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Meclizine

Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

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ACTIVE PHARMA INGREDIENTS

33 API Suppliers, 20 USDMF, 4 CEP/COS, 4 EU WC, 13 NDC API, 20 Listed Suppliers, $ API Reference Price

33 API Suppliers
20 USDMF
4 CEP/COS
4 EU WC
13 NDC API
20 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

61 FDF Dossiers, 57 FDA Orange Book, 1 Europe, 3 Listed Dossiers

61 FDF Dossiers
57 FDA Orange Book
1 Europe
3 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 12.5MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG

drugProductComposition
TABLET;ORAL - 12.5MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG

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1 Minakem
8 Rochem International Inc
18 SPI Pharma
2 Seqens
2 DKSH
3 Jai Radhe Sales
1 Pharm-RX Chemical
7 Faran Shimi Pharmaceutical
7 Boai NKY Pharmaceuticals Ltd
1 Chynops Pharma
15 Gangwal Healthcare
4 Nanjing Well Pharmaceutical
2 Pfanstiehl
1 ACG Worldwide
10 Actylis
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2 Alcedo Pharmachem
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19 BASF
1 Bioplus Life Sciences
1 Clariant
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8 Pluviaendo
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1 Qianhao Chemical (Hebei) Co., Ltd
1 Qualicaps
35 Roquette
13 Seppic
8 Shanghai Shenmei Pharmaceutical Technology Co., Ltd
1 Shanghai Welltone Material Technology Co., Ltd
1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
2 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
5 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

98 Fillers, Diluents & Binders, 50 Coating Systems & Additives, 48 Direct Compression, 42 Disintegrants & Superdisintegrants, 37 Thickeners and Stabilizers, 32 Taste Masking, 28 Lubricants & Glidants, 26 Granulation, 25 Controlled & Modified Release, 23 Solubilizers, 22 Chewable & Orodispersible Aids, 21 Co-Processed Excipients, 17 Film Formers & Plasticizers, 16 Parenteral, 15 Topical, 8 Emulsifying Agents, 7 API Stability Enhancers, 5 Rheology Modifiers, 5 Empty Capsules, 4 Vegetarian Capsules, 3 Surfactant & Foaming Agents, 2 Coloring Agents

DIGITAL CONTENT

14 NEWS #PharmaBuzz

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14 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Finished Drug Prices

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2 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

8 APIs

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8 APIs

REF. STANDARDS & IMPURITIES

3 EDQM , 2 USP , 3 Others

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3 EDQM
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 126

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

28,503,529

Annual Reports (USD Million)

Finished Drug Prices

328 RELATED EXCIPIENT COMPANIES

534EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Meclizine hydrochloride, Meclizine dihydrochloride monohydrate, 31884-77-2, Postafen, Agyrax, Bonamine

Molecular Formula

C₂₅H₃₁Cl₃N₂O

Molecular Weight

481.9 g/mol

InChI Key

KDLHYOMCWBWLMM-UHFFFAOYSA-N

FDA UNII

HDP7W44CIO

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

1 2D Structure

Meclizine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride

2.1.2 InChI

InChI=1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2

2.1.3 InChI Key

KDLHYOMCWBWLMM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.O.Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

HDP7W44CIO

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Agyrax

2. Antivert

3. Bonamine

4. Bonine

5. Chiclida

6. D Vert

7. D-vert

8. Dihydrochloride, Meclizine

9. Dvert

10. Histametizyn

11. Hydrochloride, Meclizine

12. Meclizine

13. Meclizine Dihydrochloride

14. Meclizine Hydrochloride

15. Meclizine Monohydrochloride

16. Meclozine

17. Monohydrochloride, Meclizine

18. Parachloramine

19. Ru Vert M

20. Ru-vert-m

2.3.2 Depositor-Supplied Synonyms

1. Meclizine Hydrochloride

2. Meclizine Dihydrochloride Monohydrate

3. 31884-77-2

4. Postafen

5. Agyrax

6. Bonamine

7. Hdp7w44cio

8. Meclozine Hydrochloride Monohydrate

9. Ucb-5062

10. 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride

11. Nsc-757094

12. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, Dihydrochloride, Monohydrate

13. Mfcd00941489

14. Meclizine Hcl Hydrate

15. Nsc-28728

16. Unii-hdp7w44cio

17. Antivert (tn)

18. Chembl3989555

19. Chebi:31805

20. Dtxsid30953792

21. Meclizine Hydrochloride (jan/usp)

22. Meclizine Hydrochloride [usp:jan]

23. Bcp13363

24. Meclizine Hydrochloride [jan]

25. Meclizine Hydrochloride [vandf]

26. Nsc 757094

27. 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride Monohydrate

28. Meclizine Hydrochloride [usp-rs]

29. As-13740

30. Meclizine Hydrochloride [orange Book]

31. D01317

32. Meclizine Hydrochloride [usp Monograph]

33. A821043

34. Meclizine Dihydrochloride Monohydrate [mi]

35. (+/-)-meclizine Dihydrochloride Monohydrate

36. Meclozine Hydrochloride Monohydrate [who-dd]

37. Meclizine Dihydrochloride Monohydrate, (+/-)-

38. Q27279880

39. 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine Dihydrochloride Hydrate

40. 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazinedihydrochloridehydrate

41. 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl) Piperazine Dihydrochloride Monohydrate

42. 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride Monohydrate

43. 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine--hydrogen Chloride--water (1/2/1)

44. 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine Hydrate Dihydrochloride;meclizine Dihydrochloride Monohydrate

45. 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Hydrate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₁Cl₃N₂O
Molecular Weight	481.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	480.150197 g/mol
Monoisotopic Mass	480.150197 g/mol
Topological Polar Surface Area	7.5 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	448
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	MECLIZINE HYDROCHLORIDE
Active Ingredient	MECLIZINE HYDROCHLORIDE
Company	AMNEAL PHARMS (Application Number: A201451); EPIC PHARMA LLC (Application Number: A200294); JUBILANT CADISTA (Application Number: A040659); MYLAN PHARMS INC (Application Number: A202640); PAR PHARM (Application Number: A087127); PAR PHARM (Application Number: A087128); SANDOZ (Application Number: A084092); SANDOZ (Application Number: A084843)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Cholinergic Antagonists

Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists. (See all compounds classified as Cholinergic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Emesis Suppression [PE]; Antiemetic [EPC]

API SUPPLIERS

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USDMF

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CEP/COS

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EU WC

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NDC API

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Listed Suppliers

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API Reference Price

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