Find Masitinib Mesylate manufacturers, exporters & distributors on PharmaCompass

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Synopsis

Synopsis

ACTIVE PHARMA INGREDIENTS

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USDMF

US DMFs Filed

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CEP/COS

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JDMF

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FDF

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Chemistry

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Also known as: 1048007-93-7, Masitinib (mesylate), Masivet, Ab-1010 mesylate, Masitinib mesilate, Ab 1010 mesylate
Molecular Formula
C29H34N6O4S2
Molecular Weight
594.8  g/mol
InChI Key
TXCWBWKVIZGWEQ-UHFFFAOYSA-N
FDA UNII
ZK89EG3A18

Masitinib Mesylate
Masitinib Mesylate is the orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).
1 2D Structure

Masitinib Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide
2.1.2 InChI
InChI=1S/C28H30N6OS.CH4O3S/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34;1-5(2,3)4/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32);1H3,(H,2,3,4)
2.1.3 InChI Key
TXCWBWKVIZGWEQ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
ZK89EG3A18
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide

2. Ab 1010

3. Ab-1010

4. Ab1010

5. Kinavet

6. Kinavet Ca-1

7. Masatinib

8. Masican

9. Masitinib

10. Masitinib Mesilate

11. Masitinib Methanesulfonate

12. Masivet

13. Masiviera

2.3.2 Depositor-Supplied Synonyms

1. 1048007-93-7

2. Masitinib (mesylate)

3. Masivet

4. Ab-1010 Mesylate

5. Masitinib Mesilate

6. Ab 1010 Mesylate

7. Kinavet

8. Zk89eg3a18

9. Masican

10. Masiviera

11. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-pyridin-3-yl-1,3-thiazol-2-yl)amino)phenyl)benzamide Methanesulfonate

12. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-pyridin-3-yl-1,3-thiazol-2-yl)amino)phenyl)benzamide Methanesulphonate

13. 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-phenyl]-benzamide Methanesulfonate

14. Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-n-(4-methyl-3-((4-(3-pyridinyl)-2-thiazolyl)amino)phenyl)-, Methanesulfonate (1:1)

15. Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-n-(4-methyl-3-((4-(3-pyridinyl)-2-thiazolyl)amino)phenyl)-, Methanesulphonate (1:1)

16. 4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide Mesylate

17. 928671-85-6

18. Methanesulfonic Acid;4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

19. Unii-zk89eg3a18

20. Masitinibmesylate

21. Schembl1096348

22. Dtxsid70146747

23. Bcp30695

24. Ex-a3996

25. Masitinib Mesilate [who-dd]

26. Yrb00793

27. Hy-10209a

28. Cs-1593

29. Masitinib Mesylate [green Book]

30. Masitinib Methanesulfonate [mi]

31. Sb14845

32. Ac-30896

33. As-56731

34. Ft-0707180

35. C71194

36. Masitinib Mesylate [ema Epar Veterinary]

37. A927557

38. Q27295645

39. Ab1010 Mesylate;ab-1010 Mesylate;ab 1010 Mesylate

40. Masitinib Mesylate Salt; Masitinib Mesilate;ab 1010 Mesylate Pound>>ab1010 Mesylate Pound>>ab-1010 Mesylate

41. N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Methanesulfonate

42. N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Methanesulfonate;

2.4 Create Date
2008-11-17
3 Chemical and Physical Properties
Molecular Weight 594.8 g/mol
Molecular Formula C29H34N6O4S2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass594.20829593 g/mol
Monoisotopic Mass594.20829593 g/mol
Topological Polar Surface Area164 Ų
Heavy Atom Count41
Formal Charge0
Complexity788
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Drug and Medication Information
4.1 Drug Indication

Treatment of amyotrophic lateral sclerosis.


Treatment of mastocytosis


Treatment of non resectable locally advanced or metastatic pancreatic cancer


Treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST)


Treatment of non-resectable dog mast-cell tumours (grade 2 or 3) with confirmed mutated c-KIT tyrosine-kinase receptor.


Treatment of mastocytosis


Treatment of gastro-intestinal stromal tumours


Treatment of amyotrophic lateral sclerosis


5 Pharmacology and Biochemistry
5.1 ATC Code

L01XE22


L01XE22


L01XE


L01XE


QL01XE90


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ABOUT THIS PAGE

Masitinib Manufacturers

A Masitinib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Masitinib, including repackagers and relabelers. The FDA regulates Masitinib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Masitinib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Masitinib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Masitinib Suppliers

A Masitinib supplier is an individual or a company that provides Masitinib active pharmaceutical ingredient (API) or Masitinib finished formulations upon request. The Masitinib suppliers may include Masitinib API manufacturers, exporters, distributors and traders.

click here to find a list of Masitinib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Masitinib GMP

Masitinib Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Masitinib GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Masitinib GMP manufacturer or Masitinib GMP API supplier for your needs.

Masitinib CoA

A Masitinib CoA (Certificate of Analysis) is a formal document that attests to Masitinib's compliance with Masitinib specifications and serves as a tool for batch-level quality control.

Masitinib CoA mostly includes findings from lab analyses of a specific batch. For each Masitinib CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Masitinib may be tested according to a variety of international standards, such as European Pharmacopoeia (Masitinib EP), Masitinib JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Masitinib USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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