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    Chemistry

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    Also known as: 145108-58-3, Dexmedetomidine hcl, Precedex, Dexdomitor, Dexdor, Sileo
    Molecular Formula
    C13H17ClN2
    Molecular Weight
    236.74  g/mol
    InChI Key
    VPNGEIHDPSLNMU-MERQFXBCSA-N
    FDA UNII
    1018WH7F9I
    Dexmedetomidine Hydrochloride
    A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.
    1 2D Structure

    Dexmedetomidine Hydrochloride

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole;hydrochloride
    2.1.2 InChI
    InChI=1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1
    2.1.3 InChI Key
    VPNGEIHDPSLNMU-MERQFXBCSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl
    2.1.5 Isomeric SMILES
    CC1=C(C(=CC=C1)[C@H](C)C2=CN=CN2)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    1018WH7F9I
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dexmedetomidine

    2. Hydrochloride, Dexmedetomidine

    3. Mpv 1440

    4. Mpv-1440

    5. Mpv1440

    6. Precedex

    2.3.2 Depositor-Supplied Synonyms

    1. 145108-58-3

    2. Dexmedetomidine Hcl

    3. Precedex

    4. Dexdomitor

    5. Dexdor

    6. Sileo

    7. Dexmedetomidine (hydrochloride)

    8. Cepedex

    9. Sedadex

    10. (s)-5-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole Hydrochloride

    11. (+)-medetomidine Hydrochloride

    12. Dexmedetomidine Hcl (precedex)

    13. Dexmedetomidine Hydrochloride [usan]

    14. 4-((s)-alpha,2,3-trimethylbenzyl)imidazole Monohydrochloride

    15. D-medetomidine Hydrochloride

    16. Chebi:31472

    17. 1018wh7f9i

    18. Precedex (tn)

    19. (s)-4-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazole Hydrochloride

    20. 4-[(1s)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole Hydrochloride

    21. 5-[(1s)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole;hydrochloride

    22. 145108-58-3 (hcl)

    23. 1h-imidazole, 4-[(1s)-1-(2,3-dimethylphenyl)ethyl]-, Monohydrochloride

    24. 1h-imidazole, 4-(1-(2,3-dimethylphenyl)ethyl)-, Monohydrochloride, (s)-

    25. 1h-imidazole, 5-[(1s)-1-(2,3-dimethylphenyl)ethyl]-, Hydrochloride (1:1)

    26. (s)-medetomidine Hydrochloride

    27. Primadex

    28. Unii-1018wh7f9i

    29. (s)-4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole Hydrochloride

    30. 4-[(1s)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole;hydrochloride

    31. Dexmedetomidinehcl

    32. Igalmi

    33. Mls006011569

    34. Schembl406837

    35. Chembl2106195

    36. Dtxsid40873215

    37. Dexmedetomidine Hcl [vandf]

    38. Act04745

    39. 5-[(1s)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole Hydrochloride

    40. Ac-310

    41. Hy-17034a

    42. Mfcd22683223

    43. S2090

    44. Akos024457275

    45. Akos025402024

    46. Bcp9000600

    47. Ccg-266849

    48. H08d583

    49. Dexmedetomidine Hydrochloride (jan/usp)

    50. As-12485

    51. Dexmedetomidine Hydrochloride [mi]

    52. Smr004703327

    53. Bcp0726000002

    54. Dexmedetomidine Hydrochloride [jan]

    55. Am20080946

    56. D5062

    57. Dexmedetomidine Hydrochloride [mart.]

    58. Sw219607-2

    59. 4-((s)-a,2,3-trimethylbenzyl)imidazole Hcl

    60. Dexmedetomidine Hydrochloride [usp-rs]

    61. Dexmedetomidine Hydrochloride [who-dd]

    62. D01205

    63. Dexmedetomidine Hydrochloride [ema Epar]

    64. A808325

    65. Dexmedetomidine Hydrochloride [green Book]

    66. Dexmedetomidine Hydrochloride [orange Book]

    67. Dexmedetomidine Hydrochloride [usp Monograph]

    68. Q-100166

    69. Q27114321

    70. Z1617901127

    71. Dexmedetomidine Hydrochloride (ema Epar: Veterinary)

    72. (+)-medetomidine Hydrochloride;(s)-medetomidine Hydrochloride

    73. (s)-4-(alpha,2,3-trimethybenzyl)-1h-imidazole Hydrochloride

    74. (s)-5-(1-(2,3-dimethylphenyl)ethyl)-1h-imidazolehydrochloride

    75. 4-((s)-.alpha.,2,3-trimethylbenzyl)imidazole Monohydrochloride

    2.4 Create Date
    2006-07-28
    3 Chemical and Physical Properties
    Molecular Weight 236.74 g/mol
    Molecular Formula C13H17ClN2
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count1
    Rotatable Bond Count2
    Exact Mass236.1080262 g/mol
    Monoisotopic Mass236.1080262 g/mol
    Topological Polar Surface Area28.7 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity205
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameDexmedetomidine hydrochloride
    PubMed HealthDexmedetomidine (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct, Sedative
    Drug LabelDexmedetomidine hydrochloride injection concentrate is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[...
    Active IngredientDexmedetomidine hydrochloride
    Dosage FormInjectable
    Routeinjection; Injection
    Strengtheq 200mcg base/2ml (eq 100mcg base/ml); 100mcg (base) /ml; 100mcg
    Market StatusTentative Approval; Prescription
    CompanyPar Sterile Products; Caraco; Mylan Institutional; Sandoz; Akorn

    2 of 4  
    Drug NamePrecedex
    Drug LabelPrecedex (dexmedetomidine hydrochloride) injection is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Precedex (dexmedetomidine hydrochloride) in 0.9% Sodium Chloride Injection is a sterile, nonpyrogenic ready t...
    Active IngredientDexmedetomidine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strengtheq 200mcg base/2ml (eq 100mcg base/ml); eq 200mcg base/50ml (eq 4mcg base/ml); eq 400mcg base/100ml (eq 4mcg base/ml)
    Market StatusPrescription
    CompanyHospira

    3 of 4  
    Drug NameDexmedetomidine hydrochloride
    PubMed HealthDexmedetomidine (Injection)
    Drug ClassesAnalgesic, Anesthetic Adjunct, Sedative
    Drug LabelDexmedetomidine hydrochloride injection concentrate is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[...
    Active IngredientDexmedetomidine hydrochloride
    Dosage FormInjectable
    Routeinjection; Injection
    Strengtheq 200mcg base/2ml (eq 100mcg base/ml); 100mcg (base) /ml; 100mcg
    Market StatusTentative Approval; Prescription
    CompanyPar Sterile Products; Caraco; Mylan Institutional; Sandoz; Akorn

    4 of 4  
    Drug NamePrecedex
    Drug LabelPrecedex (dexmedetomidine hydrochloride) injection is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Precedex (dexmedetomidine hydrochloride) in 0.9% Sodium Chloride Injection is a sterile, nonpyrogenic ready t...
    Active IngredientDexmedetomidine hydrochloride
    Dosage FormInjectable
    RouteInjection
    Strengtheq 200mcg base/2ml (eq 100mcg base/ml); eq 200mcg base/50ml (eq 4mcg base/ml); eq 400mcg base/100ml (eq 4mcg base/ml)
    Market StatusPrescription
    CompanyHospira

    4.2 Drug Indication

    For sedation of adult intensive care unit patients requiring a sedation level not deeper than arousal in response to verbal stimulation (corresponding to Richmond Agitation-Sedation Scale (RASS) 0 to -3).

    Non-invasive, mildly to moderately painful, procedures and examinations which require restraint, sedation and analgesia in dogs and cats.

    Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures.

    Premedication in dogs and cats before induction and maintenance of general anaesthesia.

    Alleviation of acute anxiety and fear associated with noise in dogs.

    Noninvasive, mildly to moderately painful, procedures and examinations which require restraint, sedation and analgesia in dogs and cats.

    Premedication in cats before induction and maintenance of general anaesthesia with ketamine.

    Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures.

    Premedication in dogs before induction and maintenance of general anaesthesia.

    Non-invasive, mildly to moderately painful, procedures and examinations which require restraint, sedation and analgesia in dogs and cats. Deep sedation and analgesia in dogs in concomitant use with butorphanol for medical and minor surgical procedures. Premedication in dogs and cats before induction and maintenance of general anaesthesia.

    Treatment of bipolar disorder, Treatment of schizophrenia

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Adrenergic alpha-2 Receptor Agonists

    Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)

    Analgesics, Non-Narcotic

    A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS. (See all compounds classified as Analgesics, Non-Narcotic.)

    Hypnotics and Sedatives

    Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Central alpha-2 Adrenergic Agonist [EPC]; General Anesthesia [PE]; Adrenergic alpha2-Agonists [MoA]
    5.3 ATC Code

    N05CM18

    QN05CM18

    QN05CM18

    QN05CM18

    QN05CM18

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    Dexmedetomidine Hydrochloride (IH)

    Date of Issue : 2017-07-05

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    Dexmedetomidine HCl USP

    Date of Issue : 2019-09-12

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    MEDETOMIDINE HYDROCHLORIDE

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    Submission : 1987-02-13

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    Fermion Oy

    Finland
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    CPhI Worldwide, Milan
    Booth #2B26
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothWith Fermion, start the journey of your innovative API.

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    DEXMEDETOMIDINE HYDROCHLORIDE

    VMF Number : 5721

    Submission : 2001-05-21

    Status : Active

    Type : II

    fermion

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    03

    Interquim Sa De Cv

    Spain
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    CPhI Worldwide, Milan
    Booth #24D41
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothInterquim comes from an international group of 50 companies active in the pharma, hospital, diagnostics, fine chemicals & feed sectors.

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    MEDETOMIDINE HYDROCHLORIDE

    VMF Number : 6348

    Submission : 2019-11-01

    Status : Active

    Type : II

    Interquim

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    04

    Interquim Sa De Cv

    Spain
    arrow
    CPhI Worldwide, Milan
    Booth #24D41
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothInterquim comes from an international group of 50 companies active in the pharma, hospital, diagnostics, fine chemicals & feed sectors.

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    DEXMEDETOMIDINE HYDROCHLORIDE

    VMF Number : 6379

    Submission : 2020-07-20

    Status : Active

    Type : II

    Interquim

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    05

    Cpl Sachse

    Germany
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    Luxepack
    Not Confirmed

    06

    Luxepack
    Not Confirmed

    07

    Luxepack
    Not Confirmed

    08

    Pharmatory Oy

    Finland
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    Luxepack
    Not Confirmed
    Full Screen ViewFULL SCREEN VIEW Click here to open all results in a new tab [this preview display 10 results]

    API Reference Price

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    08-Feb-2021
    26-Aug-2024
    KGS
    overview
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    Average Price (USD/KGS)

    Number of Transactions

    Total Quantity (KGS)

    Total Value (USD)

    Quantity (KGS) & Unit rate (USD/KGS) over time

    API Imports and Exports

    Importing Country Total Quantity
    (KGS)    		 Average Price
    (USD/KGS)    		 Number of Transactions

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    DOSAGE - SOLUTION;INTRAVENOUS - EQ 400MCG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 400MCG BASE/4ML (EQ 100MCG BASE/ML)

    USFDA APPLICATION NUMBER - 206628

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    DOSAGE - SOLUTION;INTRAVENOUS - EQ 400MCG BAS...DOSAGE - SOLUTION;INTRAVENOUS - EQ 400MCG BASE/100ML (EQ 4MCG BASE/ML)

    USFDA APPLICATION NUMBER - 206628

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    DOSAGE - INJECTABLE;INJECTION - EQ 1MG BASE/2...DOSAGE - INJECTABLE;INJECTION - EQ 1MG BASE/250ML (EQ 4MCG BASE/ML)

    USFDA APPLICATION NUMBER - 21038

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    DOSAGE - INJECTABLE;INJECTION - EQ 200MCG BAS...DOSAGE - INJECTABLE;INJECTION - EQ 200MCG BASE/2ML (EQ 100MCG BASE/ML)

    USFDA APPLICATION NUMBER - 21038

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    DOSAGE - INJECTABLE;INJECTION - EQ 200MCG BAS...DOSAGE - INJECTABLE;INJECTION - EQ 200MCG BASE/50ML (EQ 4MCG BASE/ML)

    USFDA APPLICATION NUMBER - 21038

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    DOSAGE - INJECTABLE;INJECTION - EQ 400MCG BAS...DOSAGE - INJECTABLE;INJECTION - EQ 400MCG BASE/100ML (EQ 4MCG BASE/ML)

    USFDA APPLICATION NUMBER - 21038

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    DOSAGE - INJECTABLE;INJECTION - EQ 80MCG BASE...DOSAGE - INJECTABLE;INJECTION - EQ 80MCG BASE/20ML (EQ 4MCG BASE/ML)

    USFDA APPLICATION NUMBER - 21038

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    Denmark.png
    Dexmedetomidine (1 MT/ annum) API needed in Denmark [ENA18951]
    A company that focuses on the marketing and distribution of various pharmaceutical products is looking for suppliers of Dexmedetomidine (1 MT/ annum) API for commercial purposes. The suppliers must support this enquiry with CEP/DMF & CoA.
    25 Jan 2024

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    25 Jan 2024

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    25 Jan 2024

    Israel.png
    Dexmedetomidine HCl API needed in Israel [ENA18348]
    A company that deals in various pharmaceutical products is looking for suppliers of Dexmedetomidine HCl API for commercial purposes. The suppliers must support this enquiry with CoA.
    16 Oct 2023

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    16 Oct 2023

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    Reply Comment (10)

    16 Oct 2023

    United_States_of_America.png
    Dexmedetomidine HCl (20 g) API needed in the United States [ENA17678]
    A biopharmaceutical company that focuses on the development and commercialization of ophthalmic formulations is looking for suppliers of Dexmedetomidine HCl (20 g) API for development purposes. The suppliers must support this enquiry with USDMF, USFDA & GMP.
    26 Jul 2023

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    26 Jul 2023

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    26 Jul 2023

    Uzbekistan.png
    Various APIs needed in Uzbekistan [ENA17520]
    A company that focuses on research, development & manufacturing of injectables is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with DMF & CoA. 1. Injectable Grade Propofol (500 g) API 2. Injectable Grade Dexmedetomidine HCl (5.9 g) API
    11 Jul 2023

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    11 Jul 2023

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    11 Jul 2023

    india-flag.png
    Various APIs needed in India [ENA16589]
    A company that focuses on the manufacturing of liquid injections, dry powder injections, eye, ear and nasal drops is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with CoA. 1. Alanyl Glutamine (20%) API 2. Dexmedetomidine HCl API 3. Nitroglycerin API
    13 Mar 2023

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    13 Mar 2023

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    13 Mar 2023

    United_States_of_America.png
    Dexmedetomidine HCl (100 g - 500 g) API needed in the United States [ENA15581]
    A biopharmaceutical company focused on the development and commercialization of ophthalmic formulations is looking for suppliers of Dexmedetomidine HCl (100 g - 500 g) API for development purposes. The suppliers must support this enquiry with USDMF, USFDA & GMP.
    17 Nov 2022

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    17 Nov 2022

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    17 Nov 2022

    Kazakhstan.png
    Dexmedetomidine Hydrochloride (MOQ) API needed in Kazakhstan [ENA14826]
    A leading pharmaceutical company that focuses on the manufacturing of infusion and injection solutions is looking for suppliers of Dexmedetomidine Hydrochloride (MOQ) API for development purpose. The suppliers must support this enquiry with DMF, GMP & CoA.
    27 Aug 2022

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    27 Aug 2022

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    27 Aug 2022

    United_States_of_America.png
    Dexmedetomidine Hydrochloride API needed in the United States [ENA11902]
    A clinical-stage biopharmaceutical company that deals in the development of transformative medicines in neuroscience and immuno-oncology is looking for suppliers of Dexmedetomidine Hydrochloride API for commercial purpose. The suppliers must support this enquiry with DMF.
    20 Nov 2021

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    20 Nov 2021

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    20 Nov 2021

    india-flag.png
    Dexmedetomidine Hydrochloride (100 g) API needed in India [ENA10929]
    A leading research and development-driven pharmaceutical company which deals in innovation, manufacturing & supplying of bulk drugs is looking for suppliers of Dexmedetomidine Hydrochloride (100 g) API for development purpose. The suppliers must support this enquiry with CoA.
    22 Jul 2021

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    22 Jul 2021

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    22 Jul 2021

    india-flag.png
    Various APIs needed in India [ENA10362]
    A pharmaceutical company that focuses on general products, Beta-Lactum/ Cephalosporins in the form of tablets, capsules, liquid-orals, ointments, creams, lotions and powdered injections is looking for suppliers of Various APIs for development purposes. The suppliers must support this enquiry with CoA. 1. BP/ USP Grade Atracurium Besylate (10 kg) API 2. BP/ USP Grade CIS Atracurium Besylate (1.5 kg) API 3. BP/ USP Grade Dexmedetomidine HCl (25 g) API 4. BP/ USP Grade Epinephrine (30 g) API 5. BP/ USP Grade Etomidate (50 g) API 6. BP/ USP Grade Norepinephrine (2 kg) API 7. BP/ USP Grade Pancuronium Bromide (150 g) API 8. BP/ USP Grade Succinylcholine chloride (10 kg) API
    07 May 2021

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    07 May 2021

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    07 May 2021

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