Permanent Polyester Support, 98.7%

164. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.02mm, Permanent Polyester Support, 98.7%

165. Manganese, Foil, Not Light Tested, 50x50mm, Thickness 0.05mm, Permanent Polyester Support, 98.7%

2.4 Create Date

2004-09-16

3 Chemical and Physical Properties

Molecular Formula	Mn
Molecular Weight	54.93804 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	0
Exact Mass	54.938043 g/mol
Monoisotopic Mass	54.938043 g/mol
Topological Polar Surface Area	0 Å²
Heavy Atom Count	1
Formal Charge	0
Complexity	0
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Trace Elements

A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)

4.2 Absorption, Distribution and Excretion

... This study investigated the tissue distribution of manganese in iron-sufficient and iron-deficient rats after welding-fume exposure. The feeding of an iron-deficient diet for 4 wk produced a depletion of body iron, such as decreased iron levels in the serum and tissues, and upregulated the divalent metal transporter 1 expression in the rat duodenum. The iron-sufficient and iron-deficient rats were then exposed to welding fumes generated from manual metal arc stainless steel at a concentration of 63.5 +/- 2.3 mg/cu m for 2 hr per day over a 30-day period. Animals were sacrificed on days 1, 15, and 30. The level of body iron in the iron-deficient rats was restored to the control level after the welding-fume exposure. However, the tissue distributions of manganese after the welding-fume exposure showed similar patterns in both the iron-sufficient and iron-deficient groups. The concentration of manganese increased in the lungs and liver on days 15 and 30, and increased in the olfactory bulb on day 30. Slight and heterogeneous increases of manganese were observed in different brain regions. Consequently, these findings suggest that the presence of Fe in the inhaled welding fumes may not have a significant effect on the uptake of Mn into the brain. Thus, the condition of iron deficiency did not seem to have any apparent effect on the transport of Mn into the brain after the inhalation of welding fumes.

PMID:17497534 Park JD et al; Inhal Toxicol 19 (6-7): 563-72 (2007)

... To investigate the movement of manganese after welding-fume exposure, six cynomolgus monkeys were acclimated and assigned to three dose groups: unexposed, low dose (31 mg/cu m total suspended particulate [TSP], 0.9 mg/cu m of Mn), and high dose (62 mg/cu m TSP, 1.95 mg/cu m of Mn) of total suspended particulate. The primates were exposed to manual metal arc stainless steel (MMA-SS) welding fumes for 2 hr per day in an inhalation chamber system equipped with an automatic fume generator. Magnetic resonance imaging (MRI) studies were conducted before the initiation of exposure and thereafter every month. The tissue Mn concentrations were then measured after a plateau was reached regarding the shortening of the MRI T1 relaxation time. A dose-dependent increase in the Mn concentration was found in the lungs, while noticeable increases in the Mn concentrations were found in certain tissues, such as the liver, kidneys, and testes. Slight increases in the Mn concentrations were found in the caudate, putamen, frontal lobe, and substantia nigra, while a dose-dependent noticeable increase was only found in the globus pallidus. Therefore, the present results indicated that a shortening of the MRI T1 relaxation time corresponded well with the Mn concentration in the globus pallidus after prolonged welding-fume exposure.

PMID:17849280 Park JD et al; Inhal Toxicol 19 (11): 965-71 (2007)

4.3 Biological Half-Life

Whole body: 2-5 weeks depending on body stores; [TDR, p. 803]

TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 803

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