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Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

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CHEMISTRY
Discover Molecule Insights

ACTIVE PHARMA INGREDIENTS

6 API Suppliers, 2 NDC API, 10 VMF, 6 Listed Suppliers, $ API Reference Price

6 API Suppliers
2 NDC API
10 VMF
6 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

6 FDF Dossiers, 6 Canada

6 FDF Dossiers
6 Canada

RELATED EXCIPIENT COMPANIES

1 Capital Farma, 1 Gangwal Chemicals

relatedExcipients
1 Capital Farma
1 Gangwal Chemicals

EXCIPIENTS BY APPLICATIONS

2 Parenteral, 1 Dry Powder Inhalation, 1 Solubilizers, 1 Taste Masking, 1 Emulsifying Agents, 1 Thickeners and Stabilizers

excipientsByApplications
2 Parenteral
1 Dry Powder Inhalation
1 Solubilizers
1 Taste Masking
1 Emulsifying Agents
1 Thickeners and Stabilizers

MARKET PLACE

6 APIs

marketPlace
6 APIs

PATENTS & EXCLUSIVITIES

11 Health Canada Patents

patents
11 Health Canada Patents

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

7EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: 359875-09-5, Cerenia, Maropitant citrate hydrate, Maropitant citrate [usan], Cj-11,972, Maropitant citrate monohydrate

Molecular Formula

C₃₈H₅₀N₂O₉

Molecular Weight

678.8 g/mol

InChI Key

PGVSXRHFXJOMGW-YBZGWEFGSA-N

FDA UNII

LXN6S3999X

Maropitant Citrate is a neurokinin receptor antagonist with antiemetic activity. This agent is approved for veterinary use only.

1 2D Structure

Maropitant

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;2-hydroxypropane-1,2,3-tricarboxylic acid;hydrate

2.1.2 InChI

InChI=1S/C32H40N2O.C6H8O7.H2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10;/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2/t30-,31-;;/m0../s1

2.1.3 InChI Key

PGVSXRHFXJOMGW-YBZGWEFGSA-N

2.1.4 Canonical SMILES

CC(C)(C)C1=CC(=C(C=C1)OC)CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O

2.1.5 Isomeric SMILES

CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5.C(C(=O)O)C(CC(=O)O)(C(=O)O)O.O

2.2 Other Identifiers

2.2.1 UNII

LXN6S3999X

2.3 Synonyms

2.3.1 MeSH Synonyms

1. (2s,2s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

2. (2s,3s)-2-benzhydryl-n-(5-(tert-butyl)-2-methoxybenzyl)quinuclidin-3-amine 2-hydroxypropane-1,2,3-tricarboxylate Hydrate

3. (2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

4. 2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine Citrate Monohydrate

5. Maropitant

2.3.2 Depositor-Supplied Synonyms

1. 359875-09-5

2. Cerenia

3. Maropitant Citrate Hydrate

4. Maropitant Citrate [usan]

5. Cj-11,972

6. Maropitant Citrate Monohydrate

7. Lxn6s3999x

8. Cj-11972

9. Maropitant Citrate (usan)

10. (2s,3s)-2-benzhydryl-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine Citrate Hydrate

11. (2s,3s)-n-(5-(1,1-dimethylethyl)-2-methoxybenzyl)-2-(diphenylmethyl)-1-azabicyclo(2.2.2)octan-3-amine 2-hydroxy-1,2,3-propanetricarboxylate (1:1), Monohydrate

12. 1-azabicyclo(2.2.2)octan-3-amine, N-((5-(1,1-dimethylethyl)-2-methoxyphenyl)methyl)-2-(diphenylmethyl)-, (2s,3s)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), Monohydrate

13. Unii-lxn6s3999x

14. Starbld0016570

15. Schembl4184310

16. Chembl2107353

17. Dtxsid70957411

18. Ex-a3585

19. Bs-49286

20. Maropitant Citrate Monohydrate [mi]

21. D04860

22. E83993

23. Maropitant Citrate [ema Epar Veterinary]

24. (2-benzhydryl-1-aza-bicyclo(2.2.2)oct-3-yl)-(5-tert-butyl-2-methoxybenzyl)amine

25. (2s,3s)-2-benzhydryl-n-(5-tert-butyl-2-methoxybenzyl) Quinuclidin-3-amine Citrate Monohydrate

26. (2s,3s)-2-benzhydryl-n-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine;2-hydroxypropane-1,2,3-tricarboxylic Acid;hydrate

27. 2-hydroxypropane-1,2,3-tricarboxylic Acid--n-[(5-tert-butyl-2-methoxyphenyl)methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine--water (1/1/1)

2.4 Create Date

2005-08-09

3 Chemical and Physical Properties

Molecular Formula	C₃₈H₅₀N₂O₉
Molecular Weight	678.8 g/mol
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	13
Exact Mass	678.35163118 g/mol
Monoisotopic Mass	678.35163118 g/mol
Topological Polar Surface Area	158 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	848
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Indication

* Tablets:

Dogs:

- For the prevention of nausea induced by chemotherapy.

- For the prevention of vomiting induced by motion sickness.

- For the prevention and treatment of vomiting, in conjunction with Cerenia solution for injection and in combination with other supportive measures.

* Solution for injection:

Dogs:

- For the treatment and prevention of nausea induced by chemotherapy.

- For the prevention of vomiting except that induced by motion sickness.

- For the treatment of vomiting, in combination with other supportive measures.

- For the prevention of perioperative nausea and vomiting and improvement in recovery from general anaesthesia after use of the -opiate receptor agonist morphine.

Cats:

- For the prevention of vomiting and the reduction of nausea, except that induced by motion sickness.

- For the treatment of vomiting, in combination with other supportive measures.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

5.2 ATC Code

QA04AD90

API SUPPLIERS

01

ChemWerth Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

CPhI WW Frankfurt

Booth #12.1F43

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

02

Rochem International Inc

U.S.A

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Suppliers Night Expo

Attending

Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF VMF

AUDIT

03

Suanfarma

Spain

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DCAT Week

Attending

Suanfarma, at the Core of a Better Life.

Contact Supplier

Spain

Virtual Booth

Digital Content

USDMF CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT

04

Alivira Animal Health

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

05

Sichuan Qingmu Pharmaceutical

China

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

06

Medilux Laboratories

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

DDL Conference

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

NDC API

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

VMF

01

Procos Spa

Italy

AES 2024

Not Confirmed

02

Procos Spa

Italy

AES 2024

Not Confirmed

03

Shandong Chuancheng Pharma Co Ltd

China

AES 2024

Not Confirmed

04

Shandong Chuancheng Pharma Co Ltd

China

AES 2024

Not Confirmed

05

Sichuan Qingmu Pharmaceutical Co Ltd

China

AES 2024

Not Confirmed

06

Wisdom Pharmaceutical Co Ltd

China

AES 2024

Not Confirmed

07

Wisdom Pharmaceutical Co Ltd

China

AES 2024

Not Confirmed

08

Zoetis Inc

U.S.A

AES 2024

Not Confirmed

09

Zoetis Inc

U.S.A

AES 2024

Not Confirmed

10

Zoetis Inc

U.S.A

AES 2024

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

Listed Suppliers

01

ChemWerth Inc

U.S.A

CPhI WW Frankfurt

Booth #12.1F43

ChemWerth works in generic API development & supply, non-infringement patent strategy development and regulatory support.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Maropitant

About the Company : Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs ...

Established in 1982, ChemWerth is a US-headquartered full-service generic active pharmaceutical ingredient (API) development and supply company. ChemWerth offers cGMP-quality APIs to regulated markets worldwide and has exclusive partnerships for new product development, compliance support and secure supply chain logistics. ChemWerth has access to over 500 APIs and more than 30 manufacturing facilities in the US, Europe, India and China. ChemWerth acts as a regulatory agent for over 25 FDA-approved facilities and sells more than 100 products. It has established its presence in 38 countries. In 2020, ChemWerth filed its 500th DMF with the FDA.

02

Rochem International Inc

U.S.A

Suppliers Night Expo

Attending

Rochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

Contact Supplier

U.S.A

Virtual Booth

Digital Content

Maropitant

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.

03

Suanfarma

Spain

DCAT Week

Attending

Suanfarma, at the Core of a Better Life.

Contact Supplier

Spain

Virtual Booth

Digital Content

Maropitant

About the Company : Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical indu...

Suanfarma founded in 1993, is a B2B life science partner committed to health & innovation by developing, manufacturing, & distributing high-quality APIs for the pharmaceutical industry innovatively & sustainably. Backed by a robust global network of 12 strategically located local offices, we cater to the needs of over 400 active customers in 70+ countries. At Suanfarma we offer our CDMO capacity for fermentation & chemical synthesis projects, offering a One Stop Shop service with a solid track record, & which allows us to achieve success in the development, scaling, manufacturing, & commercialization of an API, either innovative or generic.

04

Alivira Animal Health

India

DDL Conference

Not Confirmed

05

Medilux Laboratories

India

DDL Conference

Not Confirmed

06

Sichuan Qingmu Pharmaceutical

China

DDL Conference

Not Confirmed

FULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

API Reference Price

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BAMBOO,GACHIB","city":"HYDERABAD,TELANGANA","supplier":"PROCOS","supplierCountry":"ITALY","foreign_port":"N\/A","customer":"CRONUS PHARMA SPECIALITIES ","customerCountry":"INDIA","quantity":"2.00","actualQuantity":"2","unit":"KGS","unitRateFc":"7500","totalValueFC":"14939.7","currency":"USD","unitRateINR":"556125","date":"06-Apr-2021","totalValueINR":"1112250","totalValueInUsd":"14939.7","indian_port":"GMR HYDERABAD AVIATION-SEZ","hs_no":"29333990","bill_no":"1001878","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"VIA MATTEOTTI 249 28062 CAMERI 0 ITALY","customerAddress":"PLOT NO-51,MEENAKSHI BAMBOO,GACHIB"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q3","strtotime":1627929000,"product":"MAROPITANT CITRATE MONOHYDRATE","address":"B2-B 10TH FLAT PLOT NO.27,SECTOR-1","city":"DWARKA NEW 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LTD.","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"REYAANSH HEALTHCARE","customerCountry":"INDIA","quantity":"0.16","actualQuantity":"0.155","unit":"KGS","unitRateFc":"9600","totalValueFC":"1522","currency":"USD","unitRateINR":"740640","date":"18-Dec-2021","totalValueINR":"114799.2","totalValueInUsd":"1522","indian_port":"BOMBAY AIR","hs_no":"29333990","bill_no":"6737242","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"","customerAddress":"F 43 DEOLALI PLAZA, LAM ROAD DEOLALI CAMP, DEOLALI Contact No: 9"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1639765800,"product":"MAROPITANT CITRATE","address":"F 43 DEOLALI PLAZA, LAM ROAD DEOLALI CAMP, DEOLALI Contact No: 9","city":"NASIK","supplier":"SHANGHAI MULTI-MED UNION CO., LTD.","supplierCountry":"CHINA","foreign_port":"N\/A","customer":"REYAANSH 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","customerCountry":"INDIA","quantity":"0.45","actualQuantity":"0.45","unit":"KGS","unitRateFc":"6666.7","totalValueFC":"3043.7","currency":"USD","unitRateINR":"507000","date":"19-Feb-2022","totalValueINR":"228150","totalValueInUsd":"3043.7","indian_port":"BOMBAY AIR","hs_no":"29334900","bill_no":"7562819","productDescription":"API","marketType":"REGULATED MARKET","country":"ITALY","selfForZScoreResived":"Pharma Grade","supplierPort":"NA","supplierAddress":"","customerAddress":"3 AMARPARK APARTMENT, 1205\/2\/1 SHIROLE ROAD, SHIVAJI NAGAR Contact"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q2","strtotime":1651775400,"product":"MAROPITANT CITRATE MONOHYDRATE - (MAROPITANT CITRATE )","address":"3 AMARPARK APARTMENT, 1205\/2\/1 SHIROLE ROAD, SHIVAJI NAGAR Contact","city":"PUNE","supplier":"PROCOS","supplierCountry":"ITALY","foreign_port":"NA","customer":"VEKO CARE PRIVATE 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