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Chemistry

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Also known as: Camzyos, 1642288-47-8, Mavacamten [inn], Mavacamten [usan], Mavacamten [who-dd], Myk-461
Molecular Formula
C15H19N3O2
Molecular Weight
273.33  g/mol
InChI Key
RLCLASQCAPXVLM-NSHDSACASA-N
FDA UNII
QX45B99R3J

Mavacamten
Mavacamten is under investigation in clinical trial NCT03442764 (A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)).
1 2D Structure

Mavacamten

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
2.1.2 InChI
InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
2.1.3 InChI Key
RLCLASQCAPXVLM-NSHDSACASA-N
2.1.4 Canonical SMILES
CC(C)N1C(=O)C=C(NC1=O)NC(C)C2=CC=CC=C2
2.1.5 Isomeric SMILES
C[C@@H](C1=CC=CC=C1)NC2=CC(=O)N(C(=O)N2)C(C)C
2.2 Other Identifiers
2.2.1 UNII
QX45B99R3J
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Myk-461

2.3.2 Depositor-Supplied Synonyms

1. Camzyos

2. 1642288-47-8

3. Mavacamten [inn]

4. Mavacamten [usan]

5. Mavacamten [who-dd]

6. Myk-461

7. 6-[[(1s)-1-phenylethyl]amino]-3-propan-2-yl-1h-pyrimidine-2,4-dione

8. Qx45b99r3j

9. Sar-439152

10. (s)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1h,3h)-dione

11. Sar439152

12. 2,4(1h,3h)-pyrimidinedione, 3-(1-methylethyl)-6-(((1s)-1-phenylethyl)amino)-

13. 2,4(1h,3h)-pyrimidinedione, 3-(1-methylethyl)-6-[[(1s)-1-phenylethyl]amino]-

14. Mavacamten (myk-461)

15. Unii-qx45b99r3j

16. Myk461

17. Chembl4297517

18. Schembl16320785

19. Gtpl11265

20. Ex-a2072

21. Bdbm50575174

22. S8861

23. Who 10492

24. Db14921

25. Myk-461; Mavacamten; Sar439152

26. Sar-439152; Myk-461

27. Hy-109037

28. Cs-0031211

29. E83742

30. (s)-3-isopropyl-6-((1-phenylethyl)amino) Pyrimidine-2,4(1h,3h)-dione

31. (s)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2, 4(1h,3h)-dione

32. (s)-3-isopropyl-6-(1-phenylethylamino)pyrimidine-2,4(1h,3h)-dione

33. 3-(1-methylethyl)-6-[[(1s)-1-phenylethyl]amino]-2,4(1h,3h)-pyrimidinedione

34. 6-(((1s)-1-phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 Tetrahydropyrimidine-2,4-dione

35. 6-{[(1s)-1-phenylethyl]amino}-3-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione

2.4 Create Date
2016-02-23
3 Chemical and Physical Properties
Molecular Weight 273.33 g/mol
Molecular Formula C15H19N3O2
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass273.147726857 g/mol
Monoisotopic Mass273.147726857 g/mol
Topological Polar Surface Area61.4 Ų
Heavy Atom Count20
Formal Charge0
Complexity411
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Treatment of hypertrophic cardiomyopathy


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