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Meclizine Hydrochloride

DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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ACTIVE PHARMA INGREDIENTS

33 API Suppliers, 20 USDMF, 4 CEP/COS, 5 EU WC, 13 NDC API, 20 Listed Suppliers, $ API Reference Price

33 API Suppliers
20 USDMF
4 CEP/COS
5 EU WC
13 NDC API
20 Listed Suppliers
$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

61 FDF Dossiers, 57 FDA Orange Book, 1 Europe, 3 Listed Dossiers

61 FDF Dossiers
57 FDA Orange Book
1 Europe
3 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 12.5MG, TABLET;ORAL - 25MG, TABLET;ORAL - 50MG

drugProductComposition
TABLET;ORAL - 12.5MG
TABLET;ORAL - 25MG
TABLET;ORAL - 50MG

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2 Seqens
2 DKSH
1 Pharm-RX Chemical
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1 Shijiazhuang Huaxu Pharmaceutical
12 Sigachi Industries
2 The Dow Chemical Company
2 Ulanqab Kema New Material
1 Valens Pharmachem
5 Vasa Pharmachem
1 Zhejiang Huakang Pharmaceutical

EXCIPIENTS BY APPLICATIONS

96 Fillers, Diluents & Binders, 50 Coating Systems & Additives, 48 Direct Compression, 42 Disintegrants & Superdisintegrants, 37 Thickeners and Stabilizers, 32 Taste Masking, 28 Lubricants & Glidants, 26 Granulation, 25 Controlled & Modified Release, 23 Solubilizers, 22 Chewable & Orodispersible Aids, 21 Co-Processed Excipients, 17 Film Formers & Plasticizers, 16 Parenteral, 15 Topical, 8 Emulsifying Agents, 7 API Stability Enhancers, 5 Rheology Modifiers, 5 Empty Capsules, 4 Vegetarian Capsules, 3 Surfactant & Foaming Agents, 2 Coloring Agents

DIGITAL CONTENT

14 NEWS #PharmaBuzz

media
14 NEWS #PharmaBuzz

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions, 2 Finished Drug Prices

globalSalesInformation
2 US Medicaid Prescriptions
2 Finished Drug Prices

MARKET PLACE

8 APIs

marketPlace
8 APIs

REF. STANDARDS & IMPURITIES

3 EDQM , 2 USP , 3 Others

otherSolutions
3 EDQM
2 USP
3 Others

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 126

MARKET PLACE

API

FDF

1INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

28,503,529

Annual Reports (USD Million)

Finished Drug Prices

325 RELATED EXCIPIENT COMPANIES

532EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Meclizine hydrochloride, Meclizine dihydrochloride monohydrate, 31884-77-2, Postafen, Agyrax, Bonamine

Molecular Formula

C₂₅H₃₁Cl₃N₂O

Molecular Weight

481.9 g/mol

InChI Key

KDLHYOMCWBWLMM-UHFFFAOYSA-N

FDA UNII

HDP7W44CIO

A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

1 2D Structure

Meclizine Hydrochloride

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride

2.1.2 InChI

InChI=1S/C25H27ClN2.2ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;;/h2-13,18,25H,14-17,19H2,1H3;2*1H;1H2

2.1.3 InChI Key

KDLHYOMCWBWLMM-UHFFFAOYSA-N

2.1.4 Canonical SMILES

CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.O.Cl.Cl

2.2 Other Identifiers

2.2.1 UNII

HDP7W44CIO

2.3 Synonyms

2.3.1 MeSH Synonyms

1. Agyrax

2. Antivert

3. Bonamine

4. Bonine

5. Chiclida

6. D Vert

7. D-vert

8. Dihydrochloride, Meclizine

9. Dvert

10. Histametizyn

11. Hydrochloride, Meclizine

12. Meclizine

13. Meclizine Dihydrochloride

14. Meclizine Hydrochloride

15. Meclizine Monohydrochloride

16. Meclozine

17. Monohydrochloride, Meclizine

18. Parachloramine

19. Ru Vert M

20. Ru-vert-m

2.3.2 Depositor-Supplied Synonyms

1. Meclizine Hydrochloride

2. Meclizine Dihydrochloride Monohydrate

3. 31884-77-2

4. Postafen

5. Agyrax

6. Bonamine

7. Hdp7w44cio

8. Meclozine Hydrochloride Monohydrate

9. Ucb-5062

10. 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrate;dihydrochloride

11. Nsc-757094

12. Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, Dihydrochloride, Monohydrate

13. Mfcd00941489

14. Meclizine Hcl Hydrate

15. Nsc-28728

16. Unii-hdp7w44cio

17. Antivert (tn)

18. Chembl3989555

19. Chebi:31805

20. Dtxsid30953792

21. Meclizine Hydrochloride (jan/usp)

22. Meclizine Hydrochloride [usp:jan]

23. Bcp13363

24. Meclizine Hydrochloride [jan]

25. Meclizine Hydrochloride [vandf]

26. Nsc 757094

27. 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride Monohydrate

28. Meclizine Hydrochloride [usp-rs]

29. As-13740

30. Meclizine Hydrochloride [orange Book]

31. D01317

32. Meclizine Hydrochloride [usp Monograph]

33. A821043

34. Meclizine Dihydrochloride Monohydrate [mi]

35. (+/-)-meclizine Dihydrochloride Monohydrate

36. Meclozine Hydrochloride Monohydrate [who-dd]

37. Meclizine Dihydrochloride Monohydrate, (+/-)-

38. Q27279880

39. 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine Dihydrochloride Hydrate

40. 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazinedihydrochloridehydrate

41. 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl) Piperazine Dihydrochloride Monohydrate

42. 1-(p-chloro-.alpha.-phenylbenzyl)-4-(m-methylbenzyl)piperazine Dihydrochloride Monohydrate

43. 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine--hydrogen Chloride--water (1/2/1)

44. 1-[(4-chlorophenyl)-phenyl-methyl]-4-(m-tolylmethyl)piperazine Hydrate Dihydrochloride;meclizine Dihydrochloride Monohydrate

45. 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Hydrate

2.4 Create Date

2005-06-24

3 Chemical and Physical Properties

Molecular Formula	C₂₅H₃₁Cl₃N₂O
Molecular Weight	481.9 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	480.150197 g/mol
Monoisotopic Mass	480.150197 g/mol
Topological Polar Surface Area	7.5 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	448
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	4

4 Drug and Medication Information

4.1 Drug Information

1 of 1
Drug Name	MECLIZINE HYDROCHLORIDE
Active Ingredient	MECLIZINE HYDROCHLORIDE
Company	AMNEAL PHARMS (Application Number: A201451); EPIC PHARMA LLC (Application Number: A200294); JUBILANT CADISTA (Application Number: A040659); MYLAN PHARMS INC (Application Number: A202640); PAR PHARM (Application Number: A087127); PAR PHARM (Application Number: A087128); SANDOZ (Application Number: A084092); SANDOZ (Application Number: A084843)

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Anti-Allergic Agents

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)

Antiemetics

Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)

Histamine H1 Antagonists

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

Cholinergic Antagonists

Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists. (See all compounds classified as Cholinergic Antagonists.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Emesis Suppression [PE]; Antiemetic [EPC]

API SUPPLIERS

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USDMF

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CEP/COS

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EU WC

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NDC API

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Listed Suppliers

01

LGM Pharma

U.S.A

CPHI Middle east

Not Confirmed

LGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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U.S.A

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Meclizine Hydrochloride

About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.

02

Cohance Lifesciences

India

CPHI Middle east

Not Confirmed

Cohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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India

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Meclizine Hydrochloride

About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.

03

Jai Radhe Sales

India

CPHI Middle east

Not Confirmed

Jai Radhe Sales is your partner for all your sourcing needs.

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India

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Meclizine Hydrochloride

About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.

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04

Pharm-RX Chemical

U.S.A

CPHI Middle east

Not Confirmed

Pharm-Rx is a reputed global importer and distributor of pharmaceutical active ingredients.

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U.S.A

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Meclizine Hydrochloride

About the Company : Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritio...

Pharm-Rx has earned an outstanding reputation since its establishment in 1991, serving as a reputable importer and distributor of active ingredients to the pharmaceutical, nutritional supplement, and food industries. The company maintains an exceptionally selective approach to its suppliers, personally visiting manufacturers overseas to ensure the highest standards. The sustained growth of Pharm-Rx can be attributed to its steadfast commitment to three core values: quality ingredients, competitive pricing, and unparalleled customer service.

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05

Harika Drugs

India

CPHI Middle east

Not Confirmed

Harika Drugs has been providing a qualitative range of Bulk Drugs/ APIs since 1993.

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India

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Meclizine Hydrochloride

About the Company : Our endeavours also lie in the import, and domestic sourcing of raw materials from reliable vendors of the market. We have an excellent infrastructure with world class cGMP facilit...

Our endeavours also lie in the import, and domestic sourcing of raw materials from reliable vendors of the market. We have an excellent infrastructure with world class cGMP facilities. Our manufacturing unit is based near Hyderabad, which is equipped with the latest production equipment to produce super quality Bulk Drugs/APIs. Spread on the area of 18000 sq. m., our factory has high production capacity and as a result of which we are able to satisfy immediate and bulk requirements of our clients.

06

Calyx Chemicals & Pharmaceuticals L...

India

CPHI Middle east

Not Confirmed

07

DK Pharmachem Pvt. Ltd

India

CPHI Middle east

Not Confirmed

08

Keshava Organics

India

CPHI Middle east

Not Confirmed

09

Nishchem International Pvt. Ltd

India

CPHI Middle east

Not Confirmed

10

Srikem Laboratories Pvt. Ltd

India

CPHI Middle east

Not Confirmed

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API Reference Price

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HYDROCHLORIDE USP 43","address":"F-32\/W-6, M.I.D.C.,","city":"DIST.THANE, MAHARASHTRA","supplier":"D K PHARMA ","supplierCountry":"INDIA","foreign_port":"CAIRO","customer":"TO THE ORDER OF","customerCountry":"EGYPT","quantity":"25.00","actualQuantity":"25","unit":"KGS","unitRateFc":"95","totalValueFC":"2164.7","currency":"USD","unitRateINR":7262.9399999999996,"date":"17-Aug-2024","totalValueINR":"181573.5","totalValueInUsd":"2164.7","indian_port":"Bombay Air","hs_no":"29335990","bill_no":"3282967","productDescription":"API","marketType":"LESS REGULATED MARKET","country":"EGYPT","selfForZScoreResived":"Pharma Grade","supplierPort":"Bombay Air","supplierAddress":"F-32\/W-6, M.I.D.C.,, DIST.THANE, MAHARASHTRA","customerAddress":""},{"dataSource":"API Import","activeIngredients":"MECLIZINE HCL","year":"2021","qtr":"Q1","strtotime":1615314600,"product":"MECLIZINE HCL USP 41-(RE-IMPORT - EXPORT WIDE SB NO 3591658DT 03\/07\/2020)","address":"F-32\/W-6, M.I.D.C.,BADLAPUR,","city":"DIST.THANE, MAHARASHTRA","supplier":"DELTA PHARMA","supplierCountry":"INDIA","foreign_port":"","customer":"D K PHARMA ","customerCountry":"INDIA","quantity":"300.00","actualQuantity":"300","unit":"KGS","unitRateFc":"80","totalValueFC":"24362.2","currency":"USD","unitRateINR":"5912","date":"10-Mar-2021","totalValueINR":"1773600","totalValueInUsd":"24362.2","indian_port":"JNPT","hs_no":"29335990","bill_no":"3084238","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"","supplierAddress":"","customerAddress":"F-32\/W-6, M.I.D.C.,BADLAPUR,"},{"dataSource":"API Import","activeIngredients":"","year":"2021","qtr":"Q4","strtotime":1637087400,"product":"MECLIZINE HYDROCHLORIDE MFG LOT NO.: MEC\/006\/02\/21,MEC\/009\/02\/21, MEC\/010\/02\/21, MEC\/011\/02\/21, MEC\/012\/02\/21","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"AMNEAL PHARMACEUTICALS","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"814.00","actualQuantity":"814","unit":"KGS","unitRateFc":"410.5","totalValueFC":"339017.6","currency":"USD","unitRateINR":"31016.1","date":"17-Nov-2021","totalValueINR":"25247065","totalValueInUsd":"339017.6","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29335990","bill_no":"1004579","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"50 HORSEBLOCK RD BROOKHAVEN,NY 11719 USA US","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2022","qtr":"Q1","strtotime":1640975400,"product":"MECLIZINE HYDROCHLORIDE","address":"882\/1-871, NEAR KANKAVATI ,VILLAGE-","city":"AHMEDABAD, GUJARAT","supplier":"AMNEAL PHARMACEUTICALS","supplierCountry":"UNITED STATES","foreign_port":"N\/A","customer":"AMNEAL PHARMACEUTICALS","customerCountry":"INDIA","quantity":"350.00","actualQuantity":"350","unit":"KGS","unitRateFc":"422.8","totalValueFC":"149178.9","currency":"USD","unitRateINR":"31751","date":"01-Jan-2022","totalValueINR":"11112852","totalValueInUsd":"149178.9","indian_port":"Ahmedabad-ZIPL-SEZ","hs_no":"29335990","bill_no":"1000006","productDescription":"API","marketType":"REGULATED MARKET","country":"UNITED STATES","selfForZScoreResived":"Pharma Grade","supplierPort":"N\/A","supplierAddress":"50 HORSEBLOCK RD BROOKHAVEN,NY 11719 USA US","customerAddress":"882\/1-871, NEAR KANKAVATI ,VILLAGE-"},{"dataSource":"API Import","activeIngredients":"","year":"2024","qtr":"Q3","strtotime":1721759400,"product":"(REJECTED & RETURN) MECLIZINE HYDROCHLORIDE,USP (WILL BE RE-EXPORTED AFTER RE-PROCESS) (SB NO.4559395 DT.30.09.2022)","address":"PLOT NO.1-A SEC-16A","city":"NOIDA (U.P) INDIA","supplier":"JUBILANT CADISTA PHARMACEUTICAL ,INC","supplierCountry":"INDIA","foreign_port":"BALTIMORE","customer":"JUBILANT PHARMOVA","customerCountry":"INDIA","quantity":"190.76","actualQuantity":"190.76","unit":"KGS","unitRateFc":"475","totalValueFC":"91650.5","currency":"USD","unitRateINR":"40161.3","date":"24-Jul-2024","totalValueINR":"7661160.05","totalValueInUsd":"91650.5","indian_port":"Bangalore Air","hs_no":"29335990","bill_no":"4655239","productDescription":"Re-export","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"BALTIMORE","supplierAddress":"207.KILEY DRIVE SALISBURY MD 21801-2249 United States AmericaSDNF United States America","customerAddress":"PLOT NO.1-A SEC-16A"}]

Number of Transactions

Total Quantity (KGS)

Total Value (USD)

Quantity (KGS) & Unit rate (USD/KGS) over time

API Imports and Exports

Importing Country	Total Quantity (KGS)	Average Price (USD/KGS)	Number of Transactions

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INTERMEDIATES SUPPLIERS

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DRUG PRODUCT COMPOSITIONS

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DOSAGE - TABLET;ORAL - 12.5MG

USFDA APPLICATION NUMBER - 10721

DOSAGE - TABLET;ORAL - 25MG

USFDA APPLICATION NUMBER - 10721

DOSAGE - TABLET;ORAL - 50MG

USFDA APPLICATION NUMBER - 10721

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CHEMISTRY

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ACTIVE PHARMA INGREDIENTS

33 API Suppliers

20 USDMF

4 CEP/COS

5 EU WC

13 NDC API

20 Listed Suppliers

$ API Reference Price

INTERMEDIATES

1 Intermediates Suppliers

FINISHED DOSAGE FORMULATIONS

61 FDF Dossiers

57 FDA Orange Book

1 Europe

3 Listed Dossiers

DRUG PRODUCT COMPOSITIONS

TABLET;ORAL - 12.5MG

TABLET;ORAL - 25MG

TABLET;ORAL - 50MG

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10 Actylis

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19 BASF

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EXCIPIENTS BY APPLICATIONS

96 Fillers, Diluents & Binders

50 Coating Systems & Additives

48 Direct Compression

42 Disintegrants & Superdisintegrants