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    Bora Pharmaceuticals- Making success more certain.

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    Polfa Tarchomin is a leading Polish pharmaceutical company with 200 year tradition in manufacture and sale of pharmaceutical products.

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    Moehs Mavacamten

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    Axplora- The partner of choice for complex APIs.

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    Fareva is a one-stop-shop for API/HPAPI, OSD & Sterile products, is USFDA, EMA and PMDA-inspected and has multiple NDA & ANDA filings.

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    Chemistry

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    Also known as: Camzyos, 1642288-47-8, Mavacamten [inn], Mavacamten [usan], Mavacamten [who-dd], Myk-461
    Molecular Formula
    C15H19N3O2
    Molecular Weight
    273.33  g/mol
    InChI Key
    RLCLASQCAPXVLM-NSHDSACASA-N
    FDA UNII
    QX45B99R3J
    Mavacamten
    Mavacamten is under investigation in clinical trial NCT03442764 (A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)).
    1 2D Structure

    Mavacamten

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-[[(1S)-1-phenylethyl]amino]-3-propan-2-yl-1H-pyrimidine-2,4-dione
    2.1.2 InChI
    InChI=1S/C15H19N3O2/c1-10(2)18-14(19)9-13(17-15(18)20)16-11(3)12-7-5-4-6-8-12/h4-11,16H,1-3H3,(H,17,20)/t11-/m0/s1
    2.1.3 InChI Key
    RLCLASQCAPXVLM-NSHDSACASA-N
    2.1.4 Canonical SMILES
    CC(C)N1C(=O)C=C(NC1=O)NC(C)C2=CC=CC=C2
    2.1.5 Isomeric SMILES
    C[C@@H](C1=CC=CC=C1)NC2=CC(=O)N(C(=O)N2)C(C)C
    2.2 Other Identifiers
    2.2.1 UNII
    QX45B99R3J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Myk-461

    2.3.2 Depositor-Supplied Synonyms

    1. Camzyos

    2. 1642288-47-8

    3. Mavacamten [inn]

    4. Mavacamten [usan]

    5. Mavacamten [who-dd]

    6. Myk-461

    7. 6-[[(1s)-1-phenylethyl]amino]-3-propan-2-yl-1h-pyrimidine-2,4-dione

    8. Qx45b99r3j

    9. Sar-439152

    10. (s)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1h,3h)-dione

    11. Sar439152

    12. 2,4(1h,3h)-pyrimidinedione, 3-(1-methylethyl)-6-(((1s)-1-phenylethyl)amino)-

    13. 2,4(1h,3h)-pyrimidinedione, 3-(1-methylethyl)-6-[[(1s)-1-phenylethyl]amino]-

    14. Mavacamten (myk-461)

    15. Unii-qx45b99r3j

    16. Myk461

    17. Chembl4297517

    18. Schembl16320785

    19. Gtpl11265

    20. Ex-a2072

    21. Bdbm50575174

    22. S8861

    23. Who 10492

    24. Db14921

    25. Myk-461; Mavacamten; Sar439152

    26. Sar-439152; Myk-461

    27. Hy-109037

    28. Cs-0031211

    29. E83742

    30. (s)-3-isopropyl-6-((1-phenylethyl)amino) Pyrimidine-2,4(1h,3h)-dione

    31. (s)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2, 4(1h,3h)-dione

    32. (s)-3-isopropyl-6-(1-phenylethylamino)pyrimidine-2,4(1h,3h)-dione

    33. 3-(1-methylethyl)-6-[[(1s)-1-phenylethyl]amino]-2,4(1h,3h)-pyrimidinedione

    34. 6-(((1s)-1-phenylethyl)amino)-3-(propan-2-yl)-1,2,3,4 Tetrahydropyrimidine-2,4-dione

    35. 6-{[(1s)-1-phenylethyl]amino}-3-(propan-2-yl)pyrimidine-2,4(1h,3h)-dione

    2.4 Create Date
    2016-02-23
    3 Chemical and Physical Properties
    Molecular Weight 273.33 g/mol
    Molecular Formula C15H19N3O2
    XLogP32.1
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count4
    Exact Mass273.147726857 g/mol
    Monoisotopic Mass273.147726857 g/mol
    Topological Polar Surface Area61.4 Ų
    Heavy Atom Count20
    Formal Charge0
    Complexity411
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of hypertrophic cardiomyopathy

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    Mavacamten Manufacturers, Traders, Suppliers 1
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    We have 10 companies offering Mavacamten

    Get in contact with the supplier of your choice:

    1. Inke S.A
    2. Metrochem API Private Limited
    3. Nuray Chemicals Private Limited
    4. Dr. Reddy\'s Laboratories
    5. Moehs Iberica
    6. Shandong Chenghui Shuangda Pharmaceutical
    7. Shandong Loncom Pharmaceutical
    8. Maithri Drugs
    9. Morepen Laboratories
    10. MSN Laboratories
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