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2 RELATED EXCIPIENT COMPANIES

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 359875-09-5, Cerenia, Maropitant citrate hydrate, Maropitant citrate [usan], Cj-11,972, Maropitant citrate monohydrate
Molecular Formula
C38H50N2O9
Molecular Weight
678.8  g/mol
InChI Key
PGVSXRHFXJOMGW-YBZGWEFGSA-N
FDA UNII
LXN6S3999X

Maropitant
Maropitant Citrate is a neurokinin receptor antagonist with antiemetic activity. This agent is approved for veterinary use only.
1 2D Structure

Maropitant

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate
2.1.2 InChI
InChI=1S/C32H40N2O.C6H8O7.H2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10;/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2/t30-,31-;;/m0../s1
2.1.3 InChI Key
PGVSXRHFXJOMGW-YBZGWEFGSA-N
2.1.4 Canonical SMILES
CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O
2.1.5 Isomeric SMILES
CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O
2.2 Other Identifiers
2.2.1 UNII
LXN6S3999X
2.3 Synonyms
2.3.1 MeSH Synonyms

1. (2s,2s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

2. (2s,3s)-2-benzhydryl-n-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate Hydrate

3. (2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

4. 2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

5. Maropitant

2.3.2 Depositor-Supplied Synonyms

1. 359875-09-5

2. Cerenia

3. Maropitant Citrate Hydrate

4. Maropitant Citrate [usan]

5. Cj-11,972

6. Maropitant Citrate Monohydrate

7. Lxn6s3999x

8. Cj-11972

9. Maropitant Citrate (usan)

10. (2s,3s)-2-benzhydryl-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine Citrate Hydrate

11. (2s,3s)-n-(5-(1,1-dimethylethyl)-2-methoxybenzyl)-2-(diphenylmethyl)-1-azabicyclo(2.2.2)octan-3-amine 2-hydroxy-1,2,3-propanetricarboxylate (1:1), Monohydrate

12. 1-azabicyclo(2.2.2)octan-3-amine, N-((5-(1,1-dimethylethyl)-2-methoxyphenyl)methyl)-2-(diphenylmethyl)-, (2s,3s)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), Monohydrate

13. Unii-lxn6s3999x

14. Starbld0016570

15. Schembl4184310

16. Chembl2107353

17. Dtxsid70957411

18. Ex-a3585

19. Bs-49286

20. Maropitant Citrate Monohydrate [mi]

21. D04860

22. E83993

23. Maropitant Citrate [ema Epar Veterinary]

24. (2-benzhydryl-1-aza-bicyclo(2.2.2)oct-3-yl)-(5-tert-butyl-2-methoxybenzyl)amine

25. (2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl) Quinuclidin-3-amine Citrate Monohydrate

26. (2s,3s)-2-benzhydryl-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;2-hydroxypropane-1,2,3-tricarboxylic Acid;hydrate

27. 2-hydroxypropane-1,2,3-tricarboxylic Acid--n-[(5-tert-butyl-2-methoxyphenyl)methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine--water (1/1/1)

2.4 Create Date
2005-08-09
3 Chemical and Physical Properties
Molecular Weight 678.8 g/mol
Molecular Formula C38H50N2O9
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count11
Rotatable Bond Count13
Exact Mass678.35163118 g/mol
Monoisotopic Mass678.35163118 g/mol
Topological Polar Surface Area158 Ų
Heavy Atom Count49
Formal Charge0
Complexity848
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

* Tablets:

Dogs:

- For the prevention of nausea induced by chemotherapy.

- For the prevention of vomiting induced by motion sickness.

- For the prevention and treatment of vomiting, in conjunction with Cerenia solution for injection and in combination with other supportive measures.

* Solution for injection:

Dogs:

- For the treatment and prevention of nausea induced by chemotherapy.

- For the prevention of vomiting except that induced by motion sickness.

- For the treatment of vomiting, in combination with other supportive measures.

- For the prevention of perioperative nausea and vomiting and improvement in recovery from general anaesthesia after use of the -opiate receptor agonist morphine.

Cats:

- For the prevention of vomiting and the reduction of nausea, except that induced by motion sickness.

- For the treatment of vomiting, in combination with other supportive measures.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)


5.2 ATC Code

QA04AD90


API Reference Price

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06-Apr-2021
18-Oct-2024
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Quantity (KGS) & Unit rate (USD/KGS) over time

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ABOUT THIS PAGE

Looking for 359875-09-5 / Maropitant API manufacturers, exporters & distributors?

Maropitant manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Maropitant API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Maropitant manufacturer or Maropitant supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Maropitant manufacturer or Maropitant supplier.

PharmaCompass also assists you with knowing the Maropitant API Price utilized in the formulation of products. Maropitant API Price is not always fixed or binding as the Maropitant Price is obtained through a variety of data sources. The Maropitant Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Maropitant

Synonyms

359875-09-5, Cerenia, Maropitant citrate hydrate, Maropitant citrate [usan], Cj-11,972, Maropitant citrate monohydrate

Cas Number

359875-09-5

Unique Ingredient Identifier (UNII)

LXN6S3999X

About Maropitant

Maropitant Citrate is a neurokinin receptor antagonist with antiemetic activity. This agent is approved for veterinary use only.

Maropitant Manufacturers

A Maropitant manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Maropitant, including repackagers and relabelers. The FDA regulates Maropitant manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Maropitant API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Maropitant manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Maropitant Suppliers

A Maropitant supplier is an individual or a company that provides Maropitant active pharmaceutical ingredient (API) or Maropitant finished formulations upon request. The Maropitant suppliers may include Maropitant API manufacturers, exporters, distributors and traders.

click here to find a list of Maropitant suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Maropitant NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Maropitant as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Maropitant API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Maropitant as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Maropitant and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Maropitant NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Maropitant suppliers with NDC on PharmaCompass.

Maropitant GMP

Maropitant Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Maropitant GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Maropitant GMP manufacturer or Maropitant GMP API supplier for your needs.

Maropitant CoA

A Maropitant CoA (Certificate of Analysis) is a formal document that attests to Maropitant's compliance with Maropitant specifications and serves as a tool for batch-level quality control.

Maropitant CoA mostly includes findings from lab analyses of a specific batch. For each Maropitant CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Maropitant may be tested according to a variety of international standards, such as European Pharmacopoeia (Maropitant EP), Maropitant JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Maropitant USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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