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Also known as: 1048007-93-7, Masitinib (mesylate), Masivet, Ab-1010 mesylate, Masitinib mesilate, Ab 1010 mesylate

Molecular Formula

C₂₉H₃₄N₆O₄S₂

Molecular Weight

594.8 g/mol

InChI Key

TXCWBWKVIZGWEQ-UHFFFAOYSA-N

FDA UNII

ZK89EG3A18

Masitinib Mesylate is the orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs).

1 2D Structure

Masitinib Mesylate

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

methanesulfonic acid;4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

2.1.2 InChI

InChI=1S/C28H30N6OS.CH4O3S/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34;1-5(2,3)4/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32);1H3,(H,2,3,4)

2.1.3 InChI Key

TXCWBWKVIZGWEQ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5.CS(=O)(=O)O

2.2 Other Identifiers

2.2.1 UNII

ZK89EG3A18

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-(pyridin-3-yl)-1,3-thiazol-2-yl)amino)phenyl)benzamide

2. Ab 1010

3. Ab-1010

4. Ab1010

5. Kinavet

6. Kinavet Ca-1

7. Masatinib

8. Masican

9. Masitinib

10. Masitinib Mesilate

11. Masitinib Methanesulfonate

12. Masivet

13. Masiviera

2.3.2 Depositor-Supplied Synonyms

1. 1048007-93-7

2. Masitinib (mesylate)

3. Masivet

4. Ab-1010 Mesylate

5. Masitinib Mesilate

6. Ab 1010 Mesylate

7. Kinavet

8. Zk89eg3a18

9. Masican

10. Masiviera

11. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-pyridin-3-yl-1,3-thiazol-2-yl)amino)phenyl)benzamide Methanesulfonate

12. 4-((4-methylpiperazin-1-yl)methyl)-n-(4-methyl-3-((4-pyridin-3-yl-1,3-thiazol-2-yl)amino)phenyl)benzamide Methanesulphonate

13. 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-phenyl]-benzamide Methanesulfonate

14. Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-n-(4-methyl-3-((4-(3-pyridinyl)-2-thiazolyl)amino)phenyl)-, Methanesulfonate (1:1)

15. Benzamide, 4-((4-methyl-1-piperazinyl)methyl)-n-(4-methyl-3-((4-(3-pyridinyl)-2-thiazolyl)amino)phenyl)-, Methanesulphonate (1:1)

16. 4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide Mesylate

17. 928671-85-6

18. Methanesulfonic Acid;4-[(4-methylpiperazin-1-yl)methyl]-n-[4-methyl-3-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzamide

19. Unii-zk89eg3a18

20. Masitinibmesylate

21. Schembl1096348

22. Dtxsid70146747

23. Bcp30695

24. Ex-a3996

25. Masitinib Mesilate [who-dd]

26. Yrb00793

27. Hy-10209a

28. Cs-1593

29. Masitinib Mesylate [green Book]

30. Masitinib Methanesulfonate [mi]

31. Sb14845

32. Ac-30896

33. As-56731

34. Ft-0707180

35. C71194

36. Masitinib Mesylate [ema Epar Veterinary]

37. A927557

38. Q27295645

39. Ab1010 Mesylate;ab-1010 Mesylate;ab 1010 Mesylate

40. Masitinib Mesylate Salt; Masitinib Mesilate;ab 1010 Mesylate Pound>>ab1010 Mesylate Pound>>ab-1010 Mesylate

41. N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Methanesulfonate

42. N-(4-methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide Methanesulfonate;

2.4 Create Date

2008-11-17

3 Chemical and Physical Properties

Molecular Formula	C₂₉H₃₄N₆O₄S₂
Molecular Weight	594.8 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	7
Exact Mass	594.20829593 g/mol
Monoisotopic Mass	594.20829593 g/mol
Topological Polar Surface Area	164 Å²
Heavy Atom Count	41
Formal Charge	0
Complexity	788
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Indication

Treatment of amyotrophic lateral sclerosis.

Treatment of mastocytosis

Treatment of non resectable locally advanced or metastatic pancreatic cancer

Treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST)

Treatment of non-resectable dog mast-cell tumours (grade 2 or 3) with confirmed mutated c-KIT tyrosine-kinase receptor.

Treatment of mastocytosis

Treatment of gastro-intestinal stromal tumours

Treatment of amyotrophic lateral sclerosis

5 Pharmacology and Biochemistry

5.1 ATC Code

L01XE22

L01XE

QL01XE90

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