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    Chemistry

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    Also known as: 2753-45-9, Mebeverine hcl, Duspatalin, Colofac, Csag-144, Csag 144
    Molecular Formula
    C25H36ClNO5
    Molecular Weight
    466.0  g/mol
    InChI Key
    PLGQWYOULXPJRE-UHFFFAOYSA-N
    FDA UNII
    15VZ5AL4JN
    Mebeverine
    Mebeverine Hydrochloride is the hydrochloride salt form of mebeverine, an orally bioavailable reserpine derivative and anticholinergic agent, with spasmolytic activity. Upon administration, mebeverine targets, binds to and blocks the muscarinic receptors on smooth muscle cells in target tissues, such as the gastrointestinal (GI) tract, uterus, gallbladder and bladder. This prevents smooth muscle contraction and relaxes smooth muscle. Additionally, this may prevent spasms, ease pain and cramps in the GI tract and improve incontinence. In addition, mebeverine stabilizes excitable membranes by decreasing the permeability of ion channels and preventing intracellular calcium accumulation. This agent also blocks noradrenaline reuptake by sympathetic nerve endings and exerts a local anesthetic effect.
    1 2D Structure

    Mebeverine

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate;hydrochloride
    2.1.2 InChI
    InChI=1S/C25H35NO5.ClH/c1-6-26(19(2)17-20-9-12-22(28-3)13-10-20)15-7-8-16-31-25(27)21-11-14-23(29-4)24(18-21)30-5;/h9-14,18-19H,6-8,15-17H2,1-5H3;1H
    2.1.3 InChI Key
    PLGQWYOULXPJRE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CCCCOC(=O)C1=CC(=C(C=C1)OC)OC)C(C)CC2=CC=C(C=C2)OC.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    15VZ5AL4JN
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4-(ethyl-(4-methoxy-alpha-methylphenethyl)aminobutyl) Veratrate

    2. Duspatalin

    3. Mebeverine

    4. Spasmotalin

    2.3.2 Depositor-Supplied Synonyms

    1. 2753-45-9

    2. Mebeverine Hcl

    3. Duspatalin

    4. Colofac

    5. Csag-144

    6. Csag 144

    7. Mebeverine Hydrochloride [usan]

    8. Mebeverine (hydrochloride)

    9. Nsc-169101

    10. 15vz5al4jn

    11. 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate;hydrochloride

    12. Mls000028652

    13. Duspatal

    14. Benzoic Acid, 3,4-dimethoxy-, 4-(ethyl(2-(4-methoxyphenyl)-1-methylethyl)amino)butyl Ester, Hydrochloride

    15. Rudakol

    16. Smr000058862

    17. Dsstox_cid_25372

    18. Dsstox_rid_80834

    19. Dsstox_gsid_45372

    20. Mebeverine Hydrochloride (usan)

    21. 4-(ethyl(1-(4-methoxyphenyl)propan-2-yl)amino)butyl 3,4-dimethoxybenzoate Hydrochloride

    22. 4-{ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino}butyl 3,4-dimethoxybenzoate Hydrochloride

    23. Nsc 169101

    24. Nsc169101

    25. Einecs 220-400-0

    26. Unii-15vz5al4jn

    27. Sr-01000003159

    28. 4-(ethyl(p-methoxy-.alpha.-methylphenethyl)amino)butyl Veratrate Hydrochloride

    29. 4-[ethyl(p-methoxy-.alpha.-methylphenethyl)amino]butyl Veratrate Hydrochloride

    30. Prestwick_587

    31. Mebeverine D6 Hcl

    32. Colofac Hydrochloride

    33. Duspatal Hydrochloride

    34. Duspatalin Hydrochloride

    35. Opera_id_1589

    36. Ncgc00016617-01

    37. 4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl Veratrate Hydrochloride

    38. Cas-2753-45-9

    39. Mls001148590

    40. Mls002222299

    41. Schembl121977

    42. Spectrum1501117

    43. Regid_for_cid_17683

    44. Chembl1446650

    45. Dtxsid1045372

    46. Hms1568n22

    47. Hms1921f15

    48. Pharmakon1600-01501117

    49. Bcp28149

    50. Ex-a4568

    51. Hy-a0078

    52. Tox21_110527

    53. Ccg-39022

    54. Mebeverine Hydrochloride [mi]

    55. Mfcd00083411

    56. Nsc757840

    57. S5027

    58. Akos027420570

    59. Tox21_110527_1

    60. Cs-6931

    61. Nsc-757840

    62. 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl 3,4-dimethoxybenzoate Hydrochloride

    63. Mebeverine Hydrochloride [mart.]

    64. Veratric Acid, 4-(ethyl(p-methoxy-alpha-methylphenethyl)amino)butyl Ester, Hydrochloride

    65. Mebeverine Hydrochloride [who-dd]

    66. Ncgc00018277-06

    67. Ncgc00094900-01

    68. Ncgc00094900-02

    69. Ncgc00094900-03

    70. 3,4-dimethoxybenzoic Acid 4-[ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino]butyl Ester Hydrochloride

    71. Veratric Acid, Butyl Ester, Hydrochloride

    72. Db-047240

    73. Ft-0603620

    74. Mebeverine Hydrochloride, Analytical Standard

    75. D04868

    76. Mebeverine Hydrochloride [ep Monograph]

    77. N16922

    78. Wln: 1or Bo1 Dvo4n2&y1&1r Do1 &gh

    79. 753m459

    80. A819105

    81. Sr-01000003159-4

    82. W-109821

    83. Mebeverine Hcl Pound>>csag-144 Pound>>csag 144 Pound>>csag144

    84. 3,4-dimethoxybenzoicacid4-ethyl2-(4-methoxyphenyl)-1-methylethylaminobutylesterhydrochloride

    85. 4-(ethyl(1-(4-methoxyphenyl)propan-2-yl)amino)butyl3,4-dimethoxybenzoatehydrochloride

    86. Veratric Acid, 4-[ethyl(p-methoxy-.alpha.-methylphenethyl)amino]butyl Ester Hydrochloride

    87. 3,4-dimethoxybenzoic Acid 4-[ethyl-[1-(4-methoxyphenyl)propan-2-yl]amino]butyl Ester Hydrochloride

    88. Benzoic Acid,4-dimethoxy-, 4-[ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino]butyl Ester, Hydrochloride

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 466.0 g/mol
    Molecular Formula C25H36ClNO5
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count14
    Exact Mass465.2282009 g/mol
    Monoisotopic Mass465.2282009 g/mol
    Topological Polar Surface Area57.2 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity494
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    Anticonvulsants

    Drugs used to prevent SEIZURES or reduce their severity. (See all compounds classified as Anticonvulsants.)

    API Reference Price

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    04-Jan-2021
    31-Aug-2024
    KGS
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    Average Price (USD/KGS)

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    Quantity (KGS) & Unit rate (USD/KGS) over time

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    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    Mebeverine Manufacturers | Traders | Suppliers

    Mebeverine Manufacturers, Traders, Suppliers 1
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    We have 25 companies offering Mebeverine

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    1. LGM Pharma
    2. Metrochem API Private Limited
    3. Cohance Lifesciences
    4. Jai Radhe Sales
    5. Moehs Iberica
    6. HRV Global Life Sciences
    7. Octavius Pharma Pvt. Ltd
    8. Synthokem Labs
    9. Aspire Lifesciences Pvt Ltd
    10. Credo Life Sciences
    11. Global Calcium
    12. GPT Pharmaceuticals
    13. Guangzhou Tosun Pharmaceutical
    14. Integrin Life Sciences
    15. Meenaxy Pharma Pvt. Ltd
    16. Murli Krishna Pharma
    17. Osmopharm
    18. Pellets Pharma Limited
    19. Piramal Pharma Solutions
    20. Qualitek pharma
    21. RA CHEM PHARMA LIMITED
    22. Recordati
    23. Titan Laboratories
    24. Vasudha Pharma Chem
    25. Zim Laboratories
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